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(from DailyMed)

Famotidine 20 mg Tablet, Coated, 90-count

by Preferred Pharmaceuticals Inc. · 90 TABLET, COATED in 1 BOTTLE, PLASTIC (68788-4088-9)
NDC 68788-4088-09
🏷️ FDA NDC (as labeled) 68788-4088-9 billing pads the package segment with a zero
This package
Contains90-count Pack sizes4 compare ↓
Also priced by: Part D plans $0.0827/unit — full pricing hub ↓
Also comes in: 14 tablets 68788-4088-04 30 tablets 68788-4088-03 60 tablets 68788-4088-06
Rx only Generic On market Non-controlled
🗂️ Data synced Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

⚠️
Other active recalls for Famotidine (different manufacturers) — 1 · tap to view
These affect other manufacturers’ products for the same ingredient — not necessarily the exact NDC on this page.
Class I · Nov 6, 2025 — Microbial Contamination of Sterile Products; out of limit results obtained for endotoxin testing. (Fresenius Kabi USA, LLC) · FDA recall D-0182-2026
Each entry is an official FDA enforcement report — look up any recall number in the FDA recall database ↗

🆔 Identity & classification

FDA NDC (as labeled) 68788-4088-9
Product NDC 68788-4088
11-digit billing NDC 68788408809
NCPDP billing unit EA — each (per item)
RxCUI 310273
UNII 5QZO15J2Z8
Application # ANDA217669
SPL Set ID fd5d15b9-b1b5-48ef-ba41-8a43a7642e94
Established class (EPC) Histamine-2 Receptor Antagonist
Mechanism of action Histamine H2 Receptor Antagonists
DEA schedule Non-controlled
Marketing category ANDA
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2026-03-17
Route ORAL
Dosage form TABLET, COATED
Substance FAMOTIDINE
TE code (Orange Book) AB · RLD · RS
Why two NDCs? The FDA registers this code as 68788-4088-9 — a 5-4-1 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the package segment → 68788-4088-09. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏷️ RxNorm drug class

This medicine belongs to the Histamine-2 Receptor Antagonist class.

Pharmacologic class Histamine-2 Receptor Antagonist
Drug family (ATC) H2-receptor antagonists
How it works Histamine H2 Receptor Antagonists
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

🏭 Manufacturer & labeler

LabelerPreferred Pharmaceuticals Inc.
Application holderCONTRACT PHARMACAL CORP
FDA applicationANDA217669 (ANDA)
Labeler code68788
First marketedMar 2026
Product typeHuman Prescription Drug
Portfolio825 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

📗 Our plain-language guide HelloPharmacist
  • Famotidine is an acid reducer. Over-the-counter products like Acid Reducer or Calmicid AC are mainly for relieving or preventing heartburn and indigestion. Prescription famotidine...
  • Swallow the tablet whole with a full glass of water — don't chew it. For heartburn relief, you can take it when symptoms start. To prevent heartburn before a meal, take it 10 to 60...
  • Most people do just fine with famotidine. The most common things that come up are headache, dizziness, and constipation. Some people notice nausea or stomach discomfort too. These...
  • What side effects should I actually expect?
📖 Read our full Famotidine guide →
6
Nutrient depletion considerations

Famotidine may be associated with lower levels of 6 nutrients — worth a chat with your pharmacist, not a cause for alarm.

🧪 Full Famotidine nutrient depletion report →
An association is not a deficiency. Educational only — don't start or stop anything without professional guidance.
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

Loading inactive ingredients from the official FDA label in the background. No external source is being called by this page request.
Where does this data come from?
Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eachPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · Q2 2026 $0.0827 $7.44 / 90 tablets
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Famotidine 20 mg 00172-5728-60 Teva 100 tablets $0.029 AB Availability likely —
Famotidine 20 mg 00904-7193-06 Major 1 tablet $0.029 AB Availability likely —
Famotidine 20 mg 31722-0017-01 Camber 100 tablets $0.029 AB Availability likely —
Famotidine 20 mg 50268-0299-15 AvPAK 1 tablet $0.029 AB Availability likely —
Famotidine 20 mg 55111-0119-01 Dr.Reddy's 100 tablets $0.029 AB Availability likely —
Famotidine 20 mg 60687-0595-01 American 1 tablet $0.029 AB Availability likely —
Famotidine 20 mg 61442-0121-01 Carlsbad 2400 tablets $0.029 AB Availability likely —
famotidine 20 mg 62135-0807-90 Chartwell 90 tablets $0.029 AB Availability likely —
Famotidine 20 mg 64980-0623-01 Rising 100 tablets $0.029 AB Availability likely —
Famotidine 20 mg 65862-0859-01 Aurobindo 100 tablets $0.029 — Availability likely —
Famotidine 20 mg 67877-0842-01 Ascend 100 tablets $0.029 AB Availability likely —
Famotidine 20 mg 68001-0397-00 BluePoint 100 tablets $0.029 AB Availability likely —
Famotidine 20 mg 68645-0594-59 Legacy 60 tablets $0.029 AB Availability likely —
Famotidine 20 mg 69367-0400-10 Westminster 1000 tablets $0.029 AB Availability likely —
Famotidine 20 mg 70710-1683-00 Zydus 1000 tablets $0.029 AB Availability likely —
Famotidine 20 mg 70756-0051-11 Lifestar 100 tablets $0.029 AB Availability likely —
Famotidine 20 mg 72205-0145-05 Novadoz 500 tablets $0.029 AB Availability likely —
Good Sense Acid Reducer 20 mg 00113-0194-02 L. 1 tablet $0.143 — Availability likely —
Rugby Famotidine 20 mg 00536-1298-01 Rugby 100 tablets $0.143 — Availability likely —
Major Heartburn Relief Maximum Strength 20 mg 00904-5780-17 Major 1 tablet $0.143 — Availability likely —
Famotidine 20 mg 46122-0737-63 Amerisource 25 tablets $0.143 — Availability likely —
Famotidine 20 mg 68094-0054-65 Precision 10 tablets $0.143 — Availability likely —
famotidine 20 mg 69230-0327-01 Camber 100 tablets $0.143 — Availability likely —
Famotidine 20 mg 70000-0049-01 LEADER/ 25 tablets $0.143 — Availability likely —
Leader Acid Reducer 20 mg 70000-0654-01 Cardinal 50 tablets $0.143 — Availability likely —
Famotidine 20 mg 70000-0710-01 LEADER/ 200 tablets $0.143 — Availability likely —
foster and thrive acid reducer 20 mg 70677-1101-01 Strategic 1 tablet $0.143 — Availability likely —
famotidine 20 mg 83324-0008-50 CHAIN 50 tablets $0.143 — Availability likely —
Famotidine 20 mg 83324-0116-25 Chain 25 tablets $0.143 — Availability likely —
Pepcid 20 mg 00187-4420-10 Bausch 100 tablets — AB FDA listed —
Acid Controller 20 mg 00363-0701-01 Walgreen 85 tablets — — Discontinued —
acid controller 20 mg 00363-1203-71 Walgreen 50 tablets — — FDA listed —
Famotidine 20 mg 00363-1899-14 WALGREEN 50 tablets — — FDA listed —
Famotidine 20 mg 00363-5300-14 WALGREEN 50 tablets — — FDA listed —
Famotidine 20 mg 00615-8558-05 NCS 15 tablets — AB FDA listed —
Famotidine 20 mg 10267-5689-01 Contract 100 tablets — AB FDA listed —
Maximum Strength Acid Reducer 20 mg 11673-0697-01 TARGET 100 tablets — — FDA listed —
acid relief 20 mg 11822-1014-00 Rite 50 tablets — — FDA listed —
acid relief 20 mg 11822-1194-01 Rite 50 tablets — — FDA listed —
acid relief 20 mg 11822-6123-00 Rite 50 tablets — — FDA listed —
PEPCID AC Maximum Strength 20 mg 16837-0855-05 Kenvue 5 tablets — — Discontinued —
Maximum Strength PEPCID AC Icy Cool Mint 20 mg 16837-0889-20 Kenvue 20 tablets — — FDA listed —
Famotidine 20 mg 21130-0023-25 Albertsons 25 tablets — — FDA listed —
Maximum Strength Acid Controller 20 mg 21130-0027-05 BETTER 50 tablets — — FDA listed —
Famotidine 20 mg 21130-0033-14 Better 50 tablets — — FDA listed —
Famotidine 20 mg 21130-0191-20 SAFEWAY 200 tablets — — FDA listed —
acid controller 20 mg 21130-0521-82 Safeway 200 tablets — — FDA listed —
Signature Care Acid Controller maximum strength 20 mg 21130-0777-02 Safeway 1 tablet — — Discontinued —
Famotidine 20 mg 25000-0087-03 MARKSANS 30 tablets — — FDA listed —
Famotidine 20 mg 25000-0124-68 MARKSANS 300 tablets — — FDA listed —
heartburn prevention 20 mg 30142-0194-71 Kroger 50 tablets — — FDA listed —
TopCare Acid Reducer 20 mg 36800-0194-02 Topco 1 tablet — — FDA listed —
Acid Controller 20 mg 37808-0042-63 H 25 tablets — — FDA listed —
Famotidine 20 mg 37835-0165-50 Bi-Mart 50 tablets — — FDA listed —
equaline heartburn prevention 20 mg 41163-0001-02 United 1 tablet — — FDA listed —
Zantac 360 20 mg 41167-0361-00 Chattem, 8 tablets — — FDA listed —
Zantac 360 Cool Mint 20 mg 41167-0364-01 Chattem, 50 tablets — — Discontinued —
heartburn relief 20 mg 41250-0712-02 Meijer 1 tablet — — FDA listed —
CareOne Acid Relief 20 mg 41520-0707-02 American 1 tablet — — Discontinued —
Acid Reducer 20 mg 42507-0194-01 HyVee 1 tablet — — FDA listed —
Famotidine 20 mg 43063-0695-20 PD-Rx 20 tablets — AB FDA listed —
Acid Reducer Maximum Strength 20 mg 43598-0960-32 Dr.Reddys 170 tablets — — FDA listed —
Famotidine 20 mg 43602-0602-03 Ascent 300 tablets — — FDA listed —
Famotidine 20 mg 46708-0293-10 Alembic 100 tablets — AB FDA listed —
Famotidine 20 mg 48433-0150-20 Safecor 1 tablet — AB FDA listed —
Famotidine 20 mg 49035-0505-14 Wal-Mart 50 tablets — — FDA listed —
Equate Famotidine 20 mg 49035-0650-71 Wal-Mart 50 tablets — — FDA listed —
Maximum Strength Acid Reducer 20 mg 49483-0720-20 TIME 200 tablets — — FDA listed —
Famotidine 20 mg 50090-1044-00 A-S 30 tablets — AB FDA listed —
Famotidine 20 mg 50090-1045-00 A-S 30 tablets — AB FDA listed —
Famotidine 20 mg 50090-6582-00 A-S 30 tablets — AB FDA listed —
Famotidine 20 mg 50090-6932-00 A-S 90 tablets — AB FDA listed —
Famotidine 20 mg 50090-7178-00 A-S 30 tablets — AB FDA listed —
Famotidine 20 mg 50090-7180-00 A-S 90 tablets — AB FDA listed —
Famotidine 20 mg 50090-7829-00 A-S 90 tablets — AB FDA listed —
Zantac 360 1 per blister 6 blisters 20 mg 50269-0155-01 JC 1 tablet — — FDA listed —
Zantac 360 2 per blister 6 blisters 20 mg 50269-0156-01 JC 2 tablets — — FDA listed —
Acid Reducer 20 mg 51316-0511-63 CVS 25 tablets — — FDA listed —
Famotidine 20 mg 51407-0683-10 Golden 36000 tablets — AB FDA listed —
Famotidine 20 mg 51655-0233-25 Northwind 60 tablets — AB FDA listed —
Famotidine 20 mg 51655-0312-20 Northwind 20 tablets — AB FDA listed —
Famotidine 20 mg 53943-0101-25 Discount 25 tablets — — FDA listed —
Famotidine 20 mg 54257-0802-02 Magno-Humphries, 100 tablets — — FDA listed —
Calmicid AC Acid Reducer 20 mg 54473-0411-01 Melaleuca, 50 tablets — — FDA listed —
Famotidine 20 mg 55111-0396-08 Dr.Reddys 8 tablets — — FDA listed —
Famotidine 20 mg 55154-2628-00 Cardinal 1 tablet — AB FDA listed —
Famotidine 20 mg 55154-4313-00 Cardinal 1 tablet — AB FDA listed —
Famotidine 20 mg 55315-0435-53 Fred's, 25 tablets — — FDA listed —
Famotidine 20 mg 55319-0057-10 Family 100 tablets — — FDA listed —
Famotidine 20 mg 55319-0409-01 FAMILY 25 tablets — — FDA listed —
Famotidine 20 mg 55319-0427-10 Family 100 tablets — — FDA listed —
Famotidine 20 mg 55681-0342-03 TWIN 300 tablets — — FDA listed —
dg health heartburn prevention 20 mg 55910-0194-02 Dolgencorp 1 tablet — — FDA listed —
dg health heartburn prevention 20 mg 55910-0665-71 Dolgencorp 50 tablets — — FDA listed —
dg health acid reducer 20 mg 55910-0814-71 Dolgencorp 50 tablets — — FDA listed —
Acid Reducer 20 mg 56062-0088-02 Publix 1 tablet — — FDA listed —
maximum strength 20 mg 56062-0194-02 Publix 1 tablet — — FDA listed —
Famotidine 20 mg 57896-0319-01 Geri-Care 100 tablets — — FDA listed —
Famotidine 20 mg 58602-0706-14 Aurohealth 50 tablets — — FDA listed —
Famotidine 20 mg 58602-0829-21 Aurohealth 100 tablets — — FDA listed —
Famotidine 20 mg 58602-0859-34 Aurohealth 200 tablets — — FDA listed —
Acid Controller 20 mg 59640-0001-63 H 25 tablets — — FDA listed —
acid reducer 20 mg 59640-0023-71 H 50 tablets — — FDA listed —
acid controller 20 mg 59779-0194-63 CVS 25 tablets — — FDA listed —
Famotidine 20 mg 62332-0001-10 Alembic 100 tablets — AB FDA listed —
Famotidine 20 mg 63187-0129-10 Proficient 10 tablets — AB FDA listed —
Famotidine 20 mg 63187-0723-00 Proficient 100 tablets — AB FDA listed —
Famotidine 20 mg 63629-7013-01 Bryant 30 tablets — AB FDA listed —
Famotidine 20 mg 63868-0584-25 Chain 25 tablets — — FDA listed —
Famotidine 20 mg 63941-0011-53 Best 25 tablets — — FDA listed —
kirkland signature acid controller 20 mg 63981-0194-05 Costco 125 tablets — — FDA listed —
Zantac 360, Travel BASIX 20 mg 66715-6458-02 Lil' 2 tablets — — FDA listed —
Pepcid AC 20 mg 66715-9748-08 Lil' 1 tablet — — FDA listed —
Zantac 360 20 mg 66715-9758-05 Lil' 5 tablets — — FDA listed —
Famotidine 20 mg 67296-2133-03 Redpharm 30 tablets — AB FDA listed —
Famotidine 20 mg 67296-2186-03 Redpharm 30 tablets — AB FDA listed —
Zantac 360 20 mg 67751-0214-01 Navajo 1 tablet — — FDA listed —
Famotidine 20 mg 68016-0801-25 Chain 25 tablets — — FDA listed —
Famotidine 20 mg 68071-2306-03 NuCare 30 tablets — AB FDA listed —
Famotidine 20 mg 68071-3201-02 NuCare 20 tablets — AB FDA listed —
Famotidine 20 mg 68071-3420-03 NuCare 30 tablets — AB FDA listed —
Famotidine 20 mg 68071-3786-03 NuCare 30 tablets — AB FDA listed —
members mark acid pep 20 mg 68196-0121-00 Sam's 100 tablets — — FDA listed —
berkley and jensen famotidine 20 mg 68391-0300-78 BJWC 100 tablets — — Discontinued —
Famotidine 20 mg 68788-4021-03 Preferred 30 tablets — AB FDA listed —
Famotidine 20 mgthis 68788-4088-09 Preferred 90 tablets — AB FDA listed —
Famotidine 20 mg 68788-4119-01 Preferred 100 tablets — AB FDA listed —
Famotidine 20 mg 68788-8485-03 Preferred 30 tablets — AB FDA listed —
Famotidine 20 mg 68788-8889-01 Preferred 100 tablets — AB FDA listed —
Acid Reducer 20 mg 69168-0443-09 Allegiant 10 tablets — — FDA listed —
Acid Reducer 20 mg 69168-0445-32 Allegiant 100 tablets — AB FDA listed —
Famotidine 20 mg 69842-0087-14 CVS 50 tablets — — FDA listed —
acid reducer 20 mg 69842-0659-63 CVS 25 tablets — — FDA listed —
Famotidine 20 mg 69842-0924-14 CVS 50 tablets — — FDA listed —
Famotidine 20 mg 70518-3829-00 REMEDYREPACK 50 tablets — AB Discontinued —
Famotidine 20 mg 70518-4395-00 REMEDYREPACK 30 tablets — AB FDA listed —
Famotidine 20 mg 70518-4574-00 REMEDYREPACK 10 tablets — AB FDA listed —
Famotidine 20 mg 70771-1702-00 Zydus 1000 tablets — AB FDA listed —
Famotidine 20 mg 71205-0276-06 Proficient 6 tablets — AB FDA listed —
Famotidine 20 mg 71205-0535-06 Proficient 6 tablets — AB FDA listed —
Famotidine 20 mg 71205-0663-30 Proficient 30 tablets — — FDA listed —
Famotidine 20 mg 71335-0370-01 Bryant 30 tablets — AB FDA listed —
Famotidine 20 mg 71335-0409-01 Bryant 30 tablets — AB Discontinued —
Famotidine 20 mg 71335-1520-01 Bryant 30 tablets — AB FDA listed —
Famotidine 20 mg 71335-1950-01 Bryant 30 tablets — AB FDA listed —
Famotidine 20 mg 71335-2190-01 Bryant 30 tablets — AB FDA listed —
Famotidine 20 mg 71335-2805-00 Bryant 40 tablets — AB FDA listed —
Famotidine 20 mg 71335-9748-01 Bryant 30 tablets — AB FDA listed —
Famotidine 20 mg 71610-0399-30 Aphena 30 tablets — AB FDA listed —
Famotidine 20 mg 71610-0470-53 Aphena 60 tablets — AB FDA listed —
Famotidine 20 mg 71821-0010-12 VKT 144230 tablets — — FDA listed —
Famotidine 20 mg 72036-0026-14 Harris 50 tablets — — FDA listed —
Famotidine 20 mg 72189-0141-60 direct 60 tablets — AB FDA listed —
Famotidine 20 mg 72189-0543-20 Direct_Rx 20 tablets — AB FDA listed —
basic care heartburn prevention 20 mg 72288-0151-75 Amazon.com 90 tablets — — FDA listed —
basic care acid reducer 20 mg 72288-0194-00 Amazon.com 200 tablets — — FDA listed —
basic care acid reducer 20 mg 72288-0329-78 Amazon.com 100 tablets — — FDA listed —
Amazon Basic Care Acid Reducer 20 mg 72288-0363-14 Amazon.com 50 tablets — — FDA listed —
careone acid relief 20 mg 72476-0150-63 Retail 25 tablets — — FDA listed —
careone acid relief 20 mg 72476-0299-71 Retail 50 tablets — — FDA listed —
Curist Acid Relief 20 mg 72559-0032-23 Little 300 tablets — — FDA listed —
Famotidine 20 mg 72657-0113-20 GLENMARK 200 tablets — — FDA listed —
Famotidine 20 mg 72657-0132-01 GLENMARK 100 tablets — — FDA listed —
Famotidine 20 mg 72789-0331-20 PD-Rx 20 tablets — AB FDA listed —
Famotidine 20 mg 72865-0214-01 XLCare 100 tablets — AB FDA listed —
Welmate Famotidine 20mg 20 mg 73581-0109-01 YYBA 100 tablets — — FDA listed —
topcare acid reducer 20 mg 76162-0300-71 Topco 50 tablets — — FDA listed —
Famotidine 20 mg 76420-0712-01 Asclemed 100 tablets — AB FDA listed —
equate famotidine 20 mg 79903-0115-99 WALMART 100 tablets — — FDA listed —
Famotidine 20 mg 80425-0329-01 Advanced 30 tablets — AB FDA listed —
Famotidine 20 mg 82804-0194-06 Proficient 6 tablets — AB FDA listed —
Famotidine 20 mg 82804-0980-00 Proficient 100 tablets — AB FDA listed —
Famotidine 20 mg 82868-0077-30 Northwind 30 tablets — AB FDA listed —
Famotidine 20 mg 83008-0091-30 Quality 30 tablets — AB FDA listed —
Rolaids ACID DEFENSE 20 mg 84126-0367-25 The 25 tablets — — FDA listed —
Zantac 360 20 mg 85237-1926-01 Select 1 tablet — — FDA listed —
Acid Reducer Maximum Strength 20 mg 85828-0443-25 Grocery 25 tablets — — FDA listed —
Famotidine 20 mg 87441-0030-01 Unit 30 tablets — AB FDA listed —
Famotidine 20 mg 67296-2264-03 Redpharm 30 tablets — AB FDA listed —
Famotidine 20 mg 85766-0221-01 Sportpharm 100 tablets — AB FDA listed —
Famotidine 20 mg 80425-0589-01 Advanced 30 tablets — AB FDA listed —
Famotidine 20 mg 85534-0091-00 HAWAII 30 tablets — AB FDA listed —
About this product: this is a generic version of the medicine. FDA equivalence ratings are shown when available, and other versions are listed above, least expensive first.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️
2026
On the market since
Mar 2026
📍
2026
Currently FDA-listed
listed with the FDA
🔓
·
Generic on the market
this product is a generic
✅This is a generic drug

This product is an FDA-approved generic. Other versions of the same drug are listed under Therapeutic equivalents, least expensive first.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

📊 Medicare Part D spend CMS · PART D · 2026 (Q1)

Medicare Part D (outpatient prescription) spending for Famotidine — the program that covers self-administered drugs. 29 manufacturers.
⚠️ Drug-level data: CMS publishes Part D spending by drug, not by NDC — these figures combine every manufacturer, strength and package size sold under the name Famotidine. That’s a different level of aggregation than the Medicaid card above, which is specific to this exact 11-digit NDC (pack size included), so the two aren’t directly comparable.
Period
Total Part D spend
$40.22M
Claims incl. refills
3.8M
Beneficiaries
2.6M
Spend / beneficiary
$15.35
Spend / claim
$10.62
Trend by period
💵 About the dollar figures: spending is what Part D plans paid before confidential manufacturer rebates, so the program’s real net cost is lower. A blank patient count means fewer than 11 people — CMS hides counts that small to protect privacy. Source: CMS Medicare Quarterly Part D Spending by Drug (data.cms.gov), updated quarterly.

📦 Packaging — all sizes for this product

Package NDCDescription Marketing startStatus
68788-4088-03 30 TABLET, COATED in 1 BOTTLE, PLASTIC (68788-4088-3) 2026-03-17 Active
68788-4088-04 14 TABLET, COATED in 1 BOTTLE, PLASTIC (68788-4088-4) 2026-03-17 Active
68788-4088-06 60 TABLET, COATED in 1 BOTTLE, PLASTIC (68788-4088-6) 2026-03-17 Active
68788-4088-09 You're viewing this 90 TABLET, COATED in 1 BOTTLE, PLASTIC (68788-4088-9) 2026-03-17 Active

You're viewing the largest of 4 pack sizes for this product.

Pack size FAQ

What quantity is in NDC 68788-4088-09?
NDC 68788-4088-09 is a 90-count package — 90 tablet, coated in 1 bottle, plastic.
What is the difference between NDC 68788-4088-09 and NDC 68788-4088-04?
Both are Famotidine 20 mg Tablet, Coated — the drug itself is identical. NDC 68788-4088-09 is the 90-count package, while NDC 68788-4088-04 is the 14 tablets package.
What NDC number is used to bill for this package of Famotidine 20 mg Tablet, Coated?
Bill NDC 68788-4088-09 — the 11-digit billing format is 68788408809. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

🧭 About this NDC listing & data coverage

Finished prescription product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos — Not published for this NDC No photo available yet for this listing.
Inactive ingredients (structured) — Not published for this NDC The labeler did not submit a structured excipient list, or no SPL is available.
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data ✓ Available
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The FDA registers it as 68788-4088-9, which is what is printed on the packaging and shown on DailyMed. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero: 68788-4088-09, written without dashes as 68788408809. The Identity section at the top of this page lists every form of this code.
What do the three segments of this NDC mean?
In 68788-4088-09, the first segment (68788) is the labeler code FDA assigned to Preferred Pharmaceuticals Inc.; the middle segment (4088) identifies this specific product — its ingredient, strength, and dosage form; and the last segment (09) identifies this exact package size and type. Together they name one specific package of one specific product.
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Yes — the FDA directory lists 3 other package presentations of this same product, including 14 tablets (68788-4088-04), 30 tablets (68788-4088-03), 60 tablets (68788-4088-06). Each has its own NDC and its own page — see the package list near the top of this page.
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📄 Full prescribing information FDA SPL

The complete FDA label for this product — the official prescribing information, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration 💊 Dosage Forms and Strengths ⛔ Contraindications ⚠️ Warnings and Cautions 🤒 Adverse Reactions 🔄 Drug Interactions 👥 Use in Specific Populations 🤰 Pregnancy 🧒 Pediatric Use 🧓 Geriatric Use 🆘 Overdosage 🧬 Clinical Pharmacology 🧬 Mechanism of Action 📦 How Supplied / Storage and Handling 📦 Storage and Handling 📋 Description 💬 Information for Patients
🎯 Indications and Usage 152 words ▾

1 INDICATIONS AND USAGE Famotidine Tablets are indicated in adult and pediatric patients 40 kg and greater for the treatment of: • active duodenal ulcer (DU). • active gastric ulcer (GU). • symptomatic nonerosive gastroesophageal reflux disease (GERD). • erosive esophagitis due to GERD, diagnosed by biopsy. Famotidine Tablets are indicated in adults for the: • treatment of pathological hypersecretory conditions (e.g., Zollinger-Ellison syndrome, multiple endocrine neoplasias). • reduction of the risk of duodenal ulcer recurrence.

Famotidine is a histamine-2 (H 2 ) receptor antagonist indicated ( 1 ): In adult and pediatric patients 40 kg and greater for the treatment of: • active duodenal ulcer (DU). • active gastric ulcer. • symptomatic nonerosive gastroesophageal reflux disease (GERD). • erosive esophagitis due to GERD, diagnosed by biopsy. In adults for the: • treatment of pathological hypersecretory conditions (e.g., Zollinger Ellison syndrome, multiple endocrine neoplasias). • reduction of the risk of DU recurrence.

⏱️ Dosage and Administration ~3 min read ▾

2 DOSAGE AND ADMINISTRATION Indication Recommended Dosage ( 2.1 ) • See full prescribing information for complete dosing information, including dosing in renal impairment, and recommended treatment duration. ( 2.1 , 2.2 ) Adult and Pediatric Patients 40 kg and greater Active DU 40 mg once daily; or 20 mg twice daily Active Gastric Ulcer 40 mg once daily GERD 20 mg twice daily Erosive Esophagitis 20 mg twice daily; or 40 mg twice daily Adults Pathological Hypersecretory Conditions 20 mg every 6 hours; adjust to patient needs; maximum 160 mg every 6 hours Risk Reduction of DU Recurrence 20 mg once daily Administration ( 2.3 ): • Take once daily before bedtime or twice daily in the morning and before bedtime with or without food.

2.1Recommended Dosage Table 1 shows the recommended dosage of famotidine 20 mg and 40 mg tablets in adult and pediatric patients weighing 40 kg and greater with normal renal function. The use of famotidine 20 mg and 40 mg tablets is not recommended in pediatric patients weighing less than 40 kg because the lowest available strength (20 mg) exceeds the recommended dose for these patients. Use another famotidine formulation for pediatric patients weighing less than 40 kg.

Table 1: Recommended Dosage and Duration of Famotidine Tablets in Adult and Pediatric Patients 40 kg and Greater with Normal Renal Function Indication Recommended Dosage Recommended Duration Active duodenal ulcer (DU) 40 mg once daily; or 20 mg twice daily Both dosages demonstrated effectiveness in clinical trials [ see Clinical Studies (14) ]. Up to 8 weeks In clinical trials, the majority of patients healed within 4 weeks. For patients who do not heal after 4 weeks, consider an additional 2 to 4 weeks of treatment [ see Clinical Studies (14.1) ]. , Longer treatment durations have not been studied in clinical trials [ see Clinical Studies (14.1 , 14.2 , 14.3) ].

Active gastric ulcer 40 mg once daily Up to 8 weeks Symptomatic nonerosive GERD 20 mg twice daily Up to 6 weeks Erosive esophagitis diagnosed by endoscopy 20 mg twice daily; or 40 mg twice daily Up to 12 weeks Pathological hypersecretory conditions In pediatric patients, the safety and effectiveness of famotidine tablets have not been established for the reduction of the risk of duodenal ulcer recurrence or for treatment of pathological hypersecretory conditions [ see Use in Specific Populations (8.4) ]. Starting dosage: 20 mg every 6 hours; adjust dosage to individual patient needs Maximum dosage 160 mg every 6 hours As clinically indicated Reduction of the risk of DU recurrence 20 mg once daily 1 year or as clinically indicated

2.2Dosage in Renal Impairment Dosage adjustments of famotidine tablets are recommended for patients with moderate to severe renal impairment (creatinine clearance less than 60 mL/min) [ see Use in Specific Populations (8.6) ]. Table 2 shows the recommended maximum dosage of famotidine 20 mg or 40 mg tablets for patients with renal impairment, by indication. Use the lowest effective dose.

Some dosage adjustments may require switching to other formulations of famotidine (e.g., oral suspension, lower dose tablet). Table 2: Recommended Maximum Dosage of Famotidine Tablets in Adult and Pediatric Patients 40 kg and Greater with Moderate and Severe Renal Impairment Indication Recommended Maximum Dosages Creatinine clearance 30 to 60 mL/minute Creatinine clearance less than 30 mL/minute Active duodenal ulcer (DU) 20 mg once daily; or 40 mg every other day 20 mg every other day An alternate dosage regimen is 10 mg once daily.

Since 20 mg or 40 mg tablet strength cannot be used for this dosage regimen, use an alternate famotidine formulation. Active gastric ulcer 20 mg once daily; or 40 mg every other day 20 mg every other day Symptomatic nonerosive GERD 20 mg once daily 20 mg every other day Erosive esophagitis diagnosed by endoscopy Dosage adjustments for renal impairment are provided for both dosing regimens (20 mg twice daily and 40 mg twice daily) which sho…

💊 Dosage Forms and Strengths 64 words ▾

3 DOSAGE FORMS AND STRENGTHS • Famotidine Tablets, USP 20 mg are light yellow colored, round shaped, biconvex film-coated tablets debossed with "C" on one side and "70" on the other. • Famotidine Tablets, USP 40 mg are white colored, round shaped, biconvex film-coated tablets debossed with "C" on one side and "71" on the other. Tablets: 20 mg, 40 mg ( 3 )

⛔ Contraindications 45 words ▾

4 CONTRAINDICATIONS Famotidine tablets are contraindicated in patients with a history of serious hypersensitivity reactions (e.g., anaphylaxis) to famotidine or other histamine-2 (H 2 ) receptor antagonists. History of serious hypersensitivity reactions (e.g., anaphylaxis) to famotidine or other H 2 receptor antagonists. ( 4 )

⚠️ Warnings and Cautions 175 words ▾

5 WARNINGS AND PRECAUTIONS • Central Nervous System (CNS) Adverse Reactions: Elderly patients and patients with renal impairment at increased risk; reduce the dosage. ( 2.2 , 5.1 , 8.5 , 8.6 ) • GI Malignancy: Absence of GI symptoms does not preclude the presence of gastric malignancy; evaluate prior to initiating therapy. ( 5.2 )

5.1Central Nervous System Adverse Reactions Central nervous system (CNS) adverse reactions, including confusion, delirium, hallucinations, disorientation, agitation, seizures, and lethargy, have been reported in elderly patients and patients with moderate and severe renal impairment treated with famotidine. Since famotidine blood levels are higher in patients with renal impairment than in patients with normal renal function, dosage adjustments are recommended in patients with renal impairment [ see Dosage and Administration (2.2) , Clinical Pharmacology (12.3) ].

5.2Concurrent Gastric Malignancy In adults, symptomatic response to therapy with famotidine does not preclude the presence of gastric malignancy. Consider evaluation for gastric malignancy in adult patients who have a suboptimal response or an early symptomatic relapse after completing treatment with famotidine.

🤒 Adverse Reactions ~2 min read ▾

6 ADVERSE REACTIONS The most common adverse reactions are: headache, dizziness, constipation, and diarrhea. ( 6.1 ) To report SUSPECTED ADVERSE REACTIONS, contact Westminster Pharmaceuticals, LLC. at 1-844-221-7294 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

6.1Clinical Trial Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Famotidine was studied in 7 U.S. and international placebo- and active-controlled trials in approximately 2,500 patients [ see Clinical Studies (14) ]. A total of 1,442 patients were treated with famotidine, including 302 treated with 40 mg twice daily, 456 treated with 20 mg twice daily, 461 treated with 40 mg once daily, and 396 treated with 20 mg once daily.

The population was 17 to 91 years old, fairly well distributed between gender and race; however, the predominant race treated was Caucasian. The following adverse reactions occurred in greater than or equal to 1% of famotidine-treated patients: headache, dizziness and constipation. The following other adverse reactions were reported in less than 1% of patients in clinical trials: Body as a Whole: fever, asthenia, fatigue Cardiovascular: palpitations Gastrointestinal: elevated liver enzymes, vomiting, nausea, abdominal discomfort, anorexia, dry mouth Hematologic: thrombocytopenia Hypersensitivity: orbital edema, rash, conjunctival injection, bronchospasm Musculoskeletal: musculoskeletal pain, arthralgia Nervous System/Psychiatric: seizure, hallucinations, depression, anxiety, decreased libido, insomnia, somnolence Skin: pruritus, dry skin, flushing Special Senses: tinnitus, taste disorder Other: impotence

6.2Postmarketing Experience The following adverse reactions have been identified during post-approval use of famotidine. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Cardiovascular: arrhythmia, AV block, prolonged QT interval Gastrointestinal: cholestatic jaundice, hepatitis Hematologic: agranulocytosis, pancytopenia, leukopenia Hypersensitivity: anaphylaxis, angioedema, facial edema, urticaria Musculoskeletal: rhabdomyolysis, muscle cramps Nervous System/Psychiatric: confusion, agitation, paresthesia Respiratory: interstitial pneumonia Skin: toxic epidermal necrolysis/Stevens-Johnson syndrome

🔄 Drug Interactions 193 words ▾

7 DRUG INTERACTIONS • Drugs Dependent on Gastric pH for Absorption: Systemic exposure of the concomitant drug may be significantly reduced leading to loss of efficacy. See full prescribing information for a list of interacting drugs. ( 7.1 ) • Tizanidine (CYP1A2) Substrate: Potential for substantial increases in blood concentrations of tizanidine resulting in hypotension, bradycardia or excessive drowsiness; avoid concomitant use, if possible. ( 7.2 )

7.1Drugs Dependent on Gastric pH for Absorption Famotidine can reduce the absorption of other drugs, due to its effect on reducing intragastric acidity, leading to loss of efficacy of the concomitant drug. Concomitant administration of famotidine with dasatinib, delavirdine mesylate, cefditoren, and fosamprenavir is not recommended. See the prescribing information for other drugs dependent on gastric pH for absorption for administration instructions, including atazanavir, erlotinib, ketoconazole, itraconazole, ledipasvir/sofosbuvir, nilotinib, and rilpivirine.

7.2Tizanidine (CYP1A2 Substrate) Although not studied clinically, famotidine is considered a weak CYP1A2 inhibitor and may lead to substantial increases in blood concentrations of tizanidine, a CYP1A2 substrate. Avoid concomitant use with famotidine. If concomitant use is necessary, monitor for hypotension, bradycardia or excessive drowsiness. Refer to the full prescribing information for tizanidine.

👥 Use in Specific Populations ~3 min read ▾

8 USE IN SPECIFIC POPULATIONS • Geriatric Use: Use the lowest effective dose for an elderly patient and monitor renal function. ( 2.2 , 5.1 , 8.5 ) • Renal Impairment: Risk of CNS adverse reactions and QT prolongation in patients with moderate and severe renal impairment; reduce the dosage. ( 2.2 , 8.6 )

8.1Pregnancy Risk Summary Available data with H 2 -receptor antagonists, including famotidine, in pregnant women are insufficient to establish a drug- associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes. In animal reproduction studies, no adverse development effects were observed with oral administration of famotidine at doses up to approximately 243 and 122 times, respectively, the recommended human dose of 80 mg per day for the treatment of erosive esophagitis ( see Data ). The estimated background risk for major birth defects and miscarriage for the indicated population is unknown.

All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. In the U.S. general population, the background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2 to 4% and 15 to 20%, respectively. Data Animal Data Reproductive studies have been performed in rats and rabbits at oral doses of up to 2,000 and 500 mg/kg/day, respectively, and in both species at intravenous doses of up to 200 mg/kg/day, and have revealed no significant evidence of impaired fertility or harm to the fetus due to famotidine.

While no direct fetotoxic effects have been observed, sporadic abortions occurring only in mothers displaying marked decreased food intake were seen in some rabbits at oral doses of 200 mg/kg/day (about 49 times the recommended human dose of 80 mg per day, based on body surface area) or higher. There are, however, no adequate or well-controlled studies in pregnant women. Because animal reproductive studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

8.2Lactation Risk Summary There are limited data available on the presence of famotidine in human breast milk. There were no effects on the breastfed infant. There are no data on famotidine effects on milk production.

Famotidine is present in the milk of lactating rats ( see Data ). The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for famotidine and any potential adverse effects on the breastfed child from Famotidine or from the underlying maternal condition. Data Animal Data Transient growth depression was observed in young rats suckling from mothers treated with maternotoxic doses of famotidine at least 600 times the usual human dose.

8.4Pediatric Use The safety and effectiveness of famotidine have been established in pediatric patients for the treatment of peptic ulcer disease (i.e., duodenal ulcer, gastric ulcer) and GERD (i.e., symptomatic nonerosive GERD, erosive esophagitis as diagnosed by endoscopy). The use of famotidine and the recommended dosage of famotidine in these pediatric patients is supported by evidence from adequate and well-controlled studies of famotidine in adults and published pharmacokinetic and pharmacodynamic data in pediatric patients [ see Dosage and Administration (2.1) , Clinical Pharmacology (12.2 , 12.3) ].

In pediatric patients, the safety and effectiveness for the treatment of pathological hypersecretory conditions and reduction of risk of duodenal ulcer recurrence have not been established. Famotidine 20 and 40 mg tablets are not recommended for use in pediatric patients weighing less than 40 kg because these tablet strengths exceed the recommended dose for these patients [ see Dosage and Administration (2.1) ]. For pediatric patients weighing less than 40 kg, consider another famotidine formulation (e.g., oral suspension, lower dose tablet).

8.5Geriatric Use Of the 1,442 famotidine-treated patients in clinical studies, approximately 10% we…

🤰 Pregnancy ~1 min read ▾

8.1Pregnancy Risk Summary Available data with H 2 -receptor antagonists, including famotidine, in pregnant women are insufficient to establish a drug- associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes. In animal reproduction studies, no adverse development effects were observed with oral administration of famotidine at doses up to approximately 243 and 122 times, respectively, the recommended human dose of 80 mg per day for the treatment of erosive esophagitis ( see Data ). The estimated background risk for major birth defects and miscarriage for the indicated population is unknown.

All pregnancies have a background risk of birth defect, loss, or other adverse outcomes. In the U.S. general population, the background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2 to 4% and 15 to 20%, respectively. Data Animal Data Reproductive studies have been performed in rats and rabbits at oral doses of up to 2,000 and 500 mg/kg/day, respectively, and in both species at intravenous doses of up to 200 mg/kg/day, and have revealed no significant evidence of impaired fertility or harm to the fetus due to famotidine.

While no direct fetotoxic effects have been observed, sporadic abortions occurring only in mothers displaying marked decreased food intake were seen in some rabbits at oral doses of 200 mg/kg/day (about 49 times the recommended human dose of 80 mg per day, based on body surface area) or higher. There are, however, no adequate or well-controlled studies in pregnant women. Because animal reproductive studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

🧒 Pediatric Use 169 words ▾

8.4Pediatric Use The safety and effectiveness of famotidine have been established in pediatric patients for the treatment of peptic ulcer disease (i.e., duodenal ulcer, gastric ulcer) and GERD (i.e., symptomatic nonerosive GERD, erosive esophagitis as diagnosed by endoscopy). The use of famotidine and the recommended dosage of famotidine in these pediatric patients is supported by evidence from adequate and well-controlled studies of famotidine in adults and published pharmacokinetic and pharmacodynamic data in pediatric patients [ see Dosage and Administration (2.1) , Clinical Pharmacology (12.2 , 12.3) ].

In pediatric patients, the safety and effectiveness for the treatment of pathological hypersecretory conditions and reduction of risk of duodenal ulcer recurrence have not been established. Famotidine 20 and 40 mg tablets are not recommended for use in pediatric patients weighing less than 40 kg because these tablet strengths exceed the recommended dose for these patients [ see Dosage and Administration (2.1) ]. For pediatric patients weighing less than 40 kg, consider another famotidine formulation (e.g., oral suspension, lower dose tablet).

🧓 Geriatric Use 122 words ▾

8.5Geriatric Use Of the 1,442 famotidine-treated patients in clinical studies, approximately 10% were 65 and older. In these studies, no overall differences in safety or effectiveness were observed between elderly and younger patients. In postmarketing experience, CNS adverse reactions have been reported in elderly patients with and without renal impairment receiving famotidine [ see Warnings and Precautions (5.1) ].

Famotidine is known to be substantially excreted by the kidney, and the risk of adverse reactions to famotidine may be greater in elderly patients, particularly those with impaired renal function [ see Use in Specific Populations (8.6) ]. In general, use the lowest effective dose of famotidine for an elderly patient and monitor renal function [ see Dosage and Administration (2.2) ].

🆘 Overdosage 87 words ▾

10 OVERDOSAGE The types of adverse reactions in overdosage of famotidine are similar to the adverse reactions encountered with use of recommended dosages [ see Adverse Reactions (6.1) ]. In the event of overdosage, treatment should be symptomatic and supportive. Unabsorbed material should be removed from the gastrointestinal tract, the patient should be monitored, and supportive therapy should be employed.

Due to low binding to plasma proteins, famotidine is eliminated by hemodialysis. There is limited experience on the usefulness of hemodialysis as a treatment for famotidine overdosage.

🧬 Clinical Pharmacology ~3 min read ▾

12 CLINICAL PHARMACOLOGY

12.1Mechanism of Action Famotidine is a competitive inhibitor of histamine-2 (H 2 ) receptors. The primary clinically important pharmacologic activity of famotidine is inhibition of gastric secretion. Both the acid concentration and volume of gastric secretion are suppressed by famotidine, while changes in pepsin secretion are proportional to volume output.

12.2Pharmacodynamics Adults Famotidine inhibited both basal and nocturnal gastric secretion, as well as secretion stimulated by food and pentagastrin. After oral administration of famotidine, the onset of the antisecretory effect occurred within one hour; the maximum effect was dose-dependent, occurring within one to three hours. Duration of inhibition of secretion by doses of 20 mg and 40 mg was 10 to 12 hours.

Single evening oral doses of 20 mg and 40 mg inhibited basal and nocturnal acid secretion in all subjects; mean nocturnal gastric acid secretion was inhibited by 86% and 94%, respectively, for a period of at least 10 hours. The same doses given in the morning suppressed food-stimulated acid secretion in all subjects. The mean suppression was 76% and 84%, respectively, 3 to 5 hours after administration, and 25% and 30%, respectively, 8 to 10 hours after administration.

In some subjects who received the 20 mg dose, however, the antisecretory effect was dissipated within 6 to 8 hours. There was no cumulative effect with repeated doses. The nocturnal intragastric pH was raised by evening doses of 20 mg and 40 mg of famotidine to mean values of 5.0 and 6.4, respectively.

When famotidine was given after breakfast, the basal daytime interdigestive pH at 3 and 8 hours after 20 mg or 40 mg of famotidine was raised to about 5. Famotidine had little or no effect on fasting or postprandial serum gastrin levels. Gastric emptying and exocrine pancreatic function were not affected by famotidine.

In clinical pharmacology studies, systemic effects of famotidine in the CNS, cardiovascular, respiratory or endocrine systems were not noted. Also, no anti-androgenic effects were noted. Serum hormone levels, including prolactin, cortisol, thyroxine (T 4 ), and testosterone, were not altered after treatment with famotidine.

Pediatric Patients Pharmacodynamics of famotidine, assessed by gastric pH, were evaluated in 5 pediatric patients 2 to 13 years of age using the sigmoid E max model. These data suggest that the relationship between serum concentration of famotidine and gastric acid suppression is similar to that observed in adults (see Table 3 ). Table 3: Serum Concentrations of Famotidine Associated with Gastric Acid Reduction in Famotidine-Treated Pediatric and Adult Patients Using the Sigmoid E max model, serum concentrations of famotidine associated with 50% maximum gastric acid reduction are presented as means ± SD.

EC 50 (ng/mL) Pediatric Patients 26 ± 13 Adults Healthy adult subjects 26.5 ±

10.3Adult patients with upper GI bleeding 18.7 ±

10.8In a study examining the effect of famotidine on gastric pH and duration of acid suppression in pediatric patients, four pediatric patients ages 11 to 15 years of age using the oral formulation at a dose of 0.5 mg/kg, maintained a gastric pH above 5 for 13.5 ± 1.8 hours.

12.3Pharmacokinetics Absorption Famotidine is incompletely absorbed. The bioavailability of oral doses is 40 to 45%. Bioavailability may be slightly increased by food, or slightly decreased by antacids; however, these effects are of no clinical consequence.

Peak famotidine plasma levels occur in 1 to 3 hours. Plasma levels after multiple dosages are similar to those after single doses. Distribution Fifteen to 20% of famotidine in plasma is protein bound.

Elimination Metabolism Famotidine undergoes minimal first-pass metabolism. 25 to 30% of an oral dose was recovered in the urine as unchanged compound. The only metabolite identified in humans is the S-oxide.

Excretion Famotidine has an elimination half-life of 2.5 to 3.5 hours. Famotidine is eli…

🧬 Mechanism of Action 51 words ▾

12.1Mechanism of Action Famotidine is a competitive inhibitor of histamine-2 (H 2 ) receptors. The primary clinically important pharmacologic activity of famotidine is inhibition of gastric secretion. Both the acid concentration and volume of gastric secretion are suppressed by famotidine, while changes in pepsin secretion are proportional to volume output.

📦 How Supplied / Storage and Handling 80 words ▾

16 HOW SUPPLIED/STORAGE AND HANDLING Famotidine Tablets, USP 20 mg are light yellow colored, round shaped, biconvex film-coated tablets debossed with "C" on one side and "70" on the other. Bottles of 14 Tablets NDC -68788-4088-4 Bottles of 30 Tablets NDC -68788-4088-3 Bottles of 60 Tablets NDC -68788-4088-6 Bottles of 90 Tablets NDC -68788-4088-9 Storage Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature]. Dispense in a USP tight, light-resistant container.

📦 Storage and Handling 26 words ▾

Storage Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature]. Dispense in a USP tight, light-resistant container.

📋 Description 142 words ▾

11 DESCRIPTION The active ingredient in Famotidine Tablets, USP is a histamine-2 (H 2 ) receptor antagonist. Famotidine is N'- (aminosulfonyl)-3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio] propanimidamide. The molecular formula of famotidine is C 8 H 15 N 7 O 2 S 3 and its molecular weight is 337.43.

Its structural formula is: Each famotidine tablet for oral administration contains either 20 mg or 40 mg of famotidine USP and the following inactive ingredients: colloidal silicon dioxide, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, pregelatinized starch, sodium starch glycolate, talc, and titanium dioxide. In addition the 20 mg tablets contain ferric oxide red and ferric oxide yellow. Famotidine, USP is a white to pale yellowish white crystalline powder that is freely soluble in glacial acetic acid, slightly soluble in methanol, very slightly soluble in water, and practically insoluble in ethanol.

Meets USP Dissolution Test 2 Chemical Structure

💬 Information for Patients 133 words ▾

17 PATIENT COUNSELING INFORMATION Central Nervous System (CNS) Adverse Reactions Advise elderly patients and those with moderate and severe renal impairment of the risk of CNS adverse reactions, including confusion, delirium, hallucinations, disorientation, agitation, seizures, and lethargy [ see Warnings and Precautions (5.1) ]. Report symptoms immediately to a healthcare provider. QT Prolongation Advise patients with moderate and severe renal impairment of the risk of QT interval prolongation [ see Use in Specific Populations (8.6) ].

Report new cardiac symptoms, such as palpitations, fainting and dizziness or lightheadedness immediately to a healthcare provider. Administration Advise patients: • Take famotidine tablets once daily before bedtime or twice daily in the morning and before bedtime, as recommended. • Famotidine tablets may be taken with or without food. • Famotidine tablets may be given with antacids.

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
← 68788-4087-03 · Preferred 68788-4089-01 · Preferred →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.