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Tussin CF DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, PHENYLEPHRINE HYDROCHLORIDE 10 mg/5mL; 100 mg/5mL; 5 mg/5mL Liquid, 237 mL — NDC 53943-504-26 (Billing 53943-0504-26)

by Discount Drug Mart · 237 mL in 1 BOTTLE

This is a package of 237 mL of Tussin CF DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, PHENYLEPHRINE HYDROCHLORIDE 10 mg/5mL; 100 mg/5mL; 5 mg/5mL Liquid from Discount Drug Mart, marketed since Nov 2014 and currently FDA-listed. It is this product's only package size.

NDC 53943-0504-26
🏷️ FDA NDC (as labeled) 53943-504-26 billing pads the product segment with a zero
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Oct 1, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 53943-504-26 alone.

Record
FDA NDC Directory package listing · Human OTC drug
Code segments
53943 labeler · 504 product · 26 package
Package marketed since
Nov 19, 2014
Sample package
No — commercial package
Listing certified through
Dec 31, 2026
Barcode (UPC-A, from the NDC)
3 5394350426 6
FDA record last changed
Oct 1, 2026

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 53943-504-26
Product NDC 53943-504
11-digit billing NDC 53943050426
RxCUI 1044949
UNII 9D2RTI9KYH, 495W7451VQ, 04JA59TNSJ
Application # M012
SPL Set ID f8e7a08e-7422-4a1b-bfec-93e0b50d10cd
Established class (EPC) Expectorant
Physiologic effect Decreased Respiratory Secretion Viscosity; Increased Respiratory Secretions
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2014-11-19
Route ORAL
Dosage form LIQUID
Substance DEXTROMETHORPHAN HYDROBROMIDE; GUAIFENESIN; PHENYLEPHRINE HYDROCHLORIDE
Quick answers
  • RxCUI (RxNorm): 1044949
Why two NDCs? The FDA registers this code as 53943-504-26 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 53943-0504-26. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

RxNorm drug class

This medicine belongs to the Uncompetitive N-methyl-D-aspartate Receptor Antagonist class.

Pharmacologic class Uncompetitive N-methyl-D-aspartate Receptor Antagonist, Sigma-1 Agonist
Drug family (ATC) Other antidepressants, Opium alkaloids and derivatives
How it works Uncompetitive NMDA Receptor Antagonists, Sigma-1 Receptor Agonists
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

Clinical

🧪 What is this product?

Tussin CF is an over-the-counter liquid cough and cold medicine taken by mouth. It contains dextromethorphan, a cough suppressant typically used to reduce coughing, and guaifenesin, an expectorant commonly used to help thin and clear mucus from the airways. The product also includes phenylephrine, a nasal decongestant typically used to help relieve nasal congestion. This is an OTC monograph product, meaning it is marketed under federal guidelines for its product category rather than through individual FDA approval.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
53943-0504-26 You're viewing this Main listing 237 mL in 1 BOTTLE 2014-11-19 — Active

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Tussin Multi Symptom Cold CF 20 mg/10mL; 200 mg/10mL; 10 mg/10mL 70000-0133-01 Cardinal 1 bottle $0.018 — FDA listed —
Tussin CF 20 mg/10mL; 200 mg/10mL; 10 mg/10mL 70677-1187-01 Strategic 1 bottle $0.019 — FDA listed —
Tussin Multi Symptom Cold CF Adult 20 mg/10mL; 200 mg/10mL; 10 mg/10mL 00904-6537-20 Major 1 bottle $0.021 — Availability likely —
Tussin Multi Symptom Cold CF 20 mg/10mL; 200 mg/10mL; 10 mg/10mL 83324-0155-04 QUALITY 1 bottle $0.021 — Availability likely —
Robitussin Peak Cold Multi-Symptom Cold 10 mg/5mL; 100 mg/5mL; 5 mg/5mL 00031-8742-14 Haleon 1 bottle — — FDA listed —
Bactimicina Cough And Cold 10 mg/5mL; 100 mg/5mL; 5 mg/5mL 24286-1546-04 DLC 1 bottle — — FDA listed —
Tukol Honey Children Cough and Congestion 5 mg/2.5mL; 50 mg/2.5mL; 2.5 mg/2.5mL 50066-0301-04 Genomma 1 bottle — — FDA listed —
Tukol Multi Symptom Cold 10 mg/5mL; 100 mg/5mL; 5 mg/5mL 50066-0504-24 Genomma 118 ml — — FDA listed —
Tukol Cough and Congestion 10 mg/5mL; 100 mg/5mL; 5 mg/5mL 50066-0510-04 Genomma 1 bottle — — FDA listed —
Tukol X-Pecto Miel Multi Symptom Cold 10 mg/5mL; 100 mg/5mL; 5 mg/5mL 50066-0533-24 Genomma 118 ml — — FDA listed —
Tukol Cough And Cold Honey Flavor 100 mg/5mL; 5 mg/5mL; 10 mg/5mL 50066-0534-04 Genomma 1 bottle — — FDA listed —
GoodSense Tussin CF Multi-Symptom Cold, Raspberry 5 mg/5mL; 10 mg/5mL; 100 mg/5mL 50804-0256-04 Geiss, 118 ml — — FDA listed —
Desgen Dm 10 mg/5mL; 100 mg/5mL; 5 mg/5mL 52083-0646-16 Kramer 474 ml — — FDA listed —
Mucosan Multi-Symptom Cherry 10 mg/5mL; 5 mg/5mL; 100 mg/5mL 53145-0693-04 Menper 1 bottle — — FDA listed —
Mucosan Multi-Symptom Honey 10 mg/5mL; 100 mg/5mL; 5 mg/5mL 53145-0695-04 Menper 1 bottle — — FDA listed —
Tussin CF Multi-Symptom Cold 10 mg/5mL; 100 mg/5mL; 5 mg/5mL 53942-0504-26 DeMoulas 237 ml — — FDA listed —
Tussin CF 10 mg/5mL; 100 mg/5mL; 5 mg/5mLthis 53943-0504-26 Discount 237 ml — — FDA listed —
Multi-Symptom Cold 20 mg/10mL; 200 mg/10mL; 10 mg/10mL 55319-0201-36 Family 1 bottle — — FDA listed —
Broncomiel Adults 200 mg/10mL; 10 mg/10mL; 20 mg/10mL 55758-0512-09 Pharmadel 1 bottle — — FDA listed —
Rompe Pecho CF 10 mg/5mL; 100 mg/5mL; 5 mg/5mL 58593-0235-04 Efficient 118 ml — — Discontinued —
Tussin Multi Symptom Cold CF 20 mg/10mL; 200 mg/10mL; 10 mg/10mL 63941-0382-04 Best 1 bottle — — FDA listed —
Tussin CF 20 mg/10mL; 200 mg/10mL; 10 mg/10mL 63941-0823-04 Best 1 bottle — — FDA listed —
Tussin CF Non Drowsy Multi Symptom 20 mg/10mL; 200 mg/10mL; 10 mg/10mL 67091-0266-18 WinCo 1 bottle — — FDA listed —
Tussin CF 20 mg/10mL; 200 mg/10mL; 10 mg/10mL 67091-0470-04 WinCo 1 bottle — — FDA listed —
Tussin CF 20 mg/10mL; 200 mg/10mL; 10 mg/10mL 67091-0691-04 WinCo 1 bottle — — FDA listed —
Tussin Cf 10 mg/5mL; 100 mg/5mL; 5 mg/5mL 76281-0504-24 AptaPharma 118 ml — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2014
On the market since
Nov 2014
📍
2026
Currently FDA-listed
12 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

Loading inactive ingredients from the official FDA label in the background. No external source is being called by this page request.
Where does this data come from?
Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerDiscount Drug Mart
FDA applicationM012 (OTC MONOGRAPH DRUG)
Labeler code53943
First marketedNov 2014
Product typeHuman Otc Drug
Portfolio130 products on file

More NDCs from Discount Drug Mart labeler code 53943

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Ask a Doctor Before Use If 📄 Ask a Doctor or Pharmacist Before Use If 📄 When Using This Product 📄 Stop Use and Ask a Doctor If 🤰 If Pregnant or Breast-Feeding 📄 Keep Out of Reach of Children 📄 Other Information 📄 Questions or Comments 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 31 words ▾

Uses help loosen phlegm (mucus) and thin bronchial secretions to drain bronchial tubes temporarily relieves these symptoms occuring with a cold: nasal congestion cough due to minor throat and bronchial irritation

⏱️ Dosage and Administration 49 words ▾

Directions Do not take more than 6 doses in any 24 hour period This adult strength product is not intended for use in children under 12 years of age Age Dose adults and children 12 years and over 2 teaspoons every 4 hours children under 12 do not use

⚠️ Warnings 68 words ▾

Warnings DO NOT USE IF PRINTED SEAL UNDER CAP IS TORN OR MISSING. Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.

🧪 Active Ingredient 23 words ▾

Drug Facts Active ingredients (in each 5 mL tsp) Dextromethorphan HBr, USP 10 mg Guaifenesin, USP 100 mg Phenylephrine HCL, USP 5 mg

🧪 Inactive Ingredients 25 words ▾

Inactive ingredients Anhydrous citric acid, FD and red # 40, glycerin, menthol, natural and artifical flavor, propylene glycol, purified water, sodium benzoate, sorbitol solution, sucralose

🎯 Purpose 6 words ▾

Purpose Cough Suppressant Expectorant Naasal Decongestant

📄 Ask a Doctor Before Use If 48 words ▾

Ask a doctor before use if you have high blood pressure heart disease diabetes thyroid disease trouble urinating due to an enlarged prostate gland cough that occurs with too much phlegm (mucus) cough that lasts or is chronic such as occurs with smoking, asthma, chronic bronchitis or emphysema

📄 Ask a Doctor or Pharmacist Before Use If 18 words ▾

Ask a doctor or pharmacist before use if you are taking any other oral nasal decongestant or stimulant.

📄 When Using This Product 10 words ▾

When using this product do not use more than directed.

📄 Stop Use and Ask a Doctor If 52 words ▾

Stop use and ask a doctor if you get nervous, dizzy or sleepless symptoms do not get better within 7 days or are accompanied by fever cough lasts for more than 7 days, comes back, or is accompanied by fever, rash, or persistant headache. These could be signs of a serious condition.

🤰 If Pregnant or Breast-Feeding 10 words ▾

If pregnant or breast-feeding, as a health professional before use.

📄 Keep Out of Reach of Children 27 words ▾

Keep out of reach of children. Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

📄 Other Information 24 words ▾

Other information Keep carton for full Directions for use. store at 20°-25°C (68°-77°F) do not refrigerate dosage cup provided sodium 3 mg per teaspoonful

📄 Questions or Comments 12 words ▾

Questions? Call weekdays from 9:30 AM to 4:30 PM EST at 1-877-798-5944

📄 Package Label / Principal Display Panel 121 words ▾

DISCOUNT drug mart FOOD FAIR Tussin CF product label *COMPARE TO THE ACTIVE INGREDIENTS IN ROBITUSSIN® PEAK COLD COUGH MULTI-SYMPTOM COLD DISCOUNT drug mart FOOD FAIR Tussin CF Dextromethorphan HBr/ Guaifenesin / Phenylephrine HCL NON-DROWSY COUGH SUPPRESSANT EXPECTORANT NASAL DECONGESTANT Relieves: Cough, Mucus, Nasal Congestion Multi-Symptom Formula For ages 12 and over 8 FL OZ (237 mL) * This product is not manufactured or distributed bynPfizer, owner of the registered trademark Robitussin® BX-040 LOT: EXP: SATISFACTION GUARANTEED IF DISSASIFIED , RETURN UNUSED PORTION AND PACKAGE TO STORE WHERE PURCHASED.

IF UNABLE TO RETURN TO STORE, SEND REASON FOR DISSATISFACTION, NAME, ADDRESS AND EMPTY PACKAGE TO: DISCOUNT DRUG MART, 211 COMMERCE DRIVE, MEDINA, OHIO 44256 res AptaPharma Tussin CF AptaPharma Tussin CF1

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Tussin CF (this brand).

Top reported reactions

Pain8
Abdominal Pain Upper6
Cough6
Dyspnoea6
Headache6
Death5
Dizziness5

Age at onset

Child1
Adult9
Elderly3

Reporter sex

65 reports
Male · 37%
Female · 63%

Serious outcomes

Hospitalization16
Death6
Disabling5
Life-threatening1
Reports over time (by year) — tap or hover for the count & year
2019 2021 2023 2026 8 0
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.

About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos — Not published for this NDC No photo available yet for this listing.
Inactive ingredients (structured) — Not published for this NDC The labeler did not submit a structured excipient list, or no SPL is available.
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Discount Drug Mart. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
Discount Drug Mart is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 53943-0503-26 · Discount 53943-0505-26 · Discount →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.