FDA-filed SPL labeling · retrieved through openFDA

Menthol / Methyl Salicylate

Menthol and methyl salicylate are topical pain-relief ingredients found in patches, creams, ointments, gels, solutions, and sprays used to temporarily relieve minor aches and pains of muscles and joints from arthritis, sprains, strains, simple backache, and bruises.

Brand names Muscle RubRayo Active HeatMuscle Rub CreamHeating Pain ReliefIcy Hot +11 more
OTC Forms 6 Routes Topical · Percutaneous; Topical; Transdermal · Percutaneous, Topical, Transdermal · Transdermal
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 132 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveMar 14, 2025
Clinical labels in scope 132
AvailabilityOTC
Earliest approval/marketing year 1991
FDA-listed product records 284
Boxed warningYes
How we combine label and product data →
No current FDA shortage listed · checked Sep 23, 2026
Menthol / Methyl Salicylate at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Menthol/methyl salicylate products are applied to the skin to temporarily ease arthritis pain, backache, sprains, strains, and bruises. Use only as directed on the label — do not apply heat on top of the product, don't use it on broken skin, and wash your hands after each application. If you're pregnant (especially at 20 weeks or later), allergic to aspirin, or have heart disease, kidney disease, or high blood pressure, talk to your doctor before using.
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert

WARNING: RISK OF SERIOUS CARDIOVASCULAR AND GASTROINTESTINAL EVENTS Cardiovascular Thrombotic Events • Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use [see Warnings and Precautions ( 5.1 )] . • Diclofenac sodium topical solution is contraindicated in the setting of coronary artery bypass gra...

Read the full warning on DailyMed →

📖 Menthol / Methyl Salicylate: Patient Information Guide

A plain-language walkthrough of Menthol / Methyl Salicylate — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for

Menthol and methyl salicylate are topical (applied to the skin) pain-relief ingredients available in several forms and brands. Here is the full range of conditions they are used for across supported products:

  • Arthritis pain (joint pain and stiffness)
  • Simple backache
  • Muscle strains and sprains
  • Bruises
  • Muscle cramps (Icy Hot cream/ointment and Arthritis Hot cream)
  • Lumbago (lower back pain) — Medistik Dual Hot And Cold spray
  • Pain of tendons and ligaments — Medistik Dual Hot And Cold spray
  • Rheumatic pain — Medistik Dual Hot And Cold spray
  • Inflammation-related minor muscle and joint pain — ASYSTEM Radical Relief Gel Roll-On
  • Warm-up assistance combined with stretching and calisthenics — Cramergesic ointment
💊How it's taken

The right way to use these products depends on which form you have. All are applied to the skin only — never swallowed.

  • Creams, ointments, and gels (such as Icy Hot, Arthritis Hot, Cramergesic, ASYSTEM Radical Relief Gel Roll-On): massage a thin layer into the affected area up to 3–4 times daily; wash hands after each use.
  • Medistik Dual Hot And Cold spray: spray thinly and evenly, massage in until it disappears, up to 3–4 times per day.
  • Skin patches (such as Salonpas Pain Relief, HealthWise Pain Relief Patch): apply to a clean, dry area and leave on for the number of hours stated on your specific product — this varies by brand. Do not exceed the daily patch limit on your label.
  • Eagle Brand liquid (topical solution): apply to the affected area as directed on the product label.

Always follow your product's label or your prescriber's instructions. Do not use these products more often or for longer than the label directs.

🤒Side effects — in detail

Most people tolerate these products well, but some skin reactions can occur at the site of application:

  • Burning or warming sensation (common, usually fades within a few days of regular use)
  • Stinging sensation, especially noticeable with Medistik Dual Hot And Cold spray
  • Skin redness or irritation
  • Itching or rash

Rare but serious skin burns have been reported with products of this type — if you experience severe burning, pain, swelling, or blistering where you applied the product, stop using it immediately and get medical help. Also stop use and see a doctor if a rash or significant skin irritation develops, or if your symptoms worsen or don't improve as expected.

⚠️Warnings & precautions
  • Risk of serious skin burns: Rare but real — do not apply heat (heating pads, direct sunlight) to the treated area, and never bandage the area tightly after applying.
  • External use only: Never swallow these products. If accidentally swallowed, contact a Poison Control Center right away.
  • Do not use on broken or damaged skin: Avoid wounds, rashes, or irritated skin.
  • Aspirin/salicylate allergy: Because methyl salicylate is related to aspirin, people with an aspirin or salicylate allergy should not use these products without talking to a doctor first.
  • Pregnancy (especially after 20 weeks): Do not use methyl salicylate at 20 weeks of pregnancy or later unless a doctor specifically directs it — it may harm the unborn baby or cause delivery complications.
  • Heart attack and stroke risk: Using more than directed or for longer than directed may increase the risk of heart attack or stroke.
  • Avoid using with other topical pain-relief products on the same area at the same time.
  • Eye contact: Avoid getting product in your eyes or on mucous membranes. If eye contact occurs, rinse thoroughly with water.
🔀What it interacts with

While these are topical (skin) products, a few important interactions and precautions apply:

  • Other topical analgesics (pain-relief skin products): Do not use two topical pain products on the same area at the same time — this increases the risk of skin irritation and burns.
  • Heating pads or local heat: Applying heat over the product raises the risk of serious skin burns — always avoid.
  • Diuretics (water pills): Ask a doctor before using these products if you take a diuretic, as salicylates may interact.
  • Aspirin and salicylate-containing medications: If you already take aspirin or other salicylates, speak to your doctor before adding a topical methyl salicylate product.

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it
  • Do not use if you are allergic to aspirin, salicylates, or other NSAIDs (non-steroidal anti-inflammatory drugs) unless your doctor says it is okay.
  • Tell your doctor if you have high blood pressure, heart disease, or kidney disease before using these products.
  • Tell your doctor if you take a diuretic (water pill).
  • Tell your doctor if you have a history of stomach bleeding.
  • If you are pregnant or breastfeeding, ask a health care professional before use. At 20 weeks of pregnancy or later, do not use methyl salicylate unless your doctor specifically directs it.
  • Salonpas Pain Relief patch: not for use in anyone under 18 years old.
  • Most creams and ointments: children under 12 should not use without asking a doctor first.
  • HealthWise Pain Relief Patch and BT Pain Relief patch: not for children under 2 years of age.
  • Keep all products out of reach of children.
🚑If you take too much

These products are meant for skin use only, and accidental swallowing is a medical emergency. If any of these products is put in the mouth or swallowed — especially by a child — contact a Poison Control Center or get emergency medical help right away. Do not wait for symptoms to appear.

📦How to store it

store at 20 - 25 degrees Celsius (68-77 degrees Fahrenheit) avoid storing product in direct sunlight protect product from excessive moisture some individuals may not experience pain relief until several hours after applying the patch

📄 Written from Menthol / Methyl Salicylate’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Menthol / Methyl Salicylate — the kind of thing our pharmacy team would talk through with you at the counter.

What kinds of pain does this actually help with?
These products are designed for temporary relief of mild to moderate muscle and joint pain — things like arthritis, a sore back, sprains, strains, bruises, and cramps. Medistik Dual Hot And Cold spray also covers tendon and ligament pain and rheumatic pain. They're not intended for severe pain or conditions that need a prescription treatment.
I feel a burning sensation after I put it on — is that normal?
A mild burning or warming sensation right after you apply it is completely normal and is actually expected. It usually fades within a few days of regular use. What you should NOT ignore is severe burning, blistering, or swelling — if that happens, take it off right away and get medical help, because rare but serious skin burns have been reported with products like these.
Can I use a heating pad on top of this to get extra relief?
No — please don't. Applying heat (including heating pads or exposing the area to direct sunlight) over these products significantly raises the risk of a serious skin burn. The same goes for bandaging the area tightly. Just let the product do its job on its own.
I'm pregnant — is it safe to use?
It's especially important to avoid methyl salicylate products at 20 weeks of pregnancy or later unless your doctor has specifically told you it's okay. It can potentially cause problems for the unborn baby or complications during delivery. Before that point in pregnancy, still check with your healthcare provider first before using any of these products.
I'm allergic to aspirin. Can I still use one of these creams or patches?
Methyl salicylate is chemically related to aspirin, so if you have an aspirin or salicylate allergy, you should talk to your doctor before using any product containing it. Don't just assume the skin version is safe — your doctor needs to weigh in.
How long can I keep using this before I should see a doctor?
Most of these products are meant for short-term use — generally no more than 7 days (some products say 3 days). If your pain isn't improving, gets worse, keeps coming back, or is accompanied by redness and irritation that won't go away, stop using the product and see a doctor. It could be a sign of something that needs a different kind of treatment.
Is Menthol / Methyl Salicylate available over the counter?
Yes — Menthol / Methyl Salicylate is available over the counter (without a prescription) in at least some forms, according to its FDA labeling. Follow the package directions and ask your pharmacist if you're unsure which product is right for you.
When was Menthol / Methyl Salicylate first available?
Menthol / Methyl Salicylate has been available in the United States since at least 1991, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Menthol / Methyl Salicylate?
Menthol / Methyl Salicylate is supplied by 105 manufacturers listed in the FDA NDC Directory, including Big 5 Nutrition LLC, Hisamitsu Pharmaceutical Co., Inc., Pt. Eagle Indo Pharma.

💬 Answers drafted from Menthol / Methyl Salicylate’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

💊 How Menthol / Methyl Salicylate comes

Menthol / Methyl Salicylate is available in 6 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Topical cream, ointment or gel

On the skin
Brands Analgesic Balm Calypxo Pain Relief Cramergesic Extra Strength Heating Pain Relief Icy Hot Mentholatum Pain Relieving Muscle Rub Muscle Rub Cream Rayo Active Heat Teeter reNEW MUSCLES Pain Relieving Tiger Balm
How this form is used
What it may be used for
  • Icy Hot cream/ointment: temporarily relieves minor pain from arthritis, simple backache, muscle strains, sprains, bruises, and cramps
  • Arthritis Hot cream: temporarily relieves minor pain from arthritis, simple backache, muscle strains, sprains, bruises, and cramps
  • ASYSTEM Radical Relief Gel Roll-On: temporary relief of minor aches and pains of muscles and joints from backache, muscle ache, strains, sprains, bruises, cramps, arthritis, and inflammation
  • Cramergesic ointment: temporary relief of minor aches and pains from strains, sprains, bruises, simple backache, and arthritis; also assists in warm-up when combined with stretching and calisthenics
Important instructions
  • Icy Hot (adults and children over 12): apply a thin layer to the affected area and massage in until absorbed; repeat as needed but not more than 4 times daily; wash hands with soap and water after applying
  • Arthritis Hot (adults and children over 12): apply a thin layer, massage until absorbed; repeat as needed but not more than 3–4 times daily; wash hands with soap and water if the product contacts your hands
  • Human Science Muscle Pain Relief and Eagle Brand ointment: apply to the affected area as directed on the product label; do not use more than the directed number of times per day
  • Cramergesic: do not bandage the treated area tightly
Available strengths 62 strengths
Show 56 more strengths Show fewer strengths
100 mg/mL / 20 mg/mL 125 mg/g / 125 mg/g MENTHOL, UNSPECIFIED FORM 140 mg/g; METHYL SALICYLATE 232 mg/g MENTHOL, UNSPECIFIED FORM 0.15 g/g; METHYL SALICYLATE 0.15 g/g 180 mg/g METHYL SALICYLATE 350 mg/mL; MENTHOL, UNSPECIFIED FORM 160 mg/mL 1 g/g / 1 g/g MENTHOL 2 g/100 mL; METHYL SALICYLATE 10 g/100 mL MENTHOL 9.8 g/100 mL; METHYL SALICYLATE 17.6 g/100 mL MENTHOL, UNSPECIFIED FORM 10 g/100 g; METHYL SALICYLATE 15 g/100 g MENTHOL 10 g/100 g; METHYL SALICYLATE 15 g/100 g MENTHOL 10 g/100 mL; METHYL SALICYLATE 18 g/100 mL METHYL SALICYLATE 10 g/100 g; MENTHOL 3 g/100 g METHYL SALICYLATE 11.2 g/112 g; MENTHOL 2.24 g/112 g METHYL SALICYLATE 12 g/100 g; MENTHOL 3 g/100 g METHYL SALICYLATE 15 g/100 mL; MENTHOL 14 g/100 mL METHYL SALICYLATE 16 g/100 g; MENTHOL 8 g/100 g METHYL SALICYLATE 29.95 g/100 g; MENTHOL 13.5 g/100 g METHYL SALICYLATE 30 g/100 mL; MENTHOL 14.5 g/100 mL 0.05 kg/kg / 0.075 kg/kg 0.05; 0.1 1/kg; kg/kg 0.05 kg/kg / 0.1 kg/kg 0.1; 0.15 g/100 g; g/100 g 0.1 kg/kg / 0.15 kg/kg 1.4; 10 g/100 mL; g/100 mL 1.9; 13.7 g/100 g; g/100 g 2.24; 11.2 g/112 g; g/112 g 2.5; 10 g/106 g; g/106 g 3; 10 g/100 g; g/100 g 3; 12 g/100 g; g/100 g 3.5; 10 g/100 g; g/100 g 4; 26 g/100 g; g/100 g 5; 4 g/100 g; g/100 g 5; 5 g/100 g; g/100 g 5; 10 g/100 mL; g/100 mL 7.6; 29 g/100 g; g/100 g 8; 16 g/100 g; g/100 g 8; 26 g/100 mL; g/100 mL 9.8; 17.6 g/100 mL; g/100 mL 10; 15 g/100 g; g/100 g 10; 30 g/100 g; g/100 g 11; 22 g/100 g; g/100 g 12.5 mg/mL / 310 mg/mL 13.5; 29.95 g/100 g; g/100 g 14; 15 g/100 mL; g/100 mL 15; 30 g/100 g; g/100 g 20 mg/mL / 100 mg/mL 25 mg/g / 100 mg/g 50 mg/mL / 120 mg/mL 60 mg/mL / 200 mg/mL 80 mg/g / 300 mg/g 100 mg/mL / 100 mg/mL 100 mg/g / 300 mg/g 140 mg/g / 232 mg/g 148.8 mg/mL / 260.4 mg/mL 160 mg/mL / 350 mg/mL
202 FDA-listed product records

Skin patch

On the skin · Through the skin
Brands Max Revive Plaster Salonpas Arthritis Pain Salonpas Pain Relief
How this form is used
What it may be used for
  • Salonpas Pain Relief: temporarily relieves mild to moderate aches and pains from strains, sprains, simple backache, arthritis, and bruises
  • HealthWise Pain Relief Patch: temporarily relieves mild to moderate aches and pains from strains, sprains, simple backache, arthritis, and bruises
  • Muscle Meltdown External Analgesic Plaster and Herbal Utaplas External Analgesic Plaster: for temporary relief of minor muscle and joint aches and pains
Important instructions
  • Salonpas Pain Relief (adults 18+): apply one patch to a clean, dry area for up to 8–12 hours; a second patch may be applied if pain continues, but do not use more than 2 patches per day or for more than 3 days in a row
  • HealthWise Pain Relief Patch (adults and children 2+): clean and dry the area, apply the sticky side, and do not use more than one patch per 8-hour period; maximum 3 patches per day; discard after single use
  • Max Revive Plaster, Muscle Meltdown, and Herbal Utaplas (adults and children 12+): clean and dry the area, apply and rub to secure; patch remains effective for 8 hours; do not reuse the same patch on the same area for more than 2 days
  • BT Pain Relief: clean and dry the area before applying; patch is effective for 6 hours; wet with warm water before removing; do not use in children under 2 years
Available strengths 12 strengths
Show 6 more strengths Show fewer strengths
27 FDA-listed product records

Topical spray

On the skin
Brands Medistik Dual Hot And Cold
How this form is used
What it may be used for
  • Medistik Dual Hot And Cold spray: provides temporary soothing relief of sore muscles from strains and sprains, backaches, lumbago, pain of tendons and ligaments, and arthritic or rheumatic pain
Important instructions
  • Medistik Dual Hot And Cold (adults and children over 12): apply thinly and evenly to the affected area up to 3–4 times per day; rub or massage in until the solution vanishes
  • Medistik Dual Hot And Cold: expect a stinging or burning sensation during the first few minutes — this is normal as the formula starts working
  • Medistik Dual Hot And Cold: for hand arthritis or muscle pain, keep on for at least 10 minutes then wash hands; consult your healthcare provider if you need to use it beyond 7 days
Available strengths 3 strengths
6 FDA-listed product records

Topical solution

On the skin
Brands Eagle Brand
How this form is used
What it may be used for
  • Eagle Brand liquid: temporary relief of minor aches and pains of muscles and joints from simple backache, arthritis, strains, bruises, and sprains
Important instructions
  • Eagle Brand liquid: apply to the affected area as directed on the product label; for external use only
Available strengths 2 strengths
5 FDA-listed product records

Inhaler

On the skin · Through the skin
Available strengths 1 strength
1 FDA-listed product record

Topical (transdermal) gel

Through the skin
Available strengths 1 strength
1 FDA-listed product record

📊 Menthol / Methyl Salicylate across the U.S. market

How Menthol / Methyl Salicylate appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

6
Dose forms
105
Manufacturers
40
Brand names
284
FDA-listed product records
1991
First marketed

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Kit (1) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Big 5 Nutrition LLC9%
Hisamitsu Pharmaceutical Co., Inc.5%
Pt. Eagle Indo Pharma5%
Chattem, Inc.5%
Sunset Novelties, Inc4%
Quimicas Handal de Centroamerica SA de CV4%
Other makers67%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Menthol / Methyl Salicylate is used

A general measure of how commonly Menthol / Methyl Salicylate is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Menthol / Methyl Salicylate is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

10,307
Medicaid prescriptions filled (Q1–Q4 2025)
$82,284 gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Menthol / Methyl Salicylate prescribed? Of the 1,596 medications we measure, Menthol / Methyl Salicylate ranks #929 by Medicaid prescriptions — more than 42% of them.

Where Menthol / Methyl Salicylate ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5

Utilization by Menthol / Methyl Salicylate product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 10 mg/mL / 150 mg/mL topical cream is the most-dispensed Menthol / Methyl Salicylate product — about 90% of these Medicaid prescriptions.

menthol 10 MG/ML / methyl salicylate 150 MG/ML Topical Cream Most dispensed

9,261 Medicaid prescriptions (Q1–Q4 2025) 90% of Menthol / Methyl Salicylate prescriptions shown $73,620 gross reimbursement (before rebates) ≈ $7.95 per prescription (gross)

Summed across the 1 of 9 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 259203

menthol 100 MG/ML / methyl salicylate 150 MG/ML Topical Cream

1,046 Medicaid prescriptions (Q1–Q4 2025) 10% of Menthol / Methyl Salicylate prescriptions shown $8,664 gross reimbursement (before rebates) ≈ $8.28 per prescription (gross)

Summed across the 1 of 39 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 311498

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Menthol / Methyl Salicylate, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 2 of 48 listed Menthol / Methyl Salicylate NDCs with Medicaid activity.

🔍 Compare Menthol / Methyl Salicylate products

A representative set of FDA-listed product records for Menthol / Methyl Salicylate — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 200 of 284 products — FDA National Drug Code Directory. See every product, package size and price: browse all 284 Menthol / Methyl Salicylate NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one exact multiple-ingredient concept (MIN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). A product with a different ingredient combination belongs on a different page.

Multiple ingredients (MIN) Menthol / Methyl Salicylate RxCUI 466537 8 dose forms · 64 strengths
  1. Dose form (SCDF) Medicated Patch RxCUI 1792911 In current FDA listings
  2. Dose form (SCDF) Topical Cream RxCUI 314003 In current FDA listings
    Clinical drug / strength (SCD) menthol 10 MG/ML / methyl salicylate 150 MG/ML RxCUI 259203 menthol 100 MG/ML / methyl salicylate 100 MG/ML RxCUI 1875528 menthol 100 MG/ML / methyl salicylate 150 MG/ML RxCUI 311498 menthol 100 MG/ML / methyl salicylate 200 MG/ML RxCUI 1716100 menthol 100 MG/ML / methyl salicylate 300 MG/ML RxCUI 311500 menthol 110 MG/ML / methyl salicylate 310 MG/ML RxCUI 1300276 menthol 12.5 MG/ML / methyl salicylate 150 MG/ML RxCUI 2746494 menthol 120 MG/ML / methyl salicylate 170 MG/ML RxCUI 259102 menthol 160 MG/ML / methyl salicylate 300 MG/ML RxCUI 801678 menthol 20 MG/ML / methyl salicylate 100 MG/ML RxCUI 311503 menthol 25 MG/ML / methyl salicylate 100 MG/ML RxCUI 1148131 menthol 28.4 MG/ML / methyl salicylate 182 MG/ML RxCUI 2684042 menthol 30 MG/ML / methyl salicylate 100 MG/ML RxCUI 1486874 menthol 40 MG/ML / methyl salicylate 100 MG/ML RxCUI 2698214 menthol 40 MG/ML / methyl salicylate 250 MG/ML RxCUI 686422 menthol 50 MG/ML / methyl salicylate 100 MG/ML RxCUI 1940367 menthol 70 MG/ML / methyl salicylate 100 MG/ML RxCUI 1608491 menthol 70 MG/ML / methyl salicylate 140 MG/ML RxCUI 1102186 menthol 80 MG/ML / methyl salicylate 300 MG/ML RxCUI 311511
  3. Dose form (SCDF) Topical Lotion RxCUI 377755 In current FDA listings
    Clinical drug / strength (SCD) menthol 125 MG/ML / methyl salicylate 62.5 MG/ML RxCUI 1093359 menthol 30 MG/ML / methyl salicylate 100 MG/ML RxCUI 2589084 menthol 30 MG/ML / methyl salicylate 150 MG/ML RxCUI 702433 menthol 50 MG/ML / methyl salicylate 100 MG/ML RxCUI 2105550 menthol 50 MG/ML / methyl salicylate 140 MG/ML RxCUI 1085721 menthol 60 MG/ML / methyl salicylate 200 MG/ML RxCUI 282812
  4. Dose form (SCDF) Topical Ointment RxCUI 376511 In current FDA listings
  5. Dose form (SCDF) Topical Spray RxCUI 1101082 In current FDA listings
    Clinical drug / strength (SCD) menthol 100 MG/ML / methyl salicylate 120 MG/ML RxCUI 1738566 menthol 100 MG/ML / methyl salicylate 50 MG/ML RxCUI 1875611 menthol 30 MG/ML / methyl salicylate 100 MG/ML RxCUI 1101083 menthol 50 MG/ML / methyl salicylate 110 MG/ML RxCUI 2722189 menthol 70 MG/ML / methyl salicylate 200 MG/ML RxCUI 2737148 menthol 8 MG/ML / methyl salicylate 30 MG/ML RxCUI 1376496 menthol 91 MG/ML / methyl salicylate 290 MG/ML RxCUI 2722416

Look up RxCUI 466537 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Muscle Rub Rayo Active Heat Muscle Rub Cream Heating Pain Relief Icy Hot Analgesic Balm Calypxo Pain Relief Extra Strength Cramergesic Max Revive Plaster Teeter reNEW MUSCLES Pain Relieving Salonpas Pain Relief Salonpas Arthritis Pain Eagle Brand Medicated Oil Tiger Balm Mentholatum Pain Relieving

🏭 Manufacturers & labelers

Big 5 Nutrition LLC 19 Hisamitsu Pharmaceutical Co., Inc. 10 Pt. Eagle Indo Pharma 10 Chattem, Inc. 10 Sunset Novelties, Inc 9 Quimicas Handal de Centroamerica SA de CV 8 Borden Company (Private) Limited 7 Natureteq Inc. 6 Timing Pharmaceutical Co., Ltd PABP Branch 6 The Mentholatum Company 6 Trifecta Pharmaceuticals USA, LLC. 6 Haw Par Healthcare Ltd. 6 Geri-Care Pharmaceuticals, Corp 5 Asclemed USA, Inc 5 Implus Footcare, LLC 5 New World Imports, Inc 5 Preferred Pharmaceuticals Inc. 5 Cosco International, Inc. 5 Healthy Directions, LLC 5 Miramar Cosmetics, Inc DBA Miramar Lab 4 STL International INC 4 Delon Laboratories (1990) Ltd 4 PureTek Corporation 4 Eagle Indo Pharma, PT 4

…and 16 more on the FDA NDC directory.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Mar 14, 2025
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Menthol / Methyl Salicylate.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Menthol / Methyl Salicylate after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
132
NDC products indexed
284
Distinct labelers/manufacturers represented
105
Linked representative label
Hisamitsu Pharmaceutical Co., Inc.
Linked label effective
Mar 14, 2025
Composite sections available
27
Linked SPL Set ID
724bc4d3-0bc1-4275-a23b-4bbc62fbc0d2
Linked SPL Document ID
b15d7bd2-d065-4a54-af88-27518cc59143
Open the linked representative label on DailyMed ↗

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 132 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

For canonical ingredient pages, bounded product-attributed indication and administration excerpts may be added to the AI evidence, and the generator is instructed to preserve available product, brand, route, and form qualifiers instead of treating one label as universal. Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Hisamitsu Pharmaceutical Co., Inc. is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.