Major interaction on record — check this product against your medications before combining. Based on 7 of 10 ingredients. Check your meds →
Dietary supplement

GastroDefense Daily Therapy Ingredients & Drug Interactions

by Sovereign Laboratories

GastroDefense Daily Therapy label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking GastroDefense Daily Therapy against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

GastroDefense Daily Therapy is a dietary supplement by Sovereign Laboratories with 10 active ingredients. Its ingredients are commonly taken for constipation and regularity, prebiotic gut health, blood sugar support.Based on those ingredients, 641 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Cape Aloe, B. bifidum, Acidophilus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against GastroDefense Daily Therapy by Sovereign Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with GastroDefense Daily Therapy by Sovereign Laboratories — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of GastroDefense Daily Therapy by Sovereign Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 10 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (658 mg) without saying how much of each component you get.

GastroDefense Daily Therapy contains 10 active ingredients: L. rhamnosus, Inulin, B. bifidum, Acidophilus, B. longum, B. lactis, Cape Aloe, Oat, LactoSpore (Bacillus coagulans), and Colostrum-LD. Most are probiotics — live microorganisms meant to support digestive and immune function — plus Inulin (a plant fiber), Cape Aloe (a plant extract), and Oat.

The capsule also contains silicon dioxide and gelatin as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports balanced immune and digestive system.
  • We looked for evidence on: Constipation, Diarrhea, Antibiotic-associated diarrhea, Clostridioides difficile infection, Irritable bowel syndrome, Dysbiosis — and 2 related terms.
  • The strongest evidence on file: Aloe is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea, Irritable bowel syndrome (IBS).
  • Also on file: Inulin is rated "Possibly Effective" for Constipation.

The data we hold shows that Inulin is possibly effective for obesity, constipation, and diabetes, though evidence for constipation and diabetes remains unclear in some cases. B. bifidum is possibly effective for irritable bowel syndrome (IBS) and respiratory tract infections.

Acidophilus is possibly effective for IBS, Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. B. longum's effectiveness is not established for the conditions listed.

LactoSpore (Bacillus coagulans) is possibly effective for constipation and IBS. Cape Aloe is possibly effective for acne, obesity, diabetes, psoriasis, burns, and constipation.

Oat is likely effective for dyslipidemia (abnormal cholesterol) and coronary heart disease. We do not hold effectiveness data for L. rhamnosus, B. lactis, or Colostrum-LD.

The evidence, ingredient by ingredient Inulin Bifidobacterium Bifidum Lactobacillus Acidophilus Bifidobacterium Longum Aloe Oats Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients in this product are generally well tolerated in healthy adults. However, several cautions apply.

Inulin commonly causes gas, bloating, and constipation or diarrhea — especially at doses over 30 grams — and anaphylaxis is rare but documented. The probiotics (B. bifidum, Acidophilus, B. longum, and LactoSpore) are generally well tolerated in healthy people but warrant caution in those with weakened immune systems; rare cases of serious infection have been reported in critically ill patients.

Cape Aloe is the most concerning: oral aloe latex causes abdominal pain, cramps, and diarrhea, and long-term use can lead to serious electrolyte imbalances and muscle weakness. Oat is well tolerated as food and may cause bloating or flatulence as intake increases.

For pregnancy and breastfeeding: Inulin is likely safe, B. bifidum and Acidophilus are possibly safe in pregnancy (lactation data not on file), B. longum is possibly safe in both, Cape Aloe is possibly unsafe in both — the latex may stimulate the uterus and harm the fetus — Oat is likely safe in both as food, and LactoSpore's pregnancy and lactation safety data are not on file.

Side effects, ingredient by ingredient Inulin Bifidobacterium Bifidum Lactobacillus Acidophilus Bifidobacterium Longum Aloe Oats Bacillus Coagulans

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 7 of the 7 matched ingredients can interact with medications — Aloe, Lactobacillus Acidophilus, Oats, Inulin, Bacillus Coagulans, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications.
  • For scale: 641 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking GastroDefense Daily Therapy, check with your doctor or pharmacist if you take digoxin (Lanoxin) or any heart medication — this is the highest-severity interaction. Also discuss it if you take blood thinners, warfarin, diabetes medications, insulin, or diuretics (water pills).

If you take antibiotics, you'll need to space them apart from this product to protect the live probiotics.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is designed to support digestive health through probiotics, fiber, and plant extracts. If you take diabetes medications, blood thinners, diuretics, or digoxin, or if you are pregnant or breastfeeding, talk with your doctor or pharmacist before starting — several ingredients carry documented interactions or safety concerns.

If you take antibiotics, space them out from this product (probiotics work best when separated from antibiotics). Expect possible digestive side effects like gas and bloating, especially early on.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about GastroDefense Daily Therapy, straight from the product label.

Brand Sovereign Laboratories
Barcode (UPC) 863784000198
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jan 22, 2022
DSLD ID 258999
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for GastroDefense Daily Therapy by Sovereign Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
863784000198
IngredientAmount% DV
L. rhamnosus0 NP--
Inulin0 NP--
B. bifidum0 NP--
Acidophilus0 NP--
B. longum0 NP--
B. lactis0 NP--
Proprietary Blend658 mg--
Cape Aloe0 NP--
Oat0 NP--
LactoSpore0 NP--
Colostrum-LD0 NP--

Other ingredients: Silicon Dioxide, Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

GastroDefense Daily Therapy supports a balanced healthy immune and digestive system.

GastroDefense Daily Therapy helps promote regularity, supports immune response and maintains healthy intestinal flora for a balanced digestive system.

- Supports healthy immune response - Helps maintain a healthy microbiome - Promotes regularity - Liposomal delivery for optimal absorption

Formula

It is a proprietary formula made up of 6 powerful probiotics, inulin, oat fiber and our own Colostrum-LD bovine colostrum.

Colostrum is the first food of life and is collected from the first milking of Grade A dairy cows. Colostrum-LD is coated with bio-identical liposomal lipids extracted from milk and sunflower oils to help protect the colostrum from the digestion process for optimal absorption.

Improved! 2x more colostrum

Colostrum-LD, Cape aloe, oat, inulin, LactoSpore, acidophilus, L. rhamnosus, B. bifidum, B. longum, B. lactis

Brand IP Statement(s)

LactoSpore is a registered trademark of Sabinsa

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

658 mg each

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Adults take 1 capsule as needed or as directed by a healthcare professional. May be increased to 2 capsules.

Precautions

Warning: Contains cape aloe. Read and follow directions carefully. Do not use if you have or develop diarrhea, loose stools, or abdominal pain because cape aloe may worsen these conditions.

Consult your physician if you have frequent diarrhea or if you are pregnant, nursing, taking medication, or have a medical condition.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

GastroDefense Daily Therapy by Sovereign Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

GastroDefense Daily Therapy label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in GastroDefense Daily Therapy by Sovereign Laboratories

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

658 mg per serving

Other (inactive) ingredients: Silicon Dioxide, Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

GastroDefense Daily Therapy by Sovereign Laboratories Drug Interactions

Want to check YOUR meds against GastroDefense Daily Therapy?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
641Drugs
1 Major 485 Moderate 155 Minor

Ingredients driving the most interactions

Cape Aloe 461
B. bifidum 182
Acidophilus 182
B. longum 182
LactoSpore 182

Individual Drug Interactions

The ingredients in GastroDefense Daily Therapy interact with 641 drugs. Click any drug to see the details.

7 of the 10 ingredients in GastroDefense Daily Therapy interact with drugs. Each result below shows which ingredient is responsible. Cape Aloe B. bifidum Acidophilus B. longum LactoSpore Inulin Oat

Each ingredient & the kinds of drugs it affects

For each ingredient in GastroDefense Daily Therapy with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Cape Aloe7 drug types · 461 drugs

Digoxin (Lanoxin)

Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Overuse of aloe latex can increase the risk of adverse effects from cardiac glycoside drugs, such as digoxin, due to potassium depletion. Overuse of aloe, along with cardiac glycoside drugs, can increase the risk of toxicity.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aloe gel can inhibit platelet aggregation. This inhibition was greater than that seen with celecoxib, but less than that seen with aspirin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Preliminary clinical research suggests aloe gel might lower blood glucose levels and have additive effects when used with antidiabetes drugs. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of aloe latex might compound diuretic-induced potassium loss, increasing the risk of hypokalemia.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Due to cathartic laxative effects of aloe latex, concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, aloe latex might increase the risk of bleeding when taken with warfarin.
Aloe latex has stimulant laxative effects. In some people aloe latex can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of aloe vera.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that aloe extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cape Aloe full monograph & interactions

B. bifidum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
B. bifidum full monograph & interactions

Acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Acidophilus full monograph & interactions

B. longum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
B. longum full monograph & interactions

LactoSpore1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
LactoSpore full monograph & interactions

Inulin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, inulin might increase the risk of hypoglycemia with antidiabetes drugs.
Some clinical research shows that inulin improves glycemic control in patients with diabetes; however, it is unclear if it has hypoglycemic effects.

Likelihood Unlikely Evidence D
Inulin full monograph & interactions

Oat2 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, oats may have additive effects with antidiabetic agents and might increase the risk of hypoglycemia.
Consuming oats can decrease blood glucose in patients with diabetes. In those who require insulin, taking oats 100 grams daily for 2 days reduces the insulin dose required to achieve metabolic control.

Likelihood Possible Evidence D
Insulin

Concomitant use of oats and insulin might increase the risk of hypoglycemia.
In patients with insulin-dependent type 2 diabetes, taking oats 100 grams daily for 2 days reduces the insulin dose required to achieve metabolic control.

Likelihood Possible Evidence B
Oat full monograph & interactions
The maker

Brand information

Manufacturer and brand details for GastroDefense Daily Therapy, from the product label.

Sovereign Laboratories

See all Sovereign Laboratories products
Name
Sovereign Laboratories
Street Address
30 N. Alamos Dr.
City
Cottonwood
State
AZ
ZipCode
86326-4020
Phone Number
928-202-4031
Web Address
www.mysovlabs.com
Pharmacist Counseling Corner

GastroDefense Daily Therapy by Sovereign Laboratories: Common Questions

Does GastroDefense Daily Therapy by Sovereign Laboratories interact with any medications?
Yes. Based on its ingredients, GastroDefense Daily Therapy has a known interaction with 641 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
GastroDefense Daily Therapy contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What do the probiotics in this product do?
The probiotics — L. rhamnosus, B. bifidum, Acidophilus, B. longum, B. lactis, and LactoSpore — are live microorganisms meant to support digestive and immune function. B. bifidum and Acidophilus have the strongest evidence for irritable bowel syndrome and certain infections; the others have emerging or limited evidence.
Will this help with my constipation?
Several ingredients — Inulin, B. longum, LactoSpore, and Cape Aloe — are possibly effective for constipation based on the data we hold. That said, these ingredients work in different ways and evidence varies. Talk with your doctor about which one might work best for your situation.
Why can't I take this with antibiotics?
The probiotics in this product are live organisms. Antibiotics kill bacteria, so taking them at the same time may kill much of the probiotic before it can work. Separate the two by at least a few hours — your doctor or pharmacist can tell you the best timing.
Is Cape Aloe safe to take every day?
Cape Aloe is generally well tolerated in typical doses, but oral aloe latex — the part used in this product — can cause abdominal pain, cramps, and diarrhea. Long-term or high-dose use raises the risk of serious side effects like electrolyte imbalances and muscle weakness. Talk with your doctor before using it long-term.
Can I take this while pregnant?
Most ingredients are likely or possibly safe in pregnancy; however, Cape Aloe is possibly unsafe — the latex may stimulate the uterus and act as a strong laxative. Talk with your doctor or pharmacist before taking this product if you are pregnant, especially because of the aloe content.
Will this interact with my diabetes medication?
Yes. Cape Aloe, Oat, and Inulin may all lower blood sugar and could increase the risk of low blood sugar if you take diabetes drugs or insulin. Talk with your doctor before starting, and monitor your blood sugar closely if you do use it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

GastroDefense Daily Therapy label
Go deeper

The Full Monographs Behind GastroDefense Daily Therapy’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Inulin

Interacts with 86 drugs

Inulin is a type of plant fiber (a prebiotic) found naturally in foods like chicory root, onions, and garlic, and it is widely added to supplements and processed foods. It may help with regu...

Read the full Inulin monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph → Herb & supplement monograph

Aloe

Interacts with 461 drugs

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a strong laxative that can cause cramping and...

Read the full Aloe monograph → Herb & supplement monograph

Oats

Interacts with 86 drugs

Oats are a well-studied whole grain whose soluble fiber (beta-glucan) can help lower cholesterol and support heart health when eaten regularly. As a food, oats are safe for most people, and...

Read the full Oats monograph → Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

GastroDefense Daily Therapy's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 134 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Inulin 17 references
  1. Williams CM. Effects of inulin on lipid parameters in humans. J Nutr 1999 Jul;129(7 Suppl):1471S-3S. PubMed
  2. Pedersen A, Sandstrom B, Van Amelsvoort JM. The effect of ingestion of inulin on blood lipids and gastrointestinal symptoms in healthy females. Br J Nutr 1997;78:215-22. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Bonnema AL, Kolberg LW, Thomas W, Slavin JL. Gastrointestinal tolerance of chicory inulin products. J Am Diet Assoc 2010;110(6):865-8. PubMed
  5. Dehghan P, Gargari BP, Jafar-Abadi MA, Aliasgharzadeh A. Inulin controls inflammation and metabolic endotoxemia in women with type 2 diabetes mellitus: a randomized-controlled clinical trial. Int J Food Sci Nutr 2014;65(1):117-23. PubMed
  6. Guess ND, Dornhorst A, Oliver N, Frost GS. A randomised crossover trial: the effect of inulin on glucose homeostasis in subtypes of prediabetes. Ann Nutr Metab 2016;68(1):26-34. PubMed
  7. Marteau P, Jacobs H, Cazaubiel M, Signoret C, Prevel JM, Housez B. Effects of chicory inulin in constipated elderly people: a double-blind controlled trial. Int J Food Sci Nutr 2011;62(2):164-70. PubMed
  8. Mensink MA, Frijlink HW, van der Voort Maarschalk K, Hinrichs WL. Inulin, a flexible oligosaccharide I: review of its physicochemical characteristics. Carbohydr Polym 2015;130:405-19. PubMed
  9. Slavin J, Feirtag J. Chicory inulin does not increase stool weight or speed up intestinal transit time in healthy male subjects. Food Funct. 2011;2(1):72-7. PubMed
  10. Micka A, Siepelmeyer A, Holz A, Theis S, Schön C. Effect of consumption of chicory inulin on bowel function in healthy subjects with constipation: a randomized, double-blind, placebo-controlled trial. Int J Food Sci Nutr. 2017;68(1):82-89. PubMed
  11. Smiljanec K, Mitchell CM, Privitera OF, Neilson AP, Davy KP, Davy BM. Pre-meal inulin consumption does not affect acute energy intake in overweight and obese middle-aged and older adults: A randomized controlled crossover pilot trial. Nutr Health. 2017;23 PubMed
  12. Cai X, Yu H, Liu L, et al. Milk powder co-supplemented with inulin and resistant dextrin improves glycemic control and insulin resistance in elderly type 2 diabetes mellitus: a 12-week randomized, double-blind, placebo-controlled trial. Mol Nutr Food Res PubMed
  13. Rao M, Gao C, Xu L, et al. Effect of inulin-type carbohydrates on insulin resistance in patients with type 2 diabetes and obesity: a systematic review and meta-analysis. J Diabetes Res. 2019;2019:5101423. PubMed
  14. Mitchell CM, Davy BM, Ponder MA, et al. Prebiotic Inulin Supplementation and Peripheral Insulin Sensitivity in adults at Elevated Risk for Type 2 Diabetes: A Pilot Randomized Controlled Trial. Nutrients 2021;13(9):3235. PubMed
  15. Li L, Li P, Xu L. Assessing the effects of inulin-type fructan intake on body weight, blood glucose, and lipid profile: A systematic review and meta-analysis of randomized controlled trials. Food Sci Nutr 2021;9(8):4598-4616. PubMed
  16. Ziaei R, Shahshahan Z, Ghasemi-Tehrani H, Heidari Z, Ghiasvand R. Effects of inulin-type fructans with different degrees of polymerization on inflammation, oxidative stress and endothelial dysfunction in women with polycystic ovary syndrome: A randomized,
  17. Risso D, Kaczmarczyk M, Laurie I, et al. Moderate intakes of soluble corn fibre or inulin do not cause gastrointestinal discomfort and are well tolerated in healthy children. Int J Food Sci Nutr 2022;73(8):1104-1115. PubMed

See these in context on the Inulin monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Lactobacillus Acidophilus 15 references
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See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Longum 21 references
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Aloe 41 references
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Oats 13 references
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  11. Sobhan M, Hojati M, Vafaie SY, Ahmadimoghaddam D, Mohammadi Y, Mehrpooya M. The efficacy of colloidal oatmeal cream 1% as add-on therapy in the management of chronic irritant hand eczema: A double-blind study. Clin Cosmet Investig Dermatol. 2020;13:241-25
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Bacillus Coagulans 20 references
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