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Rite Aid Antacid and Pain Relief Aspirin, Citric Acid, Sodium Bicarbonate 325 mg; 1000 mg; 1916 mg Tablet, Effervescent — NDC 11822-4212-07 package photo

Rite Aid Antacid and Pain Relief Aspirin, Citric Acid, Sodium Bicarbonate 325 mg; 1000 mg; 1916 mg Tablet, Effervescent

by Rite Aid · 36 POUCH in 1 CARTON (11822-4212-7) / 2 TABLET, EFFERVESCENT in 1 POUCH
NDC 11822-4212-07
🏷️ FDA NDC (as labeled) 11822-4212-7 billing pads the package segment with a zero
This package
Contains2 tablet, effervescent in 1 pouch Pack sizes2 compare ↓
Also comes in: 2 tablets 11822-4212-04
OTC On market Non-controlled
🗂️ Data synced Sep 17, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

🆔 Identity & classification

FDA NDC (as labeled) 11822-4212-7
Product NDC 11822-4212
11-digit billing NDC 11822421207
RxCUI 1536675
UNII R16CO5Y76E, XF417D3PSL, 8MDF5V39QO
UPC 0011822785099
Application # M013
SPL Set ID b4797380-9cef-d640-e053-2a95a90a0665
Established class (EPC) Nonsteroidal Anti-inflammatory Drug; Platelet Aggregation Inhibitor; Calculi Dissolution Agent; Anti-coagulant
Mechanism of action Cyclooxygenase Inhibitors; Acidifying Activity; Calcium Chelating Activity
Physiologic effect Decreased Prostaglandin Production; Decreased Platelet Aggregation; Decreased Coagulation Factor Activity
Chemical class Anti-Inflammatory Agents, Non-Steroidal
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2020-03-16
Route ORAL
Dosage form TABLET, EFFERVESCENT
Substance ASPIRIN; ANHYDROUS CITRIC ACID; SODIUM BICARBONATE
Why two NDCs? The FDA registers this code as 11822-4212-7 — a 5-4-1 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the package segment → 11822-4212-07. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏷️ RxNorm drug class

This medicine belongs to the Platelet Aggregation Inhibitor class.

Pharmacologic class Platelet Aggregation Inhibitor, Nonsteroidal Anti-inflammatory Drug
Drug family (ATC) Other agents for local oral treatment, Platelet aggregation inhibitors excl. heparin, Salicylic acid and derivatives
How it works Cyclooxygenase Inhibitors
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

🏭 Manufacturer & labeler

LabelerRite Aid
FDA applicationM013 (OTC MONOGRAPH DRUG)
Labeler code11822
First marketedMar 2020
Product typeHuman Otc Drug
Portfolio88 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

🧪 What is this product?

This is an over-the-counter effervescent tablet made with aspirin, citric acid, and sodium bicarbonate, taken by mouth. Aspirin is a nonsteroidal anti-inflammatory drug typically used to relieve minor pain and reduce fever. Sodium bicarbonate functions as an antacid to neutralize stomach acid, while citric acid is included as part of the effervescent formulation that allows the tablet to dissolve and fizz in water before drinking.

6
Nutrient depletion considerations

Aspirin, Citric Acid, Sodium Bicarbonate may be associated with lower levels of 6 nutrients — worth a chat with your pharmacist, not a cause for alarm.

🧪 Full Aspirin, Citric Acid, Sodium Bicarbonate nutrient depletion report →
An association is not a deficiency. Educational only — don't start or stop anything without professional guidance.
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

💊 What it looks like

Color white
ShapeRound
ImprintL421
Size25 mm
ScoringNot scored
One label can cover several strengths, so colors may be combined — always confirm a loose pill against the dispensed prescription label or a pharmacist.
Where does this data come from?
Physical description (imprint, shape, color, scoring, coating) from this product’s FDA Structured Product Labeling (SPL), mirrored from DailyMed / openFDA.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

From the label’s inactive-ingredient section■ none

This is label-wide narrative text, not a normalized exact-product ingredient list. A label can cover multiple strengths or packages.

Where does this data come from?
Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eachPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Try another pack size: 2 tablets
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Alka-Seltzer Heartburn and Pain 1000 mg/1; 325 mg/1; 1916 mg 00280-0160-01 Bayer 2 tablets — — FDA listed —
Alka-Seltzer Original 1000 mg/1; 325 mg/1; 1916 mg 00280-4000-01 Bayer 2 tablets — — FDA listed —
Walgreens Effervescent Pain Relief 325 mg/1; 1916 mg/1; 1000 mg 00363-0421-68 Walgreens 2 tablets — — FDA listed —
Up and Up Antacid and Pain Relief 325 mg/1; 1916 mg/1; 1000 mg 11673-0187-36 Target 2 tablets — — FDA listed —
Rite Aid Antacid and Pain Relief 325 mg/1; 1000 mg/1; 1916 mgthis 11822-4212-07 Rite 2 tablets — — FDA listed —
Signature Care Effervescent Antacid and Pain Relief 1916 mg/1; 1000 mg/1; 325 mg 21130-0421-68 Safeway, 2 tablets — — FDA listed —
Kroger Effervescent Antacid and Pain Relief 325 mg/1; 1916 mg/1; 1000 mg 30142-0421-68 Kroger 2 tablets — — FDA listed —
TopCare Effervescent Antacid and Pain Relief 325 mg/1; 1916 mg/1; 1000 mg 36800-0421-68 Topco 2 tablets — — FDA listed —
Effervescent Antacid and Pain Relief 325 mg/1; 1916 mg/1; 1000 mg 37808-0421-68 H. 2 tablets — — FDA listed —
Equaline Effervescent Antacid and Pain Relief 325 mg/1; 1916 mg/1; 1000 mg 41163-0421-68 United 2 tablets — — FDA listed —
Meijer Effervescent Antacid and Pain Relief 325 mg/1; 1916 mg/1; 1000 mg 41250-0222-36 Meijer 2 tablets — — FDA listed —
Care One Original Antacid and Pain Relief 325 mg/1; 1000 mg/1; 1916 mg 41520-0444-36 Foodhold 2 tablets — — FDA listed —
Medique Medi Seltzer 325 mg/1; 1000 mg/1; 1916 mg 47682-0135-20 Unifirst 2 tablets — — FDA listed —
Equate Effervescent Antacid and Pain Relief 325 mg/1; 1916 mg/1; 1000 mg 49035-0421-68 Walmart 2 tablets — — FDA listed —
Bromo Seltzer 1916 mg/1; 1000 mg/1; 325 mg 50201-0421-02 Tower 2 tablets — — FDA listed —
Top Value Effervescent Pain Relief 325 mg/1; 1000 mg/1; 1916 mg 50201-4212-00 Tower 2 tablets — — FDA listed —
Top Value Effervescent Pain Relief 1916 mg/1; 325 mg/1; 1000 mg 50201-4213-06 Tower 2 tablets — — FDA listed —
Alka Seltzer Originial 1s Blister Pack 1000 mg/1; 325 mg/1; 1916 mg 50269-0307-06 JC 2 tablets — — FDA listed —
Good Sense Effervescent Antacid and Pain Relief 1000 mg/1; 1916 mg/1; 325 mg 50804-0421-36 Good 2 tablets — — FDA listed —
Market Basket Effervescent Antacid and Pain Relief 1916 mg/1; 325 mg/1; 1000 mg 53942-0421-36 Demoulas 2 tablets — — FDA listed —
Drug Mart Effervescent Pain Relief 325 mg/1; 1916 mg/1; 1000 mg 53943-0421-36 Discount 2 tablets — — FDA listed —
DG Health Effervescent Antacid and Pain Relief 325 mg/1; 1916 mg/1; 1000 mg 55910-0422-36 DOLGENCORP, 2 tablets — — FDA listed —
Publix Fast Relief Effervescent 325 mg/1; 1916 mg/1; 1000 mg 56062-0421-68 Publix 2 tablets — — FDA listed —
Quality Choice Effervescent Antacid and Pain Relief 325 mg/1; 1916 mg/1; 1000 mg 63868-0229-36 Chain 2 tablets — — FDA listed —
Best Choice Effervescent Antacid Pain Relief 325 mg/1; 1916 mg/1; 1000 mg 63941-0421-12 Valu 2 tablets — — FDA listed —
WinCo Foods Effervescent Antacid and Pain Relief 1916 mg/1; 1000 mg/1; 325 mg 67091-0108-36 WinCo 2 tablets — — FDA listed —
CVS Health Antacid and Pain Reliever 325 mg/1; 1916 mg/1; 1000 mg 69842-0421-36 CVS 2 tablets — — FDA listed —
Alka-Seltzer Original 325 mg/1; 1916 mg/1; 1000 mg 70264-0014-01 R 2 tablets — — FDA listed —
Alka-Seltzer Original 1000 mg/1; 325 mg/1; 1916 mg 85237-1829-01 Select 2 tablets — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️
2020
On the market since
Mar 2020
📍
2026
Currently FDA-listed
6 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

📦 Packaging — all sizes for this product

Package NDCDescription Marketing startStatus
11822-4212-04 12 POUCH in 1 CARTON (11822-4212-4) / 2 TABLET, EFFERVESCENT in 1 POUCH 2020-03-16 Active
11822-4212-07 You're viewing this 36 POUCH in 1 CARTON (11822-4212-7) / 2 TABLET, EFFERVESCENT in 1 POUCH 2022-12-09 Active

Pack size FAQ

What quantity is in NDC 11822-4212-07?
NDC 11822-4212-07 is listed by the FDA — 36 pouch in 1 carton / 2 tablet, effervescent in 1 pouch.
What NDC number is used to bill for this package of Rite Aid Antacid and Pain Relief Aspirin, Citric Acid, Sodium Bicarbonate 325 mg; 1000 mg; 1916 mg Tablet, Effervescent?
Bill NDC 11822-4212-07 — the 11-digit billing format is 11822421207. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

🧭 About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The FDA registers it as 11822-4212-7, which is what is printed on the packaging and shown on DailyMed. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero: 11822-4212-07, written without dashes as 11822421207. The Identity section at the top of this page lists every form of this code.
What do the three segments of this NDC mean?
In 11822-4212-07, the first segment (11822) is the labeler code FDA assigned to Rite Aid; the middle segment (4212) identifies this specific product — its ingredient, strength, and dosage form; and the last segment (07) identifies this exact package size and type. Together they name one specific package of one specific product.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Rite Aid. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 1 other package presentation of this same product, including 2 tablets (11822-4212-04). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
Rite Aid is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🆘 Overdosage 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose
🎯 Indications and Usage 41 words ▾

Uses Uses for the temporary relief of ■ heartburn, acid indigestion and sour stomach when accompanied by headache or body aches and pains ■ upset stomach with headache from overindulgence in food or drink ■ headache, body aches, and pain alone

⏱️ Dosage and Administration 75 words ▾

Directions ■ do not exceed recommended dosage ■ to avoid serious injury, completely dissolve tablets in 4 oz. of water before taking adults and children 12 years and over (up to 60 years of age): 2 tablets every 4 hours - do not exceed 8 tablets in 24 hours 60 years and over: 2 tablets every 4 hours - do not exceed 4 tablets in 24 hours Children under 12 years - consult a doctor

⚠️ Warnings 156 words ▾

Warnings Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. Allergy alert: Aspirin may cause a severe allergic reaction which may include: ■ hives ■ facial swelling ■ asthma (wheezing) ■ shock Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding.

The chance is higher if you ■ are age 60 or older ■ have had stomach ulcers or bleeding problems ■ take a blood thinning (anticoagulant) or steroid drug ■ take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) ■ have 3 or more alcoholic drinks every day while using this product ■ take more or for a longer time than directed

🆘 Overdosage 19 words ▾

In case of overdose In case of overdose, get medical help or contact a Poison Control Center right away.

🧪 Active Ingredient 23 words ▾

Active ingredients (in each effervescent tablet) Anhydrous citric acid 1000 mg Aspirin 325 mg (NSAID)* Sodium bicarbonate (heat-treated) 1916 mg *Nonsteroidal anti-inflammatory drug

🧪 Inactive Ingredients 4 words ▾

Inactive ingredients ■ none

🎯 Purpose 64 words ▾

Purpose Anhydrous citric acid 1000 mg. . . . . . . . . . . . . . . . . Antacid Aspirin 325 mg (NSAID)* . . . . . . . . . . . . . . . . . . . . . Pain reliever Sodium bicarbonate (heat-treated) 1916 mg. . . . . . Antacid *Nonsteroidal anti-inflammatory drug

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
← 11822-4210-03 · Rite 11822-4228-01 · RITE →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.