Medication interaction hub

What Supplements Interact with Cefadroxil?

Cefadroxil brand names: Duricef, Ultracef, Cef-Tab. Every interaction below applies to the brands too.

60 Interactions 3 Major 46 Moderate 11 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Cefadroxil? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Cefadroxil against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Cefadroxil, a cephalosporin antibiotic usually taken as a short course for skin, throat, or urinary infections, has a supplement list that deserves genuine care, not a quick skim. Three of the 60 ingredients on file rate major. Two, Siberian cocklebur and asarabacca, can damage the kidneys on their own, adding to any strain other medicines may already put on kidney function. The third, activated charcoal, soaks up the dose in the gut and can weaken the antibiotic itself.

Most of the 46 moderate entries flip the direction of harm. Nearly half the full list is probiotics, and cefadroxil can kill those live organisms, so the supplement gets wasted rather than the drug; spacing the doses well apart helps. A few fibers and absorbers can also cut how much of any oral medicine reaches the bloodstream. Eleven entries are minor, but understand the three major ones first.

— , Clinical Pharmacist · July 18, 2026

Major 3 Moderate 46 Minor 11 No known interaction 1,392

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Cefadroxil: Top Interactions at a Glance

The Cefadroxil supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 60 interacting ingredients — plus 1,392 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Cefadroxil Combinations Today

The Cefadroxil + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Bifidobacterium Bifidum + Cefadroxili

Theoretically, taking Bifidobacterium.

Read the full interaction Moderate Likelihood Probable Bacillus Coagulans + Cefadroxili

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.

Read the full interaction Moderate Likelihood Probable Lactobacillus Acidophilus + Cefadroxili

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.

Read the full interaction Moderate Likelihood Probable Bifidobacterium Longum + Cefadroxili

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.

Read the full interaction Moderate Likelihood Probable Bifidobacterium Breve + Cefadroxili

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.

Read the full interaction Moderate Likelihood Possible Flaxseed + Cefadroxili

Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.

Read the full interaction
The complete list

Every Supplement Checked Against Cefadroxil

All 1,452 ingredients in our database, ranked by severity — 60 with a Cefadroxil interaction on file and 1,392 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Cefadroxil?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Bifidobacterium Bifidum with Cefadroxil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium.

Full Bifidobacterium Bifidum + Cefadroxil answer

Can you take Bacillus Coagulans with Cefadroxil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B.

Full Bacillus Coagulans + Cefadroxil answer

Can you take Lactobacillus Acidophilus with Cefadroxil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.

Full Lactobacillus Acidophilus + Cefadroxil answer

Can you take Bifidobacterium Longum with Cefadroxil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Longum + Cefadroxil answer

Can you take Bifidobacterium Breve with Cefadroxil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.

Full Bifidobacterium Breve + Cefadroxil answer

Can you take Caffeic Acid with Cefadroxil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caffeic acid might increase the levels and clinical effects of OAT3 substrates.

Full Caffeic Acid + Cefadroxil answer

Can you take Dendrobium with Cefadroxil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. The dendrobium constituent dendrobine is reported to have convulsant effects.

Full Dendrobium + Cefadroxil answer

Can you take Flaxseed with Cefadroxil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxse...

Full Flaxseed + Cefadroxil answer

Can you take Ginkgo with Cefadroxil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.

Full Ginkgo + Cefadroxil answer

Can you take Guar Gum with Cefadroxil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Cefadroxil answer

Can you take Gum Arabic with Cefadroxil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Cefadroxil answer

Can you take Melatonin with Cefadroxil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.

Full Melatonin + Cefadroxil answer

Can you take Mountain Ash with Cefadroxil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking large amounts of fresh mountain ash berries may cause kidney damage due to its parasorbic acid constituent.

Full Mountain Ash + Cefadroxil answer

Can you take Quercetin with Cefadroxil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the effects and adverse effects of OAT3 substrates.

Full Quercetin + Cefadroxil answer

Can you take Rauwolscine with Cefadroxil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking rauwolscine with seizure threshold lowering drugs might increase the risk of adverse convulsant effects.

Full Rauwolscine + Cefadroxil answer

Can you take Rhubarb with Cefadroxil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.

Full Rhubarb + Cefadroxil answer

Can you take Slippery Elm with Cefadroxil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Cefadroxil answer

Can you take Thuja with Cefadroxil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Thuja products can contains significant amounts of thujone, a neurotoxin.

Full Thuja + Cefadroxil answer

Can you take Tragacanth with Cefadroxil?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Cefadroxil answer

Can you take Thyroid Extract with Cefadroxil?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Cefadroxil answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Cefadroxil is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Cefadroxil, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Cefadroxil sits in 6 interaction categories. Open any one to see what the group means:

Antibiotic Drugs 27 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

27 of the supplement ingredients on this page reach Cefadroxil through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Cefadroxil through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Cefadroxil through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Cefadroxil through this category.

Organic Anion Transporter 1 (Oat1) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Cefadroxil through this category.

Organic Anion Transporter 3 (Oat3) Substrates 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Cefadroxil through this category.

About Cefadroxil

Cefadroxil is an oral cephalosporin antibiotic used to treat urinary tract infections, skin and skin structure infections, and strep throat (pharyngitis/tonsillitis).

Generic name: Cefadroxil  ·  Brand names: Duricef, Ultracef, Cef-Tab.

See the full Cefadroxil drug information

Related: does Cefadroxil deplete any nutrients?

Cefadroxil has 21 reported nutrient associations in the research literature — see the Cefadroxil nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Cefadroxil

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Cefadroxil.

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Pharmacist Counseling Corner

Cefadroxil & Supplements: Common Questions

What supplements interact with Cefadroxil?
In our interaction database, 60 supplement and herbal ingredients have an interaction with Cefadroxil on file — 3 rated major, 46 moderate, and 11 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Asarabacca.
Which Cefadroxil supplement interactions are the most serious?
The 3 major-rated combinations — led by Siberian Cocklebur, Activated Charcoal and Asarabacca — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Cefadroxil?
That depends entirely on which supplement. The honest answer for Cefadroxil is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Duricef have the same supplement interactions as Cefadroxil?
Yes — Duricef, Ultracef, Cef-Tab all contain Cefadroxil, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Cefadroxil deplete any vitamins or nutrients?
It might — Cefadroxil has 21 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Cefadroxil nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Cefadroxil and my other medications?
This page covers Cefadroxil against supplements and herbal ingredients. Checking Cefadroxil against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Cefadroxil drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.