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Meijer Nighttime Sleep Aid Non Habit Forming DIPHENHYDRAMINE HYDROCHLORIDE 50 mg/30mL Liquid, 354 mL

by MEIJER DISTRIBUTION INC · 354 mL in 1 BOTTLE, PLASTIC (41250-853-12)
NDC 41250-0853-12
🏷️ FDA NDC (as labeled) 41250-853-12 billing pads the product segment with a zero
OTC On market Non-controlled
🗂️ Data synced Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

🆔 Identity & classification

FDA NDC (as labeled) 41250-853-12
Product NDC 41250-853
11-digit billing NDC 41250085312
RxCUI 1248354
UNII TC2D6JAD40
UPC 0708820059979
Application # M010
SPL Set ID fd476bfa-3e2e-470c-9180-19aa43e4af24
Established class (EPC) Histamine-1 Receptor Antagonist
Mechanism of action Histamine H1 Receptor Antagonists
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2019-04-25
Route ORAL
Dosage form LIQUID
Substance DIPHENHYDRAMINE HYDROCHLORIDE
Why two NDCs? The FDA registers this code as 41250-853-12 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 41250-0853-12. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏷️ RxNorm drug class

This medicine belongs to the Histamine-1 Receptor Antagonist class.

Pharmacologic class Histamine-1 Receptor Antagonist
Drug family (ATC) Propionic acid derivatives, Antihistamines for topical use, Aminoalkyl ethers
How it works Histamine H1 Receptor Antagonists
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

🏭 Manufacturer & labeler

LabelerMEIJER DISTRIBUTION INC
FDA applicationM010 (OTC MONOGRAPH DRUG)
Labeler code41250
First marketedApr 2019
Product typeHuman Otc Drug
Portfolio245 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

📗 Our plain-language guide HelloPharmacist
  • Diphenhydramine is mainly used to temporarily ease the stuffy, sneezy, itchy symptoms of allergies — like hay fever — and the common cold. Think runny nose, sneezing, watery or itc...
  • What exactly does diphenhydramine treat?
  • Yes, and that's one of the most important things to know about this medicine. Drowsiness is one of its most common effects — it crosses into the brain and that's what causes the se...
  • It depends on your child's age and the product. Most oral diphenhydramine products are not recommended for children under 6, and liquid products labeled for children are generally...
📖 Read our full Diphenhydramine guide →

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII XF417D3PSL
    Anhydrous citric acid is a sour, crystalline powder derived from citric acid with water removed. In medicines, it acts as a buffer to control pH, adds tartness to improve taste, and helps tablets disintegrate.
  • UNII PDC6A3C0OX
    Glycerin is a clear, thick liquid derived from plant oils or fats. It acts as a humectant to retain moisture, a sweetener, and a solvent in medications.
  • UNII EE90ONI6FF
    Potassium citrate is a salt derived from citric acid and potassium. In medicines, it acts as a buffer to adjust and maintain the pH balance of the product, helping keep it stable and palatable.
  • UNII OJ245FE5EU
    Sodium benzoate is a salt derived from benzoic acid, a preservative. It's added to medicines to prevent growth of bacteria, fungi, and other microorganisms that could spoil the product.
  • UNII 506T60A25R
    Sorbitol is a natural sugar alcohol derived from glucose. It serves as a sweetener, humectant, and bulking agent in medications to improve taste and help maintain moisture in the product.
  • UNII 96K6UQ3ZD4
    Sucralose is a synthetic sweetener made from sugar. It's added to medicines to improve taste without adding calories, helping make bitter or unpleasant-tasting drugs easier to take.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
  • UNII TTV12P4NEE
    Xanthan gum is a thickening and stabilizing ingredient made from fermented corn or other sugars. It's added to medicines to improve texture, prevent separation of liquids and solids, and help the product stay consistent.

8 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesanhydrous citric acid, flavor, glycerin, potassium citrate, purified water, sodium benzoate, sorbitol, sucralose, xanthan gum.

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Sleep Aid 50 mg/30mL 46122-0754-29 Amerisource 355 ml $0.009 — Availability likely —
Good Sense Sleep Time 50 mg/30mL 00113-0186-30 L. 177 ml $0.013 — Discontinued —
LEADER Nighttime Sleep-Aid 50 mg/30mL 70000-0174-02 CARDINAL 177 ml $0.014 — Availability likely —
Nighttime Sleep-Aid 50 mg/30mL 83324-0015-06 Chain 177 ml $0.014 — Availability likely —
Dye Free Wal Sleep Z 50 mg/30mL 00363-0753-12 WALGREEN 354 ml — — FDA listed —
Nighttime Sleep Aid 50 mg/30mL 00363-7300-12 WALGREEN 354 ml — — FDA listed —
Sleep Aid 50 mg/30mL 00363-8020-02 Walgreen 355 ml — — FDA listed —
Nighttime Sleep Aid 50 mg/30mL 11673-0285-02 TARGET 2 bottles — — FDA listed —
Sleep Aid 50 mg/30mL 11673-0750-12 TARGET 355 ml — — FDA listed —
Rite Aid Nighttime Sleep Aid Non Habit Forming 50 mg/30mL 11822-7530-01 RITE 354 ml — — FDA listed —
Nighttime Sleep-Aid 50 mg/30mL 11822-8002-01 Rite 177 ml — — FDA listed —
EZ Nite Sleep 50 mg/30mL 21130-0014-06 Safeway, 177 ml — — FDA listed —
Nightime Sleep Aid 50 mg/30mL 21130-0711-01 BETTER 354 ml — — FDA listed —
Nighttime Sleep Aid 50 mg/30mL 30142-0095-96 Kroger 2 bottles — — FDA listed —
Topcare ZZZ Sleep 50 mg/30mL 36800-0200-30 Topco 177 ml — — Discontinued —
ZzzQuil Nighttime Sleep-Aid 50 mg/30mL 37000-0500-04 The 118 ml — — FDA listed —
Nighttime Sleep Aid 50 mg/30mL 37808-0186-30 H 177 ml — — Discontinued —
Nighttime Sleep Aid 50 mg/30mL 37835-0319-30 Bi-Mart 355 ml — — FDA listed —
Diphenhydramine HCl 50 mg/30mL 37835-0519-12 BI-MART 355 ml — — FDA listed —
Equaline Night Time Sleep Aid 50 mg/30mL 41163-0186-30 United 177 ml — — Discontinued —
KROGER Nighttime Sleep-Aid 50 mg/30mL 41226-0730-12 KROGER 354 ml — — FDA listed —
nitetime sleep aid 50 mg/30mL 41250-0044-30 Meijer 177 ml — — Discontinued —
Meijer Nighttime Sleep-aid Berry Flavor 50 mg/30mL 41250-0738-12 MEIJER 354 ml — — FDA listed —
Meijer Nighttime Sleep Aid Non Habit Forming 50 mg/30mLthis 41250-0853-12 MEIJER 354 ml — — FDA listed —
Nighttime Sleep Aid 50 mg/30mL 41520-0034-06 Care 177 ml — — FDA listed —
Night Time Sleep Aid 50 mg/30mL 42507-0959-40 HyVee 355 ml — — FDA listed —
Nighttime Sleep Aid Alcohol Free 50 mg/30mL 49035-0330-02 Wal-Mart 355 ml — — FDA listed —
Sleep Aid 50 mg/30mL 49035-0704-02 Wal-Mart 355 ml — — FDA listed —
Sleep Aid NightTime 50 mg/30mL 49580-0314-02 P 355 ml — — FDA listed —
Nighttime Sleep Aid 50 mg/30mL 50844-0200-45 L.N.K. 177 ml — — Discontinued —
Nighttime Sleep Aid 50 mg/30mL 50844-0250-45 L.N.K. 177 ml — — FDA listed —
Nighttime Sleep-Aid 50 mg/30mL 53041-0633-58 Guardian 177 ml — — FDA listed —
Nighttime Sleep-Aid 50 mg/30mL 53942-0522-28 DeMoulas 354 ml — — FDA listed —
Night Time Sleep-Aid 50 mg/30mL 53943-0522-25 Discount 117 ml — — FDA listed —
Nighttime Sleep Aid 50 mg/30mL 55319-0802-02 Family 355 ml — — FDA listed —
Night Time Sleep Aid 50 mg/30mL 55910-0114-12 Dolgencorp, 355 ml — — FDA listed —
dg health sleep aid 50 mg/30mL 55910-0186-30 Dolgencorp, 177 ml — — Discontinued —
Sleep Aid NightTime 50 mg/30mL 55910-0899-12 Dolgencorp, 355 ml — — FDA listed —
Sleep Aid NightTime 50 mg/30mL 55910-0981-02 Dolgencorp, 355 ml — — FDA listed —
CVS Health Nighttime Sleep-Aid 50 mg/30mL 59779-0893-06 CVS 177 ml — — FDA listed —
Nighttime Sleep Aid, 24-7 Life BY 7-ELEVEN, 6oz 50 mg/30mL 66715-6543-04 Lil' 177 ml — — FDA listed —
Nighttime Sleep Aid Berry Flavor 50 mg/30mL 67091-0630-06 WINCO 177 ml — — FDA listed —
Premier Value Nighttime Sleep-Aid Liquid Sleep-Aid 50 mg/30mL 68016-0219-12 Chain 354 ml — — FDA listed —
Nighttime Sleep Aid Berry Flavor 50 mg/30mL 68163-0730-06 Raritan 177 ml — — FDA listed —
berkley and jensen sleep aid 50 mg/30mL 68391-0186-40 BJWC 3 bottles — — FDA listed —
Nighttime Sleep Aid 50 mg/30mL 68391-0793-09 BJWC 3 bottles — — FDA listed —
Nighttime Sleep Aid 50 mg/30mL 69168-0446-39 Allegiant 354 ml — — FDA listed —
Nighttime Sleep Aid 50 mg/30mL 69168-0486-39 Allegiant 355 ml — — FDA listed —
VICKS ZzzQuil NIGHTTIME SLEEP-AID Diphenhydramine HCl FREE OF 50 mg/30mL 69423-0795-12 The 354 ml — — FDA listed —
VICKS ZzzQuil NIGHTTIME SLEEP-AID 50 mg/30mL 69423-0812-12 The 354 ml — — FDA listed —
Vicks ZzzQuil Soothing Sleep Nighttime Sleep-Aid 50 mg/30mL 69423-0830-12 The 354 ml — — FDA listed —
Sleep-Aid 50 mg/30mL 69842-0470-02 CVS 355 ml — — FDA listed —
CVS Health Nighttime Sleep Aid 50 mg/30mL 69842-0753-12 CVS 354 ml — — FDA listed —
basic care nighttime sleep aid 50 mg/30mL 72288-0186-40 Amazon.com 355 ml — — FDA listed —
Nighttime Sleep Aid 50 mg/30mL 76162-0200-45 TOPCO 177 ml — — FDA listed —
Nighttime Sleep-Aid Non-Habit Forming 50 mg/30mL 76281-0522-24 AptaPharma 118 ml — — FDA listed —
Goodnow Sleep Aid 50 mg/30mL 82501-0186-00 Gobrands, 355 ml — — FDA listed —
Quality Choice Nighttime Sleep Aid 50 mg/30mL 83324-0336-06 QUALITY 177 ml — — FDA listed —
Vicks ZzzQuil Nighttime Sleep-Aid 84126-0306-03 The 1 kit — — FDA listed —
ZzzQuil Nighttime Sleep-Aid 50 mg/30mL 84126-0316-04 The 118 ml — — FDA listed —
VICKS ZzzQuil FREE and CLEAR NIGHTTIME SLEEP-AID 50 mg/30mL 84126-0370-12 The 354 ml — — FDA listed —
VICKS ZzzQuil FREE and CLEAR NIGHTTIME SLEEP-AID 50 mg/30mL 84126-0371-12 The 354 ml — — FDA listed —
Revasol Sleep Aid 50 mg/30mL 84379-0284-04 Rnv 118 ml — — FDA listed —
Nighttime Sleep Aid 50 mg/30mL 85828-0793-01 Grocery 354 ml — — FDA listed —
Up and Up Nighttime Sleep Aid 50 mg/30mL 11673-0186-40 Target 355 ml — — FDA listed —
Nighttime Sleep Aid 50 mg/30mL 41226-0793-02 Kroger 2 bottles — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️
2019
On the market since
Apr 2019
📍
2026
Currently FDA-listed
7 years listed
🔒
·
Generic approved (availability unconfirmed)
see note
🔒Generic approved by FDA, but pharmacy availability is not confirmed

The FDA lists approved generic versions of this medicine, but that does not always mean a pharmacy can get one today. Patent rules, launch agreements, supply and pricing can affect when generics actually arrive.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

📦 Packaging — all sizes for this product

Package NDCDescription Marketing startStatus
41250-0853-12 You're viewing this 354 mL in 1 BOTTLE, PLASTIC (41250-853-12) 2019-04-25 Active

🧭 About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos — Not published for this NDC No photo available yet for this listing.
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The FDA registers it as 41250-853-12, which is what is printed on the packaging and shown on DailyMed. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero: 41250-0853-12, written without dashes as 41250085312. The Identity section at the top of this page lists every form of this code.
What do the three segments of this NDC mean?
In 41250-0853-12, the first segment (41250) is the labeler code FDA assigned to MEIJER DISTRIBUTION INC; the middle segment (0853) identifies this specific product — its ingredient, strength, and dosage form; and the last segment (12) identifies this exact package size and type. Together they name one specific package of one specific product.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by MEIJER DISTRIBUTION INC. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
MEIJER DISTRIBUTION INC is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 📦 Storage and Handling 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose
🎯 Indications and Usage 18 words ▾

Uses for the relief of occasional sleeplessness reduces time to fall asleep if you have difficulty falling asleep

⏱️ Dosage and Administration 41 words ▾

Directions take only one dose per day (24 hours) measure with dosing cup provided adults & children 12 yrs & over 30 mL at bed time if needed or as directed by a doctor children under 12 yrs do not use

⚠️ Warnings 130 words ▾

Warnings Do not use for children under 12 years of age with any other product containing diphenhydramine, even one used on skin Ask a doctor before use if you have a breathing problem such as emphysema, or chronic bronchitis glaucoma difficulty in urination due to enlargement of the prostate gland Ask a doctor or pharmacist before use if you are taking sedatives or tranquilizers When using this product avoid alcoholic beverages Stop use and ask a doctor if sleeplessness persists continuously for more than two weeks.

Insomnia may be a symptom of serious underlying medical illness. If pregnant or breast-feeding , ask a health professional before use. Keep out of reach of children.

In case of overdose, get medical help or contact a Poison Control Center right away at 1-800-222-1222.

📦 Storage and Handling 14 words ▾

Other information each 30 mL dose contains: sodium 10 mg store at room temperature

🧪 Active Ingredient 10 words ▾

Active ingredient (in each 30 mL) Diphenhydramine HCl 50 mg

🧪 Inactive Ingredients 21 words ▾

Inactive ingredients anhydrous citric acid, flavor, glycerin, potassium citrate, purified water, sodium benzoate, sorbitol, sucralose, xanthan gum. Questions or comments? 1-866-467-2748

🎯 Purpose 3 words ▾

Purpose Nighttime sleep-aid

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
← 41250-0846-01 · Meijer 41250-0854-06 · Meijer →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.