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Clear Anti-Itch Pramoxine HCl, Zinc acetate 10 mg/mL; 1 mg/mL Lotion, 177 mL — NDC 83324-0245-06 package photo

Clear Anti-Itch Pramoxine HCl, Zinc acetate 10 mg/mL; 1 mg/mL Lotion, 177 mL

by Chain Drug Marketing Association · 177 mL in 1 BOTTLE, PLASTIC (83324-245-06)
NDC 83324-0245-06
🏷️ FDA NDC (as labeled) 83324-245-06 billing pads the product segment with a zero
OTC On market Non-controlled
🗂️ Data synced Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

🆔 Identity & classification

FDA NDC (as labeled) 83324-245-06
Product NDC 83324-245
11-digit billing NDC 83324024506
NCPDP billing unit ML — per mL (volume)
RxCUI 1234546
UNII 88AYB867L5, FM5526K07A
Application # M016
SPL Set ID 1ff6bd85-3658-47ea-b6ca-0eb5d8dbb693
Established class (EPC) Copper Absorption Inhibitor
Physiologic effect Decreased Copper Ion Absorption
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2025-02-26
Route TOPICAL
Dosage form LOTION
Substance PRAMOXINE HYDROCHLORIDE; ZINC ACETATE
GCN Seq No 035594
GCN 96616
HICL code 013244
Ingredient (HICL) Pramoxine Hcl/Zinc Acetate
HIC1 code L
Therapeutic class — broad (HIC1) Skin/Subcutaneous Tissue
HIC2 code L3
Therapeutic class — intermediate (HIC2) Protectives
HIC3 code L3P
Therapeutic class — specific (HIC3) Antipruritics,Topical
AHFS code 84:08.00.00
AHFS class Antipruritics And Local Anesthetics
FDB label name QC CLEAR ANTI-ITCH LOTION
FDB brand name Clear Anti-Itch
Legend status O — Over-the-counter (OTC) drug or device
Why two NDCs? The FDA registers this code as 83324-245-06 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 83324-0245-06. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏷️ RxNorm drug class

This medicine belongs to the Local anesthetics class.

Drug family (ATC) Local anesthetics, Anesthetics for topical use
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

🏭 Manufacturer & labeler

LabelerChain Drug Marketing Association
FDA applicationM016 (OTC MONOGRAPH DRUG)
Labeler code83324
First marketedFeb 2025
Product typeHuman Otc Drug
Portfolio128 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

Label name QC CLEAR ANTI-ITCH LOTION Ingredient Pramoxine Hcl/Zinc Acetate
🧪 What is this product?

This is an over-the-counter topical lotion marketed under FDA's OTC monograph rules for skin-itch products. It contains pramoxine hydrochloride, a local anesthetic, and zinc acetate, which is commonly used to help soothe and dry irritated skin. Together, these ingredients are typically used to provide temporary relief from itching and minor skin irritation when applied directly to affected areas.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII 3K9958V90M
    A liquid solvent derived from fermentation or chemical synthesis. In medicines, alcohol dissolves active ingredients, helps preserve the product, and improves how the body absorbs certain drugs.
  • UNII 8SKN0B0MIM
    Benzoic acid is a naturally occurring organic acid used as a preservative in medicines and foods. It helps prevent bacterial and fungal growth to extend shelf life and maintain product stability.
  • UNII 5TJD82A1ET
    A cooling crystalline substance made synthetically that is added to medicines as a fragrance, flavoring agent, and mild local irritant to produce a cooling or warming sensation on the skin or mucous membranes.
  • UNII 2968PHW8QP
    A weak organic acid derived from citrus fruits or made through fermentation. It works as a buffer to control pH, a preservative to extend shelf life, and a flavoring agent in medications.
  • UNII PDC6A3C0OX
    Glycerin is a clear, thick liquid derived from plant oils or fats. It acts as a humectant to retain moisture, a sweetener, and a solvent in medications.
  • UNII 3NXW29V3WO
    Hypromellose is a plant-based thickener made from cellulose. It's used in medicines as a binder to hold ingredients together, a coating for tablets, and a thickener for liquids.
  • UNII ZBP1YXW0H8
    A fragrant oil extracted from lavender plants, used as a flavoring and scent agent in medicines to improve taste and aroma.
  • UNII STI11B5A2X
    Polysorbate 40 is a synthetic emulsifier derived from sorbitol and fatty acids. It helps keep oils and water mixed together in liquid medications and also improves how the product flows.
  • UNII 8LGU7VM393
    Rosemary leaf oil is a natural aromatic oil extracted from rosemary plants. It's used in medicines as a flavoring agent and preservative to help protect the product from spoilage.
  • UNII 1Q73Q2JULR
    Sodium citrate is a salt derived from citric acid. It works as a buffer to maintain the medicine's pH level and may also help improve taste or act as a preservative in the formulation.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

11 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesalcohol, benzoic acid, camphor, citric acid, fragrance, glycerin, hydroxypropyl methylcellulose, Lavandula angustifolia (lavender) oil, polysorbate 40, Rosmarinus officinalis (rosemary) leaf oil, sodium citrate, water

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly $0.013 $2.34 / 177 ml
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
NADAC price history (per mL) — tap or hover for the price & month
Dec 2025 Mar 2026 Jun 2026 Sep 2026 $0.014 $0.013
▼ Down 2% over the last 10 months.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Rugby Caldyphen Clear 10 mg/mL; 1 mg/mL 00536-1269-58 Rugby 177 ml $0.013 — Availability likely —
Caldyphen Clear 10 mg/mL; 1 mg/mL 24385-0439-30 Amerisource 177 ml $0.013 — Availability likely —
Calamine Clear 10 mg/mL; 1 mg/mL 70000-0397-01 Cardinal 177 ml $0.013 — Availability likely —
Clear Anti-Itch 10 mg/mL; 1 mg/mLthis 83324-0245-06 Chain 177 ml $0.013 — Availability likely —
Sunmark Caldyphen Clear 80 mg/mL; 10 mg/mL 49348-0610-36 Strategic 177 ml $0.015 — FDA listed +15%
Caladryl Clear 10 mg/mL; 1 mg/mL 00187-5466-06 Bausch 177 ml — — FDA listed —
calahist clear 10 mg/mL; 1 mg/mL 00363-9412-97 WALGREEN 177 ml — — FDA listed —
Humco Calaclear 10 mg/mL; 1 mg/mL 00395-0400-96 Humco 177 ml — — FDA listed —
Clear Anti-Itch 10 mg/mL; 1 mg/mL 11344-0812-30 Nice-Pak 177 ml — — FDA listed —
Clear Anti Itch 10 mg/mL; 1 mg/mL 21130-0952-30 Better 177 ml — — FDA listed —
Clear Anti Itch 10 mg/mL; 1 mg/mL 36800-0218-30 Topco 177 ml — — FDA listed —
TopCare Calaclear 10 mg/mL; 1 mg/mL 36800-0267-96 TOPCO 177 ml — — FDA listed —
Clear Anti Itch 10 mg/mL; 1 mg/mL 41163-0099-30 United 177 ml — — FDA listed —
Clear Anti-Itch 10 mg/mL; 1 mg/mL 41250-0218-30 Meijer, 177 ml — — FDA listed —
Calaclear 10 mg/mL; 1 mg/mL 49035-0402-96 Wal-Mart 177 ml — — FDA listed —
Clear Anti-Itch 10 mg/mL; 1 mg/mL 55910-0218-30 Old 177 ml — — FDA listed —
Clear Anti Itch 10 mg/mL; 1 mg/mL 59640-0218-30 H 177 ml — — FDA listed —
Quality Choice Anti-Itch Clear 80 mg/mL; 10 mg/mL 63868-0097-06 Chain 177 ml — — FDA listed —
CVS Itch Relief 10 mg/mL; 1 mg/mL 69842-0400-96 CVS 177 ml — — FDA listed —
Foster and Thrive Caldyphen Clear 10 mg/mL; 1 mg/mL 70677-1199-01 Strategic 177 ml — — FDA listed —
Clear Anti-Itch 10 mg/mL; 1 mg/mL 72476-0218-30 Retail 177 ml — — FDA listed —
Clear Anti-Itch 10 mg/mL; 1 mg/mL 75981-0218-30 Perrigo 177 ml — — FDA listed —
Calamine Clear 10 mg/mL; 1 mg/mL 82645-0400-96 Pharma 177 ml — — FDA listed —
Calaclear 10 mg/mL; 1 mg/mL 82645-0923-96 Pharma 177 ml — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️
2025
On the market since
Feb 2025
📍
2026
Currently FDA-listed
1 year listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

📦 Packaging — all sizes for this product

Package NDCDescription Marketing startStatus
83324-0245-06 You're viewing this 177 mL in 1 BOTTLE, PLASTIC (83324-245-06) 2025-02-26 Active

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🤒 Adverse Reactions 📦 Storage and Handling 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose
🎯 Indications and Usage 35 words ▾

Uses for the temporary relief of pain and itching associated with minor skin irritations and rashes due to poison ivy, poison oak, or poison sumac dries the oozing and weeping of poison: -ivy -oak -sumac

⏱️ Dosage and Administration 40 words ▾

Directions shake well before applying wash affected area of skin adults and children 2 years of age and older - apply to affected area no more than 3 to 4 times daily children under 2 years - ask a doctor

⚠️ Warnings 58 words ▾

Warnings For external use only When using this product •do not get into eyes Stop use and ask a doctor if •condition worsens •symptoms last more than 7 days or clear up and occur again within a few days Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

🤒 Adverse Reactions 16 words ▾

ADVERSE REACTION Distibuted by CDMA, Inc. Novi, MI 48375 www.qualitychoice.com Questions: 800-935-2362 SATISFACTION GUARANTEED 100% QC

📦 Storage and Handling 10 words ▾

Other information store at room temperature (59⁰ - 77⁰ F)

🧪 Active Ingredient 13 words ▾

Active ingredients Pramoxine HCl 1% Zinc acetate 0.1% Purpose External analgesic Skin protectant

🧪 Inactive Ingredients 26 words ▾

Inactive ingredients alcohol, benzoic acid, camphor, citric acid, fragrance, glycerin, hydroxypropyl methylcellulose, Lavandula angustifolia (lavender) oil, polysorbate 40, Rosmarinus officinalis (rosemary) leaf oil, sodium citrate, water

🎯 Purpose 5 words ▾

Purpose External analgesic Skin protectant

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
← 83324-0242-41 · Chain 83324-0248-06 · Chain →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.