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Dietary supplement

Zeaxanthin Ingredients & Drug Interactions

by EyePromise

Zeaxanthin label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Zeaxanthin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Zeaxanthin is a dietary supplement by EyePromise with 1 active ingredient. Its ingredients are commonly taken for eye and macular health, age-related macular degeneration (amd), protection from blue light.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zeaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Zeaxanthin by EyePromise

Ask about any prescription or over-the-counter medication and we check it for interactions with Zeaxanthin by EyePromise — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Zeaxanthin by EyePromise

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: zeaxanthin, a yellow pigment found naturally in the eye that belongs to a group of compounds called carotenoids. The softgel also includes inactive ingredients like olive oil, glycerin, and carrageenan that help deliver the zeaxanthin.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Eye and macular health support.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Glaucoma, Macular telangiectasia type 2, Retinopathy of prematurity — and 4 related terms.
  • The strongest evidence on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Zeaxanthin is rated "Insufficient Reliable Evidence To Rate" for Cataracts, Glaucoma, Retinopathy of prematurity, Asthenopia (eye strain), and more.

Zeaxanthin is possibly effective for age-related macular degeneration (AMD), a common eye condition that affects central vision as you age. For age-related cognitive decline, Alzheimer disease, asthma, breast cancer, and bronchopulmonary dysplasia, there isn't enough reliable evidence in our data to rate how well it works.

The evidence, ingredient by ingredient Zeaxanthin

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Zeaxanthin is generally well tolerated at typical supplement doses. Dietary amounts from food are fine during pregnancy and breastfeeding, but there isn't enough data on concentrated supplements in these situations — talk with your doctor or pharmacist for personalized advice.

No adverse effects were reported in the available data.

Side effects, ingredient by ingredient Zeaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs (insulin, metformin, sulfonylureas, or similar), double-check your medications before starting zeaxanthin — it may increase the risk of low blood sugar.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

Zeaxanthin may help with age-related macular degeneration if you're looking to support eye health. If you take blood sugar medication, check with us before starting — zeaxanthin might lower your blood sugar further.

Your pharmacist can help you figure out if this is the right fit for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Zeaxanthin, straight from the product label.

Brand EyePromise
Barcode (UPC) 185656000106
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Jun 24, 2020
DSLD ID 229030
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Zeaxanthin by EyePromise, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Softgel(s)
Maximum serving Sizes:
1 Vegetarian Softgel(s)
Servings per container
60
UPC/BARCODE
185656000106
IngredientAmount% DV
Zeaxanthin10 mg--

Other ingredients: Olive Oil, ZeaGold, Starch, Glycerin, purified Water, Maltitol, Carrageenan

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

ZeaGold

Suggested/Recommended/Usage/Directions

Directions: Adults take 1 softgel with a meal up to twice daily, or as directed by your eye care professional.

Storage

Store at room temperature: 59 degrees - 77 degrees F (15 degrees - 25 degrees C). Do not expose to excessive heat.

Formulation

Recommended by doctors. Trusted by professional athletes. Guaranteed improvement.

Live in focus.

The starting point to naturally improving your vision.

Yeast/gluten free.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Warning: If you are pregnant or nursing, taking any medications or planning any medical procedure, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of the reach of children.

Do not use if seal under cap is broken or missing.

General Statements

60-Day money back guarantee

FDA Statement of Identity

Eye Health Dietary Supplement

Seals/Symbols

Contents Certified NSF Manufactured in the U.S.A.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Zeaxanthin by EyePromise label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Zeaxanthin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Zeaxanthin by EyePromise

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Zeaxanthin

Interacts with
86 drugs
10 mg per serving

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin monograph & interactions

Other (inactive) ingredients: Olive Oil, ZeaGold, Starch, Glycerin, Purified Water, Maltitol, Carrageenan. These complete the product’s ingredient list but are not active constituents.

Interaction report

Zeaxanthin by EyePromise Drug Interactions

Want to check YOUR meds against Zeaxanthin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Zeaxanthin 86

Individual Drug Interactions

The ingredients in Zeaxanthin interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Zeaxanthin interact with drugs. Each result below shows which ingredient is responsible. Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Zeaxanthin with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Zeaxanthin, from the product label.

EyePromise

See all EyePromise products
Name
ZeaVision Holdings Inc.
City
St. Louis
State
MO
ZipCode
63005
Phone Number
866.833.2800
Web Address
Eyepromise.com
Pharmacist Counseling Corner

Zeaxanthin by EyePromise: Common Questions

Does Zeaxanthin by EyePromise interact with any medications?
Yes. Based on its ingredients, Zeaxanthin has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Zeaxanthin contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is zeaxanthin?
Zeaxanthin is a yellow carotenoid — a type of pigment — that's found naturally in the eye, particularly in the macula (the part that gives you detailed central vision). You get it from foods like leafy greens, corn, and egg yolks.
Does zeaxanthin really help with age-related macular degeneration?
The evidence suggests it's possibly effective for AMD. That means there's some research backing it, but it's not ironclad. Talk with your eye doctor about whether it makes sense for your situation.
Is this safe to take while pregnant or breastfeeding?
Food sources of zeaxanthin are fine, but there isn't enough data on concentrated supplements during pregnancy and breastfeeding. Reach out to your doctor or pharmacist to discuss what's right for you and your baby.
Are there any side effects I should know about?
Zeaxanthin is generally well tolerated at typical doses, and no adverse effects showed up in the available data. That said, everyone's different — if you notice anything unusual after starting, let us know.
What are the inactive ingredients in this softgel?
The softgel contains olive oil, ZeaGold, starch, glycerin, purified water, maltitol, and carrageenan — these help deliver the zeaxanthin and keep the capsule stable.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Zeaxanthin is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Zeaxanthin label
Go deeper

The Full Monographs Behind Zeaxanthin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph →
Sources

Sources & How We Checked

Zeaxanthin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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