Rugby Mucus Relief D guaifenesin and pseudoephedrine hydrochloride 600 mg; 60 mg Tablet, Multilayer, Extended Release
by Rugby Laboratories · 2 BLISTER PACK in 1 CARTON (0536-1449-36) / 18 TABLET, MULTILAYER, EXTENDED RELEASE in 1 BLISTER PACK
NDC 00536-1449-36
🏷️ FDA NDC (as labeled)
0536-1449-36
billing pads the labeler segment with a zero
This package
Contains18 tablet, multilayer, extended release in 1 blister pack
Cost per ea$0.3872 NADAC
Per package$13.94 / 36 tablets
Pack sizes2 compare ↓
Also priced by: Medicaid pays $0.5281/unit — full pricing hub ↓
Also comes in:
18 tablets 00536-1449-21
OTC
Generic
On market
Non-controlled
🗂️ Data synced Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →
🆔 Identity & classification
FDA NDC (as labeled)
0536-1449-36
Product NDC
0536-1449
11-digit billing NDC
00536144936
NCPDP billing unit
EA — each (per item)
RxCUI
1305603
UNII
495W7451VQ, 6V9V2RYJ8N
Application #
ANDA214407
SPL Set ID
ec947855-d77b-46ad-88bd-cf05b6ff004b
Established class (EPC)
Expectorant
Physiologic effect
Decreased Respiratory Secretion Viscosity; Increased Respiratory Secretions
DEA schedule
Non-controlled
Marketing category
ANDA
Marketing status
On market
FDA listing status
Listed (active directory)
Marketing start
2025-04-02
Route
ORAL
Dosage form
TABLET, MULTILAYER, EXTENDED RELEASE
Substance
GUAIFENESIN; PSEUDOEPHEDRINE HYDROCHLORIDE
GPI-14
43996202307435
GCN Seq No
012073
GCN
54980
HICL code
000270
Ingredient (HICL)
Guaifenesin/Pseudoephedrne Hcl
HIC1 code
B
Therapeutic class — broad (HIC1)
Respiratory System
HIC2 code
B4
Therapeutic class — intermediate (HIC2)
Drugs Affecting The Trachea And Bronchi (Contin.1)
HIC3 code
B4W
Therapeutic class — specific (HIC3)
Decongestant-Expectorant Combinations
AHFS code
12:12.12.00
AHFS class
Alpha- And Beta-Adrenergic Agonists
FDB label name
MUCUS RELIEF D ER 600-60 MG TB
FDB brand name
Mucus Relief D
Legend status
O — Over-the-counter (OTC) drug or device
Why two NDCs?
The FDA registers this code as 0536-1449-36 — a 4-4-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the labeler segment → 00536-1449-36. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.
🏷️ RxNorm drug class
This medicine belongs to the Expectorant class.
Pharmacologic class
Expectorant
Drug family (ATC)
Expectorants
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.
🏭 Manufacturer & labeler
LabelerRugby Laboratories
Application holderL PERRIGO CO
FDA applicationANDA214407 (ANDA)
Labeler code00536
First marketedApr 2025
Product typeHuman Otc Drug
Portfolio149 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.
🩺 Clinical
Label name MUCUS RELIEF D ER 600-60 MG TB Ingredient Guaifenesin/Pseudoephedrne Hcl
📖 What it is MedlinePlus · NLM
Guaifenesin is used to relieve chest congestion. Guaifenesin may help control symptoms but does not treat the cause of symptoms or speed recovery. Guaifenesin is in a class of medications called expectorants. It works by thinning the mucus in the air passages to make it easier to cough up the mucus and clear the airways.
Read the full MedlinePlus article ↗📗 Our plain-language guide HelloPharmacist
- Yes, each ingredient does something different. Guaifenesin works on your chest — it thins and loosens the mucus in your airways so it's easier to cough up. Pseudoephedrine works on...
- What does this medicine actually do — do I need both ingredients?
- No — please don't. Extended-release tablets are designed to release the medicine slowly over about 12 hours. Crushing, chewing, or breaking them releases the whole dose at once, wh...
- Can I crush or cut the extended-release tablet if it's hard to swallow?
Patient education
Supplement & herbal interactions
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.
💬 Questions about guaifenesin and pseudoephedrine hydrochloride?
Ask a pharmacist →
Ask a licensed pharmacist directly — free, answered by our team.
💊 What it looks like
Color
Orange
ShapeOval
ImprintL6
Size17 mm
ScoringNot scored
One label can cover several strengths, so colors may be combined — always confirm a loose pill against the dispensed prescription label or a pharmacist.
Where does this data come from?
Physical description (imprint, shape, color, scoring, coating) from this product’s FDA Structured Product Labeling (SPL), mirrored from DailyMed / openFDA.
🧪 Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
-
UNII HHT01ZNK31
Carbomer Homopolymer Type B is a synthetic polymer made from acrylic acid. It absorbs water and forms a gel, so it's used in medicines as a thickener, suspending agent, and to help create a smooth texture in creams, gels, and lotions.
-
UNII GYP6Z2JR6Q
FD&C Yellow No. 6 Aluminum Lake is a yellow colorant made by combining FD&C Yellow No. 6 dye with aluminum salts. It's used to color tablets, capsules, and other medicines so they're easier to identify.
-
UNII 3NXW29V3WO
Hypromellose is a plant-based thickener made from cellulose. It's used in medicines as a binder to hold ingredients together, a coating for tablets, and a thickener for liquids.
-
UNII 70097M6I30
Magnesium stearate is a salt made from magnesium and stearic acid, a fatty substance. It's used in tablets and capsules as a lubricant and glidant to help ingredients flow smoothly during manufacturing and prevent sticking.
-
UNII OP1R32D61U
Microcrystalline cellulose is a purified form of cellulose, a natural fiber from plant sources. It acts as a binder and filler in tablets and capsules, helping hold ingredients together and give the medicine its shape and size.
-
UNII ETJ7Z6XBU4
Silicon dioxide is a naturally occurring mineral used as a glidant and anti-caking agent. It helps powder ingredients flow smoothly and prevents clumping during manufacturing and storage.
6 inactive ingredients listed in the exact product block matched to this NDC.
The official label also statescarbomer homopolymer type B, colloidal silicon dioxide, FD&C yellow #6 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, sodium starch glycolate
Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.
Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed —
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.
💲 Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per ea | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | $0.387 | $13.94 / 36 tablets |
| Medicaid paysCMS SDUD · 12 mo | $0.5281 | $19.01 / 36 tablets |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
NADAC price history (per ea) — tap or hover for the price & month
▲ Up 20% over the last 7 months.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.
🔁 Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| Guaifenesin and Pseudoephedrine HCl 600 mg/1; 60 mg 70677-1011-01 | Strategic | 18 tablets | $0.357 | — | FDA listed | save 8% |
| mucus D 600 mg/1; 60 mg 00113-8307-68 | L. | 18 tablets | $0.387 | — | Availability likely | — |
| Guaifenesin D 600 mg/1; 60 mg 00536-1333-21 | RUGBY | 18 tablets | $0.387 | — | Availability likely | — |
| Rugby Mucus Relief D 600 mg/1; 60 mgthis 00536-1449-36 | Rugby | 18 tablets | $0.387 | — | Availability likely | — |
| Leader Mucus Relief D 600 mg/1; 60 mg 70000-0720-01 | Cardinal | 18 tablets | $0.387 | — | Availability likely | — |
| Guaifenesin and Pseudoephedrine HCl 600 mg/1; 60 mg 70677-1263-01 | Strategic | 18 tablets | $0.387 | — | Availability likely | — |
| foster and thrive mucus relief d 600 mg/1; 60 mg 70677-1272-01 | Strategic | 18 tablets | $0.387 | — | Availability likely | — |
| Mucinex D 600 mg/1; 60 mg 63824-0057-18 | Reckitt | 18 tablets | $0.704 | — | FDA listed | +82% |
| Guaifenesin and Pseudoephedrine Hydrochloride 600 mg/1; 60 mg 00363-0077-18 | WALGREEN | 18 tablets | — | — | FDA listed | — |
| Mucus Relief D 600 mg/1; 60 mg 00363-1604-15 | Walgreens | 18 tablets | — | — | FDA listed | — |
| Mucus Relief D 600 mg/1; 60 mg 00363-8708-68 | Walgreen | 18 tablets | — | — | FDA listed | — |
| Guaifenesin D 600 mg/1; 60 mg 00363-9930-18 | Walgreen | 18 tablets | — | — | FDA listed | — |
| Guaifenesin and Pseudoephedrine HCl 600 mg/1; 60 mg 00363-9946-40 | WALGREEN | 18 tablets | — | — | FDA listed | — |
| Guaifenesin and Pseudoephedrine HCl 600 mg/1; 60 mg 11822-0046-01 | Rite | 18 tablets | — | — | FDA listed | — |
| Guaifenesin and Pseudoephedrine HCl 600 mg/1; 60 mg 30142-0137-12 | KROGER | 18 tablets | — | — | FDA listed | — |
| mucus d 600 mg/1; 60 mg 30142-0739-68 | Kroger | 18 tablets | — | — | FDA listed | — |
| Guaifenesin and Pseudoephedrine Hydrochloride 600 mg/1; 60 mg 41415-0994-18 | PUBLIX | 18 tablets | — | — | FDA listed | — |
| Guaifenesin and Pseudoephedrine HCl 600 mg/1; 60 mg 46122-0801-08 | Amerisource | 18 tablets | — | — | FDA listed | — |
| Mucinex D 600 mg/1; 60 mg 50090-1075-00 | A-S | 18 tablets | — | — | FDA listed | — |
| Mucinex D 600 mg/1; 60 mg 50090-1076-00 | A-S | 9 tablets | — | — | FDA listed | — |
| Mucus D 600 mg/1; 60 mg 51316-0878-68 | CVS | 18 tablets | — | — | FDA listed | — |
| Guaifenesin D 600 mg/1; 60 mg 51316-0993-18 | CVS | 18 tablets | — | — | FDA listed | — |
| Guaifenesin and Pseudoephedrine HCl 600 mg/1; 60 mg 51660-0074-18 | Ohm | 18 tablets | — | — | FDA listed | — |
| Guaifenesin and Pseudoephedrine HCL 600 mg/1; 60 mg 55111-0798-09 | Dr. | 9 tablets | — | — | FDA listed | — |
| Guaifenesin and Pseudoephedrine HCl 600 mg/1; 60 mg 58602-0833-12 | Aurohealth | 18 tablets | — | — | FDA listed | — |
| mucus relief d 600 mg/1; 60 mg 59640-0621-89 | H | 18 tablets | — | — | FDA listed | — |
| Guaifenesin and Pseudoephedrine Hydrochloride 600 mg/1; 60 mg 62011-0475-01 | STRATEGIC | 18 tablets | — | — | FDA listed | — |
| Guaifenesin and Pseudoephedrine HCl 600 mg/1; 60 mg 62207-0827-72 | Granules | 10 tablets | — | — | FDA listed | — |
| Mucus D 600 mg/1; 60 mg 69842-0095-18 | CVS | 18 tablets | — | — | FDA listed | — |
| Mucus D 600 mg/1; 60 mg 79481-0709-01 | Meijer, | 18 tablets | — | — | FDA listed | — |
| Guaifenesin and Pseudoephedrine HCl 600 mg/1; 60 mg 79481-1002-01 | Meijer | 18 tablets | — | — | FDA listed | — |
| equate mucus d 600 mg/1; 60 mg 79903-0125-18 | WALMART | 18 tablets | — | — | Discontinued | — |
| topcare mucus d 600 mg/1; 60 mg 76162-0801-89 | Topco | 1 tablet | — | — | FDA listed | — |
About this product: this is a generic version of the medicine. FDA equivalence ratings are shown when available, and other versions are listed above, least expensive first.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.
⏳ Availability & generic status
🏛️
2025
On the market since
Apr 2025
📍
2026
Currently FDA-listed
1 year listed
🔓
·
Generic on the market
this product is a generic
✅This is a generic drug
This product is an FDA-approved generic. Other versions of the same drug are listed under Therapeutic equivalents, least expensive first.
Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.
🗺️ Medicaid utilization & spend
📍 This exact package only: Medicaid data is reported per full 11-digit NDC — labeler, product and pack size — so every number here is for 00536-1449-36, not the drug overall. Other pack sizes report separately.
💊 Pharmacy benefit only: These are Medicaid outpatient pharmacy claims, billed by NDC. They exclude the medical benefit — clinic- or hospital-administered drugs billed under HCPCS J-codes — so drugs used mostly that way (e.g. Avastin, Lucentis, Keytruda) can look low or missing here. That’s expected, not an error.
📅 Q1 2026 – Q1 2026 · 1 quarter of data
ⓘ The newest quarter is usually incomplete when first published; states restate recent quarters in later CMS releases, so the latest figures typically revise upward. State coverage-policy changes can also shift quarter-to-quarter totals.
Prescriptions last 4 qtrs
40
Units reimbursed last 4 qtrs
1K
Gross reimbursed last 4 qtrs
$550.80
Avg / prescription
$13.77
Avg / unit
$0.5281
Latest quarter Q1 2026
40Rx
Medicaid pays / ea
$0.5281
gross reimbursed
vs
NADAC / ea
$0.3872
acquisition cost
=
Spread
+$0.1409
+36% vs cost
What Medicaid paid per ea (before rebates; includes the pharmacy’s dispensing fee) compared with NADAC — the average price pharmacies pay to buy the drug. A positive spread means Medicaid reimbursed more than the purchase price, before manufacturer rebates.
Fee-for-service vs managed care ⓘ
Fee-for-service · 0 Rx Managed care · 40 Rx
State Medicaid map
Units reimbursed · per 100k residents
3.86.5
gray = no data reported ⓘ
Colors are per 100,000 residents, so big states don’t automatically dominate. Tap or hover a state for its actual totals.
Tap or hover a state
…for its Medicaid breakdown
Prescriptions—
Units—
Reimbursed—
🏆 Top states by units · per 100k residents
💵 About the dollar figures: “reimbursed” is what Medicaid paid pharmacies before confidential manufacturer rebates, so the program’s real net cost is lower than these numbers. Fee-for-service and managed-care claims are combined unless split above. Source: CMS State Drug Utilization Data; per-100k rates use 2023 Census population estimates.
💊 Medicaid utilization by pack size
Medicaid (SDUD) totals over the four most recent reported quarters for every package size of this drug — handy when a specific package (e.g. a starter/titration pack) carries little or no Medicaid volume on its own.
Drug total (last 4 qtrs): 331 Rx · 8,877 units · $5,270 gross reimbursed
Tap a pack size to open its page. Source: CMS State Drug Utilization Data, last 4 quarters.
🔬 Reported adverse events (FAERS)
Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Rugby Mucus Relief D (this brand).
Top reported reactions
Reporter sex
Serious outcomes
Reports over time (by year) — tap or hover for the count & year
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.
📦 Packaging — all sizes for this product
| Package NDC | Description | Per unit | Per pack | Marketing start | Status |
|---|---|---|---|---|---|
| 00536-1449-21 | 1 BLISTER PACK in 1 CARTON (0536-1449-21) / 18 TABLET, MULTILAYER, EXTENDED RELEASE in 1 BLISTER PACK | $0.3872 / ea | $6.97 | 2025-04-02 | Active |
| 00536-1449-36 You're viewing this | 2 BLISTER PACK in 1 CARTON (0536-1449-36) / 18 TABLET, MULTILAYER, EXTENDED RELEASE in 1 BLISTER PACK | $0.3872 / ea | $13.94 | 2025-04-02 | Active |
This pack effectively ties for the lowest per-ea cost of the 2 priced pack sizes ($0.3872 NADAC).
This pack accounts for about 12% of this product's recent Medicaid fills; most go to a different pack size. See all packs ↓
Pack size FAQ
What quantity is in NDC 00536-1449-36?
NDC 00536-1449-36 is listed by the FDA — 2 blister pack in 1 carton / 18 tablet, multilayer, extended release in 1 blister pack.
What NDC number is used to bill for this package of Rugby Mucus Relief D guaifenesin and pseudoephedrine hydrochloride 600 mg; 60 mg Tablet, Multilayer, Extended Release?
Bill NDC 00536-1449-36 — the 11-digit billing format is 00536144936. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.
Prices are the latest CMS NADAC pharmacy acquisition cost per NDC; per-pack figures are per-unit × pack quantity, shown only when the pack is denominated in the same measure NADAC prices.
📄 FDA label — Drug Facts FDA SPL
The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage
⏱️ Dosage and Administration
⚠️ Warnings
🧪 Active Ingredient
🧪 Inactive Ingredients
🎯 Purpose
🎯 Indications and Usage ▾
Uses • helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive • temporarily relieves nasal congestion due to: • common cold • hay fever • upper respiratory allergies • temporarily restores freer breathing through the nose • promotes nasal and/or sinus drainage • temporarily relieves sinus congestion and pressure
⏱️ Dosage and Administration ▾
Directions • do not crush, chew, or break tablet • take with a full glass of water • this product can be administered without regard for timing of meals • adults and children 12 years and older: 2 tablets every 12 hours; not more than 4 tablets in 24 hours • children under 12 years of age: do not use
⚠️ Warnings ▾
Warnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product. Ask a doctor before use if you have • heart disease • high blood pressure • thyroid disease • diabetes • trouble urinating due to an enlarged prostate gland • persistent or chronic cough such as occurs with smoking, asthma, chronic bronchitis, or emphysema • cough accompanied by too much phlegm (mucus) When using this product • do not use more than directed Stop use and ask a doctor if • you get nervous, dizzy, or sleepless • symptoms do not get better within 7 days, come back or occur with a fever, rash, or persistent headache.
These could be signs of a serious illness. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children.
In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222).
🧪 Active Ingredient ▾
Active ingredients (in each extended-release bi-layer tablet) Guaifenesin 600 mg Pseudoephedrine HCl 60 mg
🧪 Inactive Ingredients ▾
Inactive ingredients carbomer homopolymer type B, colloidal silicon dioxide, FD&C yellow #6 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, sodium starch glycolate
🎯 Purpose ▾
Purposes Expectorant Nasal Decongestant
No label section mentions that — try another word, or open the full label on DailyMed below.
Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA.
Prefer the government’s original formatting? View this label on DailyMed ↗
For educational and professional reference only — not medical advice. Pricing reflects published
NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.