FDA-filed SPL labeling · retrieved through openFDA

Bupivacaine / Epinephrine

Bupivacaine/Epinephrine is a long-acting local anesthetic injection used to numb a specific area of the body during surgery, dental procedures, or other medical treatments.

Brand names Marcaine with EpinephrineSensorcaineSensorcaine MpfVivacaineMarcaine +1 more
Drug classes ⓘ Amide Local Anesthetic
Rx Form 1 Routes Epidural; Infiltration; Intracaudal; Perineural · Perineural · Epidural; Intracaudal; Perineural · Epidural, Infiltration, Intracaudal, Perineural +7
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 13 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveMay 29, 2026
Clinical labels in scope ⓘ13
AvailabilityRx
Earliest approval/marketing year ⓘ2005
FDA-listed product records ⓘ70
Boxed warningYes
How we combine label and product data →
✓No current FDA shortage listed · checked Sep 24, 2026
⭐ Bupivacaine / Epinephrine at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Bupivacaine/Epinephrine is a powerful, long-acting local anesthetic given by a healthcare professional to numb a specific area for surgery, dental work, or other procedures. It carries serious risks — including cardiac arrest — if it accidentally enters the bloodstream, so it is only given in controlled medical settings with emergency equipment ready. If you have questions about why it was chosen for your procedure or what to expect, your anesthesiologist or care team is the best person to ask.
How we write & review this content — our editorial policy →
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾

The highest concentration (0.75%) of this medication must NOT be used for epidural anesthesia in obstetrical (labor and delivery) patients. There have been reports of cardiac arrest — often impossible to reverse — and death in pregnant patients who received this concentration via epidural. Cardiac arrest in these cases followed seizures caused by the drug entering the bloodstream accidentally. This concentration should only be used in specific surgical situations requiring deep muscle relaxation.

This medication should only be given by clinicians who are fully trained in recognizing and managing toxic reactions, and only in settings where oxygen, emergency drugs, and resuscitation equipment are immediately available. Delays in managing a toxic reaction — or any breathing problem — can lead to a dangerous drop in blood pH (acidosis), cardiac arrest, and death.

Solutions from multi-dose vials (which contain preservatives) must never be used for epidural or spinal anesthesia, as the safety of those preservatives near the spinal cord has not been established. Using this drug as a continuous infusion directly into a joint after surgery is also not approved and has caused serious joint cartilage damage.

Read the full warning on DailyMed →

📖 Bupivacaine / Epinephrine: Patient Information Guide

A plain-language walkthrough of Bupivacaine / Epinephrine — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for▾

Bupivacaine/Epinephrine is used in adults to numb or relieve pain in a specific part of the body. Main approved uses include:

  • General and specialized surgery
  • Dental and oral surgery procedures
  • Diagnostic procedures (tests that may cause discomfort)
  • Therapeutic procedures requiring local pain control
  • Obstetrical (pregnancy-related) procedures — with important restrictions on technique and concentration
⚙️How it works▾

Bupivacaine blocks nerve signals by making it harder for nerves to fire. It raises the electrical threshold needed to trigger a nerve impulse, slows how fast impulses travel, and reduces the electrical activity in the nerve fiber. This causes a predictable numbing sequence: pain disappears first, then temperature, then touch, then proprioception (your sense of body position), and finally muscle tone.

Epinephrine is added as a vasoconstrictor — it tightens blood vessels near the injection site. This slows how fast bupivacaine is absorbed into the bloodstream, which prolongs the numbing effect and helps keep drug levels in the blood at a safer range.

💊How it's taken▾

This medication is given by injection only, by a trained healthcare professional. You will not take it at home.

  • It is injected at or near the area to be numbed — the exact technique depends on your procedure (nerve block, epidural, dental injection, etc.).
  • After a dental injection, numbing typically begins within 2–10 minutes and can last up to 7 hours.
  • The dose, concentration, and method are chosen by your care team based on your specific procedure and health status.
  • Single-dose vials should not be saved or reused after opening.
🤒Side effects — in detail▾

Like all local anesthetics, this medication can cause side effects — most are related to how much drug reaches the bloodstream.

  • Restlessness, anxiety, or tremors
  • Shivering or dizziness
  • Nausea or vomiting
  • Drop in blood pressure (hypotension)
  • Slow or irregular heartbeat
  • Allergic reactions: rash, hives, swelling

Seek emergency help immediately for seizures, trouble breathing, loss of consciousness, bluish skin color, or any sign of cardiac arrest — these indicate a serious toxic reaction requiring urgent treatment.

⚠️Warnings & precautions▾
  • Cardiac arrest risk: If bupivacaine accidentally enters a blood vessel, it can cause seizures followed by cardiac arrest that may be impossible to reverse. Emergency equipment must always be available when this drug is used.
  • Obstetrical restriction: The 0.75% concentration must never be used for epidural anesthesia during labor — it has caused deaths that could not be reversed with resuscitation.
  • Sulfite allergy risk: The epinephrine-containing formulation contains sodium metabisulfite, which can trigger severe allergic reactions or life-threatening asthma in sulfite-sensitive people.
  • Methemoglobinemia: A rare but serious condition where blood loses its ability to carry oxygen — watch for bluish skin, rapid heart rate, and confusion.
  • Joint damage: Using this drug as a continuous infusion directly into a joint (e.g., shoulder) after arthroscopic surgery is not approved and has caused permanent cartilage damage (chondrolysis).
  • Older adults: Patients 65 and older, particularly those with high blood pressure, face a higher risk of low blood pressure during anesthesia with this drug.
🔀What it interacts with▾

Several medications can interact dangerously with the epinephrine component or add to bupivacaine's toxic effects:

  • Other local anesthetics — toxic effects are additive; combined use increases heart and nervous system risks.
  • MAO inhibitors (e.g., phenelzine, tranylcypromine) — can cause severe, prolonged high blood pressure; generally avoid combining.
  • Tricyclic antidepressants (e.g., amitriptyline, nortriptyline) — same severe high blood pressure risk as MAO inhibitors.
  • Ergot-type drugs (used to control bleeding after childbirth) — risk of severe high blood pressure or stroke.
  • Non-selective beta-blockers (e.g., propranolol) — can cause dangerous rise in blood pressure and a very slow heart rate.
  • Potent inhaled anesthetics — may trigger serious heart arrhythmias (irregular heart rhythms).
  • Drugs linked to methemoglobinemia (certain nitrates, antibiotics, antimalarials, anticonvulsants) — increase the risk of a dangerous blood oxygen problem.

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it▾
  • Known allergy to bupivacaine, any amide-type local anesthetic, or sulfites — this drug is contraindicated.
  • Pregnancy: the drug crosses the placenta and can affect the baby; use in obstetrical paracervical block is strictly contraindicated due to risk of fetal slow heart rate and death.
  • Children under 12: not recommended.
  • Adults 65 and older: higher risk of low blood pressure, especially if hypertension is present — closer monitoring is needed.
  • Moderate to severe liver disease: the body may process bupivacaine more slowly, raising the risk of toxic buildup.
  • History of taking MAO inhibitors, tricyclic antidepressants, beta-blockers, or ergot drugs — tell your care team before receiving this injection.
  • Intravenous regional anesthesia (Bier Block): absolutely contraindicated — cardiac arrest and death have been reported with this technique.
🚑If you take too much▾

Too much bupivacaine in the bloodstream — from an accidental intravascular injection or excessive dosing — can cause restlessness, tremors, and seizures, followed by loss of consciousness, respiratory arrest, and cardiac arrest. Emergency treatment focuses on maintaining an open airway, providing 100% oxygen, controlling seizures with appropriate medications, and supporting circulation with fluids and vasopressors as needed. This is a medical emergency that requires immediate intervention by trained personnel with resuscitation equipment.

📡Pharmacodynamics — effects in the body▾

At normal therapeutic levels in the body, bupivacaine has minimal effects on the heart and blood vessels. However, at toxic blood concentrations, it depresses the heart's electrical conduction system — potentially causing dangerous arrhythmias (abnormal heart rhythms), reduced pumping strength, blood vessel dilation, and ultimately cardiac arrest. These cardiovascular effects are most likely when the drug accidentally enters a blood vessel directly. In the nervous system, too much bupivacaine first causes stimulation (agitation, tremors, seizures), then depression (coma, respiratory arrest).

🔬Pharmacokinetics — how your body processes it▾

How quickly bupivacaine is absorbed depends on the dose, the injection site's blood supply, and whether epinephrine is present — epinephrine slows absorption and lowers peak blood levels. Bupivacaine is highly protein-bound (about 95%), which limits how much crosses the placenta to the baby. It distributes widely in the body, with high concentrations in well-perfused organs like the liver, lungs, heart, and brain. The drug is metabolized (broken down) primarily in the liver, so liver disease can slow its clearance and raise the risk of toxic accumulation.

📦How to store it▾

Store at 20 °C to 25 °C (68 °F to 77 °F); excursions permitted between 15 °C to 30 °C (59 °F to 86 °F). protect from light.

📄 Written from Bupivacaine / Epinephrine’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Bupivacaine / Epinephrine — the kind of thing our pharmacy team would talk through with you at the counter.

What is this injection actually for — why did my doctor order it? ▾
This injection is a long-acting local anesthetic used to numb a specific part of your body during a procedure — things like surgery, dental work, or certain diagnostic tests. Your doctor chose it because it provides reliable, extended pain relief right where it's needed, without putting you fully to sleep. The epinephrine mixed in helps the numbing last longer by slowing how fast the drug absorbs into your bloodstream.
How long will the numbness last, and what will it feel like wearing off? ▾
That depends on where and how the injection is given, but bupivacaine is known for being one of the longest-acting local anesthetics available. For dental injections, numbness can last up to 7 hours. As it wears off, you may notice a gradual return of sensation — and there's often a period where you still have some pain relief even after feeling starts to come back. Your care team can give you a better estimate based on your specific procedure.
What side effects should I watch for after the injection? ▾
Most people tolerate this injection well when it's given by a trained professional. Mild dizziness, nausea, or a temporary drop in blood pressure can happen. The more serious concern is if too much drug enters your bloodstream — warning signs include restlessness, tremors, a metallic taste, or feeling suddenly unwell. Seizures, difficulty breathing, or an irregular heartbeat are emergencies. If anything feels wrong after the injection, tell your care team immediately — they'll be monitoring you closely.
Are there any medications I take that could cause a problem with this injection? ▾
Yes, a few important ones. If you take an MAO inhibitor or a tricyclic antidepressant (certain types of antidepressants), or a non-selective beta-blocker (a type of blood pressure or heart medication), the epinephrine in this injection could cause a dangerous spike in blood pressure. Certain ergot drugs used after childbirth carry the same risk. Always give your care team a complete list of your medications before any procedure — including supplements — so they can plan safely.
Is this safe if I'm pregnant? ▾
This medication can be used during some obstetrical procedures, but there are strict restrictions. One specific technique — paracervical block — is completely off the table because it has caused serious harm and death to babies. The highest concentration (0.75%) is also never used for epidural anesthesia during labor. The drug does cross the placenta, so your care team will use the lowest effective dose and monitor both you and your baby closely. Make sure your provider knows you're pregnant so they can choose the safest approach.
I'm older and have high blood pressure — is there anything special I should know? ▾
Yes, that's worth flagging with your care team. Adults 65 and older — particularly those with high blood pressure — have a higher chance of experiencing low blood pressure during anesthesia with this drug. That doesn't mean you can't receive it, but your team will monitor your blood pressure more carefully and be ready to act if it drops. Being upfront about your blood pressure history and any medications you take for it will help them plan your care safely.
Is Bupivacaine / Epinephrine available over the counter? ▾
Bupivacaine / Epinephrine is dispensed by prescription according to its FDA labeling, so it isn't sold over the counter. Your prescriber and pharmacist will determine if it's appropriate for you.
When was Bupivacaine / Epinephrine first available? ▾
Bupivacaine / Epinephrine has been available in the United States since at least 2005, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Bupivacaine / Epinephrine? ▾
Bupivacaine / Epinephrine is supplied by 8 manufacturers listed in the FDA NDC Directory, including Hospira, Inc., Fresenius Kabi USA, LLC, Henry Schein, Inc..

💬 Answers drafted from Bupivacaine / Epinephrine’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

🌿Drug & Supplement CheckerBupivacaine / Epinephrine vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Bupivacaine / Epinephrine NDCs & costs 🅰️Browse Drugs A–ZLook up any medication

💊 How Bupivacaine / Epinephrine comes

Bupivacaine / Epinephrine is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

📊 Bupivacaine / Epinephrine across the U.S. market

How Bupivacaine / Epinephrine appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

1
Dose forms ⓘ
8
Manufacturers
7
Brand names
70
FDA-listed product records ⓘ
2005
First marketed ⓘ
Hospira, Inc.60%
Fresenius Kabi USA, LLC17%
Henry Schein, Inc.9%
Septodont, Inc.7%
HF Acquisition Co LLC, DBA HealthFirst3%
General Injectables & Vaccines, Inc1%
Other makers3%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Bupivacaine / Epinephrine is used

A general measure of how commonly Bupivacaine / Epinephrine is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Bupivacaine / Epinephrine is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

89,693
Medicaid prescriptions filled (Q1–Q4 2025)
$8.8M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Bupivacaine / Epinephrine prescribed? Of the 1,597 medications we measure, Bupivacaine / Epinephrine ranks #529 by Medicaid prescriptions — more than 67% of them.

Where Bupivacaine / Epinephrine ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #529 of 1,597
#524 Nebivolol 91,607 Rx #525 Orphenadrine 91,158 Rx #526 Megestrol 91,036 Rx #527 Pimecrolimus Topical 90,935 Rx #528 Acamprosate 89,900 Rx #529 Bupivacaine / Epinephr... 89,693 Rx #530 Glyburide 89,361 Rx #531 Fluticasone / Vilanter... 85,370 Rx #532 Loratadine / Pseudoeph... 84,649 Rx #533 Gentamicin Ophthalmic 84,328 Rx #534 Ruxolitinib 84,308 Rx

Utilization by Bupivacaine / Epinephrine product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 30 mL / 5 mg/mL / 0.005 mg/mL injection is the most-dispensed Bupivacaine / Epinephrine product — about 5% of these Medicaid prescriptions.

30 ML bupivacaine hydrochloride 5 MG/ML / epinephrine 0.005 MG/ML Injection Most dispensed

4,683 Medicaid prescriptions (Q1–Q4 2025) 5% of Bupivacaine / Epinephrine prescriptions shown $258,717 gross reimbursement (before rebates) ≈ $55 per prescription (gross)

Summed across the 5 of 12 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1672919

30 ML bupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML Injection

4,676 Medicaid prescriptions (Q1–Q4 2025) 5% of Bupivacaine / Epinephrine prescriptions shown $544,677 gross reimbursement (before rebates) ≈ $116 per prescription (gross)

Summed across the 4 of 11 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1867596

bupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML Injectable Solution

2,248 Medicaid prescriptions (Q1–Q4 2025) 3% of Bupivacaine / Epinephrine prescriptions shown $389,347 gross reimbursement (before rebates) ≈ $173 per prescription (gross)

Summed across the 3 of 10 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1012377

10 ML bupivacaine hydrochloride 5 MG/ML / epinephrine 0.005 MG/ML Injection

2,115 Medicaid prescriptions (Q1–Q4 2025) 2% of Bupivacaine / Epinephrine prescriptions shown $93,279 gross reimbursement (before rebates) ≈ $44 per prescription (gross)

Summed across the 3 of 8 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1672917

10 ML bupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML Injection

1,909 Medicaid prescriptions (Q1–Q4 2025) 2% of Bupivacaine / Epinephrine prescriptions shown $102,215 gross reimbursement (before rebates) ≈ $54 per prescription (gross)

Summed across the 3 of 8 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1867594

bupivacaine hydrochloride 5 MG/ML / epinephrine 0.005 MG/ML Injectable Solution

885 Medicaid prescriptions (Q1–Q4 2025) <1% of Bupivacaine / Epinephrine prescriptions shown $201,094 gross reimbursement (before rebates) ≈ $227 per prescription (gross)

Summed across the 3 of 10 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 1012384

Other Bupivacaine / Epinephrine products — combination packs and listings not yet matched to a specific clinical product (kept visible so every prescription is accounted for)

73,177 Medicaid prescriptions (Q1–Q4 2025) 82% of Bupivacaine / Epinephrine prescriptions shown $7.2M gross reimbursement (before rebates) ≈ $99 per prescription (gross)

Summed across the 20 of 27 listed NDC products with Medicaid activity.

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Bupivacaine / Epinephrine, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 41 of 86 listed Bupivacaine / Epinephrine NDCs with Medicaid activity.

🔍 Compare Bupivacaine / Epinephrine products

A representative set of FDA-listed product records for Bupivacaine / Epinephrine — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 70 of 70 products — FDA National Drug Code Directory. See every product, package size and price: browse all 70 Bupivacaine / Epinephrine NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one exact multiple-ingredient concept (MIN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). A product with a different ingredient combination belongs on a different page.

Multiple ingredients (MIN) Bupivacaine / Epinephrine RxCUI 107606 3 dose forms · 8 strengths
  3. Dose form (SCDF) Injection RxCUI 1672916 In current FDA listings
    Clinical drug / strength (SCD) 10 ML bupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML RxCUI 1867594 10 ML bupivacaine hydrochloride 5 MG/ML / epinephrine 0.005 MG/ML RxCUI 1672917 30 ML bupivacaine hydrochloride 2.5 MG/ML / epinephrine 0.005 MG/ML RxCUI 1867596 30 ML bupivacaine hydrochloride 5 MG/ML / epinephrine 0.005 MG/ML RxCUI 1672919 30 ML bupivacaine hydrochloride 7.5 MG/ML / epinephrine 0.005 MG/ML RxCUI 1012391

Look up RxCUI 107606 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Marcaine with Epinephrine Sensorcaine Sensorcaine Mpf Vivacaine Marcaine Bupivacaine Hci And Epinephrine

🏭 Manufacturers & labelers

Hospira, Inc. 42 Fresenius Kabi USA, LLC 12 Henry Schein, Inc. 6 Septodont, Inc. 5 HF Acquisition Co LLC, DBA HealthFirst 2 General Injectables & Vaccines, Inc 1 General Injectables & Vaccines, Inc. 1 Sportpharm LLC 1

RxNorm drug class

Bupivacaine / Epinephrine belongs to the Amide Local Anesthetic class.

Pharmacologic class Amide Local Anesthetic
Drug family (ATC) Amides

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective May 29, 2026
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Bupivacaine / Epinephrine.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Bupivacaine / Epinephrine after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
13
NDC products indexed
70
Distinct labelers/manufacturers represented
8
Linked representative label ⓘ
Hospira, Inc.
Linked label effective
May 29, 2026
Composite sections available
24
Linked SPL Set ID
67578b56-7540-487e-1fba-481255620e78
Linked SPL Document ID
7040888c-2cde-4408-af99-d249985f8444
Open the linked representative label on DailyMed ↗
NDC package records associated with this linked SPL 20
00409-0525-25 Marcaine BUPIVACAINE HYDROCHLORIDE 250 mg/50mL INJECTION, SOLUTION Hospira, 00409-1530-25 Marcaine BUPIVACAINE HYDROCHLORIDE 150 mg/30mL INJECTION, SOLUTION Hospira, 00409-1559-10 Marcaine BUPIVACAINE HYDROCHLORIDE 2.5 mg/mL INJECTION, SOLUTION Hospira, 00409-1559-30 Marcaine BUPIVACAINE HYDROCHLORIDE 2.5 mg/mL INJECTION, SOLUTION Hospira, 00409-1560-10 Marcaine BUPIVACAINE HYDROCHLORIDE 5 mg/mL INJECTION, SOLUTION Hospira, 00409-1560-29 Marcaine BUPIVACAINE HYDROCHLORIDE 5 mg/mL INJECTION, SOLUTION Hospira, 00409-1582-10 Marcaine BUPIVACAINE HYDROCHLORIDE 7.5 mg/mL INJECTION, SOLUTION Hospira, 00409-1582-29 Marcaine BUPIVACAINE HYDROCHLORIDE 7.5 mg/mL INJECTION, SOLUTION Hospira, 00409-1587-50 Marcaine BUPIVACAINE HYDROCHLORIDE 2.5 mg/mL INJECTION, SOLUTION Hospira, 00409-1610-50 Marcaine BUPIVACAINE HYDROCHLORIDE 5 mg/mL INJECTION, SOLUTION Hospira, 00409-1746-10 Marcaine with Epinephrine BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE BITARTRATE 2.5 mg/mL; .0091 mg/mL INJECTION, SOLUTION Hospira, 00409-1746-30 Marcaine with Epinephrine BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE BITARTRATE 2.5 mg/mL; .0091 mg/mL INJECTION, SOLUTION Hospira, 00409-1749-10 Marcaine with Epinephrine BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE BITARTRATE 5 mg/mL; .0091 mg/mL INJECTION, SOLUTION Hospira, 00409-1749-29 Marcaine with Epinephrine BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE BITARTRATE 5 mg/mL; .0091 mg/mL INJECTION, SOLUTION Hospira, 00409-1752-50 Marcaine with Epinephrine BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE BITARTRATE 2.5 mg/mL; .0091 mg/mL INJECTION, SOLUTION Hospira, 00409-1755-50 Marcaine with Epinephrine BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE BITARTRATE 5 mg/mL; .0091 mg/mL INJECTION, SOLUTION Hospira, 00409-2253-25 Marcaine BUPIVACAINE HYDROCHLORIDE 225 mg/30mL INJECTION, SOLUTION Hospira, 00409-2510-25 Marcaine BUPIVACAINE HYDROCHLORIDE 25 mg/10mL INJECTION, SOLUTION Hospira, 00409-5010-25 Marcaine BUPIVACAINE HYDROCHLORIDE 50 mg/10mL INJECTION, SOLUTION Hospira, 00409-7535-25 Marcaine BUPIVACAINE HYDROCHLORIDE 75 mg/30mL INJECTION, SOLUTION Hospira,

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 13 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Hospira, Inc. is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.