Home › NDC Lookup › Ingredients › Naproxen Sodium › 72288-0988-75
naproxen sodium 220 mg Tablet, Film Coated, 90-count — NDC 72288-0988-75 package photo

naproxen sodium 220 mg Tablet, Film Coated, 90-count

by Amazon.com Services LLC · 1 BOTTLE in 1 CARTON (72288-988-75) / 90 TABLET, FILM COATED in 1 BOTTLE (72288-988-00)
NDC 72288-0988-75
🏷️ FDA NDC (as labeled) 72288-988-75 billing pads the product segment with a zero
OTC Generic On market Non-controlled
🗂️ Data synced Sep 17, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

⚠️
Other active recalls for Naproxen Sodium (different manufacturers) — 2 · tap to view
These affect other manufacturers’ products for the same ingredient — not necessarily the exact NDC on this page.
Class II · Mar 13, 2025 — CGMP Deviations (Glenmark Pharmaceuticals Inc., USA) · FDA recall D-0346-2025
Class II · Nov 7, 2023 — Labeling: Label Mix-Up-Indomethacin bottles may be labeled as Naproxen (Glenmark Pharmaceuticals Inc., USA) · FDA recall D-0124-2024
Each entry is an official FDA enforcement report — look up any recall number in the FDA recall database ↗

🆔 Identity & classification

FDA NDC (as labeled) 72288-988-75
Product NDC 72288-988
11-digit billing NDC 72288098875
Application # ANDA074661
SPL Set ID 9edac021-313e-431b-8021-0da3c1f0398b
Established class (EPC) Anti-Inflammatory Agents; Nonsteroidal Anti-inflammatory Drug
Mechanism of action Cyclooxygenase Inhibitors
Chemical class Non-Steroidal
DEA schedule Non-controlled
Marketing category ANDA
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2026-09-03
Route ORAL
Dosage form TABLET, FILM COATED
Substance NAPROXEN SODIUM
Why two NDCs? The FDA registers this code as 72288-988-75 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 72288-0988-75. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏭 Manufacturer & labeler

LabelerAmazon.com Services LLC
Application holderL PERRIGO CO
FDA applicationANDA074661 (ANDA)
Labeler code72288
First marketedSep 2026
Product typeHuman Otc Drug
Portfolio335 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

📗 Our plain-language guide HelloPharmacist
  • They're very similar — naproxen sodium is just the salt form of naproxen, and it dissolves in water more quickly. That means your body absorbs naproxen sodium a bit faster, so it t...
  • What's the difference between naproxen and naproxen sodium — are they the same thing?
  • You can take it either way, but taking it with food, milk, or a full glass of water is a good idea because it helps protect your stomach. Naproxen can irritate the lining of your s...
  • Can I take naproxen on an empty stomach, or do I need to eat first?
📖 Read our full Naproxen guide →
1
Nutrient depletion considerations

Naproxen Sodium may be associated with lower levels of 1 nutrient — worth a chat with your pharmacist, not a cause for alarm.

🧪 Full Naproxen Sodium nutrient depletion report →
An association is not a deficiency. Educational only — don't start or stop anything without professional guidance.
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

💊 What it looks like

Color Blue
ShapeRound
ImprintL490
Size1 mm
ScoringNot scored
One label can cover several strengths, so colors may be combined — always confirm a loose pill against the dispensed prescription label or a pharmacist.
Where does this data come from?
Physical description (imprint, shape, color, scoring, coating) from this product’s FDA Structured Product Labeling (SPL), mirrored from DailyMed / openFDA.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII 4AQJ3LG584
    A synthetic blue dye combined with aluminum to create a stable colorant. It's used in medicines and supplements to add blue color or create specific shades for product identification and appearance.
  • UNII 3NXW29V3WO
    Hypromellose is a plant-based thickener made from cellulose. It's used in medicines as a binder to hold ingredients together, a coating for tablets, and a thickener for liquids.
  • UNII 70097M6I30
    Magnesium stearate is a salt made from magnesium and stearic acid, a fatty substance. It's used in tablets and capsules as a lubricant and glidant to help ingredients flow smoothly during manufacturing and prevent sticking.
  • UNII OP1R32D61U
    Microcrystalline cellulose is a purified form of cellulose, a natural fiber from plant sources. It acts as a binder and filler in tablets and capsules, helping hold ingredients together and give the medicine its shape and size.
  • UNII 3WJQ0SDW1A
    Polyethylene glycol is a synthetic liquid or solid polymer used in medicines as a solvent, lubricant, and humectant. It helps dissolve active ingredients, reduces friction during manufacturing, and retains moisture in the final product.
  • UNII FZ989GH94E
    Povidone is a synthetic polymer made from a plastic-like material. It acts as a binder to hold tablet ingredients together and as a disintegrant to help the tablet break apart in your stomach so the medicine can be absorbed.
  • UNII 7SEV7J4R1U
    A powder made from a naturally occurring mineral. In medicines, talc works as a glidant and anti-caking agent, helping tablets and capsules flow smoothly during manufacturing and preventing clumping.
  • UNII 15FIX9V2JP
    Titanium dioxide is a bright white mineral powder commonly used as a colorant and opacifying agent. It makes pills and tablets white or lighter in color and helps make coatings non-transparent.

8 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesFD&C blue no. 2 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, talc, titanium dioxide

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eachPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Leader All Day Pain Relief 220 mg 70000-0171-01 Cardinal 100 tablets $0.059 — Discontinued —
Naproxen Sodium 220 mg 45802-0490-71 Padagis 50 tablets $0.059 — Discontinued —
Rugby All Day Relief 220 mg 00536-1093-01 Rugby 100 tablets $0.063 — Discontinued —
Naproxen Sodium 220 mg 63868-0465-01 Chain 100 tablets $0.065 — FDA listed —
rugby all day relief 220 mg 00536-1094-01 Rugby 100 tablets $0.065 — Discontinued —
Naproxen sodium 220 mg 69230-0329-01 Camber 100 tablets $0.067 — Availability likely —
foster and thrive all day pain relief 220 mg 70677-1137-01 Strategic 50 tablets $0.067 — Availability likely —
Good Sense Naproxen Sodium 220 mg 00113-0901-62 L. 24 tablets $0.067 — Availability likely —
Naproxen 220 mg 46122-0564-71 Amerisource 50 tablets $0.067 — Availability likely —
Good Sense Naproxen Sodium 220 mg 00113-4368-62 L. 24 tablets $0.067 — Availability likely —
Naproxen 220 mg 46122-0562-71 Amerisource 50 tablets $0.067 — Availability likely —
Leader All Day Pain Relief 220 mg 70000-0201-02 Cardinal 50 tablets $0.067 — Availability likely —
Naproxen Sodium 220 mg 00363-7510-20 Walgreens 20 tablets — — FDA listed —
Flanax Pain Reliever/Fever reducer 220 mg 27854-0505-01 Belmora 24 tablets — — FDA listed —
Flanax Pain Reliever/Fever Reducer 220 mg 27854-0700-01 Belmora 24 tablets — — FDA listed —
Ana-Dent PAIN RELIEF 220 mg 27854-0701-01 Belmora 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 41226-0609-05 Kroger 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 49483-0609-00 TIME 6500 tablets — — FDA listed —
All Day Pain Relief 220 mg 59726-0169-15 P 15 tablets — — FDA listed —
Naproxen Sodium 220 mg 63187-0596-24 Proficient 24 tablets — — FDA listed —
Good Sense Naproxen Sodium 220 mg 63187-0794-20 Proficient 20 tablets — — FDA listed —
betr headache pain relief 220 mg 80267-0001-71 Live 50 tablets — — FDA listed —
Bayer Aleve 220 mg 00924-6000-00 Acme 1 tablet — — FDA listed —
Pain Relief 220 mg 21130-0608-05 BETTER 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 21130-0690-05 BETTER 50 tablets — — FDA listed —
All Day Pain Relief 220 mg 37808-0068-24 H 24 tablets — — FDA listed —
Belmora Flanax 220 mg 47682-0037-50 Unifirst 1 tablet — — FDA listed —
Naproxen Sodium 220 mg 49483-0608-00 TIME 6500 tablets — — FDA listed —
Naproxen Sodium 220 mg 50090-0685-01 A-S 10 tablets — — FDA listed —
Naproxen Sodium (NSAID) Fever Reducer/ Pain Reliever 220 mg 53746-0191-05 Amneal 500 tablets — — FDA listed —
Naproxen Sodium (NSAID) Fever Reducer/ Pain Reliever 220 mg 53746-0192-05 Amneal 500 tablets — — FDA listed —
naproxen sodium 220 mg 59779-0914-75 CVS 90 tablets — — FDA listed —
Naproxen Sodium 220 mg 62207-0327-41 Granules 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 62207-0328-41 Granules 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 62207-0728-24 Granules 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 62207-0729-24 Granules 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 62207-0761-42 Granules 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 62207-0762-42 Granules 50 tablets — — FDA listed —
Flanax Pain Reliever/Fever Reducer 220 mg 67751-0125-01 Navajo 2 tablets — — FDA listed —
Aleve 220 mg 67751-0144-03 Navajo 1 tablet — — FDA listed —
Proxen Np 660 220 mg 69729-0123-12 OPMX 12 tablets — — FDA listed —
Naproxen 220 mg 71205-0595-30 Proficient 30 tablets — — FDA listed —
All Day Back and Muscle Pain Relief 220 mg 79903-0609-09 Walmart 90 tablets — — FDA listed —
Back and Muscle Pain 220 mg 11822-4170-02 Rite 100 tablets — — Discontinued —
Topcare All Day Pain Relief 220 mg 36800-0490-62 Topco 24 tablets — — FDA listed —
CareOne Naproxen Sodium 220 mg 41520-0507-48 American 90 tablets — — Discontinued —
Medique Mediproxen 220 mg 50090-2388-00 A-S 1 tablet — — FDA listed —
Naproxen Sodium 220 mg 50844-0417-14 L.N.K. 500 tablets — — FDA listed —
Back and Muscle Pain 220 mg 51316-0817-08 CVS 24 tablets — — FDA listed —
Naproxen Sodium 220mg 220 mg 53329-0688-30 Medline 100 tablets — — Discontinued —
Naproxen 220 mg 53943-0145-02 DISCOUNT 50 tablets — — FDA listed —
dg health naproxen sodium 220 mg 55910-0500-71 Dolgencorp 50 tablets — — Discontinued —
Aleve Caplets - Easy Open Arthritis Cap 220 mg 00280-6050-01 Bayer 100 tablets — — FDA listed —
Aleve 220 mg 66715-6502-02 Lil' 2 tablets — — FDA listed —
Naproxen 220 mg 68071-5039-01 NuCare 21 tablets — — FDA listed —
Naproxen Sodium 220 mg 69842-0811-62 CVS 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 79903-0231-50 WALMART 50 tablets — — FDA listed —
All Day Pain Relief 220 mg 79903-0389-50 Walmart 50 tablets — — FDA listed —
Flanax 220 mg 27854-0160-00 Belmora 100 tablets — — Discontinued —
AnaDent 220 mg 27854-0170-01 Belmora 24 tablets — — FDA listed —
Belmora Flanax 220 mg 27854-0555-01 Belmora 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 30142-0954-10 Kroger 100 tablets — — FDA listed —
TopCare All Day Pain Relief 220 mg 36800-0368-62 Topco 24 tablets — — FDA listed —
Naproxen Sodium Caplets 220 mg 43598-0058-29 Dr 200 tablets — — FDA listed —
Naproxen Sodium Back and Muscle Pain 220 mg 43598-0074-01 Dr.Reddy's 100 tablets — — FDA listed —
Naproxen Sodium 220 mg 51316-0761-20 CVS 200 tablets — — FDA listed —
DG Health Naproxen Sodium 220 mg 55910-0490-62 Dolgencorp 24 tablets — — FDA listed —
Naproxen Sodium BACK AND MUSCLE PAIN 220 mg 58602-0739-07 Aurohealth 24 tablets — — FDA listed —
Aleve Easy Open Arthritis Cap 220 mg 00280-6060-20 Bayer 200 tablets — — FDA listed —
Aleve 220 mg 66715-9702-01 Lil' 1 tablet — — Discontinued —
Lil Drug Store Pain Relief All Day 220 mg 66715-9740-04 Lil' 12 tablets — — FDA listed —
All Day Pain Relief 220 mg 00363-9608-01 WALGREENS 100 tablets — — FDA listed —
Naproxen 220 mg 71335-1282-01 Bryant 20 tablets — — FDA listed —
Amazon Basic Care Naproxen Sodium 220 mg 72288-0366-20 Amazon.com 200 tablets — — FDA listed —
Naproxen Sodium 220 mg 21130-0061-05 Safeway, 50 tablets — — FDA listed —
Naproxen 220 mg 21130-0674-52 Better 90 tablets — — FDA listed —
Flanax Menstrual Pain Reliever 220 mg 27854-0165-10 Belmora 10 tablets — — FDA listed —
Rapidol Naproxen 220 mg 55758-0048-24 Pharmadel 24 tablets — — FDA listed —
all day relief 220 mg 56062-0490-71 Publix 50 tablets — — FDA listed —
Naproxen Sodium HEADACHE PAIN 220 mg 58602-0735-07 Aurohealth 24 tablets — — FDA listed —
Aleve Back and Muscle Pain 220 mg 00280-0111-01 Bayer 10 tablets — — FDA listed —
Aleve Caplets 220 mg 00280-0114-01 Bayer 200 tablets — — FDA listed —
Aleve, TRAVEL BASIX 220 mg 66715-6411-02 Lil' 2 tablets — — FDA listed —
Naproxen Sodium 220 mg 71141-0182-32 Lidl 100 tablets — — FDA listed —
basic care naproxen sodium 220 mg 72288-0368-75 Amazon.com 90 tablets — — FDA listed —
Naproxen Sodium 220 mg 21130-0856-52 Better 90 tablets — — FDA listed —
naproxen sodium 220 mg 37808-0652-62 H 24 tablets — — FDA listed —
Naproxen Back and Muscle Pain 220 mg 50844-0714-14 L.N.K. 500 tablets — — FDA listed —
Naproxen Sodium 220 mg 51316-0762-70 CVS 270 tablets — — FDA listed —
CAREALL Naproxen 220 mg 51824-0072-01 New 100 tablets — — FDA listed —
exchange select naproxen sodium 220 mg 55301-0368-71 Army 50 tablets — — FDA listed —
Naproxen 220 mg 55319-0717-08 Family 24 tablets — — FDA listed —
Naproxen Sodium HEADACHE PAIN 220 mg 58602-0737-07 Aurohealth 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 58602-0819-07 Aurohealth 24 tablets — — FDA listed —
Artridol 220 mg 59428-0604-08 Zapotol 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 67091-0138-50 WinCo 50 tablets — — FDA listed —
Basic Care Naproxen Sodium 220 mg 72288-0489-75 Amazon.com 90 tablets — — FDA listed —
Naproxen Sodium 220 mg 79903-0232-90 WALMART 90 tablets — — FDA listed —
Aleve Caplets 220 mg 85237-1832-01 Select 1 tablet — — FDA listed —
Naproxen Sodium Headache Pain 220 mg 43598-0071-01 Dr.Reddy's 100 tablets — — FDA listed —
Naproxen Sodium 220 mg 50844-0604-09 L.N.K. 5 tablets — — FDA listed —
Naproxen Sodium 220 mg 53185-0604-12 Athlete's 100 tablets — — FDA listed —
Naproxen Sodium 220 mg 55111-0273-01 Dr.Reddy's 100 tablets — — FDA listed —
Naproxen 220 mg 55319-0406-52 Family 90 tablets — — Discontinued —
DG Health Naproxen Sodium 220 mg 55910-0481-62 Dolgencorp 24 tablets — — FDA listed —
dg health naproxen sodium 220 mg 55910-0729-62 Dolgencorp 24 tablets — — FDA listed —
Aleve Headache Pain 220 mg 00280-0112-01 Bayer 175 tablets — — FDA listed —
Aleve 220 mg 00280-6010-01 Bayer 100 tablets — — FDA listed —
All Day Pain Relief 220 mg 63941-0245-01 VALU 24 tablets — — FDA listed —
kirkland signature naproxen sodium 220 mg 63981-0368-79 Costco 400 tablets — — FDA listed —
Naproxen Sodium 220 mg 68196-0255-20 SAM'S 400 tablets — — FDA listed —
Naproxen Sodium 220 mg 68998-0144-03 Marc 100 tablets — — FDA listed —
Naproxen Sodium 220 mg 83324-0108-01 CHAIN 100 tablets — — FDA listed —
Naproxen Sodium 220 mg 11822-4171-02 Rite 100 tablets — — Discontinued —
signature care naproxen sodium 220 mg 21130-0180-62 Safeway 24 tablets — — Discontinued —
Naproxen Sodium 220 mg 21130-0593-79 Safeway 400 tablets — — FDA listed —
First Aid Direct All Day Pain Relief 220 mg 42961-0122-02 Cintas 1 tablet — — FDA listed —
Naproxen Sodium Headache Pain 220 mg 43598-0072-01 Dr.Reddy's 100 tablets — — FDA listed —
Naproxen Headache Pain 220 mg 50844-0471-14 L.N.K. 500 tablets — — FDA listed —
CAREALL Naproxen Sodium 220 mg 51824-0109-01 New 100 tablets — — FDA listed —
Naproxen Sodium 220 mg 61504-0145-02 AMERIFOODS 50 tablets — — FDA listed —
Aleve 220 mg 66715-6402-08 Lil' 30 tablets — — FDA listed —
Naproxen Sodium 220 mg 67091-0140-10 WinCo 100 tablets — — FDA listed —
Berkley and Jensen Naproxen Sodium 220 mg 68391-0368-79 BJWC 400 tablets — — FDA listed —
All Day Pain Relief 220 mg 79903-0005-10 WALMART 40 tablets — — Discontinued —
up and up naproxen sodium 220 mg 11673-0368-71 Target 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 11673-0764-05 TARGET 50 tablets — — FDA listed —
up and up naproxen sodium 220 mg 11673-0909-75 Target 90 tablets — — FDA listed —
Naproxen Sodium 220 mg 11822-6040-02 Rite 100 tablets — — Discontinued —
good sense naproxen sodium 220 mg 00113-1412-71 L. 50 tablets — — FDA listed —
Topcare All Day Pain Relief 220 mg 36800-0140-82 Topco 200 tablets — — FDA listed —
naproxen sodium 220 mg 37808-0713-79 H 400 tablets — — FDA listed —
equaline naproxen sodium 220 mg 41163-0707-71 United 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 41250-0477-62 Meijer 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 41250-0680-71 Meijer 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 43063-0909-20 PD-Rx 20 tablets — — FDA listed —
Naproxen Sodium Headache Pain Caplets 220 mg 43598-0059-52 Dr.Reddy's 225 tablets — — FDA listed —
Naproxen Sodium Back and Muscle Pain 220 mg 43598-0073-01 Dr.Reddy's 100 tablets — — FDA listed —
Medique Mediproxen 220 mg 47682-0237-33 Unifirst 1 tablet — — FDA listed —
Medique at Home Mediproxen 220 mg 47682-0737-50 Unifirst 1 tablet — — FDA listed —
Naproxen 220 mg 53943-0144-02 DISCOUNT 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 57344-0145-01 AAA 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 58602-0845-21 Aurohealth 100 tablets — — FDA listed —
Aleve 220 mg 00280-0113-01 Bayer 10 tablets — — FDA listed —
Naproxen Sodium 220 mg 63941-0444-01 VALU 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 69848-0010-01 Granules 10 tablets — — FDA listed —
Rugby All Day Relief 220 mg 71335-3009-01 Bryant 20 tablets — — FDA listed —
Naproxen Sodium 220 mg 72789-0543-14 PD-Rx 14 tablets — — FDA listed —
Pain Relief 220 mg 82501-1576-01 Gobrands, 100 tablets — — FDA listed —
Naproxen Sodium 220 mg 83324-0109-01 CHAIN 100 tablets — — FDA listed —
topcare back and muscle pain 220 mg 36800-0696-75 Topco 90 tablets — — FDA listed —
naproxen sodium 220 mg 37808-0631-82 H 200 tablets — — FDA listed —
Naproxen Sodium 220 mg 37835-0594-01 Bi-Mart 100 tablets — — FDA listed —
Care One Naproxen Sodium 220 mg 41520-0533-71 American 50 tablets — — FDA listed —
rugby all day relief 220 mg 50090-3356-00 A-S 30 tablets — — FDA listed —
All Day Relief 220 mg 56062-0368-62 Publix 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 58602-0738-07 Aurohealth 24 tablets — — FDA listed —
Aleve Caplets Soft Grip Arthritis 220 mg 00280-0115-01 Bayer 270 tablets — — FDA listed —
Aleve Gelcaps 220 mg 00280-6020-02 Bayer 90 tablets — — FDA listed —
Aleve Back and Muscle Pain 220 mg 00280-6092-02 Bayer 130 tablets — — FDA listed —
All Day Pain Relief 220 mg 63941-0144-01 VALU 24 tablets — — FDA listed —
Naproxen 220 mg 68788-7572-02 Preferred 20 tablets — — FDA listed —
Good Sense Naproxen Sodium 220 mg 68788-8443-02 Preferred 20 tablets — — FDA listed —
Good Sense Naproxen Sodium 220 mg 71335-2584-01 Bryant 20 tablets — — FDA listed —
equaline naproxen sodium 220 mg 41163-0511-62 United 24 tablets — — FDA listed —
Care One Naproxen Sodium 220 mg 41520-0349-82 American 200 tablets — — FDA listed —
Naproxen Sodium 220 mg 42507-0245-01 HYVEE 24 tablets — — FDA listed —
Bayer Aleve 220 mg 47682-0488-50 Unifirst 50 tablets — — FDA listed —
Naproxen 220 mg 50844-0261-08 L.N.K. 24 tablets — — FDA listed —
Aleve Headache Pain 220 mg 00280-0041-01 Bayer 175 tablets — — FDA listed —
Aleve Gelcaps 220 mg 00280-6070-40 Bayer 40 tablets — — FDA listed —
Naproxen Sodium 220 mg 81522-0045-05 FSA 200 tablets — — FDA listed —
Medique Mediproxen 220 mg 85766-0121-01 Sportpharm 1 tablet — — FDA listed —
Dr Simi All Day Pain Relief 220 mg 85786-0104-24 Farmacias 24 tablets — — FDA listed —
naproxen sodium 220 mg 41250-0313-82 Meijer 200 tablets — — FDA listed —
naproxen sodium 220 mg 41250-0818-62 Meijer 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 42507-0844-01 HYVEE 24 tablets — — FDA listed —
Naproxen Sodium Back and Muscle Pain Caplets 220 mg 43598-0060-52 Dr.Reddy's 225 tablets — — FDA listed —
Calmadol Pain Reliever 220 mg 48201-0007-24 GRANDALL 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 55111-0272-01 Dr.Reddy's 100 tablets — — FDA listed —
Naproxen 220 mg 57896-0954-01 Geri-Care 100 tablets — — FDA listed —
Naproxen Sodium BACK AND MUSCLE PAIN 220 mg 58602-0736-07 Aurohealth 24 tablets — — FDA listed —
Aleve Caplets Easy Open Arthritis 220 mg 00280-0130-01 Bayer 90 tablets — — FDA listed —
Aleve Easy Open Arthritis 220 mg 00280-0131-01 Bayer 200 tablets — — FDA listed —
Aleve Caplets 220 mg 00280-6000-01 Bayer 24 tablets — — FDA listed —
Aleve Headache Pain 220 mg 00280-8252-10 Bayer 10 tablets — — FDA listed —
Naproxen Sodium 220 mg 63868-0466-01 Chain 100 tablets — — FDA listed —
Naproxen Sodium 220 mg 63941-0445-01 VALU 24 tablets — — FDA listed —
All Day Pain Relief 220 mg 00363-0368-61 Walgreen 600 tablets — — Discontinued —
Naproxen Sodium 220 mg 68998-0145-03 Marc 100 tablets — — FDA listed —
All Day Pain Relief 220 mg 00363-6099-01 WALGREENS 100 tablets — — FDA listed —
Aleve 220 mg 70264-0011-01 R 50 tablets — — FDA listed —
Naproxen Sodium 220 mg 71335-1061-01 Bryant 20 tablets — — FDA listed —
Naproxen Sodium 220 mg 72036-0144-01 Harris 24 tablets — — FDA listed —
Naproxen Sodium 220 mg 72036-0145-01 Harris 24 tablets — — FDA listed —
Basic Care Naproxen Sodium 220 mg 72288-0331-62 Amazon.com 24 tablets — — Discontinued —
naproxen sodium 220 mgthis 72288-0988-75 Amazon.com 90 tablets — — FDA listed —
About this product: this is a generic version of the medicine. FDA equivalence ratings are shown when available, and other versions are listed above, least expensive first.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️
2026
On the market since
Sep 2026
📍
2026
Currently FDA-listed
listed with the FDA
🔓
·
Generic on the market
this product is a generic
✅This is a generic drug

This product is an FDA-approved generic. Other versions of the same drug are listed under Therapeutic equivalents, least expensive first.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

📊 Medicare Part D spend CMS · PART D · 2026 (Q1)

Medicare Part D (outpatient prescription) spending for Naproxen Sodium — the program that covers self-administered drugs. 4 manufacturers.
⚠️ Drug-level data: CMS publishes Part D spending by drug, not by NDC — these figures combine every manufacturer, strength and package size sold under the name Naproxen Sodium. That’s a different level of aggregation than the Medicaid card above, which is specific to this exact 11-digit NDC (pack size included), so the two aren’t directly comparable.
Period
Total Part D spend
$441.8K
Claims incl. refills
15.2K
Beneficiaries
11.4K
Spend / beneficiary
$38.70
Spend / claim
$29.13
Trend by period
💵 About the dollar figures: spending is what Part D plans paid before confidential manufacturer rebates, so the program’s real net cost is lower. A blank patient count means fewer than 11 people — CMS hides counts that small to protect privacy. Source: CMS Medicare Quarterly Part D Spending by Drug (data.cms.gov), updated quarterly.

📦 Packaging — all sizes for this product

Package NDCDescription Marketing startStatus
72288-0988-75 You're viewing this 1 BOTTLE in 1 CARTON (72288-988-75) / 90 TABLET, FILM COATED in 1 BOTTLE (72288-988-00) 2026-09-03 Active

🧭 About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos ✓ Available
Inactive ingredients (structured) ✓ Available
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The FDA registers it as 72288-988-75, which is what is printed on the packaging and shown on DailyMed. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero: 72288-0988-75, written without dashes as 72288098875. The Identity section at the top of this page lists every form of this code.
What do the three segments of this NDC mean?
In 72288-0988-75, the first segment (72288) is the labeler code FDA assigned to Amazon.com Services LLC; the middle segment (0988) identifies this specific product — its ingredient, strength, and dosage form; and the last segment (75) identifies this exact package size and type. Together they name one specific package of one specific product.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Amazon.com Services LLC. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
Amazon.com Services LLC is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
📄 FDA label
📄 FDA label 19 words ▾

No FDA label is on file for this product yet. Labels load from openFDA / DailyMed and refresh weekly.

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
← 72288-0982-34 · Amazon.com 72288-0989-26 · Amazon.com →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.