methimazole 10 mg Tablet, 100-count
🆔 Identity & classification
Where does this data come from?
🏷️ RxNorm drug class
This medicine belongs to the Thyroid Hormone Synthesis Inhibitor class.
Where does this data come from?
🏭 Manufacturer & labeler
Where does this data come from?
🩺 Clinical
Methimazole is used to treat hyperthyroidism, a condition that occurs when the thyroid gland produces too much thyroid hormone. It is also taken before thyroid surgery or radioactive iodine therapy. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
Read the full MedlinePlus article ↗- Methimazole tells your thyroid gland to stop making so much thyroid hormone. When your thyroid is overactive — like in Graves' disease — it pumps out too much hormone and speeds ev...
- What exactly is methimazole supposed to do for me?
- Usually you'll take it in three separate doses spaced about 8 hours apart throughout the day — so think morning, afternoon, and evening. Your prescriber sets the exact dose based o...
- How do I take it — do I take it all at once?
Patient education
Supplement & herbal interactions
Some supplements/herbs that may interact with Methimazole — tap one for details:
Where does this data come from?
Ask a licensed pharmacist directly — free, answered by our team.
🧪 Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
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Lactose monohydrate is a natural sugar derived from milk. It serves as a filler and binder in tablets and capsules, helping create the proper size, texture, and consistency of the medicine.
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Magnesium stearate is a salt made from magnesium and stearic acid, a fatty substance. It's used in tablets and capsules as a lubricant and glidant to help ingredients flow smoothly during manufacturing and prevent sticking.
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Silicon dioxide is a naturally occurring mineral used as a glidant and anti-caking agent. It helps powder ingredients flow smoothly and prevents clumping during manufacturing and storage.
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A plant-based carbohydrate derived from corn kernels. It acts as a filler to add bulk, a binder to hold ingredients together, and a disintegrant to help the tablet break apart in your stomach for absorption.
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A powder made from a naturally occurring mineral. In medicines, talc works as a glidant and anti-caking agent, helping tablets and capsules flow smoothly during manufacturing and preventing clumping.
5 inactive ingredients listed in the exact product block matched to this NDC.
Where does this data come from?
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
Why might an inactive ingredient be missing?
Can inactive ingredients matter?
💲 Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per ea | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | $0.125 | $12.46 / 100 tablets |
| Medicaid paysCMS SDUD · 12 mo | $0.1186 | $11.86 / 100 tablets |
| Medicare drug plans payPart D · Q2 2026 | $0.1781 | $17.81 / 100 tablets |
Where does this data come from?
🔁 Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| Methimazole 10 mg 00832-6073-11 | Upsher-Smith | 100 tablets | $0.125 | AB | Availability likely | — |
| Methimazole 10 mg 11788-0012-01 | AiPing | 100 tablets | $0.125 | AB | Availability likely | — |
| Methimazole 10 mg 23155-0071-01 | Heritage | 100 tablets | $0.125 | AB | Availability likely | — |
| Methimazole 10 mg 33342-0336-11 | Macleods | 100 tablets | $0.125 | AB | Availability likely | — |
| Methimazole 10 mg 50268-0496-15 | AvPAK | 50 tablets | $0.125 | AB | Availability likely | — |
| Methimazole 10 mg 60687-0680-01 | American | 100 tablets | $0.125 | AB | Availability likely | — |
| Methimazole 10 mg 64380-0213-01 | Strides | 100 tablets | $0.125 | AB | Availability likely | — |
| Methimazole 10 mg 64980-0265-01 | Rising | 100 tablets | $0.125 | AB | Availability likely | — |
| Methimazole 10 mg 69452-0329-20 | Bionpharma | 100 tablets | $0.125 | AB | Availability likely | — |
| methimazole 10 mgthis 72578-0213-01 | Viona | 100 tablets | $0.125 | AB | Availability likely | — |
| Methimazole 10 mg 72603-0316-01 | NORTHSTAR | 100 tablets | $0.125 | AB | Availability likely | — |
| Methimazole 10 mg 60429-0381-01 | Golden | 100 tablets | — | AB | FDA listed | — |
| Methimazole 10 mg 62135-0206-01 | Chartwell | 100 tablets | — | AB | FDA listed | — |
| Methimazole 10 mg 63629-9251-01 | Bryant | 100 tablets | — | AB | FDA listed | — |
| methimazole 10 mg 67046-1652-03 | Coupler | 30 tablets | — | AB | FDA listed | — |
| Methimazole 10 mg 68788-4063-01 | Preferred | 100 tablets | — | AB | FDA listed | — |
| Methimazole 10 mg 68788-8227-01 | Preferred | 100 tablets | — | AB | FDA listed | — |
| Methimazole 10 mg 70518-1475-00 | REMEDYREPACK | 30 tablets | — | AB | FDA listed | — |
| Methimazole 10 mg 71335-0883-01 | Bryant | 30 tablets | — | AB | FDA listed | — |
| Methimazole 10 mg 71335-2218-01 | Bryant | 30 tablets | — | AB | FDA listed | — |
| Methimazole 10 mg 71335-2349-01 | Bryant | 30 tablets | — | AB | FDA listed | — |
| Methimazole 10 mg 71335-2906-01 | Bryant | 100 tablets | — | AB | FDA listed | — |
| Methimazole 10 mg 71335-3027-01 | Bryant | 180 tablets | — | AB | FDA listed | — |
| Methimazole 10 mg 72162-1803-01 | Bryant | 100 tablets | — | AB | FDA listed | — |
| Methimazole 10 mg 73190-0085-01 | AvKARE | 100 tablets | — | AB | FDA listed | — |
| methimazole 10 mg 76483-0083-00 | SQUARE | 100 tablets | — | AB | FDA listed | — |
| Methimazole 10 mg 82804-0231-30 | Proficient | 30 tablets | — | AB | FDA listed | — |
Where does this data come from?
⏳ Availability & generic status
This product is an FDA-approved generic. Other versions of the same drug are listed under Therapeutic equivalents, least expensive first.
Where does this data come from?
🗺️ Medicaid utilization & spend
📊 Medicare Part D spend CMS · PART D · 2026 (Q1)
📦 Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Status |
|---|---|---|---|
| 72578-0213-01 You're viewing this | 100 TABLET in 1 BOTTLE (72578-213-01) | 2025-09-10 | Active |
📄 Full prescribing information FDA SPL
🎯 Indications and Usage ▾
INDICATIONS AND USAGE
⏱️ Dosage and Administration ▾
DOSAGE AND ADMINISTRATION
⛔ Contraindications ▾
CONTRAINDICATIONS
⚠️ Warnings ▾
WARNINGS First Trimester Use of Methimazole and Congenital Malformations Methimazole crosses the placental membranes and can cause fetal harm when administered in the first trimester of pregnancy. Rare instances of congenital defects, including aplasia cutis, craniofacial malformations (facial dysmorphism; choanal atresia), gastrointestinal malformations (esophageal atresia with or without tracheoesophageal fistula), omphalocele and abnormalities of the omphalomesenteric duct have occurred in infants born to mothers who received methimazole in the first trimester of pregnancy.
If methimazole is used during pregnancy or if the patient becomes pregnant while taking this drug, the patient should be warned of the potential hazard to the fetus. Because of the risk for congenital malformations associated with use of methimazole in the first trimester of pregnancy, it may be appropriate to use other agents in pregnant women requiring treatment for hyperthyroidism. If methimazole is used, the lowest possible dose to control the maternal disease should be given.
Agranulocytosis Agranulocytosis is a potentially life-threatening adverse reaction of methimazole therapy. Patients should be instructed to immediately report to their physicians any symptoms suggestive of agranulocytosis, such as fever or sore throat. Leukopenia, thrombocytopenia, and aplastic anemia (pancytopenia) may also occur.
The drug should be discontinued in the presence of agranulocytosis or aplastic anemia (pancytopenia), and the patient's bone marrow indices should be monitored. Liver Toxicity Although there have been reports of hepatotoxicity (including acute liver failure) associated with methimazole, the risk of hepatotoxicity appears to be less with methimazole than with propylthiouracil, especially in the pediatric population. Symptoms suggestive of hepatic dysfunction (anorexia, pruritus, right upper quadrant pain, etc.) should prompt evaluation of liver function (bilirubin, alkaline phosphatase) and hepatocellular integrity (ALT, AST).
Drug treatment should be discontinued promptly in the event of clinically significant evidence of liver abnormality including hepatic transaminase values exceeding 3 times the upper limit of normal. Hypothyroidism Methimazole can cause hypothyroidism necessitating routine monitoring of TSH and free T4 levels with adjustments in dosing to maintain a euthyroid state. Because the drug readily crosses placental membranes, methimazole can cause fetal goiter and cretinism when administered to a pregnant woman.
For this reason, it is important that a sufficient, but not excessive, dose be given during pregnancy (see PRECAUTIONS, Pregnancy ). Vasculitis Cases of vasculitis resulting in severe complications have been reported in patients receiving methimazole therapy. These cases of vasculitis include: leukocytoclastic cutaneous vasculitis, acute kidney injury and glomerulonephritis, alveolar/pulmonary hemorrhage, CNS vasculitis, and neuropathy.
Most cases were associated with antineutrophilic cytoplasmic antibodies (ANCA)-positive vasculitis. In some cases, vasculitis resolved/improved with drug discontinuation; however, more severe cases required treatment with additional measures including corticosteroids, immunosuppressant therapy, and plasmapheresis. If vasculitis is suspected, discontinue therapy and initiate appropriate intervention.
🤒 Adverse Reactions ▾
ADVERSE REACTIONS
🔄 Drug Interactions ▾
Drug Interactions Anticoagulants (oral) Due to potential inhibition of vitamin K activity by methimazole, the activity of oral anticoagulants (e.g., warfarin) may be increased; additional monitoring of PT/INR should be considered, especially before surgical procedures. ß-adrenergic blocking agents Hyperthyroidism may cause an increased clearance of beta blockers with a high extraction ratio. A dose reduction of beta-adrenergic blockers may be needed when a hyperthyroid patient becomes euthyroid. Digitalis glycosides Serum digitalis levels may be increased when hyperthyroid patients on a stable digitalis glycoside regimen become euthyroid; a reduced dosage of digitalis glycosides may be needed.
Theophylline Theophylline clearance may decrease when hyperthyroid patients on a stable theophylline regimen become euthyroid; a reduced dose of theophylline may be needed.
🤰 Pregnancy ▾
Pregnancy (See WARNINGS ) If methimazole is used during the first trimester of pregnancy or if the patient becomes pregnant while taking this drug, the patient should be warned of the potential hazard to the fetus. In pregnant women with untreated or inadequately treated Graves' disease, there is an increased risk of adverse events of maternal heart failure, spontaneous abortion, preterm birth, stillbirth and fetal or neonatal hyperthyroidism. Because methimazole crosses placental membranes and can induce goiter and cretinism in the developing fetus, hyperthyroidism should be closely monitored in pregnant women and treatment adjusted such that a sufficient, but not excessive, dose be given during pregnancy.
In many pregnant women, the thyroid dysfunction diminishes as the pregnancy proceeds; consequently, a reduction of dosage may be possible. In some instances, anti-thyroid therapy can be discontinued several weeks or months before delivery. Due to the rare occurrence of congenital malformations associated with methimazole use, it may be appropriate to use an alternative anti-thyroid medication in pregnant women requiring treatment for hyperthyroidism, particularly in the first trimester of pregnancy during organogenesis.
Given the potential maternal adverse effects of propylthiouracil (e.g., hepatotoxicity), it may be preferable to switch from propylthiouracil to methimazole for the second and third trimesters.
🧒 Pediatric Use ▾
Pediatric Use Because of postmarketing reports of severe liver injury in pediatric patients treated with propylthiouracil, methimazole is the preferred choice when an antithyroid drug is required for a pediatric patient. (See DOSAGE AND ADMINISTRATION .)
🆘 Overdosage ▾
OVERDOSAGE Signs and Symptoms Symptoms may include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancytopenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.
No information is available on the median lethal dose of the drug or the concentration of methimazole in biologic fluids associated with toxicity and/or death. Treatment To obtain up-to-date information about the treatment of overdose, a good resource is your certified Regional Poison Control Center. In managing overdosage, consider the possibility of multiple drug overdoses, interaction among drugs, and unusual drug kinetics in the patient.
In the event of an overdose, appropriate supportive treatment should be initiated as dictated by the patient's medical status.
🧬 Clinical Pharmacology ▾
CLINICAL PHARMACOLOGY
📦 How Supplied / Storage and Handling ▾
HOW SUPPLIED
📋 Description ▾
DESCRIPTION
💬 Information for Patients ▾
Information for Patients Patients should be advised that if they become pregnant or intend to become pregnant while taking an antithyroid drug, they should contact their physician immediately about their therapy. Inform patients that cases of vasculitis resulting in severe complications have occurred with methimazole tablets. Inform patients to promptly report symptoms that may be associated with vasculitis including new rash, hematuria or decreased urine output, dyspnea or hemoptysis (see WARNINGS and ADVERSE REACTIONS ).