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Alka-Seltzer buffered aspirin 325 mg Tablet, Effervescent — NDC 66715-5206-0 (Billing 66715-5206-00)

by Lil' Drug Store Products, Inc. · 15 POUCH in 1 BOX, UNIT-DOSE / 2 TABLET, EFFERVESCENT in 1 POUCH

This is a package of Alka-Seltzer buffered aspirin 325 mg Tablet, Effervescent from Lil' Drug Store Products, Inc., marketed since Jun 2023 and currently FDA-listed. It is this product's only package size.

NDC 66715-5206-00
🏷️ FDA NDC (as labeled) 66715-5206-0 billing pads the package segment with a zero
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 66715-5206-0 alone.

Record
FDA NDC Directory package listing · Human OTC drug
Code segments
66715 labeler · 5206 product · 0 package
Package marketed since
Jun 1, 2023
Sample package
No — commercial package
Listing certified through
Dec 31, 2026
Barcode (UPC)
0366715510600
FDA record last changed
Jul 24, 2026

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 66715-5206-0
Product NDC 66715-5206
11-digit billing NDC 66715520600
RxCUI 2606079
UNII R16CO5Y76E
UPC 0366715510600
Application # M013
SPL Set ID 0c7a60e7-0bde-9aa2-e063-6294a90a3209
Established class (EPC) Nonsteroidal Anti-inflammatory Drug; Platelet Aggregation Inhibitor
Mechanism of action Cyclooxygenase Inhibitors
Physiologic effect Decreased Prostaglandin Production; Decreased Platelet Aggregation
Chemical class Anti-Inflammatory Agents, Non-Steroidal
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2023-06-01
Route ORAL
Dosage form TABLET, EFFERVESCENT
Substance ASPIRIN
Quick answers
  • RxCUI (RxNorm): 2606079
Why two NDCs? The FDA registers this code as 66715-5206-0 — a 5-4-1 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the package segment → 66715-5206-00. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

RxNorm drug class

This medicine belongs to the Platelet Aggregation Inhibitor class.

Pharmacologic class Platelet Aggregation Inhibitor, Nonsteroidal Anti-inflammatory Drug
Drug family (ATC) Other agents for local oral treatment, Platelet aggregation inhibitors excl. heparin, Salicylic acid and derivatives
How it works Cyclooxygenase Inhibitors
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

Clinical

📗 Our plain-language guide HelloPharmacist
  • Aspirin is used to temporarily relieve common minor pains — things like headaches, backaches, muscle aches, toothaches, menstrual cramps, and discomfort from a cold — and to reduce...
  • Generally, no — aspirin should not be given to children under 12. More importantly, children and teenagers who have or are recovering from chickenpox or a flu-like illness should n...
  • Yes, stomach upset, heartburn, and nausea are real possibilities with aspirin. Taking it with a full glass of water helps. Some people tolerate enteric-coated or delayed-release fo...
  • Does aspirin upset your stomach? What can I do about it?
📖 Read our full Aspirin guide →

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eachPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
66715-5206-00 You're viewing this Main listing 15 POUCH in 1 BOX, UNIT-DOSE / 2 TABLET, EFFERVESCENT in 1 POUCH 2023-06-01 — Active

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Alka-Seltzer Original Flavor 325 mg 00280-0087-02 Bayer 2 tablets — — FDA listed —
Alka-Seltzer Pain Relief 325 mg 00280-8251-24 Bayer 2 tablets — — FDA listed —
Signature Select Effervescent Pain Relief 325 mg 21130-0295-36 Safeway 2 tablets — — FDA listed —
TopCare Effervescent Pain Relief 325 mg 36800-0789-36 TOPCO 2 tablets — — FDA listed —
HEB Effervescent Pain Relief 325 mg 37808-0861-36 H. 2 tablets — — FDA listed —
Equaline Effervescent Pain Reliever 325 mg 41163-0741-36 UNITED 2 tablets — — FDA listed —
Medique Medi-Seltzer Pain Relief 325 mg 47682-0147-20 Unifirst 2 tablets — — FDA listed —
Good Sense Effervescent Pain Relief 325 mg 50804-0422-36 Perrigo 2 tablets — — FDA listed —
CVS Effervescent Pain Reliever 325 mg 51316-0359-36 CVS 2 tablets — — FDA listed —
Market Basket Effervescent Pain Relief 325 mg 53942-0883-36 DEMOULAS 2 tablets — — FDA listed —
Drug Mart Effervescent Pain Relief 325 mg 53943-0431-36 Discount 2 tablets — — FDA listed —
Family Wellness Pain Reliever 325 mg 55319-0870-36 FAMILY 2 tablets — — FDA listed —
Dollar General Effervescent Pain Reliever 325 mg 55910-0040-36 Dolgencorp, 2 tablets — — FDA listed —
Publix Fast Relief Effervescent - Original Flavor 325 mg 56062-0358-36 PUBLIX 2 tablets — — FDA listed —
Best Choice Effervescent Pain Reliever 36 325 mg 63941-0241-12 VALU 2 tablets — — FDA listed —
Alka-Seltzer 325 mgthis 66715-5206-00 Lil' 2 tablets — — FDA listed —
Alka-Seltzer Original Flavor 325 mg 66715-6403-02 Lil' 2 tablets — — FDA listed —
Alka-Seltzer Original Flavor 325 mg 66715-6503-02 Lil' 2 tablets — — FDA listed —
Alka-Seltzer Original Flavor 325 mg 66715-9603-02 Lil' 2 tablets — — FDA listed —
Winco Foods Effervescent Pain Relief 325 mg 67091-0448-36 Winco 2 tablets — — FDA listed —
Alka-Seltzer Original Flavor 325 mg 67751-0219-01 Navajo 2 tablets — — FDA listed —
Meijer Effervescent Pain Relief 325 mg 79481-0073-06 Meijer 2 tablets — — FDA listed —
Quality Choice Effervescent Pain Relief 325 mg 83324-0018-36 CHAIN 2 tablets — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2023
On the market since
Jun 2023
📍
2026
Currently FDA-listed
3 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

Loading inactive ingredients from the official FDA label in the background. No external source is being called by this page request.
Where does this data come from?
Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerLil' Drug Store Products, Inc.
FDA applicationM013 (OTC MONOGRAPH DRUG)
Labeler code66715
First marketedJun 2023
Product typeHuman Otc Drug
Portfolio187 products on file

More NDCs from Lil' Drug Store Products, Inc. labeler code 66715

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Do Not Use 📄 Ask a Doctor Before Use If 📄 Ask a Doctor or Pharmacist Before Use If 📄 Stop Use and Ask a Doctor If 🤰 If Pregnant or Breast-Feeding 📄 Keep Out of Reach of Children 📄 Questions or Comments 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 25 words ▾

Uses Uses temporarily relieves minor aches and pains due to: headache muscle pain backache toothache menstrual pain colds minor pain of arthritis temporarily reduces fever

⏱️ Dosage and Administration 72 words ▾

Directions Directions Fully dissolve 2 tablets in 4 ounces of water before taking. Adults and children 12 years and over: take 2 tablets every 4 hours, or as directed by a doctor. Do not exceed 8 tablets in 24 hours. Adults 60 years and over: take 2 tablets every 4 hours, or as directed by a doctor. Do not exceed 4 tablets in 24 hours. Children under 12 years: consult a doctor.

⚠️ Warnings ~2 min read ▾

Warnings ​Warnings Reye's syndrome Reye's syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness. Allergy alert Allergy alert: Aspirin may cause a severe allergic reaction which may include: hives facial swelling asthma (wheezing) shock Stomach bleeding warning Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding.

The chance is higher if you are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) have 3 or more alcoholic drinks every day while using this product take more or for a longer time than directedStomach bleeding warning: This product contains an NSAID, which Do not use Do not use if you are allergic to aspirin or any other pain reliever/fever reducer if you have ever had an allergic reaction to this product or any of its ingredients Ask a doctor before use Ask a doctor before use if stomach bleeding warning applies to you you have a history of stomach problems, such as heartburn you have high blood pressure, heart disease, liver cirrhosis, or kidney disease you are taking a diuretic you have asthma you have a sodium-restricted diet Ask a doctor or pharmacist before use Ask a doctor or pharmacist before use if you are taking a prescription drug for diabetes gout arthritis Stop use and ask a doctor Stop use and ask a doctor if an allergic reaction occurs.

Seek medical help right away. you experience any of the following signs of stomach bleeding: feel faint vomit blood have bloody or black stools have stomach pain that does not get better pain gets worse or lasts more than 10 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur ringing in the ears or a loss of hearing occurs If pregnant or breast-feeding If pregnant or breast-feeding , ask a health professional before use. It is especially important not to use aspirin at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

Keep out of reach of children Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

🧪 Active Ingredient 15 words ▾

Active ingredient Active ingredient (in each tablet) Buffered aspirin 325 mg (NSAID)* *nonsteroidal anti-inflammatory drug

🧪 Inactive Ingredients 9 words ▾

Inactive ingredients Inactive ingredients anhydrous citric acid, sodium bicarbonate

🎯 Purpose 5 words ▾

Purpose Purpose Pain reliever/fever reducer

📄 Do Not Use 34 words ▾

Do not use Do not use if you are allergic to aspirin or any other pain reliever/fever reducer if you have ever had an allergic reaction to this product or any of its ingredients

📄 Ask a Doctor Before Use If 52 words ▾

Ask a doctor before use Ask a doctor before use if stomach bleeding warning applies to you you have a history of stomach problems, such as heartburn you have high blood pressure, heart disease, liver cirrhosis, or kidney disease you are taking a diuretic you have asthma you have a sodium-restricted diet

📄 Ask a Doctor or Pharmacist Before Use If 25 words ▾

Ask a doctor or pharmacist before use Ask a doctor or pharmacist before use if you are taking a prescription drug for diabetes gout arthritis

📄 Stop Use and Ask a Doctor If 85 words ▾

Stop use and ask a doctor Stop use and ask a doctor if an allergic reaction occurs. Seek medical help right away. you experience any of the following signs of stomach bleeding: feel faint vomit blood have bloody or black stools have stomach pain that does not get better pain gets worse or lasts more than 10 days fever gets worse or lasts more than 3 days redness or swelling is present new symptoms occur ringing in the ears or a loss of hearing occurs

🤰 If Pregnant or Breast-Feeding 52 words ▾

If pregnant or breast-feeding If pregnant or breast-feeding , ask a health professional before use. It is especially important not to use aspirin at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

📄 Keep Out of Reach of Children 27 words ▾

Keep out of reach of children Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

📄 Questions or Comments 11 words ▾

Questions? Questions? 1-800-986-0369 Dist. By Bayer Healthcare LLC, Whippany, NJ 07981

📄 Package Label / Principal Display Panel 29 words ▾

Alka-Seltzer® Gravity Sleeve (unit dose) - PDP/Label [Bayer logo] Alka- Seltzer ® Buffered aspirin (NSAID)/ Pain reliever/fever reducer ORIGINAL FLAVOR 15 PACKETS OF 2 EFFERVESCENT TABLETS [UPC] Pouch PDP

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Alka-Seltzer (this brand).

Top reported reactions

Chronic Kidney Disease721
Acute Kidney Injury439
Renal Failure395
End Stage Renal Disease256
Renal Injury179
Gastrooesophageal Reflux Disease118
Nephrogenic Anaemia117

Age at onset

Child1
Adolescent1
Adult65
Elderly52

Reporter sex

1,404 reports
Male · 43%
Female · 57%
Unknown · 0%

Serious outcomes

Hospitalization330
Death114
Life-threatening17
Reports over time (by year) — tap or hover for the count & year
2019 2021 2023 2026 392 0
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.

About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos — Not published for this NDC No photo available yet for this listing.
Inactive ingredients (structured) — Not published for this NDC The labeler did not submit a structured excipient list, or no SPL is available.
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Lil' Drug Store Products, Inc.. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
Lil' Drug Store Products, Inc. is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 66715-5189-00 · Lil' 66715-5305-00 · Lil' →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.