PATADAY TWICE A DAY RELIEF OLOPATADINE HYDROCHLORIDE 1 mg/mL Solution — NDC 0065-4274-01 (Billing 00065-4274-01)
NDC 0065-4274-01 (billing 00065-4274-01) is a package of PATADAY TWICE A DAY RELIEF OLOPATADINE HYDROCHLORIDE 1 mg/mL Solution from Alcon Laboratories, Inc., marketed since Feb 2020 and currently FDA-listed; retail pharmacies pay about $2.48 per mL (NADAC). It is this product's only package size.
Identity & classification
Regulatory identifiers FDA, NLM and CMS codes for this package
Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification
- GSN (GCN sequence number): 030796
- GCN: 68321
- GPI-14 (Medi-Span): 86802065102020
- HICL (First Databank): 012815
- AHFS class code: 52:02.00.00
- RxCUI (RxNorm): 1111339
- 11-digit billing NDC: 00065427401
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 1, 2026
- RxNorm (NLM RxNav) · catalog refreshed Sep 24, 2026
- Medi-Span GPI (licensed)
- First Databank (licensed) · refreshed Oct 1, 2026
RxNorm drug class
This medicine belongs to the Histamine-1 Receptor Inhibitor class.
Where does this data come from?
- RxClass (NLM) · catalog refreshed Sep 24, 2026
Clinical
Olopatadine ophthalmic is used to relieve itchy eyes caused by allergic reactions. Olopatadine is in a class of medications called mast cell stabilizers. It works by preventing the release of substances that cause eye itching.
Read the full MedlinePlus article ↗- These drops are specifically for itchy eyes caused by allergic conjunctivitis — basically when your eyes react to an allergen like pollen, pet dander, or dust. They work to block t...
- What exactly does olopatadine eye drops treat?
- The label doesn't specify an exact onset time for the eye drops, but olopatadine gets to work locally in the eye after you apply it. Use them twice a day as directed — every 6 to 8...
- How quickly will I feel relief after I use them?
Patient education
Supplement & herbal interactions
Some supplements/herbs that may interact with Olopatadine Hydrochloride — tap one for details:
Where does this data come from?
- MedlinePlus (NLM) · refreshed Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 1, 2026
Ask a licensed pharmacist directly — free, answered by our team.
Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per mL | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | $2.482 | $12.41 / 5 ml |
| Medicaid paysCMS SDUD · 12 mo | $4.39 | $21.97 / 5 ml |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
Where does this data come from?
- CMS NADAC weekly file · file of Sep 30, 2026
- CMS ASP pricing files · refreshed Sep 20, 2026
- CMS Medicaid State Drug Utilization Data · through Q4 2025
- CMS Part D plan pricing files · refreshed Sep 24, 2026
- VA National Acquisition Center price file
Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Marketing end | Status |
|---|---|---|---|---|
| 00065-4274-01 0065-4274-01 You're viewing this Main listing | 1 BOTTLE, PLASTIC in 1 CARTON (0065-4274-01) / 5 mL in 1 BOTTLE, PLASTIC | 2020-02-25 | — | Active |
Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| Eye Allergy Itch and Redness Relief 1 mg/mL 70000-0054-01 | CARDINAL | 1 bottle | $1.221 | — | Availability likely | save 51% |
| Olopatadine Hydrochloride Ophthalmic Solution 1 mg/mL 00536-1308-40 | Rugby | 1 bottle | $1.223 | — | Discontinued | save 51% |
| Eye Allergy Itch and Redness Relief 1 mg/mL 70677-1156-01 | Strategic | 1 bottle | $1.268 | — | Availability likely | save 49% |
| Olopatadine Hydrochloride 1 mg/mL 00536-1445-40 | RUGBY | 1 bottle | $1.274 | — | Availability likely | save 49% |
| olopatadine hydrochloride 1 mg/mL 16571-0882-05 | Rising | 5 ml | $1.274 | — | Availability likely | save 49% |
| Olopatadine Hydrochloride Ophthalmic 1 mg/mL 43598-0765-07 | Dr. | 1 bottle | $1.274 | — | Availability likely | save 49% |
| Olopatadine Hydrochloride 1 mg/mL 46122-0672-64 | Amerisource | 1 bottle | $1.274 | — | Availability likely | save 49% |
| Leader Olopatadine Hydrochloride Ophthalmic Solution 1 mg/mL 70000-0717-01 | CARDINAL | 1 bottle | $1.274 | — | Availability likely | save 49% |
| Olopatadine 1 mg/mL 70069-0017-01 | Somerset | 1 bottle | $1.274 | — | Availability likely | save 49% |
| Olopatadine Hcl 1 mg/mL 70512-0520-05 | Sola | 1 bottle | $1.274 | — | Availability likely | save 49% |
| Olopatadine Hydrochloride 1 mg/mL 70677-1280-01 | Strategic | 1 bottle | $1.274 | — | Availability likely | save 49% |
| Pataday Twice A Day Relief 1 mg/mLthis 00065-4274-01 | Alcon | 1 bottle | $2.482 | — | Availability likely | — |
| Olopatadine Hydrochloride 1 mg/mL 62332-0501-05 | Alembic | 1 bottle | $3.065 | — | FDA listed | +23% |
| Olopatadine Hydrochloride 1 mg/mL 00363-0200-40 | WALGREEN | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride Ophthalmic Solution 1 mg/mL 00363-0867-01 | WALGREEN | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride Ophthalmic Solution 1 mg/mL 00363-7130-05 | Walgreens | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride Ophthalmic Solution 1 mg/mL 11673-0689-05 | Target | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride 1 mg/mL 11822-0064-01 | RITE | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride Ophthalmic Solution 1 mg/mL 11822-9976-05 | Rite | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride Ophthalmic Solution 1 mg/mL 24208-0966-01 | Bausch | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride 1 mg/mL 30142-0064-64 | Kroger | 1 bottle | — | — | FDA listed | — |
| Eye Allergy Itch and Redness Relief Twice Daily Relief 1 mg/mL 43598-0826-07 | Dr. | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride 1 mg/mL 46122-0823-29 | AmerisourceBergen | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride 1 mg/mL 46708-0709-05 | Alembic | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride 1 mg/mL 50090-6341-00 | A-S | 1 bottle | — | — | FDA listed | — |
| Olopatadine 1 mg/mL 50090-7959-00 | A-S | 1 bottle | — | — | FDA listed | — |
| Olopatadine hydrochloride 1 mg/mL 51407-0663-05 | Golden | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride 1 mg/mL 51407-0938-05 | Golden | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride Ophthalmic Solution Twice Daily 1 mg/mL 55910-0109-05 | DOLGENCORP, | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride 1 mg/mL 58602-0006-40 | Aurohealth | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride 1 mg/mL 58602-0009-40 | Aurohealth | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride 1 mg/mL 58602-0012-40 | Aurohealth | 1 bottle | — | — | FDA listed | — |
| Olopatadine hydrochloride 1 mg/mL 60505-6221-00 | Apotex | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride 1 mg/mL 62332-0709-05 | Alembic | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride Ophthalmic Solution 1 mg/mL 63868-0822-05 | Chain | 1 bottle | — | — | FDA listed | — |
| olopatadine hydrochloride ophthalmic 1 mg/mL 68083-0477-01 | Gland | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride 1 mg/mL 69168-0480-02 | Allegiant | 2 bottles | — | — | FDA listed | — |
| CVS Eye Allergy Itch Relief Twice Daily 1 mg/mL 69842-0268-05 | CVS | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride 1 mg/mL 72036-0008-40 | Harris | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride 1 mg/mL 72476-0852-64 | Retail | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride 1 mg/mL 72657-0168-50 | GLENMARK | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride 1 mg/mL 76162-0020-40 | TOPCO | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride 1 mg/mL 79481-1000-01 | Meijer | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride 1 mg/mL 79903-0000-40 | Wal-Mart | 1 bottle | — | — | FDA listed | — |
| Equate Olopatadine Hydrochloride Ophthalmic Solution 1 mg/mL 79903-0319-01 | WAL-MART | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride 1 mg/mL 82442-0966-01 | TARGET | 1 bottle | — | — | FDA listed | — |
| Olopatadine Hydrochloride 1 mg/mL 85766-0111-05 | Sportpharm | 1 bottle | — | — | FDA listed | — |
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA Orange Book · refreshed Sep 3, 2026
- CMS NADAC weekly file · file of Sep 30, 2026
Availability & generic status
FDA-approved generic versions are listed, and recent pricing/market data suggests they may be available — see Therapeutic equivalents.
Where does this data come from?
- FDA Orange Book · refreshed Sep 3, 2026
Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
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UNII F5UM2KM3W7
Benzalkonium chloride is a chemical compound that works as a preservative and antimicrobial agent in medications. It prevents bacterial and fungal growth in liquid formulations to keep the product safe during storage and use.
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UNII QTT17582CB
A strong acid used to adjust and maintain the proper pH level in liquid medicines, ensuring stability and preventing breakdown of active ingredients.
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UNII 451W47IQ8X
Sodium chloride is common table salt. It's used in medicines as a buffer to maintain proper pH, as a filler to add bulk, or to adjust the osmotic balance in liquid formulations.
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UNII 55X04QC32I
A strong alkaline chemical used to adjust and maintain the pH balance of liquid medicines. It helps keep the medicine stable and ensures it stays effective during storage.
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UNII GR686LBA74
Sodium phosphate, dibasic is a salt derived from phosphoric acid. It acts as a buffer to help maintain the medicine's pH balance and may serve as a binder or filler in tablets and capsules.
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UNII 059QF0KO0R
Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
6 inactive ingredients listed in the exact product block matched to this NDC.
Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.
Where does this data come from?
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.- FDA label on DailyMed · label index refreshed Oct 1, 2026
- FDA openFDA NDC Directory · synced Oct 1, 2026
Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
Why might an inactive ingredient be missing?
Can inactive ingredients matter?
Manufacturer & labeler
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- Drugs@FDA
FDA label — Drug Facts FDA SPL
🎯 Indications and Usage ▾
Use temporarily relieves itchy and red eyes due to pollen, ragweed, grass, animal hair and dander
⏱️ Dosage and Administration ▾
Directions adults and children 2 years of age and older: put 1 drop in the affected eye(s) twice daily, every 6 to 8 hours, no more than twice per day if using other ophthalmic products while using this product, wait at least 5 minutes between each product replace cap after each use children under 2 years of age: consult a doctor
⚠️ Warnings ▾
Warnings For external use only
📦 Storage and Handling ▾
Other information only for use in the eye store between 4°-25°C (39°-77°F)
🧪 Active Ingredient ▾
Active Ingredients Purpose Olopatadine (0.1%). (equivalent to olopatadine hydrochloride 0.111%) Antihistamine and Redness Reliever
🧪 Inactive Ingredients ▾
Inactive ingredients benzalkonium chloride 0.01%, dibasic sodium phosphate, hydrochloric acid/sodium hydroxide (adjust pH), purified water, and sodium chloride
🎯 Purpose ▾
Active Ingredients Purpose Olopatadine (0.1%). (equivalent to olopatadine hydrochloride 0.111%) Antihistamine and Redness Reliever
📄 Do Not Use ▾
Do not use if solution changes color or becomes cloudy if you are sensitive to any ingredient in this product to treat contact lens related irritation
When using this product do not touch tip of container to any surface to avoid contamination remove contact lenses before use wait at least 10 minutes before reinserting contact lenses after use do not wear a contact lens if your eye is red
📄 Stop Use and Ask a Doctor If ▾
Stop use and ask a doctor if you experience: eye pain changes in vision increased redness of the eye itching worsens or lasts for more than 72 hours
📄 Keep Out of Reach of Children ▾
Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.
📄 Questions or Comments ▾
Questions? In the U.S., call 1-800-757-9195 or email [email protected] Alcon Laboratories, Inc. 6201 South Freeway Fort Worth, Texas 76134 Country of Origin: Japan NDC: 0065-4274-01 9017919-1219
📄 Package Label / Principal Display Panel ▾
PRINCIPAL DISPLAY PANEL Original Prescription Strength Pataday ® TWICE DAILY RELIEF Olopatadine hydrochloride ophthalmic solution 0.1% Antihistamine and Redness Reliever Eye Allergy Itch & Redness Relief TWICE DAILY Works in Minutes Relief from Allergens: • Pet Dander • Pollen • Grass • Ragweed STERILE 5 mL (0.17 FL OZ) Alcon Pataday ® TWICE DAILY RELIEF Eye Allergy Itch & Redness Relief Works in Minutes For Ages 2 and Older 30 DAY SUPPLY TAMPER EVIDENT: For your protection, this bottle has a seal imprinted with Alcon around the neck. ________Fill Line________ Do not use if seal is damaged or missing at time of purchase.
ACTUAL SIZE Alcon Laboratories, Inc. 6201 South Freeway Fort Worth, Texas 76134 Country of Origin: Japan NDC: 0065-4274-01 300036779-0320 LOT: EXP.: Pataday ® TWICE DAILY RELIEF Olopatadine hydrochloride ophthalmic solution 0.1% Antihistamine and Redness Reliever Eye Allergy Itch & Redness Relief 5 mL (0.17 FL OZ) STERILE Only for use in the eye. Store between 4° – 25° C (39° – 77° F) TAMPER EVIDENT: For your protection, this bottle has a seal imprinted with Alcon around the neck.
Do not use if seal is damaged or missing at time of purchase. Alcon Laboratories, Inc. 6201 South Freeway Fort Worth, TX 76134 LOT: EXP.: H15723-1219 Original Prescription Strength Pataday ® TWICE DAILY RELIEF Olopatadine hydrochloride ophthalmic solution 0.1% Antihistamine and Redness Reliever Eye Allergy Itch & Redness Relief TWICE DAILY #1 DOCTOR RECOMMENDED OTC EYE ALLERGY BRAND* Works in Minutes STERILE 5 mL (0.17 fl oz) Alcon LOT: EXP.: Pataday ® TWICE DAILY RELIEF Eye Allergy Itch & Redness Relief Works in Minutes For Ages 2 and Older 30 DAY SUPPLY TAMPER EVIDENT: For your protection, this bottle has a seal imprinted around the neck. ________Fill Line________ Do not use if seal is damaged or missing at time of purchase.
ACTUAL SIZE *Based on a survey of eye care professionals, allergists, and primary care doctors. December 2024. Alcon Laboratories, Inc.
6201 South Freeway Fort Worth, Texas 76134 Country of Origin: Japan NDC: 0065-4274-01 300071456-0325 Pataday ® TWICE DAILY RELIEF Olopatadine hydrochloride ophthalmic solution 0.1% Antihistamine and Redness Reliever Eye Allergy Itch & Redness Relief 5 mL (0.17 fl oz) STERILE Only for use in the eye. Store between 4° – 25° C (39° – 77° F) TAMPER EVIDENT: For your protection, this bottle has a seal imprinted around the neck. Do not use if seal is damaged or missing at time of purchase.
Alcon Laboratories, Inc. 6201 South Freeway Fort Worth, TX 76134 LOT: EXP.: 300071824-0425