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REFRESH Classic Polyvinyl Alcohol, Povidone 14 mg/mL; 6 mg/mL Solution/ Drops, 50 vials — NDC 00023-0506-50 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

REFRESH Classic Polyvinyl Alcohol, Povidone 14 mg/mL; 6 mg/mL Solution/ Drops, 50 vials — NDC 0023-0506-50 (Billing 00023-0506-50)

by Allergan, Inc. · 50 VIAL, SINGLE-USE in 1 CARTON / .4 mL in 1 VIAL, SINGLE-USE

This is a package of 50 vials of REFRESH Classic Polyvinyl Alcohol, Povidone 14 mg/mL; 6 mg/mL Solution/ Drops from Allergan, Inc., marketed since Sep 1985 and currently FDA-listed; retail pharmacies pay about $0.2797 per vial (NADAC).

NDC 00023-0506-50
🏷️ FDA NDC (as labeled) 0023-0506-50 billing pads the labeler segment with a zero
This package
Contains50 vials Cost per ea$0.2797 NADAC Per package$13.99 / 50 vials Pack sizes2 compare ↓
Also priced by: Medicaid pays $1.20/unit — full pricing hub ↓
Product page 00023-0506-01 Also comes in: 30 vials 0023-0506-01
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 8, 2026 · this listing last changed Oct 8, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 0023-0506-50 alone.

Record
FDA NDC Directory package listing · Human OTC drug
Code segments
0023 labeler · 0506 product · 50 package
Package marketed since
Sep 12, 1985
Sample package
No — commercial package
Listing certified through
Dec 31, 2027
Billing quantity
50 EA per package
Barcode (UPC-A, from the NDC)
3 0023050650 2
Medicaid fills, this package
10,771 prescriptions in the last four reported quarters
FDA record last changed
Oct 8, 2026
⚠️
Other active recalls for Polyvinyl Alcohol, Povidone (different manufacturers) — 1 · tap to view
These affect other manufacturers’ products for the same ingredient — not necessarily the exact NDC on this page.
Class II · Mar 3, 2026 — Lack of Assurance of Sterility (K.C. Pharmaceuticals, Inc) · FDA recall D-0416-2026
Each entry is an official FDA enforcement report — look up any recall number in the FDA recall database ↗

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 0023-0506-50
Product NDC 0023-0506
11-digit billing NDC 00023050650
NCPDP billing unit EA — each (per item)
Application # M018
SPL Set ID 31bf1d6c-9719-4060-b6a3-409a2fe7b560
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 1985-09-12
Route OPHTHALMIC
Dosage form SOLUTION/ DROPS
Substance POLYVINYL ALCOHOL, UNSPECIFIED; POVIDONE

Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification

GCN Seq No 030016
GCN 87031
HICL code 038595
Ingredient (HICL) Polyvinyl Alcohol/Povidone/Pf
HIC1 code Q
Therapeutic class — broad (HIC1) Ear/Eye/Nose/Rectum/Topical/Vagina/Other
HIC2 code Q6
Therapeutic class — intermediate (HIC2) Ophthalmic Preparations
HIC3 code Q6T
Therapeutic class — specific (HIC3) Artificial Tears
AHFS code 52:92.00.00
AHFS class Eent Drugs, Miscellaneous
FDB label name REFRESH CLASSIC EYE DROPS
FDB brand name Refresh Classic
Legend status O — Over-the-counter (OTC) drug or device
Quick answers
  • GSN (GCN sequence number): 030016
  • GCN: 87031
  • HICL (First Databank): 038595
  • AHFS class code: 52:92.00.00
Why two NDCs? The FDA registers this code as 0023-0506-50 — a 4-4-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the labeler segment → 00023-0506-50. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

Clinical

Label name REFRESH CLASSIC EYE DROPS Ingredient Polyvinyl Alcohol/Povidone/Pf
🧪 What is this product?

Refresh Classic is an over-the-counter eye drop solution containing polyvinyl alcohol and povidone. These ingredients function as lubricants and are commonly used to temporarily soothe dry, irritated eyes and provide moisture to the eye surface. This product is marketed under FDA's OTC monograph rules for ophthalmic lubricants rather than as an individually approved application.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eaPer package
Retail pharmacies payNADAC · weekly $0.280 $13.99 / 50 vials
Medicaid paysCMS SDUD · 12 mo $1.20 $59.77 / 50 vials
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
NADAC price history (per ea) — tap or hover for the price & month
Dec 2025 Jan 2026 Mar 2026 May 2026 $0.280 $0.279
Flat over the last 4 months.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Per unit Per pack Marketing startMarketing endStatus
00023-0506-01 0023-0506-01 Main listing 30 VIAL, SINGLE-USE in 1 CARTON / .4 mL in 1 VIAL, SINGLE-USE $0.3061 / ea $9.18 1985-09-12 — Active
00023-0506-50 You're viewing this 50 VIAL, SINGLE-USE in 1 CARTON / .4 mL in 1 VIAL, SINGLE-USE $0.2797 / ea $13.99 1985-09-12 — Active

This pack has the lowest per-ea cost of the 2 priced pack sizes ($0.2797 NADAC).

This pack accounts for about 9.4% of this product's recent Medicaid fills; most go to a different pack size. See all packs ↓

Pack size FAQ

What quantity is in this package?
This package contains 50 vials — 50 vial, single-use in 1 carton / .4 ml in 1 vial, single-use.
How does this package differ from NDC 00023-0506-01?
Both are REFRESH Classic Polyvinyl Alcohol, Povidone 14 mg/mL; 6 mg/mL Solution/ Drops — the drug itself is identical. This page's package is the 50 vials one, while NDC 00023-0506-01 is the 30 vials package. Per-ea NADAC also differs: $0.2797 here vs $0.3061 for the 30 vials pack.
What NDC number is used to bill for this package of REFRESH Classic Polyvinyl Alcohol, Povidone 14 mg/mL; 6 mg/mL Solution/ Drops?
Use the 11-digit billing form listed in the identifiers section of this page. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

Prices are the latest CMS NADAC pharmacy acquisition cost per NDC; per-pack figures are per-unit × pack quantity, shown only when the pack is denominated in the same measure NADAC prices.

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
REFRESH Classic 14 mg/mL; 6 mg/mLthis 00023-0506-50 Allergan, 50 vials $0.280 — Availability likely —
Refresh Classic 14 mg/mL; 6 mg/mL 50090-2358-01 A-S 30 vials — — FDA listed —
Minidrops 6 mg/mL; 14 mg/mL 64108-0212-12 Optics 30 vials — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
1985
On the market since
Sep 1985
📍
2026
Currently FDA-listed
41 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII QTT17582CB
    A strong acid used to adjust and maintain the proper pH level in liquid medicines, ensuring stability and preventing breakdown of active ingredients.
  • UNII 451W47IQ8X
    Sodium chloride is common table salt. It's used in medicines as a buffer to maintain proper pH, as a filler to add bulk, or to adjust the osmotic balance in liquid formulations.
  • UNII 55X04QC32I
    A strong alkaline chemical used to adjust and maintain the pH balance of liquid medicines. It helps keep the medicine stable and ensures it stays effective during storage.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

4 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesPurified water and sodium chloride. May also contain hydrochloric acid and/or sodium hydroxide (to adjust pH).

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerAllergan, Inc.
FDA applicationM018 (OTC MONOGRAPH DRUG)
Labeler code00023
First marketedSep 1985
Product typeHuman Otc Drug
Portfolio188 products on file

More NDCs from Allergan, Inc. labeler code 00023

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Stop Use and Ask a Doctor If 📄 Keep Out of Reach of Children 📄 Other Information 📄 Questions or Comments 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 31 words ▾

Uses For the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun. May be used as a protectant against further irritation.

⏱️ Dosage and Administration 24 words ▾

Directions To open, TWIST AND PULL TAB TO REMOVE . Instill 1 or 2 drops in the affected eye(s) as needed and discard container.

⚠️ Warnings 94 words ▾

Warnings For external use only. To avoid contamination, do not touch tip of container to any surface. Do not reuse.

Once opened, discard . Do not touch unit-dose tip to eye. If solution changes color or becomes cloudy , do not use.

Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

🧪 Active Ingredient 8 words ▾

Active ingredient s Polyvinyl Alcohol 1.4% Povidone 0.6%

🧪 Inactive Ingredients 18 words ▾

Inactive ingredients Purified water and sodium chloride. May also contain hydrochloric acid and/or sodium hydroxide (to adjust pH).

🎯 Purpose 5 words ▾

Purpose Eye lubricant Eye lubricant

📄 Stop Use and Ask a Doctor If 33 words ▾

Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours.

📄 Keep Out of Reach of Children 19 words ▾

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

📄 Other Information 26 words ▾

Other information Use only if single-use container is intact. Use before expiration date marked on container. Store at 59°-77°F (15°-25°C). RETAIN THIS CARTON FOR FUTURE REFERENCE.

📄 Questions or Comments 7 words ▾

Questions or comments? 1.800. 678.1605 refreshbrand.com v1.0DFL0506

📄 Package Label / Principal Display Panel 50 words ▾

Principal Display Panel NDC 0023-0506-01 PRESERVATIVE-FREE Refresh ® CLASSIC Lubricant Eye Drops Moisturizing Relief For Dry, Irritated Eyes 30 Vials 0.01 fl oz (0.4 mL) each Sterile NDC 0023-0506-01 PRESERVATIVE-FREE Refresh® CLASSIC Lubricant Eye Drops Moisturizing Relief For Dry, Irritated Eyes 30 Vials 0.01 fl oz (0.4 mL) each Sterile

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

Medicaid utilization & spend

📍 This exact package only: Medicaid data is reported per full 11-digit NDC — labeler, product and pack size — so every number here is for this package alone, not the drug overall. Other pack sizes report separately.
💊 Pharmacy benefit only: These are Medicaid outpatient pharmacy claims, billed by NDC. They exclude the medical benefit — clinic- or hospital-administered drugs billed under HCPCS J-codes — so drugs used mostly that way (e.g. Avastin, Lucentis, Keytruda) can look low or missing here. That’s expected, not an error.
📅 Q1 2025 – Q1 2026 · 5 quarters of data
ⓘ The newest quarter is usually incomplete when first published; states restate recent quarters in later CMS releases, so the latest figures typically revise upward. State coverage-policy changes can also shift quarter-to-quarter totals.
Prescriptions last 4 qtrs
10.8K
Units reimbursed last 4 qtrs
239.3K
Gross reimbursed last 4 qtrs
$286K
Avg / prescription
$26.56
Avg / unit
$1.1954
Latest quarter Q1 2026
3KRx
Medicaid pays / ea
$1.1954
gross reimbursed
vs
NADAC / ea
$0.2797
acquisition cost
=
Spread
+$0.9157
+327% vs cost
What Medicaid paid per ea (before rebates; includes the pharmacy’s dispensing fee) compared with NADAC — the average price pharmacies pay to buy the drug. A positive spread means Medicaid reimbursed more than the purchase price, before manufacturer rebates.
Fee-for-service vs managed care ⓘ
79% FFS 21% MCO
Fee-for-service · 8,483 Rx Managed care · 2,288 Rx
State Medicaid map
Alaska: no data reported AK Maine: no data reported ME Washington: no data reported WA Idaho: no data reported ID Montana: no data reported MT North Dakota: no data reported ND Minnesota: 18,236 units · 318 per 100k residents MN Wisconsin: 19,237 units · 325 per 100k residents WI Michigan: no data reported MI New York: 149,867 units · 766 per 100k residents NY Vermont: no data reported VT New Hampshire: no data reported NH Oregon: no data reported OR Nevada: 804 units · 25.2 per 100k residents NV Wyoming: no data reported WY South Dakota: no data reported SD Iowa: no data reported IA Illinois: 960 units · 7.7 per 100k residents IL Indiana: 5,676 units · 82.7 per 100k residents IN Ohio: 10,200 units · 86.6 per 100k residents OH Pennsylvania: 9,459 units · 73.0 per 100k residents PA New Jersey: 2,552 units · 27.5 per 100k residents NJ Massachusetts: no data reported MA California: 3,664 units · 9.4 per 100k residents CA Utah: no data reported UT Colorado: no data reported CO Nebraska: 3,116 units · 158 per 100k residents NE Missouri: no data reported MO Kentucky: no data reported KY West Virginia: no data reported WV Virginia: 4,120 units · 47.3 per 100k residents VA Maryland: no data reported MD Connecticut: 1,960 units · 54.2 per 100k residents CT Rhode Island: no data reported RI Arizona: 1,494 units · 20.1 per 100k residents AZ New Mexico: 6,392 units · 302 per 100k residents NM Kansas: no data reported KS Arkansas: no data reported AR Tennessee: no data reported TN North Carolina: no data reported NC South Carolina: 1,300 units · 24.2 per 100k residents SC Delaware: no data reported DE Oklahoma: no data reported OK Louisiana: no data reported LA Mississippi: no data reported MS Alabama: no data reported AL Georgia: no data reported GA D.C.: 248 units · 36.5 per 100k residents DC Hawaii: no data reported HI Texas: no data reported TX Florida: no data reported FL
Units reimbursed · per 100k residents
7.7766
gray = no data reported ⓘ
Colors are per 100,000 residents, so big states don’t automatically dominate. Tap or hover a state for its actual totals.
Tap or hover a state
…for its Medicaid breakdown
🏆 Top states by units · per 100k residents
1 New York 766 /100k
2 Wisconsin 325 /100k
3 Minnesota 318 /100k
4 New Mexico 302 /100k
5 Nebraska 158 /100k
6 Ohio 86.6 /100k
7 Indiana 82.7 /100k
8 Pennsylvania 73.0 /100k
National units — by quarter
💵 About the dollar figures: “reimbursed” is what Medicaid paid pharmacies before confidential manufacturer rebates, so the program’s real net cost is lower than these numbers. Fee-for-service and managed-care claims are combined unless split above. Source: CMS State Drug Utilization Data; per-100k rates use 2023 Census population estimates.

Medicaid utilization by pack size

Medicaid (SDUD) totals over the four most recent reported quarters for every package size of this drug — handy when a specific package (e.g. a starter/titration pack) carries little or no Medicaid volume on its own.
30 vials00023-0506-01 103,512 Rx · $2,042,061
50 vials this page00023-0506-50 10,771 Rx · $286,049
Drug total (last 4 qtrs): 114,283 Rx · 1,676,115 units · $2,328,109 gross reimbursed
Tap a pack size to open its page. Source: CMS State Drug Utilization Data, last 4 quarters.
← 00023-0403-05 · Allergan, 00023-0667-04 · Allergan, →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.