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J0640

J0640 – Injection, leucovorin calcium, per 50 mg · NDC Crosswalk & Billing Units

HCPCS Level II J-code · Medicare Part B drug billing
J-code ● 43 NDCs crosswalked per 50 MG $2.932/unit ASP+6%

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

📋 J0640 summary

J0640 is a HCPCS Level II J-code used to bill leucovorin calcium, per 50 mg, billed per 50 MG. The number of billing units to report depends on the dose administered and the NDC/package billed — use the calculator below.

Code J0640 Billing unit 50 MG Payment limit $2.932/unit NDC-Crosswalk 43 Quarter Q3 2026 RxCUI Atlas Trace the drug concept →

⚠ An NDC↔HCPCS crosswalk and a published payment limit do not guarantee payer coverage or payment. Always verify the current payer policy and claim format before billing.

🗂️ Key billing facts

HCPCS codeJ0640
DescriptorInjection, leucovorin calcium, per 50 mg
Billing unit50 MG
Payment limit / unit$2.932
Est. ASP / unit$2.766 est.
Mapped NDCs43
Data periodQ3 2026
Last updated2026-08-20

🧾 Billing & reimbursement HCPCS · CMS · EFF. Q3 2026

📅 Payment limits effective Q3 2026 — from the CMS Medicare Part B Payment Limit File (revised quarterly).
Medicare payment limit / unit
$2.932
Est. ASP / unit
$2.766 est.
Est. after 2% sequester
$2.873
HCPCS dosage
50 MG
The CMS payment limit is the Medicare Part B drug allowance (ASP + 6%, statutory). After the 2% federal sequester the effective payment is ≈ ASP + 4.3%; estimated ASP = payment limit ÷ 1.06. Source: CMS Medicare Part B Payment Limit File (quarterly), Q3 2026.
Full HCPCS code details (official CMS record)
Long descriptionInjection, leucovorin calcium, per 50 mg
CoverageD — Special coverage instructions apply
Pricing indicator51 — Drug — priced under the ASP methodology
Type of service1 — Medical care
BETOS-2O1E
ASC payment group—
Action codeN — No maintenance this year
Effective date1997-01-01
Date added1982-01-01
Source: CMS HCPCS Level II code file (imported via admin).

🧮 Dosing & billing-units calculator HCPCS UNITS

One billing unit of J0640 = 50 mg. Enter a regimen to convert dose → billing units and project a full course.
Billing units = dose ÷ HCPCS unit size. Most payers require whole units — round per the payer's policy. “Est. Medicare pay” uses the current payment limit. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (JZ when none is discarded) where allowed. Always verify payer-specific rounding before billing.

🔁 NDCs that bill under J0640 WITH EST. MEDICARE PAY

43 NDCs map to J0640. Bill units = how many HCPCS units one package represents. Est. pay / pkg = payment limit ($2.932/unit) × that package's bill units.
NDC (11-digit)DrugLabelerPackageStrength Bill units Est. pay / pkg NADAC / unit StatusSource
00143-9368-01 Leucovorin Calcium 200 mg/20mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION Hikma 1 VIAL in 1 BOX, UNIT-DOSE (0143-9368-01)... 200 mg/20mL 4 $11.73 — ● Active CMS + PDAC
00143-9552-01 Leucovorin Calcium 350 mg/17.5mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION Hikma 1 VIAL in 1 BOX, UNIT-DOSE (0143-9552-01)... 350 mg/17.5mL 7 $20.52 — ● Active CMS + PDAC
00143-9553-01 Leucovorin Calcium 200 mg/20mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION Hikma 1 VIAL in 1 BOX, UNIT-DOSE (0143-9553-01)... 200 mg/20mL 4 $11.73 — ● Active CMS + PDAC
00143-9554-01 Leucovorin Calcium 100 mg/10mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION Hikma 1 VIAL in 1 BOX (0143-9554-01) / 10 mL in... 100 mg/10mL 2 $5.86 — ● Active CMS + PDAC
00143-9555-01 Leucovorin Calcium 50 mg/5mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION Hikma 1 VIAL in 1 BOX (0143-9555-01) / 5 mL in... 50 mg/5mL 1 $2.93 — ● Active CMS + PDAC
25021-0813-10 Leucovorin Calcium 50 mg/5mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION Sagent 10 VIAL in 1 CARTON (25021-813-10) / 5 mL... 50 mg/5mL 10 $29.32 — ● Active CMS ASP
25021-0814-30 Leucovorin Calcium 100 mg/10mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION Sagent 1 VIAL in 1 CARTON (25021-814-30) / 10 mL... 100 mg/10mL 2 $5.86 — ● Active CMS ASP
25021-0815-30 Leucovorin Calcium 200 mg/20mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION Sagent 1 VIAL in 1 CARTON (25021-815-30) / 20 mL... 200 mg/20mL 4 $11.73 — ● Active CMS ASP
25021-0816-30 Leucovorin Calcium 350 mg/17.5mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION Sagent 1 VIAL in 1 CARTON (25021-816-30) / 17.5... 350 mg/17.5mL 7 $20.52 — ● Active CMS ASP
25021-0816-67 Leucovorin Calcium Sagent — — 7 $20.52 — — CMS ASP
25021-0828-50 Leucovorin Calcium 500 mg/50mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION Sagent 1 VIAL in 1 CARTON (25021-828-50) / 50 mL... 500 mg/50mL 10 $29.32 — ● Active CMS + PDAC
63323-0631-10 Leucovorin calcium 10 mg/mL INJECTION Fresenius 1 VIAL, SINGLE-USE in 1 CARTON (63323-631-... 10 mg/mL 2 $5.86 — ● Active CMS ASP
63323-0631-50 Leucovorin calcium 10 mg/mL INJECTION Fresenius 1 VIAL, SINGLE-USE in 1 CARTON (63323-631-... 10 mg/mL 10 $29.32 — ● Active CMS ASP
63323-0710-50 Leucovorin Calcium 200 mg/20mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION Fresenius 1 VIAL in 1 BOX (63323-710-50) / 20 mL in... 200 mg/20mL 4 $11.73 — ● Active CMS ASP
63323-0711-00 Leucovorin Calcium 500 mg/50mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION Fresenius 1 VIAL in 1 BOX (63323-711-00) / 50 mL in... 500 mg/50mL 10 $29.32 — ● Active CMS ASP
67457-0528-10 LEUCOVORIN CALCIUM 100 mg/10mL INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION Mylan 1 VIAL, SINGLE-DOSE in 1 CARTON (67457-528... 100 mg/10mL 2 $5.86 — ● Active CMS + PDAC
67457-0529-20 LEUCOVORIN CALCIUM 200 mg/20mL INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION Mylan 1 VIAL, SINGLE-DOSE in 1 CARTON (67457-529... 200 mg/20mL 4 $11.73 — ● Active CMS + PDAC
67457-0530-35 LEUCOVORIN CALCIUM 350 mg/17.5mL INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION Mylan 1 VIAL, SINGLE-DOSE in 1 CARTON (67457-530... 350 mg/17.5mL 7 $20.52 — ● Active CMS + PDAC
68001-0416-36 Leucovorin Calcium 100 mg/10mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION BluePoint 1 VIAL in 1 BOX (68001-416-36) / 10 mL in... 100 mg/10mL 2 $5.86 — ● Active CMS + PDAC
68001-0417-37 Leucovorin Calcium 200 mg/20mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION BluePoint 1 VIAL in 1 BOX, UNIT-DOSE (68001-417-37)... 200 mg/20mL 4 $11.73 — ● Active CMS + PDAC
68001-0418-38 Leucovorin Calcium 350 mg/17.5mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION BluePoint 1 VIAL in 1 BOX, UNIT-DOSE (68001-418-38)... 350 mg/17.5mL 7 $20.52 — ● Active CMS + PDAC
68001-0648-36 leucovorin calcium 100 mg/10mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION BluePoint 1 VIAL, SINGLE-DOSE in 1 CARTON (68001-648... 100 mg/10mL 2 $5.86 — ● Active CMS + PDAC
68001-0649-37 leucovorin calcium 200 mg/20mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION BluePoint 1 VIAL, SINGLE-DOSE in 1 CARTON (68001-649... 200 mg/20mL 4 $11.73 — ● Active CMS + PDAC
68001-0650-38 leucovorin calcium 350 mg/17.5mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION BluePoint 1 VIAL, SINGLE-DOSE in 1 CARTON (68001-650... 350 mg/17.5mL 7 $20.52 — ● Active CMS + PDAC
68462-0767-35 Leucovorin Calcium 350 mg/17.5mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION GLENMARK 1 VIAL in 1 CARTON (68462-767-35) / 17.5... 350 mg/17.5mL 7 $20.52 — ● Active CMS + PDAC
70436-0116-82 Leucovorin Calcium 50 mg/1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION Slate 10 VIAL in 1 BOX (70436-116-82) / 1 INJEC... 50 mg/1 10 $29.32 — ● Active CMS + PDAC
70436-0117-80 Leucovorin Calcium 100 mg/1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION Slate 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLU... 100 mg/1 2 $5.86 — ● Active CMS + PDAC
70436-0118-80 Leucovorin Calcium 200 mg/1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION Slate 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLU... 200 mg/1 4 $11.73 — ● Active CMS + PDAC
70436-0119-80 Leucovorin Calcium 350 mg/1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION Slate 1 INJECTION, POWDER, LYOPHILIZED, FOR SOLU... 350 mg/1 7 $20.52 — ● Active CMS + PDAC
70436-0120-80 Leucovorin Calcium 500 mg/1 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION Slate 500 INJECTION, POWDER, LYOPHILIZED, FOR SO... 500 mg/1 10 $29.32 — ● Active CMS + PDAC
71288-0160-10 leucovorin calcium 50 mg/5mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION Meitheal 1 VIAL, SINGLE-DOSE in 1 CARTON (71288-160... 50 mg/5mL 1 $2.93 — ● Active CMS + PDAC
71288-0161-20 leucovorin calcium 100 mg/10mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION Meitheal 1 VIAL, SINGLE-DOSE in 1 CARTON (71288-161... 100 mg/10mL 2 $5.86 — ● Active CMS + PDAC
71288-0162-30 leucovorin calcium 200 mg/20mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION Meitheal 1 VIAL, SINGLE-DOSE in 1 CARTON (71288-162... 200 mg/20mL 4 $11.73 — ● Active CMS + PDAC
71288-0163-30 leucovorin calcium 350 mg/17.5mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION Meitheal 1 VIAL, SINGLE-DOSE in 1 CARTON (71288-163... 350 mg/17.5mL 7 $20.52 — ● Active CMS + PDAC
71288-0164-50 leucovorin calcium 500 mg/50mL INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION Meitheal 1 VIAL, SINGLE-DOSE in 1 CARTON (71288-164... 500 mg/50mL 10 $29.32 — ● Active CMS + PDAC
49452-4036-04 Leucovorin Calcium 1 g/g POWDER Spectrum .1 g in 1 BOTTLE (49452-4036-4) 1 g/g 20 $58.64 — ● Active PDAC
51927-2692-00 LEUCOVORIN CALCIUM (USP; ANHYDROUS) Unknown — — 20 $58.64 — — PDAC
68001-0286-38 LEUCOVORIN CALCIUM (SDV,PF,LATEX-FREE) 350 MG Unknown — — 7 $20.52 — — PDAC
68001-0285-40 LEUCOVORIN CALCIUM (SDV,PF,LATEX-FREE) 50 MG Unknown — — 1 $2.93 — — PDAC
68001-0285-37 LEUCOVORIN CALCIUM (SDV,PF,LATEX-FREE) 200 MG Unknown — — 4 $11.73 — — PDAC
68001-0285-36 LEUCOVORIN CALCIUM (PF,LATEX-FREE) 100 MG Unknown — — 2 $5.86 — — PDAC
00703-5145-01 LEUCOVORIN CALCIUM (PF) 350 MG Unknown — — 7 $20.52 — — PDAC
00703-5140-01 LEUCOVORIN CALCIUM (VIAL,PF) 100 MG Unknown — — 2 $5.86 — — PDAC
NDC→HCPCS mappings come from the CMS ASP NDC-HCPCS crosswalk; additional DME MAC / DMEPOS mappings come from PDAC and are labeled separately. NADAC from CMS (weekly). “Status” reflects the product's marketing / obsolete flag in the NDC directory. Presence or absence here does not determine Medicare coverage. Linked NDCs open the full product page.

📊 Medicare utilization & spend CMS · PART B · 2026 (Q1)

Period
Total Part B spend
$1.1M
Claims
21,924
Beneficiaries
6,357
Spend / beneficiary
$172.52
Spend / claim
$50.02
Trend by period
Where J0640 ranks among Part B drugs · 2026 (Q1) · neighbors ±5
Total spending — #371 of 824
#366 GLUCAGON EMERGENCY K... J1611 $1.16M #367 ALBUTEROL SULFATE(J7... J7613 $1.14M #368 ADZYNMA J7171 $1.14M #369 NOVAVAX COVID (EUA... 91304 $1.11M #370 ALHEMO PEN J7173 $1.11M #371 LEUCOVORIN CALCIUM J0640 $1.1M #372 TRETTEN J7181 $1.09M #373 PNEUMOVAX 23 90732 $1.09M #374 XYNTHA SOLOFUSE* J7185 $1.07M #375 DEFINITY RT* Q9957 $1.06M #376 CYTAL, PER SQUARE CE... Q4166 $1.04M
Total claims — #96 of 824
#91 SYNVISC-ONE* J7325 24,623 #92 BUPIVACAINE HCL* J0665 24,071 #93 BCG (TICE STRAIN)(J9... J9030 23,898 #94 ELUCIREM* A9573 23,837 #95 OHTUVAYRE J7601 22,564 #96 LEUCOVORIN CALCIUM J0640 21,924 #97 ABRAXANE* J9264 21,913 #98 GRANISETRON HCL J1626 21,847 #99 DEXTENZA J1096 21,748 #100 POSFREA J2468 21,414 #101 CAPECITABINE* J8522 21,052

Full breakdown by period (2)
PeriodTotal spendBeneficiariesClaims$/beneficiary$/claim
2026 (Q1) $1.1M 6,357 21,924 $172.52 $50.02
2025 (Q1-Q4) $4.59M 13,214 95,762 $347.38 $47.93
Provider-administered (Part B) spend, calculated for the whole HCPCS code (CMS does not publish Medicare spend per individual NDC). Self-administered use is covered under Part D instead. A blank patient count means fewer than 11 people — CMS hides counts that small to protect privacy. Source: CMS Medicare Quarterly Part B Spending by Drug (data.cms.gov), updated quarterly.

📈 Medicare Part B claims detail CMS PSPS · 2024

Calendar-year 2024 Medicare Part B fee-for-service activity for this HCPCS code, summed across all carriers, localities and specialties (CMS Physician/Supplier Procedure Summary). A “service” is one billed line/unit — not one claim — so counts run higher than claim counts.
Allowed charges
$4.69M
Medicare paid
$3.61M
Submitted services
1,358,934
Denial rate
6.6%
Allowed / service
$3.70
Submitted charges
$30.49M
Source: CMS Physician/Supplier Procedure Summary (PSPS), CY2024 — Medicare Part B carrier + DME fee-for-service claims (excludes Medicare Advantage). Figures are for the whole HCPCS code, which may cover uses beyond this drug. ⚠ CMS hides any figure covering fewer than 11 patients (a privacy rule), so totals — especially denials and low-volume codes — run a little low.

🗺️ Where J0640 is utilized CMS · BY PROVIDER · 2024

Medicare Part B services for this code by the rendering provider's state — 629,119 services across 43 states & territories in 2024 (CMS reports include DC and U.S. territories). Switch to per 100k to compare states fairly regardless of population. Hover or tap a state for its top ZIP codes.
Hover or tap a state to see its numbers + top ZIP codes.
Per-capita = services ÷ 2023 state population × 100,000 (so high-population states aren't automatically "hotter"). Counts reflect the provider's location, not the patient's. Providers with fewer than 11 patients are hidden by CMS for privacy, so totals run low and per-100k can be noisy in small states — read this as relative geography, not exact counts. Source: CMS Medicare Physician & Other Practitioners — by Provider and Service, 2024.

📊 What bills under J0640

J-codes are billing codes often used for drugs billed under the medical benefit. This connects the billing code to the NDC package records it covers, by ingredient and labeler.

NDC products by ingredient
leucovorin calcium 15
Leucovorin Calcium 10
LEUCOVORIN CALCIUM 3
NDC products by labeler
BluePoint Laboratories 6
Hikma Pharmaceuticals USA Inc. 5
Slate Run Pharmaceuticals, LLC 5
Meitheal Pharmaceuticals Inc. 5
Mylan Institutional LLC 3
Sagent Pharmaceuticals 2
Spectrum Laboratory Products, Inc. 1
GLENMARK PHARMACEUTICALS INC., USA 1

🗃️ Data sources & freshness

Every figure on this page is computed from public datasets. Here's what each section draws on and how current it is.
HCPCS code & descriptor
CMS HCPCS Level II code file
Loaded
Payment limit & billing unit
CMS Medicare Part B ASP Pricing File (quarterly)
Q3 2026 · as of 2026-08-20
NDC ↔ HCPCS crosswalk
CMS ASP NDC-HCPCS crosswalk + DMEPDAC (PDAC)
43 NDCs mapped
NADAC acquisition cost
CMS National Average Drug Acquisition Cost (weekly)
Not available for mapped NDCs
Utilization & spend
CMS Part B Spending by Drug · PSPS · Physician & Other Practitioners
Latest data year 2026
Figures are estimates for reference and may lag the source files. Always verify against the current CMS files and your payer's policy before submitting claims.

⚠️ Practical billing caveats

  • A crosswalk is not coverage. An NDC mapping or a published payment limit does not guarantee a payer will cover or pay this code. Check the specific plan's policy.
  • Units ≠ milligrams. Bill the number of HCPCS units (dose ÷ the code's unit size), not the milligram dose. Use the calculator above.
  • Discarded drug. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (and JZ when nothing is discarded) where the payer allows.
  • Rounding & partial units. Many payers require whole units; round per the payer's policy, not automatically up.
  • The code can cover more than this drug. Some HCPCS codes span multiple products or strengths — confirm the exact code for the product administered.
  • Figures lag. ASP limits change quarterly and utilization data are released with a delay. Verify against the current CMS files before billing.

❓ J0640 billing FAQ

What is HCPCS code J0640?
J0640 is a HCPCS Level II J-code used to bill Injection, leucovorin calcium, per 50 mg under Medicare Part B and most medical (not pharmacy) benefits.
What is the billing unit for J0640?
One unit of J0640 represents 50 MG. Report the number of units equal to the dose administered divided by 50 MG.
How many units of J0640 should I bill?
Divide the dose administered by the code's unit size (50 MG) to get the number of billing units, then round per your payer's policy. The calculator on this page converts a dose into billing units and projects a full course.
How much does Medicare pay for J0640?
The Medicare Part B payment limit is $2.932 per unit (Q3 2026), based on ASP + 6%. After the 2% sequester the effective payment is about $2.873 per unit. Payment limits are revised quarterly.
Which NDCs bill under J0640?
43 NDCs currently map to J0640 in the CMS ASP NDC-HCPCS crosswalk. See the NDC crosswalk table above for each product, package, billing units and estimated reimbursement.
Does a crosswalk mean J0640 is covered?
No. An NDC-to-HCPCS crosswalk and a published payment limit do not guarantee coverage or payment. Coverage depends on the payer, the diagnosis and the site of care — always verify the current policy before billing.
For professional billing reference only — verify against the current CMS files before submitting claims.