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Dendracin Neurodendraxcin Methyl Salicylate, Menthol and Capsaicin 18 g/60mL; 6 g/60mL; .015 g/60mL Lotion — NDC 27495-0014-04 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

Dendracin Neurodendraxcin Methyl Salicylate, Menthol and Capsaicin 18 g/60mL; 6 g/60mL; .015 g/60mL Lotion — NDC 27495-014-04 (Billing 27495-0014-04)

by Physicians Science & Nature Inc. · 50 BOTTLE in 1 CARTON / 120 mL in 1 BOTTLE

This is a package of Dendracin Neurodendraxcin Methyl Salicylate, Menthol and Capsaicin 18 g/60mL; 6 g/60mL; .015 g/60mL Lotion from Physicians Science & Nature Inc., marketed since Jul 2011 and currently FDA-listed.

NDC 27495-0014-04
🏷️ FDA NDC (as labeled) 27495-014-04 billing pads the product segment with a zero
This package
Contains120 mL in 1 bottle Pack sizes2 compare ↓
Product page 27495-0014-02 Also comes in: 50 bottles 27495-014-02
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 8, 2026 · this listing last changed Aug 27, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 27495-014-04 alone.

Record
FDA NDC Directory package listing · Human OTC drug
Code segments
27495 labeler · 014 product · 04 package
Package marketed since
Jul 22, 2011
Sample package
No — commercial package
Listing certified through
Dec 31, 2026
Barcode (UPC)
0327495014047
FDA record last changed
Aug 27, 2026

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 27495-014-04
Product NDC 27495-014
11-digit billing NDC 27495001404
NCPDP billing unit ML — per mL (volume)
RxCUI 1116967, 1116971
UNII LAV5U5022Y, L7T10EIP3A, S07O44R1ZM
UPC 0327495014047
Application # M017
SPL Set ID 05742cd5-ece2-4007-bdf0-46b76d23df74
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2011-07-22
Route TOPICAL
Dosage form LOTION
Substance METHYL SALICYLATE; MENTHOL; CAPSAICIN

Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification

GPI-14 90809903304124
GPI class Dendracin Neurodendraxcin
GCN Seq No 067619
GCN 30211
HICL code 002572
Ingredient (HICL) Capsaicin/Me-Salicylate/Menth
HIC1 code L
Therapeutic class — broad (HIC1) Skin/Subcutaneous Tissue
HIC2 code L6
Therapeutic class — intermediate (HIC2) Irritants
HIC3 code L6A
Therapeutic class — specific (HIC3) Irritants/Counter-Irritants
AHFS code 84:92.00.00
AHFS class Skin And Mucous Membrane Agents, Misc.
FDB label name DENDRACIN LOTION
FDB brand name Dendracin
Legend status O — Over-the-counter (OTC) drug or device
Quick answers
  • GSN (GCN sequence number): 067619
  • GCN: 30211
  • GPI-14 (Medi-Span): 90809903304124
  • HICL (First Databank): 002572
  • AHFS class code: 84:92.00.00
  • RxCUI (RxNorm): 1116967
Why two NDCs? The FDA registers this code as 27495-014-04 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 27495-0014-04. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

RxNorm drug class

This medicine belongs to the Capsaicin and similar agents class.

Drug family (ATC) Capsaicin and similar agents, Other local anesthetics
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

Clinical

Label name DENDRACIN LOTION Ingredient Capsaicin/Me-Salicylate/Menth
🧪 What is this product?

Dendracin Neurodendraxcin is a topical lotion marketed as an over-the-counter monograph product. It contains methyl salicylate, menthol, and capsaicin, which are commonly used in topical preparations to provide warming or cooling sensations and temporary relief of minor muscle and joint discomfort. Methyl salicylate and menthol function as counterirritants that produce heat or cold feelings on the skin, while capsaicin is typically included for similar counterirritant effects. This type of lotion is applied directly to the skin over the affected area.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer gPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Try another pack size: 50 bottles
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
27495-0014-02 27495-014-02 Main listing 50 BOTTLE in 1 CARTON / 60 mL in 1 BOTTLE 2011-07-22 — Active
27495-0014-04 You're viewing this 50 BOTTLE in 1 CARTON / 120 mL in 1 BOTTLE 2011-07-22 — Active

Pack size FAQ

What quantity is in this package?
This package is listed by the FDA — 50 bottle in 1 carton / 120 ml in 1 bottle.
What NDC number is used to bill for this package of Dendracin Neurodendraxcin Methyl Salicylate, Menthol and Capsaicin 18 g/60mL; 6 g/60mL; .015 g/60mL Lotion?
Use the 11-digit billing form listed in the identifiers section of this page. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Dendracin Neurodendraxcin 18 g/60mL; 6 g/60mL; .015 g/60mLthis 27495-0014-04 Physicians 50 bottles — — FDA listed —
Dendracin Neurodendraxcin 18 g/60mL; 6 g/60mL; .015 g/60mL 63187-0136-02 Proficient 50 bottles — — FDA listed —
Dendracin Neurodendraxcin 18 g/60mL; 6 g/60mL; .015 g/60mL 68788-7696-01 Preferred 120 ml — — FDA listed —
Dendracin Neurodendraxcin 18 g/60mL; 6 g/60mL; .015 g/60mL 80425-0458-01 Advanced 120 ml — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2011
On the market since
Jul 2011
📍
2026
Currently FDA-listed
15 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII ZY81Z83H0X
    Aloe vera leaf is a plant extract derived from the aloe plant. It is used in medicines as a natural moisturizer and skin-soothing agent in topical formulations.
  • UNII 8GQS4E66YY
    A synthetic polymer made from acrylic compounds. It forms a coating on tablets or capsules to control how and where the medicine releases in the digestive system.
  • UNII U3RSY48JW5
    Benzocaine is a local anesthetic chemical used in small amounts as a numbing agent in topical medicines like lozenges and sprays. It helps reduce discomfort in the mouth or throat where the product is applied.
  • UNII F8XAG1755S
    A plant-derived oil from borage seeds, rich in fatty acids. It's used in formulations as an emollient and skin-conditioning agent to help maintain moisture and improve texture.
  • UNII 936JST6JCN
    Cetyl alcohol is a waxy, fatty substance derived from plant or animal sources. It acts as an emulsifier and thickener in medicines, helping blend oil and water components and giving products a smooth, creamy texture.
  • UNII YOW8V9698H
    Dimethyl sulfoxide is a clear liquid solvent derived from wood pulp. In medicines, it helps dissolve or carry active ingredients and improve how the body absorbs the drug.
  • UNII BYR0546TOW
    DMDM hydantoin is a preservative chemical used to prevent the growth of bacteria and fungi in medicines. It helps keep the product safe and stable throughout its shelf life.
  • UNII C5529G5JPQ
    Ginger is a plant-derived ingredient used as a flavoring agent to add taste and aroma to medicines. It may also provide mild soothing properties to support product palatability.
  • UNII 230OU9XXE4
    A waxy substance made from glycerin and stearic acid that acts as an emulsifier to blend oily and watery ingredients together. It also helps thicken and stabilize the medicine's texture.
  • UNII 1DI56QDM62
    A natural fatty substance from soybeans that helps mix oil and water-based ingredients together. It acts as an emulsifier and lubricant in medicines to improve texture and help the product break down properly in your body.
  • UNII A2I8C7HI9T
    Methylparaben is a preservative derived from benzoic acid that prevents growth of bacteria, fungi, and mold in medicines. It extends the product's shelf life and maintains safety during storage.
  • UNII YD01N1999R
    A waxy substance made from polyethylene glycol and stearic acid. It helps mix oil and water-based ingredients together and serves as an emulsifier and solubilizer in liquid and semi-solid medicines.
  • UNII TUF2IVW3M2
    Poloxamer 407 is a synthetic polymer made from ethylene oxide and propylene oxide. In medicines, it acts as a thickener, emulsifier, and solubilizer to help mix ingredients and create the right texture.
  • UNII 6DC9Q167V3
    Propylene glycol is a clear liquid derived from petroleum or vegetable sources. It acts as a solvent, humectant, and preservative in medicines, helping dissolve active ingredients and maintain product stability.
  • UNII Z8IX2SC1OH
    Propylparaben is a chemical preservative used to prevent bacterial and fungal growth in medicines and personal care products. It helps extend shelf life and maintain product safety during storage.
  • UNII 65A9F4P024
    A synthetic compound derived from the amino acid glutamate and stearic acid. It acts as an emulsifier and surfactant to help mix oil and water-based ingredients, keeping the medicine uniform throughout.
  • UNII 4ELV7Z65AP
    Stearic acid is a fatty acid derived from plant or animal sources. It acts as a binder and lubricant in tablets and capsules, helping them hold together and flow smoothly during manufacturing.
  • UNII 9O3K93S3TK
    Trolamine is an alkaline compound used as a pH buffer and emulsifier in medicines. It helps neutralize acids, stabilize formulations, and enable mixing of oil and water-based ingredients.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

19 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesAloe Barbadensis (Aloe Vera) Leaf Juice, Ammonium Acryloyldimethyltaurate/VP Copolymer, Benzocaine, Borago Officinalis Seed Oil (Borage Oil), Cetyl Alcohol, Dimethyl Sulfoxide, DMDM Hydantoin, Glyceryl Stearate, Methylparaben, PEG 100 Stearate, Poloxamer 407, Propylene Glycol, Propylparaben, Lecithin (Soy), Stearic Acid, Sodium Stearoyl Glucamate, Triethanolamine, Water, Officinale Root Extract.

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerPhysicians Science & Nature Inc.
FDA applicationM017 (OTC MONOGRAPH DRUG)
Labeler code27495
First marketedJul 2011
Product typeHuman Otc Drug
Portfolio2 products on file

More NDCs from Physicians Science & Nature Inc. labeler code 27495

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Do Not Use 📄 Stop Use and Ask a Doctor If 📄 Keep Out of Reach of Children 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 21 words ▾

USES: For temporary relief of mild pain due to muscular strain, arthritis, and simple back pain. Does not cure any disease.

⏱️ Dosage and Administration 64 words ▾

DIRECTIONS: Use only as directed. Shake before each use. Prior to first use, rub small amount to check for sensitivity. Gently rub over painful areas. Dry before contact with clothes or bedding to avoid staining. Wash hands after use. Do not use more than 4 times daily or if pregnant or nursing. If placed into eyes, rinse with cold water and call a doctor.

⚠️ Warnings 50 words ▾

WARNINGS: For external use only. Do not use in eyes, mouth, on mucous membranes, or genitals. Do not allow treated skin to contact infants or pets. Do not tightly bandage. Do not use with heating pad. Do not use with other topical pain products. May stain furniture, clothing or bedding.

🧪 Active Ingredient 9 words ▾

ACTIVE INGREDIENTS Methyl Salicylate 30% Menthol 10% Capsaicin 0.025%

🧪 Inactive Ingredients 47 words ▾

INACTIVE INGREDIENTS: Aloe Barbadensis (Aloe Vera) Leaf Juice, Ammonium Acryloyldimethyltaurate/VP Copolymer, Benzocaine, Borago Officinalis Seed Oil (Borage Oil), Cetyl Alcohol, Dimethyl Sulfoxide, DMDM Hydantoin, Glyceryl Stearate, Methylparaben, PEG 100 Stearate, Poloxamer 407, Propylene Glycol, Propylparaben, Lecithin (Soy), Stearic Acid, Sodium Stearoyl Glucamate, Triethanolamine, Water, Officinale Root Extract.

🎯 Purpose 3 words ▾

Purpose Topical Analgesic

📄 Do Not Use 37 words ▾

Do Not Use: On cuts or infected skin, on children less than 12 years old, in large amounts, especially over raw or blistered skin, if allergic to any ingredients, PABA, aspirin products, or sulfa. Store below 90°F/32°C.

📄 Stop Use and Ask a Doctor If 36 words ▾

Stop Use and Ask a Physician: For severe undiagnosed pain. If pain worsens or persist for more than 7 days. If pain clears up and then recurs in a few days. If itching or rash occurs.

📄 Keep Out of Reach of Children 19 words ▾

Keep away from children and pets. If swallowed get medical help or contact a Poison Control Center right away.

📄 Package Label / Principal Display Panel 42 words ▾

Principal Display Panel Physician's Science and Nature Inc. DENDRACIN Neurodendraxcin ® Professional Formula Dermatologically Tested Hypoallergenic Topical Pain Relief Lotion Deep Penetrating Action 60 ml (2 fl oz) NDC 27495-014-02 120 ml (4 fl oz) NDC 27495-014-04 2 oz Label 4oz Label

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Physicians Science & Nature Inc.. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 1 other package presentation of this same product, including 50 bottles (27495-0014-02). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
Physicians Science & Nature Inc. is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 27495-0008-02 · Physicians 27505-0004-05 · MDD →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.