Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.
Muscle Rub menthol and methyl salicylate 100 mg/g; 150 mg/g Cream — NDC 0536-1349-57 (Billing 00536-1349-57)
by Rugby Laboratories · 1 TUBE in 1 CARTON / 85 g in 1 TUBE
This is a package of Muscle Rub menthol and methyl salicylate 100 mg/g; 150 mg/g Cream from Rugby Laboratories, marketed since Feb 2022 and currently FDA-listed; retail pharmacies pay about $0.0365 per g (NADAC). It is this product's only package size.
NDC 00536-1349-57
🏷️ FDA NDC (as labeled)
0536-1349-57
billing pads the labeler segment with a zero
🗂️ FDA directory synced Oct 8, 2026 · this listing last changed Oct 8, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →
NDC database record
One package, one record: these facts belong to NDC 0536-1349-57 alone.
- Record
- FDA NDC Directory package listing · Human OTC drug
- Code segments
- 0536 labeler · 1349 product · 57 package
- Package marketed since
- Feb 28, 2022
- Sample package
- No — commercial package
- Listing certified through
- Dec 31, 2027
- Barcode (UPC-A, from the NDC)
- 3 0536134957 8
- Medicaid fills, this package
- 1,112 prescriptions in the last four reported quarters
- FDA record last changed
- Oct 8, 2026
Identity & classification
Regulatory identifiers FDA, NLM and CMS codes for this package
FDA NDC (as labeled)
0536-1349-57
Product NDC
0536-1349
11-digit billing NDC
00536134957
NCPDP billing unit
GM — per gram (weight)
Application #
M017
SPL Set ID
7c6f49d9-0ecd-494a-abd3-cdda6d6e5d06
DEA schedule
Non-controlled
Marketing category
OTC MONOGRAPH DRUG
Marketing status
On market
FDA listing status
Listed (active directory)
Marketing start
2022-02-28
Route
TOPICAL
Dosage form
CREAM
Substance
MENTHOL; METHYL SALICYLATE
Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification
GCN Seq No
061801
GCN
97586
HICL code
002583
Ingredient (HICL)
Methyl Salicylate/Menthol
HIC1 code
L
Therapeutic class — broad (HIC1)
Skin/Subcutaneous Tissue
HIC2 code
L6
Therapeutic class — intermediate (HIC2)
Irritants
HIC3 code
L6A
Therapeutic class — specific (HIC3)
Irritants/Counter-Irritants
AHFS code
28:08.04.24
AHFS class
Salicylates
FDB label name
MUSCLE RUB 15%-10% CREAM
FDB brand name
Muscle Rub
Legend status
O — Over-the-counter (OTC) drug or device
Quick answers
- GSN (GCN sequence number): 061801
- GCN: 97586
- HICL (First Databank): 002583
- AHFS class code: 28:08.04.24
Why two NDCs?
The FDA registers this code as 0536-1349-57 — a 4-4-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the labeler segment → 00536-1349-57. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.
- FDA openFDA NDC Directory · synced Oct 8, 2026
- FDA label on DailyMed · label index refreshed Oct 6, 2026
- RxNorm (NLM RxNav) · catalog refreshed Oct 1, 2026
- Medi-Span GPI (licensed)
- First Databank (licensed) · refreshed Oct 8, 2026
Clinical
Label name MUSCLE RUB 15%-10% CREAM Ingredient Methyl Salicylate/Menthol
📗 Our plain-language guide HelloPharmacist
- It is used on the skin for short-term relief of minor muscle and joint aches. That includes arthritis, backache, strains, sprains and bruises. Some products, like Diclofenac Sodium...
- Apply it only to clean, intact skin, and follow your product's directions on how often. Wash your hands after using creams or handling patches, and keep it away from your eyes. Don...
- A short burning feeling, redness or mild irritation where you apply it is the most common. It usually fades in several days. Stop and call your doctor if you get severe burning, bl...
- Be careful. Methyl salicylate is a salicylate, related to aspirin, and labels say to talk to a doctor first if you are prone to allergic reactions to aspirin or salicylates. Some l...
Patient education
Supplement & herbal interactions
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.
- MedlinePlus (NLM) · refreshed Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 6, 2026
💬 Questions about menthol and methyl salicylate?
Ask a pharmacist →
Ask a licensed pharmacist directly — free, answered by our team.
Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per g | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | $0.037 | $3.10 / 85 g |
| Medicaid paysCMS SDUD · 12 mo | $0.0928 | $7.89 / 85 g |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
NADAC price history (per g) — tap or hover for the price & month
▲ Up 18% over the last 13 months.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.
- CMS NADAC weekly file · file of Oct 7, 2026
- CMS ASP pricing files · refreshed Sep 20, 2026
- CMS Medicaid State Drug Utilization Data · through Q1 2026
- CMS Part D plan pricing files · refreshed Sep 24, 2026
- VA National Acquisition Center price file
Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Marketing end | Status |
|---|---|---|---|---|
| 00536-1349-57 You're viewing this Main listing | 1 TUBE in 1 CARTON / 85 g in 1 TUBE | 2022-02-28 | — | Active |
Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| Muscle Rub 100 mg/g; 150 mg/gthis 00536-1349-57 | Rugby | 1 tube | $0.037 | — | Availability likely | — |
| Dr Sheffield Muscle Rub Cream 100 mg/g; 150 mg/g 11527-0057-40 | Sheffield | 1 tube | — | — | FDA listed | — |
| Arthritis Hot 10 g/100g; 15 g/100g 41167-0600-03 | Chattem, | 1 tube | — | — | FDA listed | — |
| CVS Muscle Rub 150 mg/g; 100 mg/g 51316-0994-03 | CVS | 85 g | — | — | FDA listed | — |
| CAREALL Muscle Rub Ultra Strength 100 mg/g; 150 mg/g 51824-0007-03 | New | 85 g | — | — | FDA listed | — |
| CAREALL Muscle Rub Ultra Strength 100 mg/g; 150 mg/g 51824-0105-03 | New | 85 g | — | — | FDA listed | — |
| Analgesic Balm 10 g/100g; 15 g/100g 57896-0116-01 | Geri-Care | 1 tube | — | — | FDA listed | — |
| DynaRub 10 g/100g; 15 g/100g 67777-0113-50 | Dynarex | 72 tubes | — | — | FDA listed | — |
| Dr Sheffield Muscle Rub Cream 100 mg/g; 150 mg/g 68071-1624-05 | NuCare | 35 g | — | — | FDA listed | — |
| Rugby Muscle Rub Cream 100 mg/g; 150 mg/g 68071-3789-03 | NuCare | 1 tube | — | — | FDA listed | — |
| Muscle Rub Cream 10 g/100g; 15 g/100g 68788-8544-08 | Preferred | 1 tube | — | — | FDA listed | — |
| Rugby Muscle Rub Cream 100 mg/g; 150 mg/g 68788-8729-08 | Preferred | 1 tube | — | — | FDA listed | — |
| Muscle Rub Cream .1 g/100g; .15 g/100g 69396-0024-05 | Trifecta | 1 tube | — | — | FDA listed | — |
| Muscle Rub Cream 10 g/100g; 15 g/100g 69396-0110-30 | Trifecta | 1 tube | — | — | FDA listed | — |
| Pain Reliever Cream 10 g/100g; 15 g/100g 69396-0151-01 | Trifecta | 1 tube | — | — | FDA listed | — |
| TheraCare Muscle and Join Pain Relieving Cream 100 mg/g; 150 mg/g 71101-0012-01 | Veridian | 1 tube | — | — | FDA listed | — |
| AsperFlex 100 mg/g; 150 mg/g 71399-6854-03 | Akron | 85 g | — | — | FDA listed | — |
| Calypxo HP Pain Relief 15 g/100g; 10 g/100g 76420-0999-01 | Asclemed | 113 g | — | — | FDA listed | — |
| Muscle Rub 10 g/100g; 15 g/100g 87236-0005-01 | Aldermed | 1 tube | — | — | FDA listed | — |
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.
- FDA openFDA NDC Directory · synced Oct 8, 2026
- FDA Orange Book · refreshed Oct 3, 2026
- CMS NADAC weekly file · file of Oct 7, 2026
Availability & generic status
🏛️
2022
On the market since
Feb 2022
📍
2026
Currently FDA-listed
4 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found
We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.
- FDA Orange Book · refreshed Oct 3, 2026
Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
🧪 Avoiding an ingredient? See Menthol / Methyl Salicylate inactive ingredients by manufacturer: every current product's list side by side, so you can ask your pharmacy for the version that does not list it.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
-
UNII 4Q93RCW27E
A synthetic polymer made from acrylic acid that's crosslinked for stability. It acts as a thickener and gelling agent in creams and gels, helping the medicine spread evenly and maintain its texture.
-
UNII 936JST6JCN
Cetyl alcohol is a waxy, fatty substance derived from plant or animal sources. It acts as an emulsifier and thickener in medicines, helping blend oil and water components and giving products a smooth, creamy texture.
-
UNII 8Q0Z18J1VL
A surfactant derived from oleic acid, a naturally occurring fatty acid. It helps mix oil and water-based ingredients together in formulations, improving product stability and texture.
-
UNII 4ELV7Z65AP
Stearic acid is a fatty acid derived from plant or animal sources. It acts as a binder and lubricant in tablets and capsules, helping them hold together and flow smoothly during manufacturing.
-
UNII 9O3K93S3TK
Trolamine is an alkaline compound used as a pH buffer and emulsifier in medicines. It helps neutralize acids, stabilize formulations, and enable mixing of oil and water-based ingredients.
-
UNII 059QF0KO0R
Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
6 inactive ingredients listed in the exact product block matched to this NDC.
The official label also statesCarbomer, Cetyl Alcohol, Oleth-3 Phosphate, Stearic acid, Triethanolamine, Purified Water
Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.
Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed —
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.- FDA label on DailyMed · label index refreshed Oct 6, 2026
- FDA openFDA NDC Directory · synced Oct 8, 2026
Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.
Manufacturer & labeler
LabelerRugby Laboratories
FDA applicationM017 (OTC MONOGRAPH DRUG)
Labeler code00536
First marketedFeb 2022
Product typeHuman Otc Drug
Portfolio149 products on file
More NDCs from Rugby Laboratories labeler code 00536
- Rugby Menthol Hot Cold Patch 5 g/100g Patch NDC 0536-1332-15
- Guaifenesin D Guaifenesin and Pseudoephedrine Hydrochloride 600 mg; 60 mg Tablet, Extended Release NDC 0536-1333-21
- Dextromethorphan HBr 15 mg Liquid Gels 15 mg Capsule, Liquid Filled NDC 0536-1334-34
- Nicotine 2 mg Lozenge NDC 0536-1337-09
- Maxi Nicotine nicotine polacrilex 4 mg Lozenge NDC 0536-1338-09
- rugby cough syrup dextromethorphan hydrobromide, guaifenesin 20 mg/20mL; 200 mg/20mL Solution NDC 0536-1348-97
- Rugby Benzoyl Peroxide Wash Acne Medication 100 mg/g Lotion NDC 0536-1351-42
- Rugby Lidocaine Lidocaine 4% 4 g/100g Cream NDC 0536-1357-95
- Rugby Nicotine Polacrilex Gum, Mint Flavor 2 mg Gum, Chewing NDC 0536-1362-06
- Loratadine ODT 10 mg Tablet, Orally Disintegrating NDC 0536-1367-07
- Lansoprazole 15 mg Capsule, Delayed Release NDC 0536-1368-13
- Rugby Nicotine Polacrilex Gum, Mint Flavor 4 mg Gum, Chewing NDC 0536-1372-06
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.
- FDA openFDA NDC Directory · synced Oct 8, 2026
- Drugs@FDA
FDA label — Drug Facts FDA SPL
The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage
⏱️ Dosage and Administration
⚠️ Warnings
🧪 Active Ingredient
🧪 Inactive Ingredients
🎯 Purpose
📄 Keep Out of Reach of Children
📄 Package Label / Principal Display Panel
🎯 Indications and Usage ▾
Uses For temporary relief of minor aches and pains of muscle and joints associated with simple backaches, arthritis, strains, bruises and sprains
⏱️ Dosage and Administration ▾
Directions Adults and children 2 years of age and older; Apply to affected area not more than 3 to 4 times daily. Children under 2 years of age; consult a doctor. Unless treating hands, wash hands throughly with soap and water immediately after use.
⚠️ Warnings ▾
Warnings For external use only Avoid contact with eyes and mucous membranes If conditions worsens, or if symtoms persist for more than 7 days or clear up and occur again within a few days, discontinue use of this product and consult a doctor. Do not apply to wounds or damaged skin. Do not apply bandage tightly.
Do not use with a heating pad or on wounds, damaged, broken (open) or irritated skin. Discontinue use if excessive irritation of skin develops. If pregnant or breast feeding, ask a health professional before use.
A temporary burning sensation may occur upon application, but generally disappears in a few days.
🧪 Active Ingredient ▾
Active Ingredients Menthol - 10% Methyl salicylate - 15%
🧪 Inactive Ingredients ▾
Inactive ingredients Carbomer, Cetyl Alcohol, Oleth-3 Phosphate, Stearic acid, Triethanolamine, Purified Water
🎯 Purpose ▾
Purpose Topical Analgesic Topical Analgesic
📄 Keep Out of Reach of Children ▾
Keep this and all drugs out of the reach of children. If swallowed, get medical help or contact a Poison Control Center immediately.
📄 Package Label / Principal Display Panel ▾
Principal Display Panel - 3.0 oz Carton Rugby Greaseless MUSCLE RUB Cream 10% Menthol / 15% Methyl Salicylate Topical Analgesic Net WT.
3.0OZ (85g) Principal Display Panel - 3.0 oz Carton
Principal Display Panel - 3.0 oz Tube Rugby Greaseless MUSCLE RUB Cream 10% Menthol / 15% Methyl Salicylate Topical Analgesic Net WT.
3.0OZ (85g) Principal Display Panel - 3.0 oz Tube
No label section mentions that — try another word, or open the full label on DailyMed below.
Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA.
Prefer the government’s original formatting? View this label on DailyMed ↗
Medicaid utilization & spend
📍 This exact package only: Medicaid data is reported per full 11-digit NDC — labeler, product and pack size — so every number here is for this package alone, not the drug overall. Other pack sizes report separately.
💊 Pharmacy benefit only: These are Medicaid outpatient pharmacy claims, billed by NDC. They exclude the medical benefit — clinic- or hospital-administered drugs billed under HCPCS J-codes — so drugs used mostly that way (e.g. Avastin, Lucentis, Keytruda) can look low or missing here. That’s expected, not an error.
📅 Q1 2025 – Q1 2026 · 5 quarters of data
ⓘ The newest quarter is usually incomplete when first published; states restate recent quarters in later CMS releases, so the latest figures typically revise upward. State coverage-policy changes can also shift quarter-to-quarter totals.
Prescriptions last 4 qtrs
1.1K
Units reimbursed last 4 qtrs
98.5K
Gross reimbursed last 4 qtrs
$9.1K
Avg / prescription
$8.22
Avg / unit
$0.0928
Latest quarter Q1 2026
235Rx
Medicaid pays / g
$0.0928
gross reimbursed
vs
NADAC / g
$0.0365
acquisition cost
=
Spread
+$0.0563
+154% vs cost
What Medicaid paid per g (before rebates; includes the pharmacy’s dispensing fee) compared with NADAC — the average price pharmacies pay to buy the drug. A positive spread means Medicaid reimbursed more than the purchase price, before manufacturer rebates.
Fee-for-service vs managed care ⓘ
Fee-for-service · 122 Rx Managed care · 990 Rx
State Medicaid map
Units reimbursed · per 100k residents
37.92,037
gray = no data reported ⓘ
Colors are per 100,000 residents, so big states don’t automatically dominate. Tap or hover a state for its actual totals.
Tap or hover a state
…for its Medicaid breakdown
Prescriptions—
Units—
Reimbursed—
🏆 Top states by units · per 100k residents
National units — by quarter
💵 About the dollar figures: “reimbursed” is what Medicaid paid pharmacies before confidential manufacturer rebates, so the program’s real net cost is lower than these numbers. Fee-for-service and managed-care claims are combined unless split above. Source: CMS State Drug Utilization Data; per-100k rates use 2023 Census population estimates.
Reported adverse events (FAERS)
Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Muscle Rub (this brand).
Top reported reactions
Age at onset
Reporter sex
Male · 38%
Female · 62%
Unknown · 0%
Serious outcomes
Reports over time (by year) — tap or hover for the count & year
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.
For educational and professional reference only — not medical advice. Pricing reflects published
NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.