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J2250

J2250 – Injection, midazolam hydrochloride, per 1 mg · NDC Crosswalk & Billing Units

HCPCS Level II J-code · Medicare Part B drug billing

J-code ● 77 NDCs crosswalked per 1 MG $0.143/unit ASP+6%

This page is curated, coded, and maintained by Dr. Brian Staiger, PharmD

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

📋 J2250 summary

J2250 is a HCPCS Level II J-code used to bill midazolam hydrochloride, per 1 mg, billed per 1 MG. The number of billing units to report depends on the dose administered and the NDC/package billed — use the calculator below.

Brand names associated with J2250: Midazolam, Midazolam Hydrochloride

Code J2250 Billing unit 1 MG Payment limit $0.143/unit NDC-Crosswalk 77 Quarter Q3 2026 RxCUI Atlas Trace the drug concept →

⚠ An NDC↔HCPCS crosswalk and a published payment limit do not guarantee payer coverage or payment. Always verify the current payer policy and claim format before billing.

🗂️ Key billing facts

HCPCS codeJ2250

DescriptorInjection, midazolam hydrochloride, per 1 mg

Billing unit1 MG

Payment limit / unit$0.143

Est. ASP / unit$0.135 est.

Mapped NDCs77

Data periodQ3 2026

Last updated2026-08-20

💊 About Midazolam DRUG GUIDE

Midazolam is used in several different forms depending on the setting.

Injectable midazolam (given by IV or IM shot) is used before and during surgery or procedures — such as endoscopy, cardiac catheterization, or bronchoscopy — to cause sedation, reduce anxiety, and prevent memory of the event.

It can also be used to start general anesthesia or to keep heavily sedated, ventilated patients comfortable in a critical care unit.

Midazolam HCl oral syrup is used specifically in children for sedation and anxiety relief before procedures or anesthesia induction, in a monitored medical setting only.Nayzilam nasal spray is indicated for a different purpose: the acute treatment of seizure clusters (also called acute repetitive seizures) in people aged 12 and older who have epilepsy.

Read the full Midazolam drug guide →

Clinical overview from our editorial drug guide for Midazolam. For billing reference, see the sections above.

🧾 Billing & reimbursement HCPCS · CMS · EFF. Q3 2026

📅 Payment limits effective Q3 2026 — from the CMS Medicare Part B Payment Limit File (revised quarterly).

Medicare payment limit / unit

$0.143

Est. ASP / unit

$0.135 est.

Est. after 2% sequester

$0.140

HCPCS dosage

1 MG

The CMS payment limit is the Medicare Part B drug allowance (ASP + 6%, statutory). After the 2% federal sequester the effective payment is ≈ ASP + 4.3%; estimated ASP = payment limit ÷ 1.06. Source: CMS Medicare Part B Payment Limit File (quarterly), Q3 2026.

Full HCPCS code details (official CMS record)

Long descriptionInjection, midazolam hydrochloride, per 1 mg

CoverageD — Special coverage instructions apply

Pricing indicator51 — Drug — priced under the ASP methodology

Type of service1 — Medical care

BETOS-2O1E

ASC payment group—

Action codeN — No maintenance this year

Effective date1997-01-01

Date added1996-01-01

Source: CMS HCPCS Level II code file (imported via admin).

🧮 Dosing & billing-units calculator HCPCS UNITS

One billing unit of J2250 = 1 mg. Enter a regimen to convert dose → billing units and project a full course.

Dose per administration (mg) Frequency — every days Number of doses NDC / package billed (optional)

Billing units = dose ÷ HCPCS unit size. Most payers require whole units — round per the payer's policy. “Est. Medicare pay” uses the current payment limit. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (JZ when none is discarded) where allowed. Always verify payer-specific rounding before billing.

🔁 NDCs that bill under J2250 LEAST EXPENSIVE FIRST

77 NDCs map to J2250. Bill units = how many HCPCS units one package represents. Est. pay / pkg = payment limit ($0.143/unit) × that package's bill units.

NDC (11-digit)	Drug	Labeler	Package	Strength	Bill units	Est. pay / pkg	NADAC / unit	Status	Source
00641-6057-25	Midazolam 1 mg/mL INJECTION	Hikma	25 VIAL in 1 CARTON (0641-6057-25) / 2 mL...	1 mg/mL	50	$7.15	$0.234	● Active	CMS ASP
00641-6209-25	Midazolam 1 mg/mL INJECTION	Hikma	25 VIAL in 1 CARTON (0641-6209-25) / 2 mL...	1 mg/mL	50	$7.15	$0.234	● Active	CMS ASP
00641-6281-25	Midazolam 1 mg/mL INJECTION	Hikma	25 VIAL in 1 CARTON (0641-6281-25) / 2 mL...	1 mg/mL	50	$7.15	$0.234	● Active	CMS + PDAC
23155-0600-41	Midazolam hydrochloride 1 mg/mL INJECTION, SOLUTION	Heritage	25 VIAL, SINGLE-DOSE in 1 CARTON (23155-60...	1 mg/mL	50	$7.15	$0.234	● Active	CMS + PDAC
63323-0411-12	Midazolam 1 mg/mL INJECTION, SOLUTION	Fresenius	25 VIAL in 1 TRAY (63323-411-12) / 2 mL i...	1 mg/mL	50	$7.15	$0.234	● Active	CMS + PDAC
72572-0430-25	Midazolam 1 mg/mL INJECTION	Civica,	25 VIAL in 1 CARTON (72572-430-25) / 2 mL...	1 mg/mL	50	$7.15	$0.234	● Active	CMS + PDAC
00409-2596-05	Midazolam 5 mg/mL INJECTION, SOLUTION	Hospira,	10 VIAL, MULTI-DOSE in 1 CARTON (0409-2596...	5 mg/mL	500	$71.50	$0.382	● Active	CMS + PDAC
00641-6060-10	Midazolam 5 mg/mL INJECTION	Hikma	10 VIAL in 1 CARTON (0641-6060-10) / 10 m...	5 mg/mL	500	$71.50	$0.382	● Active	CMS ASP
00641-6190-10	Midazolam 5 mg/mL INJECTION	Hikma	10 VIAL in 1 CARTON (0641-6190-10) / 10 m...	5 mg/mL	500	$71.50	$0.382	● Active	CMS ASP
00641-6211-10	Midazolam 5 mg/mL INJECTION	Hikma	10 VIAL in 1 CARTON (0641-6211-10) / 10 m...	5 mg/mL	500	$71.50	$0.382	● Active	CMS ASP
23155-0601-42	Midazolam hydrochloride 5 mg/mL INJECTION, SOLUTION	Heritage	10 VIAL, MULTI-DOSE in 1 CARTON (23155-601...	5 mg/mL	500	$71.50	$0.382	● Active	CMS + PDAC
00409-0001-25	Midazolam 1 mg/mL INJECTION, SOLUTION	Hospira,	25 VIAL, SINGLE-DOSE in 1 CARTON (0409-000...	1 mg/mL	50	$7.15	$0.420	● Active	CMS + PDAC
00409-2305-17	MIDAZOLAM 1 mg/mL INJECTION, SOLUTION	Hospira,	25 VIAL, SINGLE-DOSE in 1 TRAY (0409-2305-...	1 mg/mL	50	$7.15	$0.420	● Active	CMS ASP
25021-0661-10	midazolam 5 mg/mL INJECTION, SOLUTION	Sagent	10 VIAL in 1 CARTON (25021-661-10) / 10 m...	5 mg/mL	500	$71.50	$0.450	● Active	CMS ASP
63323-0412-10	Midazolam 5 mg/mL INJECTION, SOLUTION	Fresenius	10 VIAL in 1 TRAY (63323-412-10) / 10 mL...	5 mg/mL	500	$71.50	$0.450	● Active	CMS + PDAC
00641-6063-25	Midazolam 5 mg/mL INJECTION	Hikma	25 VIAL in 1 CARTON (0641-6063-25) / 2 mL...	5 mg/mL	250	$35.75	$0.505	● Active	CMS ASP
00409-2308-02	MIDAZOLAM 5 mg/mL INJECTION, SOLUTION	Hospira,	10 VIAL, SINGLE-DOSE in 1 CARTON (0409-230...	5 mg/mL	100	$14.30	$0.567	● Active	CMS + PDAC
00409-2308-50	MIDAZOLAM 5 mg/mL INJECTION, SOLUTION	Hospira,	10 VIAL, SINGLE-DOSE in 1 CARTON (0409-230...	5 mg/mL	100	$14.30	$0.567	● Active	CMS + PDAC
00409-2308-01	MIDAZOLAM 5 mg/mL INJECTION, SOLUTION	Hospira,	10 VIAL, SINGLE-DOSE in 1 CARTON (0409-230...	5 mg/mL	50	$7.15	$1.221	● Active	CMS + PDAC
00409-2308-49	MIDAZOLAM 5 mg/mL INJECTION, SOLUTION	Hospira,	10 VIAL, SINGLE-DOSE in 1 CARTON (0409-230...	5 mg/mL	50	$7.15	$1.221	● Active	CMS + PDAC
00404-9780-10	Midazolam 1 mg/mL INJECTION	Henry	1 VIAL in 1 BAG (0404-9780-10) / 10 mL in...	1 mg/mL	10	$1.43	—	● Active	CMS ASP
00404-9801-10	Midazolam 5 mg/mL INJECTION	Henry	1 VIAL in 1 BAG (0404-9801-10) / 10 mL in...	5 mg/mL	50	$7.15	—	● Active	CMS ASP
00404-9912-10	Midazolam HCl	Henry	—	—	10	$1.43	—	—	CMS ASP
00404-9913-05	Midazolam 1 mg/mL INJECTION	Henry	1 VIAL in 1 BAG (0404-9913-05) / 5 mL in...	1 mg/mL	5	$0.72	—	● Active	CMS ASP
00404-9914-10	Midazolam HCl	Henry	—	—	50	$7.15	—	—	CMS ASP
00404-9915-05	Midazolam 5 mg/mL INJECTION, SOLUTION	Henry	1 VIAL in 1 BAG (0404-9915-05) / 5 mL in...	5 mg/mL	25	$3.58	—	● Active	CMS ASP
00404-9916-01	Midazolam Hydrochloride 5 mg/mL INJECTION, SOLUTION	Henry	1 VIAL, SINGLE-DOSE in 1 BAG (0404-9916-01...	5 mg/mL	5	$0.72	—	● Active	CMS ASP
00404-9916-02	Midazolam Hydrochloride 5 mg/mL INJECTION, SOLUTION	Henry	1 VIAL, SINGLE-DOSE in 1 BAG (0404-9916-02...	5 mg/mL	10	$1.43	—	● Active	CMS ASP
00409-2305-05	MIDAZOLAM 1 mg/mL INJECTION, SOLUTION	Hospira,	10 VIAL, SINGLE-DOSE in 1 CARTON (0409-230...	1 mg/mL	50	$7.15	—	● Active	CMS + PDAC
00409-2305-50	MIDAZOLAM 1 mg/mL INJECTION, SOLUTION	Hospira,	10 VIAL, SINGLE-DOSE in 1 CARTON (0409-230...	1 mg/mL	50	$7.15	—	● Active	CMS + PDAC
00409-2587-05	Midazolam 1 mg/mL INJECTION, SOLUTION	Hospira,	10 VIAL, MULTI-DOSE in 1 CARTON (0409-2587...	1 mg/mL	100	$14.30	—	● Active	CMS + PDAC
00409-2596-03	Midazolam 5 mg/mL INJECTION, SOLUTION	Hospira,	10 VIAL, MULTI-DOSE in 1 CARTON (0409-2596...	5 mg/mL	250	$35.75	—	● Active	CMS + PDAC
00641-6056-10	Midazolam 1 mg/mL INJECTION	Hikma	10 VIAL in 1 CARTON (0641-6056-10) / 10 m...	1 mg/mL	100	$14.30	—	● Active	CMS ASP
00641-6059-10	Midazolam 1 mg/mL INJECTION	Hikma	10 VIAL in 1 CARTON (0641-6059-10) / 5 mL...	1 mg/mL	50	$7.15	—	● Active	CMS ASP
00641-6061-25	Midazolam 5 mg/mL INJECTION	Hikma	25 VIAL in 1 CARTON (0641-6061-25) / 1 mL...	5 mg/mL	125	$17.88	—	● Active	CMS ASP
00641-6210-10	Midazolam 1 mg/mL INJECTION	Hikma	10 VIAL in 1 CARTON (0641-6210-10) / 5 mL...	1 mg/mL	50	$7.15	—	● Active	CMS ASP
00641-6219-10	Midazolam 5 mg/mL INJECTION	Hikma	10 SYRINGE in 1 CARTON (0641-6219-10) / 2...	5 mg/mL	100	$14.30	—	● Active	CMS + PDAC
00641-6220-10	Midazolam 1 mg/mL INJECTION	Hikma	10 SYRINGE in 1 CARTON (0641-6220-10) / 2...	1 mg/mL	20	$2.86	—	● Active	CMS + PDAC
23155-0601-41	Midazolam hydrochloride 5 mg/mL INJECTION, SOLUTION	Heritage	10 VIAL, MULTI-DOSE in 1 CARTON (23155-601...	5 mg/mL	250	$35.75	—	● Active	CMS + PDAC
25021-0655-02	midazolam 1 mg/mL INJECTION, SOLUTION	Sagent	10 VIAL in 1 CARTON (25021-655-02) / 2 mL...	1 mg/mL	20	$2.86	—	● Active	CMS ASP
50090-5342-00	Midazolam Hydrochloride 5 mg/mL INJECTION, SOLUTION	A-S	10 VIAL in 1 BOX (50090-5342-0) / 10 mL i...	5 mg/mL	500	$71.50	—	● Active	CMS ASP
50090-5342-01	Midazolam Hydrochloride 5 mg/mL INJECTION, SOLUTION	A-S	10 mL in 1 VIAL (50090-5342-1)	5 mg/mL	50	$7.15	—	● Active	CMS ASP
50090-5472-00	Midazolam Hydrochloride 1 mg/mL INJECTION, SOLUTION	A-S	10 VIAL in 1 BOX (50090-5472-0) / 10 mL i...	1 mg/mL	100	$14.30	—	● Active	CMS ASP
63323-0411-10	Midazolam 1 mg/mL INJECTION, SOLUTION	Fresenius	10 VIAL in 1 TRAY (63323-411-10) / 10 mL...	1 mg/mL	100	$14.30	—	● Active	CMS + PDAC
63323-0411-25	Midazolam 1 mg/mL INJECTION, SOLUTION	Fresenius	25 VIAL in 1 TRAY (63323-411-25) / 5 mL i...	1 mg/mL	125	$17.88	—	● Active	CMS + PDAC
63323-0412-02	Midazolam 5 mg/mL INJECTION, SOLUTION	Fresenius	10 VIAL in 1 TRAY (63323-412-02) / 2 mL i...	5 mg/mL	100	$14.30	—	● Active	CMS + PDAC
63323-0412-25	Midazolam 5 mg/mL INJECTION, SOLUTION	Fresenius	25 VIAL in 1 TRAY (63323-412-25) / 1 mL i...	5 mg/mL	125	$17.88	—	● Active	CMS + PDAC
70069-0816-10	Midazolam 2 mg/2mL INJECTION, SOLUTION	SOMERSET	10 VIAL in 1 CARTON (70069-816-10) / 2 mL...	2 mg/2mL	20	$2.86	—	● Active	CMS + PDAC
70860-0600-02	Midazolam HCl	Athenex	—	—	50	$7.15	—	—	CMS + PDAC
70860-0601-05	Midazolam HCl	Athenex	—	—	250	$35.75	—	—	CMS + PDAC
70860-0601-10	Midazolam HCl	Athenex	—	—	500	$71.50	—	—	CMS + PDAC
72572-0432-10	Midazolam 1 mg/mL INJECTION	Civica,	10 VIAL in 1 CARTON (72572-432-10) / 5 mL...	1 mg/mL	50	$7.15	—	● Active	CMS + PDAC
72611-0741-25	Midazolam HCl	Almaject,	—	—	50	$7.15	—	—	CMS + PDAC
72611-0749-10	Midazolam HCl	Almaject,	—	—	500	$71.50	—	—	CMS + PDAC
76045-0001-20	Midazolam 2 mg/2mL INJECTION, SOLUTION	Fresenius	24 BLISTER PACK in 1 CARTON (76045-001-20)...	2 mg/2mL	48	$6.86	—	● Active	CMS + PDAC
76045-0211-20	Midazolam 2 mg/2mL INJECTION, SOLUTION	Fresenius	24 BLISTER PACK in 1 CARTON (76045-211-20)...	2 mg/2mL	48	$6.86	—	● Active	CMS + PDAC
70069-0817-10	Midazolam 5 mg/5mL INJECTION, SOLUTION	SOMERSET	10 VIAL in 1 CARTON (70069-817-10) / 5 mL...	5 mg/5mL	1	$0.14	—	● Active	PDAC
76045-0002-10	Midazolam 5 mg/mL INJECTION, SOLUTION	Fresenius	24 BLISTER PACK in 1 CARTON (76045-002-10)...	5 mg/mL	5	$0.72	—	● Active	PDAC
00409-2305-61	MIDAZOLAM HCL AMERINET CHOICE (VIAL,FLIPTOP,PF) 1 MG/ML	Unknown	—	—	1	$0.14	—	—	PDAC
00409-2305-62	MIDAZOLAM HCL AMERINET CHOICE (VIAL,FLIPTOP,PF) 1 MG/ML	Unknown	—	—	1	$0.14	—	—	PDAC
47781-0589-17	MIDAZOLAM HCL (LATEX-FREE) 5 MG/1 ML	Unknown	—	—	5	$0.72	—	—	PDAC
47781-0588-68	MIDAZOLAM HCL (LATEX-FREE) 1 MG/1 ML	Unknown	—	—	1	$0.14	—	—	PDAC
47781-0589-91	MIDAZOLAM HCL (LATEX-FREE) 5 MG/1 ML	Unknown	—	—	5	$0.72	—	—	PDAC
76045-0003-20	MIDAZOLAM (PF) 5 MG/ML	Unknown	—	—	5	$0.72	—	—	PDAC
64679-0764-03	MIDAZOLAM (SDV,PF) 1 MG/1 ML	Unknown	—	—	1	$0.14	—	—	PDAC
64679-0764-01	MIDAZOLAM (SDV,PF) 1 MG/1 ML	Unknown	—	—	1	$0.14	—	—	PDAC
64679-0764-02	MIDAZOLAM (SDV,PF) 1 MG/1 ML	Unknown	—	—	1	$0.14	—	—	PDAC
64679-0765-01	MIDAZOLAM (SDV,PF) 5 MG/1 ML	Unknown	—	—	5	$0.72	—	—	PDAC
64679-0764-04	MIDAZOLAM (SDV,PF) 1 MG/1 ML	Unknown	—	—	1	$0.14	—	—	PDAC
64679-0765-04	MIDAZOLAM (SDV,PF) 5 MG/1 ML	Unknown	—	—	5	$0.72	—	—	PDAC
64679-0765-03	MIDAZOLAM (SDV,PF) 5 MG/1 ML	Unknown	—	—	5	$0.72	—	—	PDAC
64679-0765-02	MIDAZOLAM (SDV,PF) 5 MG/1 ML	Unknown	—	—	5	$0.72	—	—	PDAC
00409-2596-52	NOVAPLUS MIDAZOLAM HYDROCHLORIDE (10X5ML) 5 MG/ML	Unknown	—	—	5	$0.72	—	—	PDAC
00409-2596-53	MIDAZOLAM HCL NOVATION (FTV,10X10ML,LATEX-FREE) 5 MG/ML	Unknown	—	—	5	$0.72	—	—	PDAC
00409-2307-60	MIDAZOLAM HCL (10X1ML,PF,CARPUJECT) 5 MG/ML	Unknown	—	—	5	$0.72	—	—	PDAC
00409-2306-62	MIDAZOLAM HCL (LUER LOCK,STERILE,PF) 1 MG/ML	Unknown	—	—	1	$0.14	—	—	PDAC
63323-0412-05	MIDAZOLAM HCL (M.D.V.) 5 MG/ML	Unknown	—	—	5	$0.72	—	—	PDAC

NDC→HCPCS mappings come from the CMS ASP NDC-HCPCS crosswalk; additional DME MAC / DMEPOS mappings come from PDAC and are labeled separately. NADAC from CMS (weekly). “Status” reflects the product's marketing / obsolete flag in the NDC directory. Presence or absence here does not determine Medicare coverage. Linked NDCs open the full product page.

📊 Medicare utilization & spend CMS · PART B · 2026 (Q1)

Period

Total Part B spend

$8K

Claims

19,674

Beneficiaries

16,364

Spend / beneficiary

$0.49

Spend / claim

$0.40

Trend by period

Where J2250 ranks among Part B drugs · 2026 (Q1) · neighbors ±5

Total spending — #695 of 824

#690 DEXTROSE IN WATER(J7... J7060 $9.4K #691 CEFTAZIDIME* J0713 $9.3K #692 BLEOMYCIN SULFATE J9040 $9.1K #693 MORPHINE SULFATE(J22... J2270 $8.2K #694 BUPIVACAINE HCL* J0665 $8.1K #695 MIDAZOLAM HCL J2250 $8K #696 PFIZER COVID (6M-4... 91318 $7.4K #697 BORTEZOMIB(J9049) J9049 $6.9K #698 ARGATROBAN-0.9% NACL... J0883 $6.7K #699 DIHYDROERGOTAMINE ME... J1110 $6.5K #700 PROGRAF(J7525)* J7525 $6.4K

Total claims — #111 of 824

#106 MONOVISC J7327 20,428 #107 ZILRETTA J3304 20,149 #108 UDENYCA AUTOINJECTOR... Q5111 19,977 #109 HYMOVIS ONE* J7322 19,847 #110 OSENVELT* Q5157 19,782 #111 MIDAZOLAM HCL J2250 19,674 #112 RITUXAN J9312 19,253 #113 AZACITIDINE* J9025 19,241 #114 EMEND* J1453 19,071 #115 ALBUKED-25(P9047)* P9047 18,777 #116 MONOFERRIC J1437 18,337

Full breakdown by period (2)

Period	Total spend	Beneficiaries	Claims	$/beneficiary	$/claim
2026 (Q1)	$8K	16,364	19,674	$0.49	$0.40
2025 (Q1-Q4)	$37.1K	57,212	90,965	$0.65	$0.41

Provider-administered (Part B) spend, calculated for the whole HCPCS code (CMS does not publish Medicare spend per individual NDC). Self-administered use is covered under Part D instead. A blank patient count means fewer than 11 people — CMS hides counts that small to protect privacy. Source: CMS Medicare Quarterly Part B Spending by Drug (data.cms.gov), updated quarterly.

📈 Medicare Part B claims detail CMS PSPS · 2024

Calendar-year 2024 Medicare Part B fee-for-service activity for this HCPCS code, summed across all carriers, localities and specialties (CMS Physician/Supplier Procedure Summary). A “service” is one billed line/unit — not one claim — so counts run higher than claim counts.

Allowed charges

$33.5K

Medicare paid

$25.5K

Submitted services

301,274

Denial rate

21.6%

Allowed / service

$0.14

Submitted charges

$2.72M

Source: CMS Physician/Supplier Procedure Summary (PSPS), CY2024 — Medicare Part B carrier + DME fee-for-service claims (excludes Medicare Advantage). Figures are for the whole HCPCS code, which may cover uses beyond this drug. ⚠ CMS hides any figure covering fewer than 11 patients (a privacy rule), so totals — especially denials and low-volume codes — run a little low.

🗺️ Where J2250 is utilized CMS · BY PROVIDER · 2024

Medicare Part B services for this code by the rendering provider's state — 243,537 services across 49 states & territories in 2024 (CMS reports include DC and U.S. territories). Switch to per 100k to compare states fairly regardless of population. Hover or tap a state for its top ZIP codes.

Hover or tap a state to see its numbers + top ZIP codes.

Per-capita = services ÷ 2023 state population × 100,000 (so high-population states aren't automatically "hotter"). Counts reflect the provider's location, not the patient's. Providers with fewer than 11 patients are hidden by CMS for privacy, so totals run low and per-100k can be noisy in small states — read this as relative geography, not exact counts. Source: CMS Medicare Physician & Other Practitioners — by Provider and Service, 2024.

📊 What bills under J2250

J-codes are billing codes often used for drugs billed under the medical benefit. This connects the billing code to the NDC package records it covers, by ingredient and labeler.

NDC products by ingredient

MIDAZOLAM HYDROCHLORIDE 14

Midazolam 7

Midazolam hydrochloride 3

Midazolam Hydrochloride 3

midazolam hydrochloride 2

NDC products by labeler

Hospira, Inc. 12

Fresenius Kabi USA, LLC 5

Civica, Inc. 4

Hikma Pharmaceuticals USA Inc. 3

Heritage Pharmaceuticals Inc. d/b/... 3

SOMERSET THERAPEUTICS, LLC 2

🗃️ Data sources & freshness

Every figure on this page is computed from public datasets. Here's what each section draws on and how current it is.

HCPCS code & descriptor

CMS HCPCS Level II code file

Loaded

Payment limit & billing unit

CMS Medicare Part B ASP Pricing File (quarterly)

Q3 2026 · as of 2026-08-20

NDC ↔ HCPCS crosswalk

CMS ASP NDC-HCPCS crosswalk + DMEPDAC (PDAC)

77 NDCs mapped

NADAC acquisition cost

CMS National Average Drug Acquisition Cost (weekly)

Available for mapped NDCs

Utilization & spend

CMS Part B Spending by Drug · PSPS · Physician & Other Practitioners

Latest data year 2026

Figures are estimates for reference and may lag the source files. Always verify against the current CMS files and your payer's policy before submitting claims.

⚠️ Practical billing caveats

A crosswalk is not coverage. An NDC mapping or a published payment limit does not guarantee a payer will cover or pay this code. Check the specific plan's policy.
Units ≠ milligrams. Bill the number of HCPCS units (dose ÷ the code's unit size), not the milligram dose. Use the calculator above.
Discarded drug. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (and JZ when nothing is discarded) where the payer allows.
Rounding & partial units. Many payers require whole units; round per the payer's policy, not automatically up.
The code can cover more than this drug. Some HCPCS codes span multiple products or strengths — confirm the exact code for the product administered.
Figures lag. ASP limits change quarterly and utilization data are released with a delay. Verify against the current CMS files before billing.

❓ J2250 billing FAQ

What is HCPCS code J2250?

J2250 is a HCPCS Level II J-code used to bill Injection, midazolam hydrochloride, per 1 mg under Medicare Part B and most medical (not pharmacy) benefits.

What is the billing unit for J2250?

One unit of J2250 represents 1 MG. Report the number of units equal to the dose administered divided by 1 MG.

How many units of J2250 should I bill?

Divide the dose administered by the code's unit size (1 MG) to get the number of billing units, then round per your payer's policy. The calculator on this page converts a dose into billing units and projects a full course.

How much does Medicare pay for J2250?

The Medicare Part B payment limit is $0.143 per unit (Q3 2026), based on ASP + 6%. After the 2% sequester the effective payment is about $0.140 per unit. Payment limits are revised quarterly.

Which NDCs bill under J2250?

77 NDCs currently map to J2250 in the CMS ASP NDC-HCPCS crosswalk. See the NDC crosswalk table above for each product, package, billing units and estimated reimbursement.

Does a crosswalk mean J2250 is covered?

No. An NDC-to-HCPCS crosswalk and a published payment limit do not guarantee coverage or payment. Coverage depends on the payer, the diagnosis and the site of care — always verify the current policy before billing.

For professional billing reference only — verify against the current CMS files before submitting claims.