Medication interaction hub

What Supplements Interact with Famotidine?

Famotidine brand names: Pepcid, Famotidine, Pepcid AC, Famotidine Injection. Every interaction below applies to the brands too.

41 Interactions 1 Major 19 Moderate 21 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Famotidine? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Famotidine against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Famotidine (Pepcid) treats heartburn and acid reflux, a low-stakes job most days, but its interaction list earns genuine caution because one entry is rated major. That entry is activated charcoal, which can bind famotidine in the gut and sharply cut how much of the drug reaches your blood. Milder versions of the same absorption problem account for the biggest share of the 41 ingredients on file, mostly bulky fibers like glucomannan that should be swallowed well apart from your dose.

The rest split a few ways. Alcohol may hit you harder, since acid reducers in famotidine's family can raise blood alcohol levels. A small group of ingredients may slow how your kidneys clear the drug, nudging its level upward. And six, melatonin among them, could theoretically raise seizure risk when paired with it. Beyond that single major, 19 entries rate moderate and 21 minor, so get clear on charcoal first, then work down.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 19 Minor 21 No known interaction 1,411

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Famotidine: Top Interactions at a Glance

The Famotidine supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 41 interacting ingredients — plus 1,411 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Famotidine Combinations Today

The Famotidine + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Betaine Hydrochloride + Famotidinei

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.

Read the full interaction Moderate Likelihood Possible Quercetin + Famotidinei

Theoretically, concomitant use might increase the effects and adverse effects of OAT3 substrates.

Read the full interaction Minor Likelihood Possible Blessed Thistle + Famotidinei

Theoretically, blessed thistle might decrease the effectiveness of H2-blockers.

Read the full interaction Minor Likelihood Possible Cubebs + Famotidinei

Theoretically, due to reports that cubebs increases stomach acid, cubebs might decrease the effectiveness of H2-blockers.

Read the full interaction Minor Likelihood Possible Quassia + Famotidinei

Theoretically, due to reports that quassia increases stomach acid, quassia might decrease the effectiveness of H2-blockers.

Read the full interaction Minor Likelihood Possible Blond Psyllium + Famotidinei

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Famotidine

All 1,452 ingredients in our database, ranked by severity — 41 with a Famotidine interaction on file and 1,411 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Famotidine?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Betaine Hydrochloride with Famotidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.

Full Betaine Hydrochloride + Famotidine answer

Can you take Quercetin with Famotidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the effects and adverse effects of OAT3 substrates.

Full Quercetin + Famotidine answer

Can you take Blessed Thistle with Famotidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, blessed thistle might decrease the effectiveness of H2-blockers.

Full Blessed Thistle + Famotidine answer

Can you take Cubebs with Famotidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, due to reports that cubebs increases stomach acid, cubebs might decrease the effectiveness of H2-blockers.

Full Cubebs + Famotidine answer

Can you take Quassia with Famotidine?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, due to reports that quassia increases stomach acid, quassia might decrease the effectiveness of H2-blockers.

Full Quassia + Famotidine answer

Can you take Activated Charcoal with Famotidine?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the rout...

Full Activated Charcoal + Famotidine answer

Can you take Coffee Charcoal with Famotidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Coffee charcoal can reduce the absorption of orally administered drugs and should be separated from oral drug administration by at least two...

Full Coffee Charcoal + Famotidine answer

Can you take European Mandrake with Famotidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use might increase absorption of some drugs because of inhibited gastrointestinal (GI) motility caused by European...

Full European Mandrake + Famotidine answer

Can you take Glucomannan with Famotidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Famotidine answer

Can you take African Wild Potato with Famotidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence shows that African wild potato extract inhibits OAT3.

Full African Wild Potato + Famotidine answer

Can you take Banderol with Famotidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Small lab studies have found that Banderol may also inhibit OATP1B3 (Organic Anion Transporting Polypeptide 1B3), in addition to OATP1B1.

Full Banderol + Famotidine answer

Can you take Beer with Famotidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use might increase blood alcohol levels and adverse effects.

Full Beer + Famotidine answer

Can you take Biofeedback with Famotidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that electroencephalogram (EEG) biofeedback might lower the seizure threshold in some patients.

Full Biofeedback + Famotidine answer

Can you take Caffeic Acid with Famotidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caffeic acid might increase the levels and clinical effects of OAT3 substrates.

Full Caffeic Acid + Famotidine answer

Can you take Dendrobium with Famotidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. The dendrobium constituent dendrobine is reported to have convulsant effects.

Full Dendrobium + Famotidine answer

Can you take Ginkgo with Famotidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.

Full Ginkgo + Famotidine answer

Can you take Guar Gum with Famotidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Famotidine answer

Can you take Gum Arabic with Famotidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Famotidine answer

Can you take Melatonin with Famotidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.

Full Melatonin + Famotidine answer

Can you take Rauwolscine with Famotidine?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.

Full Rauwolscine + Famotidine answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Famotidine is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Famotidine, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Famotidine sits in 4 interaction categories. Open any one to see what the group means:

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Famotidine through this category.

H2-Blockers 14 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

14 of the supplement ingredients on this page reach Famotidine through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Famotidine through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Famotidine through this category.

About Famotidine

Famotidine is an H2 blocker used to treat ulcers, acid reflux, heartburn, and conditions where the stomach produces too much acid.

Generic name: Famotidine  ·  Brand names: Pepcid, Famotidine, Pepcid AC, Famotidine Injection.

See the full Famotidine drug information

Related: does Famotidine deplete any nutrients?

Famotidine has 24 reported nutrient associations in the research literature — see the Famotidine nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Famotidine

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Famotidine.

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Products that contain Famotidine-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Famotidine.

ModuProst by Nature's Harmony contains African Wild Potato
Pharmacist Counseling Corner

Famotidine & Supplements: Common Questions

What supplements interact with Famotidine?
In our interaction database, 41 supplement and herbal ingredients have an interaction with Famotidine on file — 1 rated major, 19 moderate, and 21 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Activated Charcoal, Coffee Charcoal, European Mandrake.
Which Famotidine supplement interactions are the most serious?
The 1 major-rated combination — led by Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Famotidine?
That depends entirely on which supplement. The honest answer for Famotidine is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Pepcid have the same supplement interactions as Famotidine?
Yes — Pepcid, Famotidine, Pepcid AC, Famotidine Injection all contain Famotidine, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Famotidine deplete any vitamins or nutrients?
It might — Famotidine has 24 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Famotidine nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Famotidine and my other medications?
This page covers Famotidine against supplements and herbal ingredients. Checking Famotidine against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Famotidine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.