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Menstrual Relief Maximum Strength Multi Symptom Acetaminophen, Pamabrom, Pyrilamine maleate 500 mg; 25 mg; 15 mg Tablet, Film Coated, 20-count — NDC 70000-0145-01 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

Menstrual Relief Maximum Strength Multi Symptom Acetaminophen, Pamabrom, Pyrilamine maleate 500 mg; 25 mg; 15 mg Tablet, Film Coated, 20-count — NDC 70000-0145-1 (Billing 70000-0145-01)

by Cardinal Health 110, LLC. DBA Leader · 1 BOTTLE in 1 CARTON / 20 TABLET, FILM COATED in 1 BOTTLE

This is a package of 20 tablets of Menstrual Relief Maximum Strength Multi Symptom Acetaminophen, Pamabrom, Pyrilamine maleate 500 mg; 25 mg; 15 mg Tablet, Film Coated from Cardinal Health 110, LLC. DBA Leader, marketed since Jan 2015 and currently FDA-listed; retail pharmacies pay about $0.0926 per tablet (NADAC). It is this product's only package size.

NDC 70000-0145-01
🏷️ FDA NDC (as labeled) 70000-0145-1 billing pads the package segment with a zero
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Oct 1, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 70000-0145-1
Product NDC 70000-0145
11-digit billing NDC 70000014501
NCPDP billing unit EA — each (per item)
Application # M027
SPL Set ID 8df6e174-8ee3-46cc-98ef-2b9a801b7b78
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2015-01-13
Route ORAL
Dosage form TABLET, FILM COATED
Substance ACETAMINOPHEN; PAMABROM; PYRILAMINE MALEATE

Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification

GCN Seq No 004467
GCN 72790
HICL code 001863
Ingredient (HICL) Acetaminophen/Pyrilam/Pamabrom
HIC1 code H
Therapeutic class — broad (HIC1) Nervous System (Except Autonomic)
HIC2 code H3
Therapeutic class — intermediate (HIC2) Analgesics
HIC3 code H3E
Therapeutic class — specific (HIC3) Analgesic/Antipyretics,Non-Salicylate
AHFS code 28:08.16.00
AHFS class Non-Opioid Analgesics
FDB label name MENSTRUAL RELIEF CAPLET
FDB brand name Menstrual Relief
Legend status O — Over-the-counter (OTC) drug or device
Quick answers
  • GSN (GCN sequence number): 004467
  • GCN: 72790
  • HICL (First Databank): 001863
  • AHFS class code: 28:08.16.00
Why two NDCs? The FDA registers this code as 70000-0145-1 — a 5-4-1 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the package segment → 70000-0145-01. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

Clinical

Label name MENSTRUAL RELIEF CAPLET Ingredient Acetaminophen/Pyrilam/Pamabrom
🧪 What is this product?

This is an over-the-counter film-coated tablet taken by mouth, marketed under FDA's monograph rules for menstrual symptom relief. It contains acetaminophen, a pain reliever commonly used to reduce aches and fever, combined with pamabrom, a mild diuretic typically included to ease bloating and water retention. Pyrilamine maleate is an antihistamine that may help reduce cramping sensations. The product is intended for temporary relief of multiple menstrual discomforts in one dose.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
7
Nutrient depletion considerations

Acetaminophen, Pamabrom, Pyrilamine may be associated with lower levels of 7 nutrients — worth a chat with your pharmacist, not a cause for alarm.

🧪 Full Acetaminophen, Pamabrom, Pyrilamine nutrient depletion report →
An association is not a deficiency. Educational only — don't start or stop anything without professional guidance.
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eaPer package
Retail pharmacies payNADAC · weekly $0.093 $1.85 / 20 tablets
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
NADAC price history (per ea) — tap or hover for the price & month
Mar 2021 Jan 2026 May 2026 Sep 2026 $0.093 $0.088
▲ Up 6% over the last 12 months.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
70000-0145-01 You're viewing this Main listing 1 BOTTLE in 1 CARTON / 20 TABLET, FILM COATED in 1 BOTTLE 2015-01-13 — Active

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Menstrual Relief Maximum Strength Multi Symptom 500 mg/1; 25 mg/1; 15 mgthis 70000-0145-01 Cardinal 20 tablets $0.093 — Availability likely —
Menstrual Pain Relief 500 mg/1; 25 mg/1; 15 mg 83324-0057-20 Chain 20 tablets $0.093 — Availability likely —
Midol Complete Caffeine Free 500 mg/1; 25 mg/1; 15 mg 00280-0078-01 Bayer 24 tablets — — FDA listed —
menstrual pain relief maximum strength 500 mg/1; 25 mg/1; 15 mg 11822-6790-04 Rite 40 tablets — — FDA listed —
Menstrual Relief Maximum Strength 500 mg/1; 25 mg/1; 15 mg 36800-0979-10 Topco 40 tablets — — FDA listed —
Green Guard Cramp Relief 15 mg/1; 500 mg/1; 25 mg 47682-0049-80 Unifirst 2 tablets — — FDA listed —
Medi First Plus PMS Relief 25 mg/1; 15 mg/1; 500 mg 47682-0723-80 Unifirst 2 tablets — — FDA listed —
Medi First PMS Relief 25 mg/1; 15 mg/1; 500 mg 47682-0823-80 Unifirst 2 tablets — — FDA listed —
Menstrual Relief Maximum Strength 500 mg/1; 25 mg/1; 15 mg 50844-0679-27 L.N.K. 32 tablets — — FDA listed —
Multi-Symptom PMS Relief 500 mg/1; 25 mg/1; 15 mg 51316-0679-27 CVS 32 tablets — — FDA listed —
Menstrual Relief Maximum Strength 500 mg/1; 25 mg/1; 15 mg 55301-0679-27 ARMY 32 tablets — — FDA listed —
Menstrual Relief Maximum Strength 500 mg/1; 25 mg/1; 15 mg 55319-0979-27 Family 32 tablets — — FDA listed —
PMS Relief Maximum Strength 500 mg/1; 25 mg/1; 15 mg 59779-0879-08 CVS 24 tablets — — Discontinued —
Pamprin Multi-Symptom Maximum Strength 15 mg/1; 25 mg/1; 500 mg 71687-3003-01 Focus 20 tablets — — FDA listed —
Premsyn pms Premenstrual Pain Relief 500 mg/1; 25 mg/1; 15 mg 71687-3102-04 Focus 40 tablets — — FDA listed —
Thompson Cramp Relief 500 mg/1; 25 mg/1; 15 mg 73408-0923-80 Thompson 2 tablets — — FDA listed —
Menstrual Pain Relief Maximum Strength / Multi Symptom 500 mg/1; 25 mg/1; 15 mg 55910-0967-27 DOLGENCORP, 32 tablets — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2015
On the market since
Jan 2015
📍
2026
Currently FDA-listed
11 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

What it looks like

Color purple
ShapeOval
Imprint44;679
Size17 mm
ScoringNot scored
One label can cover several strengths, so colors may be combined — always confirm a loose pill against the dispensed prescription label or a pharmacist.
Where does this data come from?
Physical description (imprint, shape, color, scoring, coating) from this product’s FDA Structured Product Labeling (SPL), mirrored from DailyMed / openFDA.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII M28OL1HH48
    Croscarmellose sodium is a plant-based substance derived from cellulose. It acts as a disintegrant, helping tablets and capsules break down quickly in the digestive system so the medicine can be absorbed.
  • UNII 2S7830E561
    Crospovidone is a synthetic polymer derived from povidone. It acts as a disintegrant, helping the tablet or capsule break apart quickly in the stomach so the active ingredient can be absorbed.
  • UNII 4AQJ3LG584
    A synthetic blue dye combined with aluminum to create a stable colorant. It's used in medicines and supplements to add blue color or create specific shades for product identification and appearance.
  • UNII 6T47AS764T
    Red 40 Lake is a synthetic colorant made by combining Red 40 dye with aluminum hydroxide. It's used to give tablets, capsules, and other medicines a red or pink color for identification and appearance.
  • UNII 70097M6I30
    Magnesium stearate is a salt made from magnesium and stearic acid, a fatty substance. It's used in tablets and capsules as a lubricant and glidant to help ingredients flow smoothly during manufacturing and prevent sticking.
  • UNII OP1R32D61U
    Microcrystalline cellulose is a purified form of cellulose, a natural fiber from plant sources. It acts as a binder and filler in tablets and capsules, helping hold ingredients together and give the medicine its shape and size.
  • UNII 3WJQ0SDW1A
    Polyethylene glycol is a synthetic liquid or solid polymer used in medicines as a solvent, lubricant, and humectant. It helps dissolve active ingredients, reduces friction during manufacturing, and retains moisture in the final product.
  • UNII 532B59J990
    Polyvinyl alcohol is a synthetic polymer made from plant-derived materials. It's used as a binder to hold ingredients together, a film-former in coatings, and a thickener in liquid formulations.
  • UNII FZ989GH94E
    Povidone is a synthetic polymer made from a plastic-like material. It acts as a binder to hold tablet ingredients together and as a disintegrant to help the tablet break apart in your stomach so the medicine can be absorbed.
  • UNII 46N107B71O
    Shellac is a natural resin secreted by the lac beetle. It's used as a coating on tablets and capsules to control how quickly the medicine dissolves and to improve appearance and stability.
  • UNII ETJ7Z6XBU4
    Silicon dioxide is a naturally occurring mineral used as a glidant and anti-caking agent. It helps powder ingredients flow smoothly and prevents clumping during manufacturing and storage.
  • UNII O8232NY3SJ
    A plant-based carbohydrate derived from corn kernels. It acts as a filler to add bulk, a binder to hold ingredients together, and a disintegrant to help the tablet break apart in your stomach for absorption.
  • UNII 4ELV7Z65AP
    Stearic acid is a fatty acid derived from plant or animal sources. It acts as a binder and lubricant in tablets and capsules, helping them hold together and flow smoothly during manufacturing.
  • UNII 7SEV7J4R1U
    A powder made from a naturally occurring mineral. In medicines, talc works as a glidant and anti-caking agent, helping tablets and capsules flow smoothly during manufacturing and preventing clumping.
  • UNII 15FIX9V2JP
    Titanium dioxide is a bright white mineral powder commonly used as a colorant and opacifying agent. It makes pills and tablets white or lighter in color and helps make coatings non-transparent.

15 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statescorn starch, croscarmellose sodium, crospovidone, FD&C blue #2 aluminum lake, FD&C red #40 aluminum lake, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, povidone, shellac wax, silicon dioxide, stearic acid, talc, titanium dioxide

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerCardinal Health 110, LLC. DBA Leader
FDA applicationM027 (OTC MONOGRAPH DRUG)
Labeler code70000
First marketedJan 2015
Product typeHuman Otc Drug
Portfolio163 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 📦 Storage and Handling 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Do Not Use 📄 Ask a Doctor Before Use If 📄 Ask a Doctor or Pharmacist Before Use If 📄 When Using This Product 📄 Stop Use and Ask a Doctor If 🤰 If Pregnant or Breast-Feeding 📄 Keep Out of Reach of Children 📄 Questions or Comments 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 21 words ▾

Uses for the temporary relief of these symptoms associated with menstrual periods: headache bloating cramps backache muscular aches irritability water-weight gain

⏱️ Dosage and Administration 47 words ▾

Directions do not take more than directed adults and children 12 years and over: take 2 caplets with water every 6 hours as needed do not exceed 6 caplets in a 24 hour period or as directed by a doctor children under 12 years: ask a doctor

⚠️ Warnings ~1 min read ▾

Warnings Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take more than 4,000 mg of acetaminophen in 24 hours with other drugs containing acetaminophen 3 or more alcoholic drinks every day while using this product Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include: skin reddening blisters rash If a skin reaction occurs, stop use and seek medical help right away.

Do not use with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. if you have ever had an allergic reaction to this product or any of its ingredients Ask a doctor before use if you have difficulty in urination due to enlargement of the prostate gland liver disease a breathing problem such as emphysema or chronic bronchitis glaucoma Ask a doctor or pharmacist before use if you are taking the blood thinning drug warfarin taking sedatives or tranquilizers When using this product drowsiness may occur avoid alcoholic beverages excitability may occur, especially in children alcohol, sedatives and tranquilizers may increase drowsiness use caution when driving a motor vehicle or operating machinery Stop use and ask a doctor if pain gets worse or lasts more than 10 days fever gets worse or lasts more than 3 days new symptoms occur redness or swelling is present These could be signs of a serious condition.

If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. In case of accidental overdose, get medical help or contact a Poison Control Center right away.

Prompt medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.

📦 Storage and Handling 20 words ▾

Other information store at 25ºC (77ºF); excursions permitted between 15º-30ºC (59º-86ºF) see end flap for expiration date and lot number

🧪 Active Ingredient 15 words ▾

Active ingredients (in each caplet) Acetaminophen 500 mg Pamabrom 25 mg Pyrilamine maleate 15 mg

🧪 Inactive Ingredients 35 words ▾

Inactive ingredients corn starch, croscarmellose sodium, crospovidone, FD&C blue #2 aluminum lake, FD&C red #40 aluminum lake, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, povidone, shellac wax, silicon dioxide, stearic acid, talc, titanium dioxide

🎯 Purpose 5 words ▾

Purpose Pain reliever Diuretic Antihistamine

📄 Do Not Use 43 words ▾

Do not use with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. if you have ever had an allergic reaction to this product or any of its ingredients

📄 Ask a Doctor Before Use If 30 words ▾

Ask a doctor before use if you have difficulty in urination due to enlargement of the prostate gland liver disease a breathing problem such as emphysema or chronic bronchitis glaucoma

📄 Ask a Doctor or Pharmacist Before Use If 20 words ▾

Ask a doctor or pharmacist before use if you are taking the blood thinning drug warfarin taking sedatives or tranquilizers

📄 When Using This Product 33 words ▾

When using this product drowsiness may occur avoid alcoholic beverages excitability may occur, especially in children alcohol, sedatives and tranquilizers may increase drowsiness use caution when driving a motor vehicle or operating machinery

📄 Stop Use and Ask a Doctor If 41 words ▾

Stop use and ask a doctor if pain gets worse or lasts more than 10 days fever gets worse or lasts more than 3 days new symptoms occur redness or swelling is present These could be signs of a serious condition.

🤰 If Pregnant or Breast-Feeding 10 words ▾

If pregnant or breast-feeding, ask a health professional before use.

📄 Keep Out of Reach of Children 44 words ▾

Keep out of reach of children. In case of accidental overdose, get medical help or contact a Poison Control Center right away. Prompt medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.

📄 Questions or Comments 4 words ▾

Questions or comments? 1-800-426-9391

📄 Package Label / Principal Display Panel 141 words ▾

Principal Display Panel LEADER™ NDC 70000-0145-1 Maximum Strength Multi-Symptom Menstrual Relief Acetaminophen | Pamabrom | Pyrilamine maleate Pain Reliever | Diuretic | Antihistamine Relieves: Cramps, Bloating, Irritability, Headache and Backache 20 CAPLETS ACTUAL SIZE COMPARE TO MAXIMUM STRENGTH PAMPRIN® MULTI-SYMPTOM active ingredients* 100% Money Back Guarantee TAMPER EVIDENT: DO NOT USE IF IMPRINTED SAFETY SEAL UNDER CAP IS BROKEN OR MISSING *This product is not manufactured or distributed by Focus Consumer Healthcare, LLC, owner of the registered trademark Maximum Strength Pamprin® Multi-Symptom.

50844 REV0718B67909 DISTRIBUTED BY CARDINAL HEALTH DUBLIN, OHIO 43017 www.myleader.com 1-800-200-6313 ©2024 Cardinal Health. All Rights Reserved. CARDINAL HEALTH, the Cardinal Health LOGO, LEADER, and the LEADER LOGO are trademarks or registered trademarks of Cardinal Health.

All other marks are the property of their respective owners. 100% Money Back Guarantee Return to place of purchase. Leader 44-679 Leader 44-679

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Menstrual Relief Maximum Strength Multi Symptom (this brand).

Top reported reactions

Dizziness1
Dyspnoea1
Heart Rate Increased1
Speech Disorder1

Reporter sex

1 reports
Female · 100%
Reports over time (by year) — tap or hover for the count & year
2021 2022 2024 2026 1 0
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.
← 70000-0141-01 · Cardinal 70000-0146-01 · Cardinal →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.