Medication interaction hub

What Supplements Interact with Methimazole?

Methimazole brand name: Tapazole. Every interaction below applies to the brands too.

64 Interactions 4 Major 51 Moderate 9 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Methimazole? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Methimazole against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Methimazole (Tapazole) treats an overactive thyroid, and because the drug can stress the liver on its own, this list calls for real vigilance. Of the 64 supplements on file, 4 are rated major, with 51 moderate and 9 minor. The largest group, 38 ingredients, adds liver strain to a medicine already capable of it. Siberian cocklebur is the most dangerous, with documented cases of liver failure, and regular beer or wine sits in that same major category.

A second cluster of 17 can change how much of an oral dose reaches you. Activated charcoal is the strongest, capable of pulling methimazole out of your system, and thick fiber supplements blunt absorption; take those well away from your tablet. The last 9 act on the thyroid themselves, several through their iodine content, and stacking them with methimazole can tip you toward an underactive thyroid. Sort out the four major entries first; the rest mostly needs watching and spacing.

— , Clinical Pharmacist · July 18, 2026

Major 4 Moderate 51 Minor 9 No known interaction 1,388

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Methimazole: Top Interactions at a Glance

The Methimazole supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 64 interacting ingredients — plus 1,388 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Methimazole Combinations Today

The Methimazole + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Probable Iodine + Methimazolei

Iodine might alter the effects of antithyroid drugs.

Read the full interaction Moderate Likelihood Possible Dulse + Methimazolei

Theoretically, due to its iodine content, dulse might alter the effects of antithyroid drugs.

Read the full interaction Moderate Likelihood Possible Bamboo + Methimazolei

Theoretically, long-term bamboo use might increase the effects and adverse effects of antithyroid drugs, possibly leading to hypothyroidism.

Read the full interaction Minor Likelihood Likely Thyroid Extract + Methimazolei

Food and medications can interfere with thyroid hormone absorption.

Read the full interaction Moderate Likelihood Possible Turmeric + Methimazolei

Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.

Read the full interaction Moderate Likelihood Possible Sweet Clover + Methimazolei

Theoretically, concomitant use of sweet clover with hepatoxic drugs might increase the risk of hepatotoxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Methimazole

All 1,452 ingredients in our database, ranked by severity — 64 with a Methimazole interaction on file and 1,388 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Methimazole?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Iodine with Methimazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Iodine might alter the effects of antithyroid drugs.

Full Iodine + Methimazole answer

Can you take Dulse with Methimazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, due to its iodine content, dulse might alter the effects of antithyroid drugs.

Full Dulse + Methimazole answer

Can you take Bamboo with Methimazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, long-term bamboo use might increase the effects and adverse effects of antithyroid drugs, possibly leading to hypothyroidism.

Full Bamboo + Methimazole answer

Can you take Thyroid Extract with Methimazole?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Methimazole answer

Can you take Turmeric with Methimazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Turmeric + Methimazole answer

Can you take Ascophyllum Nodosum with Methimazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Due to its iodine content, Ascophyllum nodosum might alter the effects of antithyroid drugs.

Full Ascophyllum Nodosum + Methimazole answer

Can you take Ashwagandha with Methimazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.

Full Ashwagandha + Methimazole answer

Can you take Babassu with Methimazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that babassu has antithyroid effects.

Full Babassu + Methimazole answer

Can you take Baikal Skullcap with Methimazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Baikal skullcap and antithyroid drugs may result in additive activity and increase the risk of hypothyroid...

Full Baikal Skullcap + Methimazole answer

Can you take Black Cohosh with Methimazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking black cohosh with hepatotoxic drugs may increase the risk of liver damage.

Full Black Cohosh + Methimazole answer

Can you take Boldo with Methimazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking boldo with hepatotoxic drugs might increase the risk of hepatic injury and disease.

Full Boldo + Methimazole answer

Can you take Buchu with Methimazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Buchu contains pulegone, a known hepatotoxin.

Full Buchu + Methimazole answer

Can you take Camphor with Methimazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of camphor with other hepatotoxic drugs might increase the risk of liver damage.

Full Camphor + Methimazole answer

Can you take Cassia Cinnamon with Methimazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.

Full Cassia Cinnamon + Methimazole answer

Can you take Chaparral with Methimazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chaparral might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Chaparral + Methimazole answer

Can you take Comfrey with Methimazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, comfrey might have additive adverse effects on the liver when used with hepatotoxic drugs.

Full Comfrey + Methimazole answer

Can you take Ephedra with Methimazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Ephedra + Methimazole answer

Can you take Epistane with Methimazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Epistane + Methimazole answer

Can you take Fo-ti with Methimazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, fo-ti might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Fo-ti + Methimazole answer

Can you take Fucus Vesiculosus with Methimazole?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Due to its iodine content, Fucus vesiculosus might alter the effects of antithyroid drugs.

Full Fucus Vesiculosus + Methimazole answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Methimazole is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Methimazole, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Methimazole sits in 3 interaction categories. Open any one to see what the group means:

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Methimazole through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Methimazole through this category.

Antithyroid Drugs 9 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

9 of the supplement ingredients on this page reach Methimazole through this category.

About Methimazole

Methimazole is a prescription tablet used to treat hyperthyroidism caused by Graves' disease or toxic multinodular goiter, and to prepare patients for thyroid surgery or radioactive iodine therapy.

Generic name: Methimazole  ·  Brand name: Tapazole.

See the full Methimazole drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Methimazole

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Methimazole.

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Products that contain Methimazole-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Methimazole.

Zi Sheng Teapills by Plum Flower contains Siberian Cocklebur Cold Away by Health Concerns contains Siberian Cocklebur Sugar Coated Bi Yan Pian by Plum Flower contains Siberian Cocklebur Pe Min Kan Wan by Plum Flower contains Siberian Cocklebur
Pharmacist Counseling Corner

Methimazole & Supplements: Common Questions

What supplements interact with Methimazole?
In our interaction database, 64 supplement and herbal ingredients have an interaction with Methimazole on file — 4 rated major, 51 moderate, and 9 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Methimazole supplement interactions are the most serious?
The 4 major-rated combinations — led by Siberian Cocklebur, Activated Charcoal, Beer and Wine — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Methimazole?
That depends entirely on which supplement. The honest answer for Methimazole is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Tapazole have the same supplement interactions as Methimazole?
Yes — Tapazole all contain Methimazole, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Methimazole and my other medications?
This page covers Methimazole against supplements and herbal ingredients. Checking Methimazole against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Methimazole drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.