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Hemorrhoidal Mineral, Petrolatum, Phenylephrine Hydrochloride 140 mg/g; 749 mg/g; 2.5 mg/g Ointment — NDC 51316-228-02 (Billing 51316-0228-02)

by CVS PHARMACY, INC · 1 TUBE in 1 BOX / 57 g in 1 TUBE

This is a package of Hemorrhoidal Mineral, Petrolatum, Phenylephrine Hydrochloride 140 mg/g; 749 mg/g; 2.5 mg/g Ointment from CVS PHARMACY, INC, marketed since Jun 2022 and currently FDA-listed.

NDC 51316-0228-02
🏷️ FDA NDC (as labeled) 51316-228-02 billing pads the product segment with a zero
This package
Contains57 g in 1 tube Pack sizes2 compare ↓
Product page 51316-0228-01 Also comes in: 28 g 51316-228-01
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 8, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 51316-228-02 alone.

Record
FDA NDC Directory package listing · Human OTC drug
Code segments
51316 labeler · 228 product · 02 package
Package marketed since
Jun 15, 2022
Sample package
No — commercial package
Listing certified through
Dec 31, 2027
Barcode (UPC)
0050428031179
FDA record last changed
Jul 24, 2026

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 51316-228-02
Product NDC 51316-228
11-digit billing NDC 51316022802
RxCUI 1372298
UNII T5L8T28FGP, 4T6H12BN9U, 04JA59TNSJ
UPC 0050428031179
Application # M015
SPL Set ID 93482a9b-145b-42d4-96db-599c281a39f1
Established class (EPC) alpha-1 Adrenergic Agonist
Mechanism of action Adrenergic alpha1-Agonists
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2022-06-15
Route TOPICAL
Dosage form OINTMENT
Substance MINERAL OIL; PETROLATUM; PHENYLEPHRINE HYDROCHLORIDE
Quick answers
  • RxCUI (RxNorm): 1372298
Why two NDCs? The FDA registers this code as 51316-228-02 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 51316-0228-02. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

RxNorm drug class

This medicine belongs to the Softeners, emollients class.

Drug family (ATC) Softeners, emollients
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

Clinical

🧪 What is this product?

This is an over-the-counter topical ointment marketed under FDA's monograph rules for hemorrhoidal products. It contains mineral oil and petrolatum, which are typically used to soften and lubricate the affected area, and phenylephrine hydrochloride, a decongestant that is commonly used to help reduce swelling and discomfort associated with hemorrhoids. The ointment is applied directly to the skin in the rectal area.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer gPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Try another pack size: 28 g
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
51316-0228-01 51316-228-01 Main listing 1 TUBE in 1 BOX / 28 g in 1 TUBE 2022-06-15 — Active
51316-0228-02 You're viewing this 1 TUBE in 1 BOX / 57 g in 1 TUBE 2022-06-15 — Active

Pack size FAQ

What quantity is in this package?
This package is listed by the FDA — 1 tube in 1 box / 57 g in 1 tube.
What NDC number is used to bill for this package of Hemorrhoidal Mineral, Petrolatum, Phenylephrine Hydrochloride 140 mg/g; 749 mg/g; 2.5 mg/g Ointment?
Use the 11-digit billing form listed in the identifiers section of this page. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Good Sense Hemorrhoidal 14 g/100g; 74.9 g/100g; .25 g/100g 00113-0188-16 L. 1 tube $0.057 — Availability likely —
Hemorrhoidal .25 g/100g; 14 g/100g; 74.9 g/100g 00536-1288-06 Rugby 1 tube $0.057 — Availability likely —
Hemorrhoidal 14 g/100g; 74.9 g/100g; .25 g/100g 45802-0188-16 Padagis 1 tube $0.057 — Availability likely —
GNP Hemorrhoidal 2.5 mg/g; 749 mg/g; 140 mg/g 46122-0677-46 Amerisource 1 tube $0.057 — Availability likely —
Hemorrhoidal .25 g/100g; 14 g/100g; 74.9 g/100g 70000-0046-01 Cardinal 1 tube $0.057 — Availability likely —
foster and thrive hemorrhoidal 14 g/100g; 74.9 g/100g; .25 g/100g 70677-1108-01 Strategic 1 tube $0.057 — Availability likely —
Walgreens 2.5 mg/g; 140 mg/g; 749 mg/g 00363-6503-01 Walgreens 1 tube — — FDA listed —
Hemorrhoidal Pain Relief 2.5 mg/g; 140 mg/g; 749 mg/g 00363-9876-02 WALGREENS 1 tube — — FDA listed —
Preparation H 2.5 mg/g; 140 mg/g; 749 mg/g 00573-2871-04 Haleon 1 tube — — FDA listed —
Hemorrhoidal 14 g/100g; 74.9 g/100g; .25 g/100g 11822-0006-00 Rite 1 tube — — Discontinued —
Hemorrhoidal 2.5 mg/g; 749 mg/g; 140 mg/g 13709-0319-01 NeilMed 1 tube — — FDA listed —
Hemorrhoidal Pain Relief 749 mg/g; 140 mg/g; 2.5 mg/g 13709-0334-01 Neilmed 1 tube — — FDA listed —
signature care hemorrhoidal 14 g/100g; 74.9 g/100g; .25 g/100g 21130-0577-16 Safeway 1 tube — — FDA listed —
Hemorrhoidal 14 g/100g; 74.9 g/100g; .25 g/100g 21130-0687-16 Safeway 1 tube — — FDA listed —
Signature Care Hemorrhoidal 749 mg/g; 2.5 mg/g; 140 mg/g 21130-0789-14 Better 1 tube — — FDA listed —
Hemorrhoidal 14 g/100g; 74.9 g/100g; .25 g/100g 30142-0188-16 Kroger 1 tube — — FDA listed —
topcare hemorrhoidal 14 g/100g; 74.9 g/100g; .25 g/100g 36800-0499-16 Topco 1 tube — — FDA listed —
Equaline Hemorrhoidal 14 g/100g; 74.9 g/100g; .25 g/100g 41163-0188-16 United 1 tube — — FDA listed —
hemorrhoidal 14 g/100g; 74.9 g/100g; .25 g/100g 41250-0188-16 Meijer 1 tube — — FDA listed —
careone hemorrhoidal 14 g/100g; 74.9 g/100g; .25 g/100g 41520-0188-16 American 1 tube — — FDA listed —
0.25 % PHENYLEPHRINE HCl HEMORRHOIDAL 14 g/100g; 74.9 g/100g; .25 g/100g 43473-0094-02 Nantong 1 tube — — FDA listed —
Equate Hemorrhoidal 14 g/100g; 74.9 g/100g; .25 g/100g 49035-0188-16 Wal-Mart 1 tube — — FDA listed —
Hemorrhoidal 140 mg/g; 749 mg/g; 2.5 mg/gthis 51316-0228-02 CVS 1 tube — — FDA listed —
CAREALL Hemorrhoidal 140 mg/g; 749 mg/g; 2.5 mg/g 51824-0079-02 New 56 g — — FDA listed —
Hemorrhoid Anesthetic .14 g/g; .749 g/g; .0025 g/g 52000-0057-01 Universal 1 tube — — Discontinued —
0.25 % PHENYLEPHRINE HCl HEMORRHOIDAL 14 g/100g; 74.9 g/100g; .25 g/100g 52000-0438-02 Universal 1 tube — — FDA listed —
Exchange Select Hemorrhoidal 14 g/100g; 74.9 g/100g; .25 g/100g 55301-0188-16 Army 1 tube — — FDA listed —
Family Wellness Hemorrhoidal 749 mg/g; 140 mg/g; 2.5 mg/g 55319-0381-56 Family 1 tube — — FDA listed —
TheraPlus Plus .25 g/100g; 14 g/100g; 74.9 g/100g 55621-0005-01 Zhejiang 42 g — — FDA listed —
Family Wellness .25 g/100g; 14 g/100g; 74.9 g/100g 55621-0006-01 Zhejiang 1 tube — — FDA listed —
ProCure Hemorrhoidal 74.9 g/100g; .25 g/100g; 14 g/100g 55681-0021-02 Twin 56.6 g — — FDA listed —
DG Health Hemorrhoidal 14 g/100g; 74.9 g/100g; .25 g/100g 55910-0188-16 Dolgencorp, 1 tube — — FDA listed —
Hemorrhoidal 14 g/100g; 74.9 g/100g; .25 g/100g 56062-0188-16 Publix 1 tube — — FDA listed —
Hemorrhoidal 14 g/100g; 74.9 g/100g; .25 g/100g 63187-0505-02 Proficient 1 tube — — FDA listed —
HemorrhoidalOintment 14 g/100g; 74.9 g/100g; .25 g/100g 68016-0528-00 Pharmacy 1 tube — — FDA listed —
HemorrhoidalOintment 14 g/100g; 74.9 g/100g; .25 g/100g 69396-0020-01 Trifecta 1 tube — — FDA listed —
HemorrhoidalOintment 14 g/100g; 74.9 g/100g; .25 g/100g 69396-0082-02 Trifecta 1 tube — — FDA listed —
HemorrhoidalOintment 74.9 g/100g; .25 g/100g; 14 g/100g 69396-0083-01 Trifecta 1 tube — — FDA listed —
HemorrhoidalOintment 14 g/100g; 74.9 g/100g; .25 g/100g 69396-0133-20 Trifecta 1 tube — — FDA listed —
hemorrhoidal 749 mg/g; 2.5 mg/g; 140 mg/g 69452-0448-38 Bionpharma 1 tube — — FDA listed —
Family wellness 14 g/100g; 74.9 g/100g; .25 g/100g 69571-0006-02 FRONT 1 tube — — FDA listed —
TheraCare Hemorrhoidal 14 g/100g; 74.9 g/100g; .25 g/100g 71101-0935-01 Veridian 1 tube — — FDA listed —
Hemorrhoidal 14 g/100g; 74.9 g/100g; .25 g/100g 72162-2282-02 Bryant 1 tube — — FDA listed —
Basic Care Hemorrhoidal 14 g/100g; 74.9 g/100g; .25 g/100g 72288-0188-16 Amazon.com 1 tube — — FDA listed —
Hemorrhoidal .25 g/100g; 14 g/100g; 74.9 g/100g 83324-0045-02 Chain 1 tube — — FDA listed —
Hemorrhoidal 14 g/100g; 74.9 g/100g; .25 g/100g 85766-0140-57 Sportpharm 1 tube — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2022
On the market since
Jun 2022
📍
2026
Currently FDA-listed
4 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

Loading inactive ingredients from the official FDA label in the background. No external source is being called by this page request.
Where does this data come from?
Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerCVS PHARMACY, INC
FDA applicationM015 (OTC MONOGRAPH DRUG)
Labeler code51316
First marketedJun 2022
Product typeHuman Otc Drug
Portfolio104 products on file

More NDCs from CVS PHARMACY, INC labeler code 51316

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Ask a Doctor Before Use If 📄 Ask a Doctor or Pharmacist Before Use If 📄 When Using This Product 📄 Stop Use and Ask a Doctor If 🤰 If Pregnant or Breast-Feeding 📄 Keep Out of Reach of Children 📄 Questions or Comments 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 41 words ▾

Uses helps relieve the local itching and discomfort associated with hemorrhoids temporarily shrinks hemorrhoid tissue and relieves burning temporarily provides a coating for relief of anorectal discomforts temporarily protects the inflamed, irritated anorectal surface to help make bowel movements less painful

⏱️ Dosage and Administration 107 words ▾

Directions Adults: when practical, cleanse the affected area by patting or blotting with an appropriate cleansing wipe. Gently dry by patting or blotting with a tissue or a soft cloth before applying ointment. apply to the affected area up to 4 times daily, especially at night, in the morning or after each bowel movement intrarectal use: remove cover from applicator, attach applicator to tube, lubricate applicator well and gently insert applicator into the rectum, thoroughly cleanse applicator after each use and replace cover also apply ointment to external area regular use provides continual therapy for relief of symptoms Children under 12 years of age: ask a doctor.

⚠️ Warnings 124 words ▾

Warnings For external use only Ask a doctor before use if you have heart disease high blood pressure thyroid disease diabetes difficulty in urination due to enlargement of the prostate gland Ask a doctor or pharmacist before use if you are presently taking a prescription drug for high blood pressure or depression. When using this product do not exceed the recommended daily dosage unless directed by a doctor Stop use and ask a doctor if bleeding occurs condition worsens or does not improve within 7 days introduction of applicator into the rectum causes additional pain If pregnant or breast-feeding, ask a health professional before use.

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.(1-800-222-1222)

🧪 Active Ingredient 13 words ▾

Active ingredients Mineral oil 14% Petrolatum 74.9% Phenylephrine HCI 0.25% Purpose Protectant Vasoconstrictor

🧪 Inactive Ingredients 15 words ▾

Inactive ingredients Beeswax, Benzoic acid, Cetyl alcohol, Glycerol, Methylparaben, Polyoxyethylene lauryl ether, Propylparaben, Stearyl alcohol

🎯 Purpose 3 words ▾

Purpose Protectant Vasoconstrictor

📄 Ask a Doctor Before Use If 26 words ▾

Ask a doctor before use if you have heart disease high blood pressure thyroid disease diabetes difficulty in urination due to enlargement of the prostate gland

📄 Ask a Doctor or Pharmacist Before Use If 21 words ▾

Ask a doctor or pharmacist before use if you are presently taking a prescription drug for high blood pressure or depression.

📄 When Using This Product 16 words ▾

When using this product do not exceed the recommended daily dosage unless directed by a doctor

📄 Stop Use and Ask a Doctor If 27 words ▾

Stop use and ask a doctor if bleeding occurs condition worsens or does not improve within 7 days introduction of applicator into the rectum causes additional pain

🤰 If Pregnant or Breast-Feeding 10 words ▾

If pregnant or breast-feeding, ask a health professional before use.

📄 Keep Out of Reach of Children 19 words ▾

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.(1-800-222-1222)

📄 Questions or Comments 9 words ▾

Questions? Weekdays 9 AM to 4 PM EST 1-800-639-3803

📄 Package Label / Principal Display Panel 12 words ▾

Package Labeling:28g Outer Label28g Inner Label28g

Package Labeling:57g Outer Label57g Inner Label57g

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos — Not published for this NDC No photo available yet for this listing.
Inactive ingredients (structured) — Not published for this NDC The labeler did not submit a structured excipient list, or no SPL is available.
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by CVS PHARMACY, INC. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 1 other package presentation of this same product, including 1 tube (51316-0228-01). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
CVS PHARMACY, INC is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 51316-0227-00 · CVS 51316-0229-00 · CVS →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.