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Refresh Optive Carboxymethylcellulose Sodium, Glycerin 5 mg/mL; 9 mg/mL Solution/ Drops, 5 vials — NDC 00023-3416-05 package photo

Refresh Optive Carboxymethylcellulose Sodium, Glycerin 5 mg/mL; 9 mg/mL Solution/ Drops, 5 vials

by Allergan, Inc. · 5 VIAL, SINGLE-USE in 1 CARTON (0023-3416-05) / .4 mL in 1 VIAL, SINGLE-USE
NDC 00023-3416-05
🏷️ FDA NDC (as labeled) 0023-3416-05 billing pads the labeler segment with a zero
This package
Contains5 vials Pack sizes3 compare ↓
Also comes in: 30 vials 00023-3416-30 60 vials 00023-3416-60
OTC On market Non-controlled
🗂️ Data synced Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

🆔 Identity & classification

FDA NDC (as labeled) 0023-3416-05
Product NDC 0023-3416
11-digit billing NDC 00023341605
RxCUI 1100650
UNII K679OBS311, PDC6A3C0OX
Application # M018
SPL Set ID 37e99aa8-02d6-4efb-a862-90bc7fcd5ca5
Established class (EPC) Non-Standardized Chemical Allergen
Physiologic effect Increased Histamine Release; Cell-mediated Immunity; Increased IgG Production
Chemical class Allergens; Glycerol
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2008-08-22
Route OPHTHALMIC
Dosage form SOLUTION/ DROPS
Substance CARBOXYMETHYLCELLULOSE SODIUM; GLYCERIN
GPI-14 86209902122012
GCN Seq No 064505
GCN 14449
HICL code 035927
Ingredient (HICL) Carboxymethylcell/Glycerin/Pf
HIC1 code Q
Therapeutic class — broad (HIC1) Ear/Eye/Nose/Rectum/Topical/Vagina/Other
HIC2 code Q6
Therapeutic class — intermediate (HIC2) Ophthalmic Preparations
HIC3 code Q6T
Therapeutic class — specific (HIC3) Artificial Tears
AHFS code 52:92.00.00
AHFS class Eent Drugs, Miscellaneous
FDB label name REFRESH OPTIVE SENSITIVE DROPS
FDB brand name Refresh Optive Sensitive
Legend status O — Over-the-counter (OTC) drug or device
Why two NDCs? The FDA registers this code as 0023-3416-05 — a 4-4-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the labeler segment → 00023-3416-05. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏭 Manufacturer & labeler

LabelerAllergan, Inc.
FDA applicationM018 (OTC MONOGRAPH DRUG)
Labeler code00023
First marketedAug 2008
Product typeHuman Otc Drug
Portfolio188 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

Label name REFRESH OPTIVE SENSITIVE DROPS Ingredient Carboxymethylcell/Glycerin/Pf
🧪 What is this product?

Refresh Optive is an over-the-counter eye drop solution containing carboxymethylcellulose sodium and glycerin. Both ingredients function as lubricants and are typically used to help soothe and moisten dry eyes. Carboxymethylcellulose sodium is a thickening agent that helps the drops stay on the eye surface longer, while glycerin adds moisture and protective coating. This product is an OTC monograph drug, meaning it follows FDA's standard rules for over-the-counter lubricating eye drops.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII R57ZHV85D4
    Boric acid is a weak acid derived from boron. In medicines, it typically serves as a buffer to help maintain the product's pH level and may act as a preservative in certain formulations.
  • UNII M4I0D6VV5M
    Calcium chloride is a salt compound that acts as a firming agent and source of calcium ions in medications. It's used in formulations to help maintain tablet structure, improve texture, or serve as a buffering agent.
  • UNII RA96B954X6
    Erythritol is a sugar alcohol derived from fermented fruits or grains. It's used as a sweetener and bulking agent in medicines to improve taste without adding significant calories.
  • UNII 0G389FZZ9M
    Levocarnitine is an amino acid derivative that helps transport fatty acids in cells. In medications, it serves as an active nutritional component rather than a typical inactive binder or filler.
  • UNII 02F3473H9O
    A mineral salt used in medications as a source of magnesium. It helps bind ingredients together, improve texture, and maintain the product's stability during storage.
  • UNII 660YQ98I10
    Potassium chloride is a mineral salt used in medicines as a buffer and to help maintain the proper pH balance and stability of the formulation during storage and use.
  • UNII 91MBZ8H3QO
    Sodium borate is an inorganic salt compound used in medicines as a buffer to help maintain a stable pH level, and sometimes as a mild preservative or cleansing agent in topical formulations.
  • UNII B22547B95K
    A salt derived from citric acid that helps maintain the proper acid-base balance in the medicine. It's used as a buffer to keep the product stable and at the right pH level.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

9 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesBoric acid; calcium chloride dihydrate; erythritol; levocarnitine; magnesium chloride hexahydrate; potassium chloride; purified water; sodium borate decahydrate; and sodium citrate dihydrate.

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Try another pack size: 30 vials 60 vials
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Refresh RELIEVA PF 5 mg/mL; 10 mg/mL 00023-4515-30 Allergan, 30 vials $0.453 — Availability likely —
Refresh Tears Pf 5 mg/mL; 9 mg/mL 00023-3110-10 Allergan, 1 bottle $1.254 — Availability likely —
Refresh Relieva PF Xtra 5 mg/mL; 9 mg/mL 00023-3782-10 Allergan, 1 bottle $1.254 — Availability likely —
Refresh Optive 5 mg/mL; 9 mg/mL 00023-3240-01 Allergan, 2 bottles — — Discontinued —
Refresh Optive 5 mg/mL; 9 mg/mLthis 00023-3416-05 Allergan, 5 vials — — FDA listed —
Refresh Relieva 5 mg/mL; 9 mg/mL 00023-6630-03 Allergan, 1 bottle — — FDA listed —
Refresh Relieva Preservative Free 5 mg/mL; 9 mg/mL 00023-6634-01 Allergan, 1 bottle — — FDA listed —
Equate Lubricant Eye Drops .5 g/100mL; .9 g/100mL 11716-0365-05 Hanlim 1 bottle — — FDA listed —
Medics Choice Fresh and Soothe 5 mg/mL; 9 mg/mL 55651-0200-01 KC 1 bottle — — FDA listed —
Medics Choice Fresh and Soothe 5 mg/mL; 9 mg/mL 73669-0200-01 Unimed 1 bottle — — FDA listed —
Equate Optimal Hydration Lubricant Eye Drops .5 g/100mL; .9 g/100mL 79903-0258-05 Walmart, 1 bottle — — FDA listed —
Equate Lubricant Eye Drops .5 g/100mL; .9 g/100mL 79903-0365-05 Walmart 1 bottle — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️
2008
On the market since
Aug 2008
📍
2026
Currently FDA-listed
18 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

💊 Medicaid utilization by pack size

Medicaid (SDUD) totals over the four most recent reported quarters for every package size of this drug — handy when a specific package (e.g. a starter/titration pack) carries little or no Medicaid volume on its own.
30 vials00023-3416-30 46,827 Rx · $1,162,135
60 vials00023-3416-60 11,522 Rx · $291,028
5 vials this page00023-3416-05 No Medicaid data
Drug total (last 4 qtrs): 58,349 Rx · 1,111,786 units · $1,453,164 gross reimbursed
Tap a pack size to open its page. Source: CMS State Drug Utilization Data, last 4 quarters.

🔬 Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Carboxymethylcellulose Sodium, Glycerin — the ingredient across all brands.

Top reported reactions

Eye Irritation673
Eye Pain515
Vision Blurred351
Cataract318
Ocular Hyperaemia270
Dry Eye263
Foreign Body Sensation In Eyes147

Age at onset

Infant1
Child2
Adolescent2
Adult208
Elderly492

Reporter sex

3,468 reports
Male · 21%
Female · 78%
Unknown · 0%

Serious outcomes

Hospitalization199
Disabling40
Death32
Life-threatening11
Reports over time (by year) — tap or hover for the count & year
2019 2021 2023 2026 642 0
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.

📦 Packaging — all sizes for this product

Package NDCDescription Per unit Per pack Marketing startStatus
00023-3416-05 You're viewing this 5 VIAL, SINGLE-USE in 1 CARTON (0023-3416-05) / .4 mL in 1 VIAL, SINGLE-USE — — 2008-08-22 Active
00023-3416-30 30 VIAL, SINGLE-USE in 1 CARTON (0023-3416-30) / .4 mL in 1 VIAL, SINGLE-USE $0.3420 / ea $10.26 2008-08-22 Active
00023-3416-60 60 VIAL, SINGLE-USE in 1 CARTON (0023-3416-60) / .4 mL in 1 VIAL, SINGLE-USE — — 2008-08-22 Active

This pack shows little to no recent Medicaid volume — a different pack size carries most fills. See all packs ↓

Pack size FAQ

What quantity is in NDC 00023-3416-05?
NDC 00023-3416-05 contains 5 vials — 5 vial, single-use in 1 carton / .4 ml in 1 vial, single-use.
What is the difference between NDC 00023-3416-05 and NDC 00023-3416-30?
Both are Refresh Optive Carboxymethylcellulose Sodium, Glycerin 5 mg/mL; 9 mg/mL Solution/ Drops — the drug itself is identical. NDC 00023-3416-05 is the 5 vials package, while NDC 00023-3416-30 is the 30 vials package.
What NDC number is used to bill for this package of Refresh Optive Carboxymethylcellulose Sodium, Glycerin 5 mg/mL; 9 mg/mL Solution/ Drops?
Bill NDC 00023-3416-05 — the 11-digit billing format is 00023341605. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

Prices are the latest CMS NADAC pharmacy acquisition cost per NDC; per-pack figures are per-unit × pack quantity, shown only when the pack is denominated in the same measure NADAC prices.

🧭 About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The FDA registers it as 0023-3416-05, which is what is printed on the packaging and shown on DailyMed. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero: 00023-3416-05, written without dashes as 00023341605. The Identity section at the top of this page lists every form of this code.
What do the three segments of this NDC mean?
In 00023-3416-05, the first segment (00023) is the labeler code FDA assigned to Allergan, Inc.; the middle segment (3416) identifies this specific product — its ingredient, strength, and dosage form; and the last segment (05) identifies this exact package size and type. Together they name one specific package of one specific product.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Allergan, Inc.. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 2 other package presentations of this same product, including 30 vials (00023-3416-30), 60 vials (00023-3416-60). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
Allergan, Inc. is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose
🎯 Indications and Usage 31 words ▾

Uses For the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun. May be used as a protectant against further irritation.

⏱️ Dosage and Administration 46 words ▾

Directions To open, TWIST AND PULL TAB TO REMOVE. Instill 1 or 2 drops in the affected eye(s) as needed and discard container. *Follow your eye doctor’s instructions if you are using this product after an eye surgery (e.g., LASIK) to relieve eye dryness and discomfort.

⚠️ Warnings 94 words ▾

Warnings For external use only. To avoid contamination, do not touch tip of container to any surface. Do not reuse.

Once opened, discard. Do not touch unit-dose tip to eye . If solution changes color or becomes cloudy , do not use.

Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours. Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

🧪 Active Ingredient 7 words ▾

Active ingredients Carboxymethylcellulose sodium 0.5% Glycerin 0.9%

🧪 Inactive Ingredients 23 words ▾

Inactive ingredients Boric acid; calcium chloride dihydrate; erythritol; levocarnitine; magnesium chloride hexahydrate; potassium chloride; purified water; sodium borate decahydrate; and sodium citrate dihydrate.

🎯 Purpose 5 words ▾

Purpose Eye lubricant Eye lubricant

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
← 00023-3348-07 · Allergan, 00023-3507-05 · Allergan, →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.