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Spironolactone and hydrochlorothiazide 25 mg; 25 mg Tablet, 30-count — NDC 72888-040-01 (Billing 72888-0040-01)

by Advagen Pharma Ltd. · 30 TABLET in 1 BOTTLE

This is a package of 30 tablets of Spironolactone and hydrochlorothiazide 25 mg; 25 mg Tablet from Advagen Pharma Ltd., marketed since Sep 2026 and currently FDA-listed. It is the main listing for this product, which comes in 3 package sizes.

NDC 72888-0040-01
🏷️ FDA NDC (as labeled) 72888-040-01 billing pads the product segment with a zero
This package
Contains30-count Pack sizes3 compare ↓
Main listing for product 72888-040 · Also comes in: 100 tablets 72888-040-02 1000 tablets 72888-040-03
Rx only Generic On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 8, 2026 · this listing last changed Oct 8, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 72888-040-01 alone.

Record
FDA NDC Directory package listing · Human prescription drug
Code segments
72888 labeler · 040 product · 01 package
Package marketed since
Sep 10, 2026
Sample package
No — commercial package
Listing certified through
Dec 31, 2027
Barcode (UPC-A, from the NDC)
3 7288804001 1
FDA record last changed
Oct 8, 2026

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 72888-040-01
Product NDC 72888-040
11-digit billing NDC 72888004001
Application # ANDA220884
SPL Set ID 5b333a2a-14ce-8106-e063-6394a90aff6c
Established class (EPC) Aldosterone Antagonist; Thiazide Diuretic
Mechanism of action Aldosterone Antagonists
Physiologic effect Increased Diuresis
Chemical class Thiazides
DEA schedule Non-controlled
Marketing category ANDA
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2026-09-10
Route ORAL
Dosage form TABLET
Substance SPIRONOLACTONE; HYDROCHLOROTHIAZIDE
TE code (Orange Book) AB · RLD · RS
Why two NDCs? The FDA registers this code as 72888-040-01 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 72888-0040-01. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

Clinical

📗 Our plain-language guide HelloPharmacist
  • It treats high blood pressure and fluid buildup from heart failure, cirrhosis, or nephrotic syndrome. It combines two diuretics that work together. It is meant for people who need...
  • Take it by mouth as your prescriber directs, once a day or split into doses. Don’t add potassium supplements unless your prescriber says so. If you’re unsure about timing or a miss...
  • Nausea, diarrhea, cramping, dizziness, headache, and tiredness can happen. Standing up slowly helps with lightheadedness. Some people notice breast tenderness or enlargement, or me...
  • Call right away for muscle weakness, an irregular heartbeat, confusion, eye pain, vision changes, a severe rash, or yellowing of your skin. Also report unusual bruising, bleeding,...
📖 Read our full Spironolactone and Hydrochlorothiazide guide →

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer eachPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Try another pack size: 100 tablets 1000 tablets
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
72888-0040-01 You're viewing this Main listing 30 TABLET in 1 BOTTLE 2026-09-10 — Active
72888-0040-02 72888-040-02 100 TABLET in 1 BOTTLE 2026-09-10 — Active
72888-0040-03 72888-040-03 1000 TABLET in 1 BOTTLE 2026-09-10 — Active

You're viewing the smallest of 3 pack sizes for this product.

Pack size FAQ

What quantity is in this package?
This is a 30-count package — 30 tablet in 1 bottle.
How does this package differ from NDC 72888-0040-02?
Both are Spironolactone and hydrochlorothiazide 25 mg; 25 mg Tablet — the drug itself is identical. This page's package is the 30-count one, while NDC 72888-0040-02 is the 100 tablets package.
What NDC number is used to bill for this package of Spironolactone and hydrochlorothiazide 25 mg; 25 mg Tablet?
Use the 11-digit billing form listed in the identifiers section of this page. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Spironolactone and Hydrochlorothiazide 25 mg/1; 25 mg 66993-0188-02 Prasco 100 tablets $0.483 AB Availability likely —
Spironolactone and Hydrochlorothiazide 25 mg/1; 25 mg 42292-0017-20 Mylan 100 tablets $0.483 AB Availability likely —
Spironolactone and Hydrochlorothiazide 25 mg/1; 25 mg 53489-0144-01 Sun 100 tablets $0.483 AB Availability likely —
Spironolactone and Hydrochlorothiazide 25 mg/1; 25 mg 00378-0403-01 Mylan 100 tablets $0.483 AB Availability likely —
Spironolactone and Hydrochlorothiazide 25 mg/1; 25 mg 63629-1068-01 Bryant 100 tablets — AB FDA listed —
Spironolactone and Hydrochlorothiazide 25 mg/1; 25 mg 63629-1071-01 Bryant 30 tablets — AB FDA listed —
Spironolactone and Hydrochlorothiazide 25 mg/1; 25 mg 71335-2202-01 Bryant 100 tablets — AB FDA listed —
Spironolactone and Hydrochlorothiazide 25 mg/1; 25 mg 63629-1069-01 Bryant 500 tablets — AB FDA listed —
Spironolactone and Hydrochlorothiazide 25 mg/1; 25 mg 71335-2674-01 Bryant 100 tablets — AB FDA listed —
Spironolactone and Hydrochlorothiazide 25 mg/1; 25 mg 72162-1625-01 Bryant 100 tablets — AB FDA listed —
Spironolactone and Hydrochlorothiazide 25 mg/1; 25 mg 48433-0090-20 Safecor 100 tablets — AB FDA listed —
Spironolactone and hydrochlorothiazide 25 mg/1; 25 mgthis 72888-0040-01 Advagen 30 tablets — AB FDA listed —
About this product: this is a generic version of the medicine. FDA equivalence ratings are shown when available, and other versions are listed above, least expensive first.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2026
On the market since
Sep 2026
📍
2026
Currently FDA-listed
listed with the FDA
🔓
·
Generic on the market
this product is a generic
✅This is a generic drug

This product is an FDA-approved generic. Other versions of the same drug are listed under Therapeutic equivalents, least expensive first.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

🧪 Avoiding an ingredient? See Spironolactone and Hydrochlorothiazide inactive ingredients by manufacturer: every current product's list side by side, so you can ask your pharmacy for the version that does not list it.

Loading inactive ingredients from the official FDA label in the background. No external source is being called by this page request.
Where does this data come from?
Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerAdvagen Pharma Ltd.
Application holderRUBICON RESEARCH LTD
FDA applicationANDA220884 (ANDA)
Labeler code72888
First marketedSep 2026
Product typeHuman Prescription Drug
Portfolio25 products on file

More NDCs from Advagen Pharma Ltd. labeler code 72888

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

Full prescribing information FDA SPL

The complete FDA label for this product — the official prescribing information, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
📄 FDA label
📄 FDA label 19 words ▾

No FDA label is on file for this product yet. Labels load from openFDA / DailyMed and refresh weekly.

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Spironolactone and hydrochlorothiazide — the ingredient across all brands.

Top reported reactions

Dyspnoea97
Fatigue73
Nausea70
Headache69
Diarrhoea68
Dizziness51
Cough48

Age at onset

Child3
Adult64
Elderly60

Reporter sex

751 reports

Serious outcomes

Hospitalization264
Death45
Life-threatening8
Disabling7
Reports over time (by year) — tap or hover for the count & year
2022 2023 2024 2026 149 45
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.

About this NDC listing & data coverage

Finished prescription product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos — Not published for this NDC No photo available yet for this listing.
Inactive ingredients (structured) — Not published for this NDC The labeler did not submit a structured excipient list, or no SPL is available.
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data ✓ Available
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by Advagen Pharma Ltd.. Listing status can change — the directory data on this page refreshes weekly.
Does this product come in other package sizes?
Yes — the FDA directory lists 2 other package presentations of this same product, including 100 tablets (72888-0040-02), 1000 tablets (72888-0040-03). Each has its own NDC and its own page — see the package list near the top of this page.
Who lists this product with the FDA?
Advagen Pharma Ltd. is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as a prescription product, so it is dispensed under a prescriber's order. Your pharmacist can tell you whether any over-the-counter forms of the same medication exist.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 72888-0039-05 · Advagen 72888-0041-13 · Advagen →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.