Home › NDC Lookup › Ingredients › Chlorhexidine Gluconate 2% Solution › 21749-0416-89
Antimicrobial Foam Handwash Chlorhexidine Gluconate 2% Solution 20 mg/mL Liquid, 1200 mL — NDC 21749-0416-89 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

Antimicrobial Foam Handwash Chlorhexidine Gluconate 2% Solution 20 mg/mL Liquid, 1200 mL — NDC 21749-416-89 (Billing 21749-0416-89)

by GOJO Industries, Inc. · 1200 mL in 1 BOTTLE

This is a package of 1,200 mL of Antimicrobial Foam Handwash Chlorhexidine Gluconate 2% Solution 20 mg/mL Liquid from GOJO Industries, Inc., marketed since Apr 2018 and currently FDA-listed. It is the main listing for this product, which comes in 2 package sizes.

NDC 21749-0416-89
🏷️ FDA NDC (as labeled) 21749-416-89 billing pads the product segment with a zero
This package
Contains1200 mL Pack sizes2 compare ↓
Main listing for product 21749-416 · Also comes in: 1250 ml 21749-416-90
OTC Brand On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 21749-416-89
Product NDC 21749-416
11-digit billing NDC 21749041689
RxCUI 1245230
UNII MOR84MUD8E
Application # NDA019422
SPL Set ID 743021cd-38c3-3825-e053-2a91aa0aa7f2
Physiologic effect Decreased Cell Wall Integrity
DEA schedule Non-controlled
Marketing category NDA
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2018-04-01
Route TOPICAL
Dosage form LIQUID
Substance CHLORHEXIDINE GLUCONATE
Quick answers
  • RxCUI (RxNorm): 1245230
Why two NDCs? The FDA registers this code as 21749-416-89 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 21749-0416-89. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

RxNorm drug class

This medicine belongs to the Antiinfectives and antiseptics for local oral treatment class.

Drug family (ATC) Antiinfectives and antiseptics for local oral treatment, Antiinfectives, Biguanides and amidines
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

Clinical

📗 Our plain-language guide HelloPharmacist
  • It treats gingivitis, which means red, swollen gums that may bleed. You use it between dental visits as part of a program with your dentist. It has not been tested in people with A...
  • It can. Staining of teeth and other mouth surfaces is one of the most common side effects. You may also notice more tartar and changes in taste. Your dentist should remove tartar a...
  • Anyone allergic to chlorhexidine gluconate or any ingredient in the product should avoid it. Serious allergic reactions, including anaphylaxis, have been reported with dental produ...
  • Keep it out of reach of children. A small child who swallows 1 or 2 ounces may have stomach upset, nausea or signs of alcohol intoxication. Get medical help if more than 4 ounces i...
📖 Read our full Chlorhexidine guide →

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Try another pack size: 1250 ml
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
21749-0416-89 You're viewing this Main listing 1200 mL in 1 BOTTLE 2018-04-01 — Active
21749-0416-90 21749-416-90 1250 mL in 1 BOTTLE 2018-04-01 — Active

You're viewing the smallest of 2 pack sizes for this product.

Pack size FAQ

What quantity is in this package?
This package contains 1200 mL — 1200 ml in 1 bottle.
How does this package differ from NDC 21749-0416-90?
Both are Antimicrobial Foam Handwash Chlorhexidine Gluconate 2% Solution 20 mg/mL Liquid — the drug itself is identical. This page's package is the 1200 mL one, while NDC 21749-0416-90 is the 1250 ml package.
What NDC number is used to bill for this package of Antimicrobial Foam Handwash Chlorhexidine Gluconate 2% Solution 20 mg/mL Liquid?
Use the 11-digit billing form listed in the identifiers section of this page. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Dyna-Hex 2 2 g/100mL 00116-1021-01 Xttrium 15142 ml — — Discontinued —
Dyna-Hex 2 20 mg/mL 00116-1022-18 Xttrium 535 ml — — FDA listed —
Provon Antimicrobial Foam Handwash 20 mg/mL 00116-8500-89 Xttrium 1200 ml — — FDA listed —
Bactoshield CHG Chlorhexidine Gluconate 20 mg/mL 11084-0038-03 SC 118 ml — — FDA listed —
Bactoshield CHG 20 mg/mL 11084-0126-03 SC 118 ml — — FDA listed —
Antimicrobial Skin Cleanser 20 mg/mL 21749-0106-32 Gojo 946 ml — — FDA listed —
Purell Antimicrobial Foam 20 mg/mL 21749-0225-53 GOJO 535 ml — — FDA listed —
Antimicrobial Foam Handwash 20 mg/mLthis 21749-0416-89 GOJO 1200 ml — — FDA listed —
Antiseptic Foam Handwash 20 mg/mL 21749-0461-89 GOJO 1200 ml — — FDA listed —
Provon Antimicrobial Foam Handwash 20 mg/mL 21749-0850-53 Gojo 535 ml — — FDA listed —
Scrub, Scrub-Stat, Foam Safe, Micro-Guard 20 mg/mL 42939-0124-19 AVA, 946 ml — — FDA listed —
Scrub, Scrub-Stat, Foam Safe, Micro-Guard 20 mg/mL 42939-0127-01 AVA, 118 ml — — FDA listed —
Scrub-Stat 20 mg/mL 47593-0463-11 Ecolab 3780 ml — — FDA listed —
Scrub-Stat 20 mg/mL 47593-0467-21 Ecolab 208000 ml — — Discontinued —
foaming hand wash 20 mg/mL 53329-0994-84 Medline 1000 ml — — FDA listed —
About this product: this is the brand-name version. We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2018
On the market since
Apr 2018
📍
2026
Currently FDA-listed
8 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII 2968PHW8QP
    A weak organic acid derived from citrus fruits or made through fermentation. It works as a buffer to control pH, a preservative to extend shelf life, and a flavoring agent in medications.
  • UNII S38J6RZN16
    Hydroxyethyl cellulose is a plant-derived thickening agent made from cellulose. In medicines, it acts as a binder to hold ingredients together, a thickener to adjust product texture, and a film-former to create smooth coatings on tablets.
  • UNII ND2M416302
    Isopropyl alcohol is a clear liquid solvent derived from petroleum. In medicines, it dissolves active ingredients and other components, helps the product flow smoothly, and aids in sterilization during manufacturing.
  • UNII 4F6FC4MI8W
    Lauramine oxide is a surfactant, a substance that helps mix oil and water together. It's used in medicines to improve how ingredients blend and to help the product dissolve or spread properly.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

5 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesCitric acid, cocamide DEA, hydroxyethlycellulose, isopropyl alcohol, lauramine oxide, aqua

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerGOJO Industries, Inc.
Application holderXTTRIUM LABORATORIES INC
FDA applicationNDA019422 (NDA)
Labeler code21749
First marketedApr 2018
Product typeHuman Otc Drug
Portfolio79 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Do Not Use 📄 Ask a Doctor Before Use If 📄 When Using This Product 📄 Keep Out of Reach of Children 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 2 words ▾

Antimicrobial Handwash

⏱️ Dosage and Administration 5 words ▾

Directions:/ Mood de Uso: Directions

⚠️ Warnings 80 words ▾

Warnings/Precauciones For external use only Allergy Alert: This product may cause a severe allergic reaction. Symptoms may include: wheezing/difficulty breathing shock facial swelling hives rash If an allergic reaction occurs, stop use and seek medical help right away Para Use Externo Únicamente Alerta De Allergia: Este producto puede causar un reacción alérgica severa. Los síntomas pueden incluir: sibilancias/dificultad para respirar shock hinchazón facial urticaria sarpullido En caso de ocurrir alguna reacción alérgica, detenga el uso y busque ayuda de inmediato

🧪 Active Ingredient 6 words ▾

Chlorhexidine Gluconate/Gluconato de chlorhexidina 20 MG/G

🧪 Inactive Ingredients 10 words ▾

Citric acid, cocamide DEA, hydroxyethlycellulose, isopropyl alcohol, lauramine oxide, aqua

🎯 Purpose 1 words ▾

Antiseptic

📄 Do Not Use 28 words ▾

Do not use/No debe usante If you are allergic to chlorhexidine gluconate or any other ingredients Si es alérgico al gluconato de chlorhexidina o a cualquier otro ingrediente

📄 Ask a Doctor Before Use If 43 words ▾

Stop use an ask a doctor if/ Mantengase fuera consulte a su médico si Irrititation, sensitization or allergic reaction occurs. These may be signs of a serious condition. Reacciones de irritación, sensibilización o reacciones alérgicas aparecen. Estos son signos de una condicíon seria.

📄 When Using This Product 121 words ▾

When using this product/ Cuando use este producto Keep out of eyes, ear and mouth. May cause serious and permenant eye injury if placed or kept in the eye during surgical procedures or may cause deafness when instilled in the middle of the ear through perforated eardrums. If solution should contact these areas, rinse out promptly and thoroughly with water.

Evite el contacto con los ojos, oídos, y boca. Puede causar daño ocular serio y permanente si se coloca o permanece en el ojo durante procedimientos quirúrgicos o puede causar sordera si se instila en el oído medio a través de tímpano perforado. Si la solución llegara a tener contacto con estas àreas, enjuague lo más pronto posible con suficiente agua.

📄 Keep Out of Reach of Children 36 words ▾

Keep out of reach of children If swallowed, get medical help or contact a poison control center right away. En caso de ingestión, busque ayuda médica o contacte al centro de control de intoxicación de inmediato.

📄 Package Label / Principal Display Panel 48 words ▾

Chlorhexidine Gluconate 2% Solution NDC 21749-416-89 GOJO Industries, Inc Akron, OH 44309 +330 255-6000 www.GOJO.com GOJOLTXINTLLBL Net Wt 1200 mL Chlorhexidine Gluconate 2% Solution NDC 21749-416-90 GOJO Industries, Inc Akron, OH 44309 +330 255-6000 www.GOJO.com GOJOADXINTLLBL Net Wt 1250 mL LTX PDP Page 1 Page 2 ADX PDP

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Chlorhexidine Gluconate 2% Solution — the ingredient across all brands.

Top reported reactions

Angina Pectoris1
Burning Sensation1
Hyperkeratosis1
Paraesthesia1
Skin Exfoliation1

Reporter sex

2 reports

Serious outcomes

Disabling1
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.

About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by GOJO Industries, Inc.. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 1 other package presentation of this same product, including 1250 ml (21749-0416-90). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
GOJO Industries, Inc. is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 21749-0400-08 · GOJO 21749-0423-33 · GOJO →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.