Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.
Plus Rinse Emergency Eyewash Purified Water 99.1 mL/100mL Liquid, 500 mL — NDC 72598-022-20 (Billing 72598-0022-20)
by INNOVATIVE SAFETY SUPPLY INC. · 500 mL in 1 BOTTLE
This is a package of 500 mL of Plus Rinse Emergency Eyewash Purified Water 99.1 mL/100mL Liquid from INNOVATIVE SAFETY SUPPLY INC., marketed since May 2019 and currently FDA-listed.
NDC 72598-0022-20
🏷️ FDA NDC (as labeled)
72598-022-20
billing pads the product segment with a zero
This package
Contains500 mL
Pack sizes3 compare ↓
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →
Identity & classification
Regulatory identifiers FDA, NLM and CMS codes for this package
FDA NDC (as labeled)
72598-022-20
Product NDC
72598-022
11-digit billing NDC
72598002220
RxCUI
1053429
UNII
059QF0KO0R
Application #
M018
SPL Set ID
b3f47d26-39e4-4aea-bb92-358def52b652
DEA schedule
Non-controlled
Marketing category
OTC MONOGRAPH DRUG
Marketing status
On market
FDA listing status
Listed (active directory)
Marketing start
2019-05-06
Route
OPHTHALMIC
Dosage form
LIQUID
Substance
WATER
Quick answers
- RxCUI (RxNorm): 1053429
Why two NDCs?
The FDA registers this code as 72598-022-20 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 72598-0022-20. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 1, 2026
- RxNorm (NLM RxNav) · catalog refreshed Oct 1, 2026
- Medi-Span GPI (licensed)
- First Databank (licensed) · refreshed Oct 1, 2026
Clinical
📗 Our plain-language guide HelloPharmacist
- It can seem a little odd at first. In these products, sterile water plays the essential role of carrying or dissolving the actual active medication — like insulin — so it can be sa...
- Why is 'water' listed as the active ingredient on my medicine?
- No — these are very different products that should never be used interchangeably. Sterile Water for Injection is used only as a diluent for other drugs given by needle, and it must...
- Is Sterile Water for Injection the same as the eye wash or the irrigation product?
Patient education
Supplement & herbal interactions
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.
- MedlinePlus (NLM) · refreshed Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 1, 2026
💬 Questions about Purified Water?
Ask a pharmacist →
Ask a licensed pharmacist directly — free, answered by our team.
Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per mL | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | Not in the retail survey — common for institutional, discontinued, or low-volume packs. | |
| Medicaid paysCMS SDUD · 12 mo | No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data. | |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
ℹ️
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.
- CMS NADAC weekly file
- CMS ASP pricing files · refreshed Sep 20, 2026
- CMS Medicaid State Drug Utilization Data · refreshed Oct 2, 2026
- CMS Part D plan pricing files · refreshed Sep 24, 2026
- VA National Acquisition Center price file
Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Marketing end | Status |
|---|---|---|---|---|
| 72598-0022-20 You're viewing this | 500 mL in 1 BOTTLE | 2019-05-06 | — | Active |
| 72598-0022-01 72598-022-01 Main listing | 1000 mL in 1 BOTTLE | 2019-05-06 | — | Active |
| 72598-0022-02 72598-022-02 | 200 mL in 1 BOTTLE | 2019-05-06 | — | Active |
You're viewing one of 3 pack sizes for this product.
Pack size FAQ
What quantity is in this package?
This package contains 500 mL — 500 ml in 1 bottle.
How does this package differ from NDC 72598-0022-02?
Both are Plus Rinse Emergency Eyewash Purified Water 99.1 mL/100mL Liquid — the drug itself is identical. This page's package is the 500 mL one, while NDC 72598-0022-02 is the 200 ml package.
What NDC number is used to bill for this package of Plus Rinse Emergency Eyewash Purified Water 99.1 mL/100mL Liquid?
Use the 11-digit billing form listed in the identifiers section of this page. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.
Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| Rugby Eye Wash 99.05 g/100mL 00536-1224-97 | Rugby | 1 bottle | $0.029 | — | Availability likely | — |
| Leader Eye Wash 99.05 g/100mL 70000-0018-01 | Cardinal | 1 bottle | $0.029 | — | Availability likely | — |
| Quality Choice Eye Wash 99.05 g/100mL 83324-0192-04 | Chain | 1 bottle | $0.029 | — | Availability likely | — |
| Walgreens Sterile Soothing Eye Wash 99.05 mL/100mL 00363-0700-04 | Walgreens | 1 bottle | — | — | FDA listed | — |
| Rite Aid Eye Wash 99.05 g/100mL 11822-2313-01 | Rite | 1 bottle | — | — | FDA listed | — |
| Eye Wash 99.05 mL/100mL 11822-9860-08 | Rite | 1 bottle | — | — | Discontinued | — |
| Advanced Eye Relief Eye Wash 99.05 mL/100mL 24208-0005-04 | Bausch | 1 applicator | — | — | FDA listed | — |
| Eye Wash 99.05 mL/100mL 30142-0010-18 | Kroger | 1 bottle | — | — | FDA listed | — |
| Eye Wash 991 mg/mL 49687-0010-01 | CMC | 1 tube | — | — | FDA listed | — |
| Rugby Eye Wash 99.05 g/100mL 50090-7440-00 | A-S | 1 bottle | — | — | FDA listed | — |
| Medics Choice Soothing Eye Wash 99.05 g/100mL 55651-0555-01 | KC | 118 ml | — | — | FDA listed | — |
| Eye Wash 99.05 mL/100mL 59779-0337-09 | CVS | 1 bottle | — | — | FDA listed | — |
| Plus Rinse Emergency Eyewash 99.1 mL/100mLthis 72598-0022-20 | INNOVATIVE | 500 ml | — | — | FDA listed | — |
| Eye Wash 991 mg/mL 82001-0001-00 | Jiangxi | 30 ml | — | — | FDA listed | — |
| Eye Wash 991 mg/mL 82996-0007-01 | Hubei | 15 ml | — | — | FDA listed | — |
| Eye Wash 99.1 mL/100mL 84219-0007-15 | M-star | 15 ml | — | — | FDA listed | — |
| Huanggang Eye Wash 99 mL/100mL 85426-0002-01 | Huanggang | 15 ml | — | — | Discontinued | — |
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA Orange Book · refreshed Sep 3, 2026
- CMS NADAC weekly file
Availability & generic status
🏛️
2019
On the market since
May 2019
📍
2026
Currently FDA-listed
7 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found
We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.
- FDA Orange Book · refreshed Sep 3, 2026
Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
-
UNII 451W47IQ8X
Sodium chloride is common table salt. It's used in medicines as a buffer to maintain proper pH, as a filler to add bulk, or to adjust the osmotic balance in liquid formulations.
1 inactive ingredient listed in the exact product block matched to this NDC.
The official label also statesSterile Sodium Chloride
Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.
Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed —
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.- FDA label on DailyMed · label index refreshed Oct 1, 2026
- FDA openFDA NDC Directory · synced Oct 1, 2026
Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.
Manufacturer & labeler
LabelerINNOVATIVE SAFETY SUPPLY INC.
FDA applicationM018 (OTC MONOGRAPH DRUG)
Labeler code72598
First marketedMay 2019
Product typeHuman Otc Drug
Portfolio2 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.
- FDA openFDA NDC Directory · synced Oct 1, 2026
- Drugs@FDA
FDA label — Drug Facts FDA SPL
The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage
⏱️ Dosage and Administration
⚠️ Warnings
🧪 Active Ingredient
🧪 Inactive Ingredients
🎯 Purpose
📄 Do Not Use
📄 Ask a Doctor Before Use If
📄 When Using This Product
📄 Keep Out of Reach of Children
📄 Questions or Comments
📄 Package Label / Principal Display Panel
🎯 Indications and Usage ▾
Uses For rinsing the eyes to reduce risk of severe injury caused by chemicals or particulate contamination
⏱️ Dosage and Administration ▾
Directions do not dilute solution or reuse bottle use only unopened bottle to open, twist cap in the direction of the arrow avoid contamination of the integrated eyecup place integrated eyecup over affected eye(s) tilt head backward open eyelid(s) wide control rate of flow by pressure on bottle thoroughly bathe eye(s) with solution allow solution to flow away from eye(s) rinse until the bottle is empty and continue rinsing with Plum Emergency Eyewash until you reach a doctor continue rinsing with water if necessary obtain medical treatment.
⚠️ Warnings ▾
Warnings For external use only Do not use for injection for intraocular surgery internally If solution changes color or becomes cloudy. When using this product avoid contamination do not reuse. Once opened, discard. Ask a doctor if you have eye pain changes in vision redness or irritation of the eye after use an injury caused by alkali Keep out of reach of children If swallowed, get medical help or contact a Poison Control Center right away.
🧪 Active Ingredient ▾
Active ingredient Purified water 99.1%
🧪 Inactive Ingredients ▾
Inactive ingredients Sterile Sodium Chloride
🎯 Purpose ▾
Purpose Emergency eyewash
📄 Do Not Use ▾
Do not use for injection for intraocular surgery internally If solution changes color or becomes cloudy.
📄 Ask a Doctor Before Use If ▾
Ask a doctor if you have eye pain changes in vision redness or irritation of the eye after use an injury caused by alkali
📄 When Using This Product ▾
When using this product avoid contamination do not reuse. Once opened, discard.
📄 Keep Out of Reach of Children ▾
Keep out of reach of children If swallowed, get medical help or contact a Poison Control Center right away.
📄 Questions or Comments ▾
Questions or Comments? Call toll-free number 1-844-405-7233
📄 Package Label / Principal Display Panel ▾
Principal Display Panel NDC : 72598-022-20 Plus Rinse Emergency Eyewash Compliance: ANSI/ISEA Z358.1-2014 (As Personal Eyewash Only) Innovative SAFETY SUPPLY Labeler: Innovative Safety Supply Inc, 368 Edson St, Saskatoon, SK/S7J 0P9/Canada. www.plusrinse.com Sterile - 500 ml (16.9 fl oz) NDC: 72598-022-01 Plus Rinse Emergency Eyewash Compliance: ANSI/ISEA Z358.1-2014 (As Personal Eyewash Only) Innovative SAFETY SUPPLY Labeler: Innovative Safety Supply Inc, 368 Edson St, Saskatoon, SK/S7J 0P9/Canada. www.plusrinse.com Sterile - 1000 ml (33.8 fl oz) NDC: 72598-022-02 Plus Rinse Emergency Eyewash Compliance: ANSI/ISEA Z358.1-2014 (As Personal Eyewash Only) Innovative SAFETY SUPPLY Labeler: Innovative Safety Supply Inc, 368 Edson St, Saskatoon, SK/S7J 0P9/Canada. www.plusrinse.com Sterile - 200 ml (6.8 fl oz) pic1 pic2 pic3
No label section mentions that — try another word, or open the full label on DailyMed below.
Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA.
Prefer the government’s original formatting? View this label on DailyMed ↗
About this NDC listing & data coverage
Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
| NDC identity (package / product / labeler codes) | ✓ Available |
| Labeler | ✓ Available |
| Product & package description | ✓ Available |
| Marketing category & status | ✓ Available |
| Active ingredient / dosage form / route | ✓ Available |
| FDA label (SPL via DailyMed) | ✓ Available |
| Package photos | ✓ Available |
| Inactive ingredients (structured) | ✓ Available |
| NADAC pharmacy acquisition price (CMS) | — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey. |
| Orange Book / therapeutic-equivalence data | — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope. |
| HCPCS J-code billing crosswalk | — Not published for this NDC Most self-administered / retail products have no J-code — that is normal. |
| Medicaid utilization (CMS SDUD) | — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold. |
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.
Questions about this listing
Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by INNOVATIVE SAFETY SUPPLY INC.. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 2 other package presentations of this same product, including 200 ml (72598-0022-02), 1000 ml (72598-0022-01). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
INNOVATIVE SAFETY SUPPLY INC. is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
For educational and professional reference only — not medical advice. Pricing reflects published
NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.