J2405 NDC Crosswalk, Billing Units, ASP Payment & Medicare Reimbursement

📋 J2405 summary

J2405 is a HCPCS Level II J-code used to bill ondansetron hydrochloride, per 1 mg, billed per 1 MG. The number of billing units to report depends on the dose administered and the NDC/package billed — use the calculator below.

Brand names associated with J2405: Ondansetron Hcl(J2405), Ondansetron, Ondansetron Hydrochloride

Code J2405 Billing unit 1 MG Payment limit $0.088/unit NDC-Crosswalk 44 Quarter Q3 2026 RxCUI Atlas Trace the drug concept →

⚠ An NDC↔HCPCS crosswalk and a published payment limit do not guarantee payer coverage or payment. Always verify the current payer policy and claim format before billing.

🗂️ Key billing facts

HCPCS codeJ2405

DescriptorInjection, ondansetron hydrochloride, per 1 mg

Billing unit1 MG

Payment limit / unit$0.088

Est. ASP / unit$0.083 est.

Mapped NDCs44

Data periodQ3 2026

Last updated2026-08-20

💊 About Ondansetron DRUG GUIDE

Ondansetron is used to prevent nausea and vomiting in several situations.

Oral forms (tablets, orally disintegrating tablets, and oral solution) are approved to prevent nausea and vomiting from highly or moderately emetogenic (nausea-causing) cancer chemotherapy, from radiation therapy to the abdomen or whole body, and from surgery.Ondansetron injection (given intravenously or intramuscularly in a clinical setting) is approved to prevent nausea and vomiting from emetogenic cancer chemotherapy — including high-dose cisplatin — in adults and children as young as 6 months old, as well as to prevent postoperative nausea and vomiting.

Read the full Ondansetron drug guide →

Clinical overview from our editorial drug guide for Ondansetron. For billing reference, see the sections above.

🧾 Billing & reimbursement HCPCS · CMS · EFF. Q3 2026

📅 Payment limits effective Q3 2026 — from the CMS Medicare Part B Payment Limit File (revised quarterly).

Medicare payment limit / unit

$0.088

Est. ASP / unit

$0.083 est.

Est. after 2% sequester

$0.086

HCPCS dosage

1 MG

The CMS payment limit is the Medicare Part B drug allowance (ASP + 6%, statutory). After the 2% federal sequester the effective payment is ≈ ASP + 4.3%; estimated ASP = payment limit ÷ 1.06. Source: CMS Medicare Part B Payment Limit File (quarterly), Q3 2026.

Full HCPCS code details (official CMS record)

Long descriptionInjection, ondansetron hydrochloride, per 1 mg

CoverageD — Special coverage instructions apply

Pricing indicator51 — Drug — priced under the ASP methodology

Type of service1 — Medical care

BETOS-2O1E

ASC payment group—

Action codeN — No maintenance this year

Effective date1997-01-01

Date added1993-01-01

Source: CMS HCPCS Level II code file (imported via admin).

🧮 Dosing & billing-units calculator HCPCS UNITS

One billing unit of J2405 = 1 mg. Enter a regimen to convert dose → billing units and project a full course.

Dose per administration (mg) Frequency — every days Number of doses NDC / package billed (optional)

Billing units = dose ÷ HCPCS unit size. Most payers require whole units — round per the payer's policy. “Est. Medicare pay” uses the current payment limit. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (JZ when none is discarded) where allowed. Always verify payer-specific rounding before billing.

🔁 NDCs that bill under J2405 LEAST EXPENSIVE FIRST

44 NDCs map to J2405. Bill units = how many HCPCS units one package represents. Est. pay / pkg = payment limit ($0.088/unit) × that package's bill units.

NDC (11-digit)	Drug	Labeler	Package	Strength	Bill units	Est. pay / pkg	NADAC / unit	Status	Source
16729-0298-05	ondansetron 2 mg/mL INJECTION	Accord	20 mL in 1 VIAL (16729-298-05)	2 mg/mL	40	$3.52	$0.164	● Active	CMS + PDAC
00409-4759-01	Ondansetron 2 mg/mL INJECTION, SOLUTION	Hospira,	1 VIAL, MULTI-DOSE in 1 CARTON (0409-4759-...	2 mg/mL	40	$3.52	$0.170	● Active	CMS + PDAC
00641-6079-01	Ondansetron 2 mg/mL INJECTION	Hikma	20 mL in 1 CARTON (0641-6079-01)	2 mg/mL	40	$3.52	$0.170	● Active	CMS ASP
00641-6286-01	Ondansetron 2 mg/mL INJECTION	Hikma	20 mL in 1 VIAL, MULTI-DOSE (0641-6286-01)	2 mg/mL	40	$3.52	$0.170	● Active	CMS + PDAC
23155-0549-31	ONDANSETRON 2 mg/mL INJECTION	Heritage	1 VIAL in 1 CARTON (23155-549-31) / 20 mL...	2 mg/mL	40	$3.52	$0.170	● Active	CMS + PDAC
23155-0550-31	ONDANSETRON 2 mg/mL INJECTION	Heritage	1 VIAL in 1 CARTON (23155-550-31) / 20 mL...	2 mg/mL	40	$3.52	$0.170	● Active	CMS ASP
63323-0374-20	Ondansetron 2 mg/mL INJECTION	Fresenius	1 VIAL in 1 BOX (63323-374-20) / 20 mL in...	2 mg/mL	40	$3.52	$0.170	● Active	CMS + PDAC
72266-0124-01	Ondansetron 2 mg/mL INJECTION	Fosun	1 VIAL in 1 CARTON (72266-124-01) / 20 mL...	2 mg/mL	40	$3.52	$0.170	● Active	CMS + PDAC
00409-0009-25	Ondansetron 2 mg/mL INJECTION, SOLUTION	Hospira,	25 VIAL, SINGLE-DOSE in 1 TRAY (0409-0009-...	2 mg/mL	100	$8.80	$0.177	● Active	CMS + PDAC
00409-2271-25	Ondansetron 2 mg/mL INJECTION, SOLUTION	Hospira,	25 VIAL, SINGLE-DOSE in 1 TRAY (0409-2271-...	2 mg/mL	100	$8.80	$0.177	● Active	CMS + PDAC
00409-4755-03	Ondansetron 2 mg/mL INJECTION, SOLUTION	Hospira,	25 VIAL, SINGLE-DOSE in 1 TRAY (0409-4755-...	2 mg/mL	100	$8.80	$0.177	● Active	CMS ASP
00641-6078-25	Ondansetron 2 mg/mL INJECTION	Hikma	25 VIAL in 1 CARTON (0641-6078-25) / 2 mL...	2 mg/mL	100	$8.80	$0.177	● Active	CMS ASP
00641-6080-25	Ondansetron 2 mg/mL INJECTION	Hikma	25 VIAL in 1 CARTON (0641-6080-25) / 2 mL...	2 mg/mL	100	$8.80	$0.177	● Active	CMS ASP
23155-0547-42	ONDANSETRON 2 mg/mL INJECTION	Heritage	25 VIAL in 1 CARTON (23155-547-42) / 2 mL...	2 mg/mL	100	$8.80	$0.177	● Active	CMS + PDAC
23155-0548-42	ONDANSETRON 2 mg/mL INJECTION	Heritage	25 VIAL in 1 CARTON (23155-548-42) / 2 mL...	2 mg/mL	100	$8.80	$0.177	● Active	CMS ASP
25021-0777-02	ondansetron 2 mg/mL INJECTION, SOLUTION	Sagent	25 VIAL in 1 CARTON (25021-777-02) / 2 mL...	2 mg/mL	100	$8.80	$0.177	● Active	CMS ASP
36000-0012-25	ONDANSETRON HYDROCHLORIDE 2 mg/mL SOLUTION	Baxter	25 VIAL, SINGLE-DOSE in 1 CARTON (36000-01...	2 mg/mL	100	$8.80	$0.177	● Active	CMS ASP
60505-6130-05	ONDANSETRON 2 mg/mL INJECTION	Apotex	25 VIAL, SINGLE-USE in 1 CARTON (60505-613...	2 mg/mL	100	$8.80	$0.177	● Active	CMS + PDAC
63323-0373-02	Ondansetron 2 mg/mL INJECTION	Fresenius	25 VIAL in 1 TRAY (63323-373-02) / 2 mL i...	2 mg/mL	100	$8.80	$0.177	● Active	CMS + PDAC
65219-0323-02	Ondansetron 2 mg/mL INJECTION	Fresenius	25 VIAL in 1 TRAY (65219-323-02) / 2 mL i...	2 mg/mL	100	$8.80	$0.177	● Active	CMS + PDAC
72266-0123-25	Ondansetron 2 mg/mL INJECTION	Fosun	25 VIAL in 1 CARTON (72266-123-25) / 2 mL...	2 mg/mL	100	$8.80	$0.177	● Active	CMS + PDAC
72572-0520-25	Ondansetron 2 mg/mL INJECTION	Civica,	25 VIAL in 1 CARTON (72572-520-25) / 2 mL...	2 mg/mL	100	$8.80	$0.177	● Active	CMS + PDAC
00404-9930-02	ONDANSETRON 2 mg/mL INJECTION	Henry	1 VIAL, SINGLE-USE in 1 BAG (0404-9930-02)...	2 mg/mL	4	$0.35	—	● Active	CMS ASP
51662-1245-01	ONDANSETRON 2 mg/mL INJECTION	HF	2 mL in 1 VIAL, SINGLE-DOSE (51662-1245-1)	2 mg/mL	4	$0.35	—	● Active	CMS ASP
51662-1245-03	ONDANSETRON 2 mg/mL INJECTION	HF	25 POUCH in 1 CASE (51662-1245-3) / 1 VIA...	2 mg/mL	100	$8.80	—	● Active	CMS ASP
51662-1377-01	ONDANSETRON 2 mg/mL INJECTION	HF	20 mL in 1 VIAL (51662-1377-1)	2 mg/mL	40	$3.52	—	● Active	CMS ASP
70860-0776-02	Ondansetron HCl	Athenex	—	—	100	$8.80	—	—	CMS + PDAC
70860-0777-21	Ondansetron HCl	Athenex	—	—	400	$35.20	—	—	CMS + PDAC
76045-0216-20	ONDANSETRON 4 mg/2mL INJECTION, SOLUTION	Fresenius	24 BLISTER PACK in 1 CARTON (76045-216-20)...	4 mg/2mL	96	$8.45	—	● Active	CMS + PDAC
64679-0727-02	ONDANSETRON (MDV) 2 MG/1 ML	Unknown	—	—	2	$0.18	—	—	PDAC
00143-9890-10	Ondansetron 2 mg/mL INJECTION	West-Ward	10 VIAL, MULTI-DOSE in 1 CARTON (0143-9890...	2 mg/mL	2	$0.18	—	● Active	PDAC
60505-6130-00	ONDANSETRON 2 MG/1 ML	Unknown	—	—	2	$0.18	—	—	PDAC
23155-0547-41	ONDANSETRON 2 mg/mL INJECTION	Heritage	10 VIAL in 1 CARTON (23155-547-41) / 2 mL...	2 mg/mL	2	$0.18	—	● Active	PDAC
00409-4755-61	AMERINET CHOICE ONDANSETRON (5X2ML,SDV,USP) 2 MG/ML	Unknown	—	—	2	$0.18	—	—	PDAC
62991-2599-02	ONDANSETRON HYDROCHLORIDE (1X1000GM)	Unknown	—	—	1,000	$88.00	—	—	PDAC
62991-2599-01	ONDANSETRON HYDROCHLORIDE (1X100GM)	Unknown	—	—	1,000	$88.00	—	—	PDAC
70860-0777-20	ONDANSETRON (MDV) 2 MG/1 ML	Unknown	—	—	2	$0.18	—	—	PDAC
16729-0297-83	ONDANSETRON (5X2ML,SINGLE DOSE) 2 MG/1 ML	Unknown	—	—	2	$0.18	—	—	PDAC
67457-0441-20	ONDANSETRON HCL (1X20ML;MDV;USP,PF) 2 MG/ML	Unknown	—	—	2	$0.18	—	—	PDAC
67457-0440-22	ONDANSETRON HCL (25X2ML; SDV;USP,PF) 2 MG/ML	Unknown	—	—	2	$0.18	—	—	PDAC
23155-0196-43	ONDANSETRON 2 MG/ML	Unknown	—	—	2	$0.18	—	—	PDAC
63275-9955-07	ONDANSETRON HCL	Unknown	—	—	1,000	$88.00	—	—	PDAC
63275-9955-06	ONDANSETRON HCL	Unknown	—	—	1,000	$88.00	—	—	PDAC
63275-9955-01	ONDANSETRON HCL	Unknown	—	—	1,000	$88.00	—	—	PDAC

NDC→HCPCS mappings come from the CMS ASP NDC-HCPCS crosswalk; additional DME MAC / DMEPOS mappings come from PDAC and are labeled separately. NADAC from CMS (weekly). “Status” reflects the product's marketing / obsolete flag in the NDC directory. Presence or absence here does not determine Medicare coverage. Linked NDCs open the full product page.

⚠️ Don't confuse J2405 with… RELATED CODES

Adjacent HCPCS codes that share an ingredient or formulation with J2405. Billing units and payment limits differ — confirm the exact code, strength and form before billing.

Code	Descriptor	Billing unit	Payment limit / unit	How it differs from J2405
Q0162	Ondansetron oral	1 MG	$0.016	Related ingredient or formulation — confirm strength, form and billing unit before substituting.

Related codes matched on shared ingredient (CMS Medicare Part B Spending feed). Billing units and payment limits from the CMS ASP Pricing File. Always verify the precise HCPCS code for the product and strength administered.

📊 Medicare utilization & spend CMS · PART B · 2026 (Q1)

Period

Total Part B spend

$35.4K

Claims

43,411

Beneficiaries

17,282

Spend / beneficiary

$2.05

Spend / claim

$0.82

Trend by period

Where J2405 ranks among Part B drugs · 2026 (Q1) · neighbors ±5

Total spending — #622 of 824

#617 MAGNESIUM SULFATE-D5... J3475 $38.6K #618 FAMOTIDINE J1308 $37.8K #619 ZINPLAVA J0565 $36.7K #620 ESANO ACA, PER SQ CM... Q4275 $36.1K #621 DERMACYTE AMN MEM AL... Q4248 $35.9K #622 ONDANSETRON HCL(J240... J2405 $35.4K #623 ZIEXTENZO Q5120 $35.2K #624 ALKERAN* J9245 $35.1K #625 GANCICLOVIR SODIUM J1570 $34.8K #626 BYOOVIZ Q5124 $34.5K #627 DEPO-ESTRADIOL J1000 $33.6K

Total claims — #55 of 824

#50 FAMOTIDINE J1308 51,954 #51 GAMMAGARD LIQUID J1569 49,707 #52 HYALGAN* J7321 48,959 #53 INFLIXIMAB* J1745 48,117 #54 ARANESP(J0881) J0881 47,666 #55 ONDANSETRON HCL(J240... J2405 43,411 #56 CINVANTI J0185 42,275 #57 PALONOSETRON HCL J2469 41,742 #58 SYFOVRE J2781 41,654 #59 IZERVAY J2782 41,264 #60 GAMMAKED* J1561 40,877

Full breakdown by period (2)

Period	Total spend	Beneficiaries	Claims	$/beneficiary	$/claim
2026 (Q1)	$35.4K	17,282	43,411	$2.05	$0.82
2025 (Q1-Q4)	$153.9K	52,173	190,859	$2.95	$0.81

Provider-administered (Part B) spend, calculated for the whole HCPCS code (CMS does not publish Medicare spend per individual NDC). Self-administered use is covered under Part D instead. A blank patient count means fewer than 11 people — CMS hides counts that small to protect privacy. Source: CMS Medicare Quarterly Part B Spending by Drug (data.cms.gov), updated quarterly.

📈 Medicare Part B claims detail CMS PSPS · 2024

Calendar-year 2024 Medicare Part B fee-for-service activity for this HCPCS code, summed across all carriers, localities and specialties (CMS Physician/Supplier Procedure Summary). A “service” is one billed line/unit — not one claim — so counts run higher than claim counts.

Allowed charges

$146.3K

Medicare paid

$112.4K

Submitted services

1,928,913

Denial rate

14.9%

Allowed / service

$0.09

Submitted charges

$12.52M

Source: CMS Physician/Supplier Procedure Summary (PSPS), CY2024 — Medicare Part B carrier + DME fee-for-service claims (excludes Medicare Advantage). Figures are for the whole HCPCS code, which may cover uses beyond this drug. ⚠ CMS hides any figure covering fewer than 11 patients (a privacy rule), so totals — especially denials and low-volume codes — run a little low.

🗺️ Where J2405 is utilized CMS · BY PROVIDER · 2024

Medicare Part B services for this code by the rendering provider's state — 1,433,025 services across 49 states & territories in 2024 (CMS reports include DC and U.S. territories). Switch to per 100k to compare states fairly regardless of population. Hover or tap a state for its top ZIP codes.

Hover or tap a state to see its numbers + top ZIP codes.

Per-capita = services ÷ 2023 state population × 100,000 (so high-population states aren't automatically "hotter"). Counts reflect the provider's location, not the patient's. Providers with fewer than 11 patients are hidden by CMS for privacy, so totals run low and per-100k can be noisy in small states — read this as relative geography, not exact counts. Source: CMS Medicare Physician & Other Practitioners — by Provider and Service, 2024.

📊 What bills under J2405

J-codes are billing codes often used for drugs billed under the medical benefit. This connects the billing code to the NDC package records it covers, by ingredient and labeler.

NDC products by ingredient

Ondansetron 6

ONDANSETRON 6

ONDANSETRON HYDROCHLORIDE 4

ondansetron 1

NDC products by labeler

Fresenius Kabi USA, LLC 4

Hospira, Inc. 3

Heritage Pharmaceuticals Inc. d/b/... 2

Fosun Pharma USA Inc. 2

Civica, Inc. 2

West-Ward Pharmaceuticals Corp 1

Hikma Pharmaceuticals USA Inc. 1

Accord Healthcare, Inc. 1

🔗 Related NDC directory pages

🧪 All Ondansetron NDCsIngredient 🧪 All Ondansetron NDCsIngredient 🧪 All Ondansetron Hydrochloride NDCsIngredient 🧪 All Ondansetron NDCsIngredient 🏭 All Fresenius labeler NDCsLabeler 63323 🏭 All Hospira, labeler NDCsLabeler 00409 🏭 All Heritage labeler NDCsLabeler 23155 🏭 All Fosun labeler NDCsLabeler 72266 📚 All Serotonin-3 Receptor Antagonist NDCsDrug class

🗃️ Data sources & freshness

Every figure on this page is computed from public datasets. Here's what each section draws on and how current it is.

HCPCS code & descriptor

CMS HCPCS Level II code file

Loaded

Payment limit & billing unit

CMS Medicare Part B ASP Pricing File (quarterly)

Q3 2026 · as of 2026-08-20

NDC ↔ HCPCS crosswalk

CMS ASP NDC-HCPCS crosswalk + DMEPDAC (PDAC)

44 NDCs mapped

NADAC acquisition cost

CMS National Average Drug Acquisition Cost (weekly)

Available for mapped NDCs

Utilization & spend

CMS Part B Spending by Drug · PSPS · Physician & Other Practitioners

Latest data year 2026

Figures are estimates for reference and may lag the source files. Always verify against the current CMS files and your payer's policy before submitting claims.

⚠️ Practical billing caveats

A crosswalk is not coverage. An NDC mapping or a published payment limit does not guarantee a payer will cover or pay this code. Check the specific plan's policy.
Units ≠ milligrams. Bill the number of HCPCS units (dose ÷ the code's unit size), not the milligram dose. Use the calculator above.
Discarded drug. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (and JZ when nothing is discarded) where the payer allows.
Rounding & partial units. Many payers require whole units; round per the payer's policy, not automatically up.
The code can cover more than this drug. Some HCPCS codes span multiple products or strengths — confirm the exact code for the product administered.
Figures lag. ASP limits change quarterly and utilization data are released with a delay. Verify against the current CMS files before billing.

❓ J2405 billing FAQ

What is HCPCS code J2405?

J2405 is a HCPCS Level II J-code used to bill Injection, ondansetron hydrochloride, per 1 mg under Medicare Part B and most medical (not pharmacy) benefits.

What is the billing unit for J2405?

One unit of J2405 represents 1 MG. Report the number of units equal to the dose administered divided by 1 MG.

How many units of J2405 should I bill?

Divide the dose administered by the code's unit size (1 MG) to get the number of billing units, then round per your payer's policy. The calculator on this page converts a dose into billing units and projects a full course.

How much does Medicare pay for J2405?

The Medicare Part B payment limit is $0.088 per unit (Q3 2026), based on ASP + 6%. After the 2% sequester the effective payment is about $0.086 per unit. Payment limits are revised quarterly.

Which NDCs bill under J2405?

44 NDCs currently map to J2405 in the CMS ASP NDC-HCPCS crosswalk. See the NDC crosswalk table above for each product, package, billing units and estimated reimbursement.

Does a crosswalk mean J2405 is covered?

No. An NDC-to-HCPCS crosswalk and a published payment limit do not guarantee coverage or payment. Coverage depends on the payer, the diagnosis and the site of care — always verify the current policy before billing.

J2405 – Injection, ondansetron hydrochloride, per 1 mg · NDC Crosswalk & Billing Units