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XtraCare Deep Cleaning Astringent Salicylic Acid 5 mg/237mg Gel, 237 mg — NDC 57337-0035-01 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

XtraCare Deep Cleaning Astringent Salicylic Acid 5 mg/237mg Gel, 237 mg — NDC 57337-035-01 (Billing 57337-0035-01)

by Rejoice International · 237 mg in 1 BOTTLE

This is a package of 237 mg of XtraCare Deep Cleaning Astringent Salicylic Acid 5 mg/237mg Gel from Rejoice International, marketed since Nov 2013 and currently FDA-listed. It is this product's only package size.

NDC 57337-0035-01
🏷️ FDA NDC (as labeled) 57337-035-01 billing pads the product segment with a zero
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 57337-035-01
Product NDC 57337-035
11-digit billing NDC 57337003501
RxCUI 346298
UNII O414PZ4LPZ
UPC 0849607050007
Application # M006
SPL Set ID 20cb8584-8a31-40a8-8a47-d9fa8ec8abcf
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2013-11-26
Route TOPICAL
Dosage form GEL
Substance SALICYLIC ACID
Quick answers
  • RxCUI (RxNorm): 346298
Why two NDCs? The FDA registers this code as 57337-035-01 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 57337-0035-01. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

RxNorm drug class

This medicine belongs to the Salicylic acid and derivatives class.

Drug family (ATC) Salicylic acid and derivatives, Other antifungals for topical use, Antiinflammatory agents, non-steroids
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

Clinical

📖 What it is MedlinePlus · NLM

Topical salicylic acid is used to help clear and prevent pimples and skin blemishes in people who have acne. Topical salicylic acid is also used to treat skin conditions that involve scaling or overgrowth of skin cells such as psoriasis (a skin disease in which red, scaly patches form on some areas of the body), ichthyoses (inborn conditions that cause skin dryness and scaling), dandruff, corns, calluses, and warts on the hands or feet. Topical salicylic acid should not be used to treat genital warts, warts on the face, warts with hair growing from them, warts in the nose or mouth, moles, or b...

Read the full MedlinePlus article ↗
📗 Our plain-language guide HelloPharmacist
  • It is used in a facial routine for acne-prone and oil-prone skin. The routine includes a cleanser, serum, toner and emulsion. Salicylic acid helps loosen and shed dead skin cells.
  • Use the cleanser morning and evening, and the serum in the morning after cleansing. Use the toner in the evening on dry skin, and the emulsion at night after cleansing. Avoid your...
  • Mild stinging, burning, itching, dryness and extra peeling can happen. If dryness or peeling bothers you, try using the serum or toner every other day. If it gets excessive, stop a...
  • It is best not to. Using another topical acne medication at the same time makes irritation and dryness more likely. If you get irritated, use only one at a time.
📖 Read our full Salicylic Acid Topical guide →

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer gPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
57337-0035-01 You're viewing this Main listing 237 mg in 1 BOTTLE 2013-11-26 — Active

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Walgreens Acne Control Gel 20 mg/mL 00363-0269-83 WALGREEN 1 tube — — FDA listed —
Artistry Studio Done With Zit Acne Treatment Clearing Gel 20 mg/mL 10056-0045-00 Access 1 tube — — FDA listed —
Hero Cosmetics Pimple Correct Salicylic Acid Acne Treatment 20 mg/mL 10237-0003-00 Church 1 tube — — FDA listed —
Acne Treatment Gel 20 mg/mL 31720-0301-08 S+ 1 bottle — — FDA listed —
Eradikate Acne Mark Fading 2 g/100mL 43479-0112-51 KATE 1 bottle — — FDA listed —
Clarifying Peel 2 g/100mL 46007-0102-11 Skin 20 ml — — Discontinued —
ACNE SolutionS CLINICAL ADVANCED CLEARING gel 20 mg/mL 49527-0221-01 CLINIQUE 1 bottle — — Discontinued —
Thayers Since 1847 Natural Remedies Blemish Clearing Witch Hazel Aloe Vera Formula Cleanser 20 mg/mL 49967-0051-01 L'Oreal 118 ml — — FDA listed —
CeraVe Developed with Dermatologists Acne Control Acne Treatment 20 mg/mL 49967-0172-01 L'Oreal 1 tube — — FDA listed —
Thayers Since 1847 Natural Remedies Blemish Clearing Witch Hazel Aloe Vera Formula Balm 20 mg/mL 49967-0530-01 L'Oreal 118 ml — — FDA listed —
Vichy Laboratoires Normaderm Phytoaction Acne Control Daily Moisturizer 20 mg/mL 49967-0606-01 L'Oreal 1 bottle — — FDA listed —
Vichy Laboratoires Normaderm Acne Control Daily Moisturizer 20 mg/mL 49967-0660-01 L'Oreal 1 bottle — — FDA listed —
clear days ahead fast-acting salicylic acid acne spot treatment .3 g/15mL 50184-1020-01 Philosophy 15 ml — — FDA listed —
Dr. Dennis Gross Alpha Beta On the Spot Eliminator 20 mg/mL 51326-0057-01 Topiderm, 1 tube — — FDA listed —
GOODBYE ACNE Complete treatment gel .9638 g/48.19g 54031-0069-01 Peter 48.19 g — — FDA listed —
BRODA Acne .4 g/20g 54111-0112-50 Bentley 20 g — — FDA listed —
XtraCare Deep Cleaning Astringent 5 mg/237mgthis 57337-0035-01 Rejoice 237 mg — — FDA listed —
Acne Defense Spot Treatment Merle Norman 2 g/100g 57627-0201-02 Merle 1 tube — — FDA listed —
Image Clear Cell Acne Spot Treatment 20 g/1000g 60232-5022-01 Swiss-American 14 g — — FDA listed —
Dry It Out Acne Spot Treatment 2 g/100mL 61197-0122-00 Pacifica 29 ml — — FDA listed —
Gm Collin Puracne 20 mg/mL 64127-0195-01 Laboratoires 1 tube — — FDA listed —
Overnight Clearing 20 mg/mL 68479-0706-00 Dermalogica, 2 ml — — FDA listed —
Milani Erase Base Blemish Control Primer 20 mg/mL 68577-0103-00 Cosmax 1 tube — — FDA listed —
PCA SKIN Intensive Clarity Treatment 2 g/100g 68726-0359-02 CP 1 tube — — FDA listed —
PCA Gel 2 g/100mL 68726-0445-02 CP 1 bottle — — FDA listed —
Spot Stopper Acne Spot Treatment 2 g/100mL 69366-0412-32 The 1 tube — — FDA listed —
First Aid Beauty FAB Acne Spot Treatment 2 g/100mL 69423-0724-22 The 1 tube — — FDA listed —
Vichy Laboratoires Normaderm Phytoaction Acne Control Moisturizer 20 mg/mL 69625-0605-01 COSMETIQUE 1 bottle — — FDA listed —
Vichy Laboratoires Normaderm Acne Control Daily Moisturizer 20 mg/mL 69625-0617-01 Cosmetique 1 bottle — — FDA listed —
Vichy Laboratoires Normaderm Acne Control Moisturizer 20 mg/mL 69625-0661-01 COSMETIQUE 1 bottle — — FDA listed —
CVS Health Advanced Acne Spot Treatment 20 mg/mL 69842-0464-52 CVS 1 tube — — FDA listed —
Neutrogena Rapid Clear Acne Eliminating Spot 20 mg/mL 69968-0472-01 Kenvue 1 tube — — FDA listed —
Clean and Clear Acne Spot Treatment 20 mg/mL 69968-0804-01 Kenvue 1 tube — — FDA listed —
Neutrogena Rapid Clear Acne Eliminating Spot 20 mg/mL 69968-0825-01 Kenvue 1 tube — — FDA listed —
Clean and Clear Acne Spot Treatment 20 mg/g 69968-1016-01 Kenvue 1 tube — — FDA listed —
Treat So Deep Acne-Fighting Treatment 2 g/100mL 70626-0106-15 ASPIRE 1 tube — — FDA listed —
Acne Treatment Maximum Strength 2 g/100g 70631-0358-02 Young 1 tube — — FDA listed —
Acne Spot Treatment 2 g/100mL 70764-0105-51 CONTROL 1 bottle — — FDA listed —
innisfree Gentle Retinol Salicylic Acne Serum 1 g/50mL 71220-0088-02 Innisfree 1 tube — — FDA listed —
Peace Out Acne Moisturizer 20 mg/mL 71494-0008-01 Peace 1 jar — — FDA listed —
Acne Gel Pen 20 mg/mL 71714-0004-01 Tiege 1.3 ml — — FDA listed —
Eradikate Acne Mark Fading 2 g/100mL 72204-0903-02 Rare 1 bottle — — FDA listed —
ULTA All Clear SERUM 20 mg/g 79959-0011-01 APR 1 tube — — FDA listed —
The INKEY List C 50 Serum 20 mg/mL 81136-0020-01 Brand 1 bottle — — Discontinued —
The INKEY List Beta Hydroxy Acid Serum 20 mg/mL 81136-0021-01 Brand 1 bottle — — FDA listed —
Vichy Laboratoires Normaderm Acne Control Daily Moisturizer 20 mg/mL 82046-0617-01 LOreal 1 bottle — — FDA listed —
Curology Acne-Clearing Gel Serum 2 g/100mL 82575-0500-00 Curology, 1 tube — — FDA listed —
Good Molecules Maximum Strength Acne Gel Cream 2 g/100mL 82730-0102-01 Good 1 tube — — FDA listed —
Starface Acne Spot Treatment 20 mg/mL 83171-0003-01 Starface 1 tube — — FDA listed —
Dermacleanse Acne Spot Treatment .02 g/mL 83313-0062-01 ZENMED 30 ml — — FDA listed —
Skinkure Acne Eraser Spot Treatment 20 mg/mL 83865-0100-10 SKINKURE, 30 ml — — FDA listed —
Tula Skincare Clear It Up Acne Clearing and Tone Correcting Gel 2 g/100mL 84126-0121-15 The 1 tube — — FDA listed —
SEYTU Spot 2 g/100mL 84271-0002-00 Omnilife 1 tube — — FDA listed —
Perricone MD Acne Relief Maximum Strength Spot Gel 2 g/100g 84448-0538-14 THG 1 tube — — FDA listed —
Nativae Milia Acne Serum 20 mg/mL 85065-0557-00 CDE 30 ml — — FDA listed —
TRSTAY LUXE Clarifying Acne Repair Serum .02 g/mL 85277-0001-01 Guangdong 1 bottle — — FDA listed —
Duolaq 20 mg/mL 87110-0001-01 METHODIQ 1 bottle — — FDA listed —
HerbaGlow Baiwooxia Anti-Acne Gel 2 g/100g 87351-0087-01 Kungpo 1 jar — — FDA listed —
The Acne Spot Treatment 2 g/100g 87415-0100-04 Spotless, 1 tube — — FDA listed —
Acne Treatment 2 g/100mL 87799-0999-10 Bio 30 ml — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2013
On the market since
Nov 2013
📍
2026
Currently FDA-listed
13 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII 3K9958V90M
    A liquid solvent derived from fermentation or chemical synthesis. In medicines, alcohol dissolves active ingredients, helps preserve the product, and improves how the body absorbs certain drugs.
  • UNII ZY81Z83H0X
    Aloe vera leaf is a plant extract derived from the aloe plant. It is used in medicines as a natural moisturizer and skin-soothing agent in topical formulations.
  • UNII 9DBA0SBB0L
    A synthetic red dye derived from coal tar used as a colorant in medicines and cosmetics. It gives tablets, capsules, and liquids their red or pink appearance for identification and visual appeal.
  • UNII 4ERD2076EF
    A synthetic liquid made by combining polyethylene glycol with castor oil. It works as a solubilizer and emulsifier to help mix water and oil-based ingredients, keeping the medicine uniform throughout the product.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

5 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesInactive Ingredients water, alcohol, PEG-40 hydrogenated castor oil, fragrance, aloe barbadensis leaf juice, d&c red no.33

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerRejoice International
FDA applicationM006 (OTC MONOGRAPH DRUG)
Labeler code57337
First marketedNov 2013
Product typeHuman Otc Drug
Portfolio40 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Keep Out of Reach of Children 📄 Other Information 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 6 words ▾

Use for the treatment of acne

⏱️ Dosage and Administration 74 words ▾

Directions cleanse the skin thoroughly before applying medication moisten a cotton ball or pad cover the entire affected rea with a thin layer 1 to 3 times daily because excessive drying of the skin may occur, start with one application daily, then gradually increase to 2 to 3 times daily if needed or as directed by a physician. If bothersome drying or peeking occurs, reduce application to once a day or every other day.

⚠️ Warnings 64 words ▾

Warnings For external use only Flammable, keep away from open flame When using this product avoid contact with eyes. If contact occurs, immediately flush with water. using other topical acne medications at the same time or immediately following use of this product may increase dryness or irritation of the skin. If this occurs, only one medication should be used unless directed by a doctor.

🧪 Active Ingredient 9 words ▾

Active Ingredient Purpose Salicylic Acid 2% ................ Acne Medication

🧪 Inactive Ingredients 16 words ▾

Inactive Ingredients water, alcohol, PEG-40 hydrogenated castor oil, fragrance, aloe barbadensis leaf juice, d&c red no.33

🎯 Purpose 31 words ▾

XtraCare (salicylic acid) deep cleaning astringent cleans deep treats acne helps prevent pimples Compare to Clean & Clear® Deep Cleaning Astringent 8 fl. oz. (237 mL) salicylic acid deep cleaning astringent

📄 Keep Out of Reach of Children 6 words ▾

keep out of reach of children

📄 Other Information 27 words ▾

*This product is not manufactured or distributed by Johnson&Johnson, the distributor of clean&clear®deep cleansing astringent. DISTRIBUTED BY: REJOICE INTERNATIONAL INC. NORTHVILLE, MI 48168 USA MADE IN CHINA

📄 Package Label / Principal Display Panel 2 words ▾

label image

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

Medicare Part D spend CMS · PART D · 2026 (Q1)

Medicare Part D (outpatient prescription) spending for Salicylic Acid (matched by generic name) — the program that covers self-administered drugs. 2 manufacturers.
⚠️ Drug-level data: CMS publishes Part D spending by drug, not by NDC — these figures combine every manufacturer, strength and package size sold under the name Salicylic Acid. That’s a different level of aggregation than the Medicaid card above, which is specific to this exact 11-digit NDC (pack size included), so the two aren’t directly comparable.
Period
Total Part D spend
$11.2K
Claims incl. refills
43
Beneficiaries
35
Spend / beneficiary
$319.01
Spend / claim
$259.66
Trend by period
💵 About the dollar figures: spending is what Part D plans paid before confidential manufacturer rebates, so the program’s real net cost is lower. A blank patient count means fewer than 11 people — CMS hides counts that small to protect privacy. Source: CMS Medicare Quarterly Part D Spending by Drug (data.cms.gov), updated quarterly.

About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Rejoice International. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
Rejoice International is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 57337-0034-01 · Rejoice 57337-0036-01 · Rejoice →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.