Selenium Sulfide
Selenium sulfide is a medicated ingredient, found mostly in anti-dandruff shampoos, used to relieve flaking and itching from dandruff and seborrheic dermatitis and to help keep them from coming back.
🧬 Where this information comes from
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 51 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
Selenium sulfide is one of the classic dandruff-shampoo ingredients, used to relieve flaking and itching from dandruff and seborrheic dermatitis (a red, flaky, itchy skin condition) and keep them from returning, apparently by slowing how fast scalp skin cells are made; it has been around since about 1951 and is available generically and over the counter. It is generally well tolerated; what people notice most is scalp irritation, hair that feels oilier or drier, and occasionally some hair discoloration. Use it only on the scalp, never on broken or inflamed skin, and stop and see a doctor if flaking worsens or does not improve with regular use.
Clinical pearls
- Leave the lather on your scalp for several minutes before rinsing, because a quick wash-and-rinse wastes much of the benefit.
- Rinse very thoroughly, especially with blond, gray or color-treated hair, since leftover product can discolor hair.
- Keep it out of your eyes and off the genital area, and if it gets in your eyes, rinse well with water.
- Store it out of children's reach, and if anyone swallows some, get medical help or call Poison Control right away.
Patient Information Guide A plain-language walkthrough of Selenium Sulfide, written from its FDA label.
What Selenium Sulfide Is Used For
▾
Selenium sulfide is used on the scalp for dandruff-related problems. Supported uses include:
- Relieving flaking and itching from dandruff
- Relieving flaking and itching from seborrheic dermatitis
- Helping prevent dandruff and seborrheic dermatitis from coming back
- Some products (such as Silvagle, Prosoria Medicated and Hairitage) also list relief of irritation, redness and scaling
How Selenium Sulfide Works
▾
Selenium sulfide appears to slow the growth of cells in the top layer of skin and in the hair follicles. This reduces the production of flaky skin cells. How it works when applied to the skin is not yet fully known.
Selenium Sulfide Dosage
▾
Selenium sulfide shampoos are applied to wet hair and scalp, massaged in, and rinsed out. Most labels suggest using them at least twice a week for best results, or as directed by a doctor.
- Many products say to shake the bottle well first.
- Some say you can repeat the wash if desired.
- CVS Gold says to leave it on for 3-5 minutes before rinsing.
- Some Head and Shoulders and other dandruff products say to rinse for at least 5 minutes if used on bleached, tinted, gray or permed hair.
Follow your product label and your prescriber's advice.
Dosing details from the FDA-approved label
From the Selenium Sulfide prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.
- Dandruff (Selsun Blue shampoo)
- Shake well
- Wet hair, massage onto scalp, rinse
- Repeat if desired
- For best results, use at least twice a week or as directed by a doctor
- Dandruff (Hairitage Wash It Away Anti-Dandruff, oily or dry flaky scalp)
- Shake well before each use
- Apply to wet hair and massage, from scalp to ends
- Rinse thoroughly and follow with Hairitage Balancing Conditioner
- Substitute Hairitage Anti-Dandruff Shampoo with your regular shampoo every other wash, or when you notice oily and/or flaky scalp (dry and/or flaky scalp for the dry scalp product)
- For best results use at least twi
- Dandruff (Head and Shoulders Clinical Strength products)
- For best results use at least twice a week or as directed by a doctor
- For maximum dandruff control, use every time you shampoo
- Shake before use
- Wet hair, massage onto scalp, rinse, repeat if desired
- If used on bleached, tinted, grey, or permed hair, rinse for 5 minutes.
- Dandruff (generic Dandruff shampoo)
- Shake well
- For maximum dandruff control, use every time you shampoo
- Wet hair, massage onto scalp, rinse, repeat if desired
- For best results use at least twice a week or as directed by a doctor
- If used on bleached, gray, tinted or permed hair, rinse for at least 5 minutes.
- Prosoria Medicated lotion/shampoo
- For best results use at least twice a week or as directed by a doctor
- For maximum control, use every time you shampoo
- Shake bottle before use
- Wet hair, massage onto scalp, rinse, repeat if desired
- CVS Gold shampoo
- Apply a generous amount to wet hair, massage onto scalp and work evenly to the ends
- Leave on for 3-5 minutes
- Rinse thoroughly
- For best results use at least twice a week or as directed by a doctor
- Dandruff (Amazon Basics, Walgreens shampoos)
- Shake well
- Wet hair
- Massage onto scalp
- Rinse
- Repeat if desired
- For best results use at least twice a week or as directed by a doctor
- For maximum dandruff control, use every time you shampoo
Read the label’s full dosing text
DOSAGE AND ADMINISTRATION: Shake well before use. For seborrheic dermatitis and dandruff: Wet skin and apply to areas to be cleansed. Massage gently into the skin working into a full lather. Rinse thoroughly and pat dry. Generally, two applications each week for two weeks will control symptoms. Subsequently, shampoo may be used less frequently or as directed by a physician. It should not be applied more frequently than necessary to maintain control. For tinea versicolor: Wet skin and apply to areas to be cleansed. Massage gently into the skin working into a full lather. Allow product to remain on skin for ten minutes, then rinse thoroughly and pat dry. Repeat procedure once a day for seven days or as directed by a physician.
Read the full Dosage and Administration section on DailyMed →
Selenium Sulfide Side Effects
▾
Side effects are mostly limited to the scalp and hair.
Common side effects
- Skin irritation
- Increase in normal hair loss (occasionally reported)
- Hair discoloration (rinsing thoroughly helps avoid it)
- Oiliness of hair and scalp
- Dryness of hair and scalp
- Occasional increase in normal hair loss
- Hair discoloration, which thorough rinsing can help avoid or minimize
When to get medical help
- Stop use and call a doctor if your condition gets worse or does not improve after regular use as directed.
- Stop use if you have an allergic reaction.
- If swallowed, get medical help or call Poison Control right away.
- If it gets in your eyes, rinse thoroughly with water.
Stop use if you have an allergic reaction. Ask a doctor if your condition worsens or does not improve.
Selenium Sulfide Warnings and Precautions
▾
- For external use only. Swallowing it needs medical help or a call to Poison Control right away.
- Do not use on broken skin or inflamed areas.
- Avoid the eyes. If contact occurs, rinse thoroughly with water.
- Avoid the genital area, where it may cause irritation and burning.
- Stop use and ask a doctor if your condition gets worse or does not improve with regular use.
- Keep out of reach of children.
Before Taking Selenium Sulfide
▾
- Do not use it if you know or suspect you are allergic to any ingredient in the product.
- Avoid using it on broken or inflamed skin.
- Keep it away from children.
Selenium Sulfide Overdose
▾
Selenium sulfide is for external use only. For the 2.5% topical suspension (lotion), there have been no documented reports of serious toxicity in humans from swallowing it. Animal studies suggest that large amounts could be harmful, so emptying the stomach should be considered after a large accidental swallow. If anyone swallows it, get medical help or call Poison Control right away.
What Selenium Sulfide Does in the Body
▾
Selenium sulfide appears to have a cytostatic effect (it slows cell growth) on cells of the epidermis (outer skin layer) and follicular epithelium (the lining of hair follicles). This reduces corneocyte production, meaning fewer flaky skin cells form.
How to Store Selenium Sulfide
▾
Store at 20°C to 25°C (68°F to 77°F), excursions permitted between 15°C to 30°C (between 59°F to 86°F). Protect from freezing and excessive heat.
Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
Selenium Sulfide: Pharmacist Answers to Common Questions
Quick, plain-English answers to the questions patients ask most about Selenium Sulfide — the kind of thing our pharmacy team would talk through with you at the counter.
What is selenium sulfide used for?
▾
How often should I use it?
▾
What side effects might I notice?
▾
Is there anything I should avoid?
▾
When should I stop using it and call someone?
▾
Is Selenium Sulfide available over the counter?
▾
When was Selenium Sulfide first available?
▾
Who makes Selenium Sulfide?
▾
Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
More About Selenium Sulfide on HelloPharmacist
Selenium Sulfide Forms and Strengths (How It Comes)
Selenium Sulfide is available in 2 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Selenium Sulfide inactive ingredients by manufacturer.
Topical cream, ointment or gel
How this form is used
- Careone Medicated Dandruff and CareOne Moisturizing Dandruff with Aloe are used for relief of flaking and itching from dandruff and seborrheic dermatitis, and to help prevent recurrence.
- CareOne Medicated Dandruff with Menthol is used for relief of flaking and itching from dandruff and seborrheic dermatitis, and to help prevent recurrence.
- CVS Health MAXIMUM STRENGTH Dandruff is used for relief of flaking and itching from dandruff and seborrheic dermatitis, and to help prevent recurrence.
- CVS Gold: apply a generous amount to wet hair, massage onto the scalp and work to the ends, leave on 3-5 minutes, then rinse thoroughly.
- amazon basics maximum strength dandruff: shake well, wet hair, massage onto scalp, rinse, and repeat if desired.
- amazon basics maximum strength dandruff: use at least twice a week for best results, or as directed by a doctor.
Show 3 more strengths Show fewer strengths
Topical solution
How this form is used
- Silvagle Selenium Sulfide Anti DandruffShampoo relieves scalp itching, flaking, scaling, irritation and redness.
- Silvagle Selenium Sulfide Anti DandruffShampoo helps prevent recurrence of dandruff and seborrheic dermatitis.
Selenium Sulfide on the U.S. Market: Products, Makers and Brands
How Selenium Sulfide appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
28 companies list 46 Selenium Sulfide product records with the FDA, mostly as topical cream, ointment or gel, topical solution; the earliest marketing or approval year on record is 1951. Brand names on the directory include Head and Shoulders Intensive Treatment Dandruff Shampoo, Selsun Blue, Selsun and 13 more; the rest are generics.
FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
Also listed with the FDA, not a patient dose form: Powder (4) · Unfinished solution (1) — bulk drug substance and unfinished product sold to compounders and other manufacturers to finish, and multi-item kits. These aren’t counted in the dose-form total above.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
How Widely Selenium Sulfide Is Used (Medicaid Data)
A general measure of how commonly Selenium Sulfide is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Selenium Sulfide is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Selenium Sulfide prescribed? Of the 1,601 medications we measure, Selenium Sulfide ranks #578 by Medicaid prescriptions — more than 64% of them.
Utilization by Selenium Sulfide product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
selenium sulfide 22.5 MG/ML Medicated Shampoo Most dispensed
Summed across the 1 of 10 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 706548
selenium sulfide 10 MG/ML Medicated Shampoo
Summed across the 1 of 73 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 204642
Other Selenium Sulfide products — combination packs and listings not yet matched to a specific clinical product (kept visible so every prescription is accounted for)
Summed across the 1 of 12 listed NDC products with Medicaid activity.
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Selenium Sulfide, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 3 of 95 listed Selenium Sulfide NDCs with Medicaid activity.
Compare Selenium Sulfide Products
A representative set of FDA-listed product records for Selenium Sulfide — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Topical cream, ointment or gel | ||||
| 10 mg/mL | Topical | Amazon.com Services Llc | OTC MONOGRAPH DRUG | View NDC → |
| 1000 mg/100 mL | Topical | Apollo Health and Beauty Care | OTC MONOGRAPH DRUG | View NDC → |
| 10 mg/mL | Topical | Cardinal Health, 110 dba LEADER | OTC MONOGRAPH DRUG | View NDC → |
| 2.5 g/250 mL | Topical | Cavtech Holding Llc | OTC MONOGRAPH DRUG | View NDC → |
| 1 g/100 mL | Topical | Chattem, Inc. × 3 listings | OTC MONOGRAPH DRUG | View NDC → |
| 23 mg/mL | Topical | Cintex Services, LLC | UNAPPROVED DRUG OTHER | View NDC → |
| 10 mg/mL | Topical | CVS Health × 2 listings | OTC MONOGRAPH DRUG | View NDC → |
| 0.6 g/100 mL | Topical | Davines S.p.A. | OTC MONOGRAPH DRUG | View NDC → |
| 10 mg/mL | Topical | Family Dollar Services Inc | OTC MONOGRAPH DRUG | View NDC → |
| 10 mg/mL | Topical | Goodsense | OTC MONOGRAPH DRUG | View NDC → |
| 10 mg/mL | Topical | H E B | OTC MONOGRAPH DRUG | View NDC → |
| 23 mg/mL | Topical | KMM Pharmaceuticals, LLC | UNAPPROVED DRUG OTHER | View NDC → |
| 22.5 mg/mL | Topical | Laser Pharmaceuticals, LLC | UNAPPROVED DRUG OTHER | View NDC → |
| 23 mg/mL | Topical | Laser Pharmaceuticals, LLC | UNAPPROVED DRUG OTHER | View NDC → |
| 10 mg/mL | Topical | Meijer, Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 10 mg/mL | Topical | Meijer Distribution, Inc × 2 listings | OTC MONOGRAPH DRUG | View NDC → |
| 1.77 g/177 mL | Topical | Nuvothera, Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 2.5 mg/100 mL | Topical | Padagis Israel Pharmaceuticals Ltd | ANDA | View NDC → |
| 10 mg/mL | Topical | Retail Business Services, LLC | OTC MONOGRAPH DRUG | View NDC → |
| 10 mg/mL | Topical | Rugby Laboratories | OTC MONOGRAPH DRUG | View NDC → |
| 10 mg/mL | Topical | Target Corporation × 2 listings | OTC MONOGRAPH DRUG | View NDC → |
| 1 g/100 mL | Topical | The Procter & Gamble Manufacturing Company × 9 listings | OTC MONOGRAPH DRUG | View NDC → |
| 10 mg/mL | Topical | Topco Associates | OTC MONOGRAPH DRUG | View NDC → |
| 10 mg/mL | Topical | Treasurewise Llc | OTC MONOGRAPH DRUG | View NDC → |
| 10 mg/mL | Topical | Wal-Mart Stores, Inc. | OTC MONOGRAPH DRUG | View NDC → |
| 10 mg/mL | Topical | Walgreen Company × 4 listings | OTC MONOGRAPH DRUG | View NDC → |
| 22.5 mg/mL | Topical | Westminster Pharmaceuticals, LLC | UNAPPROVED DRUG OTHER | View NDC → |
| 💊Topical solution | ||||
| 1 mg/100 mg | Topical | Guangzhou Baosijie Biotechnology Co., Ltd | OTC MONOGRAPH DRUG | View NDC → |
| 1 mg/384 mL | Topical | Maesa, LLC. | OTC MONOGRAPH DRUG | View NDC → |
| 0.1 g/mL | Topical | Maesa, LLC. | OTC MONOGRAPH DRUG | View NDC → |
Showing 46 of 46 products — FDA National Drug Code Directory. See every product, package size and price: browse all 46 Selenium Sulfide NDCs →
Selenium Sulfide Side Effects Reported to the FDA (FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Selenium Sulfide — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Selenium Sulfide in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
Selenium Sulfide FDA Approval History
How Selenium Sulfide went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
Selenium Sulfide Recall History
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
The FDA’s enforcement reports list no Selenium Sulfide recalls since July 2021.
✅No Selenium Sulfide recalls on record since July 2021Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Oct 8, 2026.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.
RxCUI 36345 2 dose forms · 6 strengths
-
Dose form (SCDF) Medicated Shampoo RxCUI 377509In current FDA listingsClinical drug / strength (SCD) 6 MG/MLRxCUI 124594610 MG/MLRxCUI 20464222.5 MG/MLRxCUI 70654823 MG/MLRxCUI 143694025 MG/MLRxCUI 238600 -
Dose form (SCDF) Topical Foam RxCUI 727146No current FDA listingClinical drug / strength (SCD) 22.5 MG/MLRxCUI 727147
Look up RxCUI 36345 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
Selenium Sulfide Supply and Shortage Status
Whether Selenium Sulfide is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
💵 What Selenium Sulfide Costs Pharmacies (NADAC Benchmark)
The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.
| Form | Strength | Pharmacy acquisition benchmark | |
|---|---|---|---|
| Lotion · Topical | 2.5 mg/100 mL | $0.078 per mL | NDC details & price history |
Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.
Selenium Sulfide Brand Names
Selenium Sulfide is sold under 16 brand names in the FDA directory — Head and Shoulders Intensive Treatment Dandruff Shampoo, Selsun Blue, Selsun, Exsel and others. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.
Who Makes Selenium Sulfide: Manufacturers and Labelers
28 companies list Selenium Sulfide products with the FDA. By number of product records, the largest are The Procter & Gamble Manufacturing Company, Walgreen Company, Chattem, Inc.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.
…and 4 more on the FDA NDC directory.
Selenium Sulfide Drug Class (RxNorm)
Selenium Sulfide belongs to the Other antifungals for topical use class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
Sources for This Selenium Sulfide Page
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How this page is built
HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Padagis Israel Pharmaceuticals Ltd is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →