J2597
J2597 – Injection, desmopressin acetate, per 1 mcg · NDC Crosswalk & Billing Units
HCPCS Level II J-code · Medicare Part B drug billing
J-code
● 26 NDCs crosswalked per 1 MCG $3.562/unit ASP+6%
📋 J2597 summary
J2597 is a HCPCS Level II J-code used to bill desmopressin acetate, per 1 mcg, billed per 1 MCG. The number of billing units to report depends on the dose administered and the NDC/package billed — use the calculator below.
Brand names associated with J2597: Ddavp*, Desmopressin Acetate, Ddavp
Code J2597
Billing unit 1 MCG Payment limit $3.562/unit NDC-Crosswalk 26
Quarter Q3 2026
RxCUI Atlas Trace the drug concept →
⚠ An NDC↔HCPCS crosswalk and a published payment limit do not guarantee payer coverage or payment. Always verify the current payer policy and claim format before billing.
🗂️ Key billing facts
HCPCS codeJ2597
DescriptorInjection, desmopressin acetate, per 1 mcg
Billing unit1 MCG
Payment limit / unit$3.562
Est. ASP / unit$3.360 est.
Mapped NDCs26
Data periodQ3 2026
Last updated2026-08-20
🧾 Billing & reimbursement HCPCS · CMS · EFF. Q3 2026
📅 Payment limits effective Q3 2026 — from the CMS Medicare Part B Payment Limit File (revised quarterly).
Medicare payment limit / unit
$3.562
Est. ASP / unit
$3.360 est.
Est. after 2% sequester
$3.491
HCPCS dosage
1 MCG
The CMS payment limit is the Medicare Part B drug allowance (ASP + 6%, statutory). After the 2% federal sequester the effective payment is ≈ ASP + 4.3%; estimated ASP = payment limit ÷ 1.06. Source: CMS Medicare Part B Payment Limit File (quarterly), Q3 2026.
Full HCPCS code details (official CMS record)
Long descriptionInjection, desmopressin acetate, per 1 mcg
CoverageD — Special coverage instructions apply
Pricing indicator51 — Drug — priced under the ASP methodology
Type of service1 — Medical care
BETOS-2O1E
ASC payment groupYY
Action codeN — No maintenance this year
Effective date1997-01-01
Date added1996-01-01
Source: CMS HCPCS Level II code file (imported via admin).
🧮 Dosing & billing-units calculator HCPCS UNITS
One billing unit of J2597 = 1 mcg. Enter a regimen to convert dose → billing units and project a full course.
Billing units = dose ÷ HCPCS unit size. Most payers require whole units — round per the payer's policy. “Est. Medicare pay” uses the current payment limit. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (JZ when none is discarded) where allowed. Always verify payer-specific rounding before billing.
🔁 NDCs that bill under J2597 LEAST EXPENSIVE FIRST
26 NDCs map to J2597. Bill units = how many HCPCS units one package represents. Est. pay / pkg = payment limit ($3.562/unit) × that package's bill units.
| NDC (11-digit) | Drug | Labeler | Package | Strength | Bill units | Est. pay / pkg | NADAC / unit | Status | Source |
|---|---|---|---|---|---|---|---|---|---|
| 25021-0460-01 | desmopressin acetate 4 ug/mL INJECTION, SOLUTION | Sagent | 10 VIAL in 1 CARTON (25021-460-01) / 1 mL... | 4 ug/mL | 40 | $142.48 | $20.441 | ● Active | CMS + PDAC |
| 25021-0461-10 | desmopressin acetate 40 ug/10mL INJECTION, SOLUTION | Sagent | 1 VIAL in 1 CARTON (25021-461-10) / 10 mL... | 40 ug/10mL | 40 | $142.48 | $20.441 | ● Active | CMS + PDAC |
| 39822-6200-02 | Desmopressin Acetate 4 ug/mL INJECTION, SOLUTION | XGen | 10 VIAL in 1 CARTON (39822-6200-2) / 1 mL... | 4 ug/mL | 40 | $142.48 | $20.441 | ● Active | CMS + PDAC |
| 39822-6250-01 | Desmopressin Acetate 4 ug/mL INJECTION, SOLUTION | XGen | 1 VIAL in 1 CARTON (39822-6250-1) / 10 mL... | 4 ug/mL | 40 | $142.48 | $20.441 | ● Active | CMS + PDAC |
| 43598-0053-11 | Desmopressin Acetate 4 ug/mL INJECTION, SOLUTION | Dr. | 1 VIAL in 1 CARTON (43598-053-11) / 10 mL... | 4 ug/mL | 40 | $142.48 | $20.441 | ● Active | CMS + PDAC |
| 65219-0293-01 | Desmopressin Acetate 4 ug/mL INJECTION, SOLUTION | Fresenius | 10 VIAL, SINGLE-DOSE in 1 CARTON (65219-29... | 4 ug/mL | 40 | $142.48 | $20.441 | ● Active | CMS + PDAC |
| 65219-0295-10 | Desmopressin Acetate 4 ug/mL INJECTION, SOLUTION | Fresenius | 1 VIAL, MULTI-DOSE in 1 CARTON (65219-295-... | 4 ug/mL | 40 | $142.48 | $20.441 | ● Active | CMS + PDAC |
| 69918-0901-10 | Desmopressin Acetate 4 ug/mL SOLUTION | Nordic | 1 VIAL, MULTI-DOSE in 1 CARTON (69918-901-... | 4 ug/mL | 40 | $142.48 | $20.441 | ● Active | CMS ASP |
| 69918-0901-11 | Desmopressin Acetate 4 ug/mL SOLUTION | Nordic | 1 VIAL, MULTI-DOSE in 1 CARTON (69918-901-... | 4 ug/mL | 40 | $142.48 | $20.441 | ● Active | CMS + PDAC |
| 69918-0901-12 | Desmopressin Acetate 4 ug/mL SOLUTION | Nordic | 1 VIAL, MULTI-DOSE in 1 CARTON (69918-901-... | 4 ug/mL | 40 | $142.48 | $20.441 | ● Active | CMS + PDAC |
| 70095-0026-02 | Desmopressin Acetate 4 ug/mL INJECTION, SOLUTION | Sun | 10 VIAL, SINGLE-DOSE in 1 CARTON (70095-02... | 4 ug/mL | 40 | $142.48 | $20.441 | ● Active | CMS + PDAC |
| 70095-0031-01 | Desmopressin Acetate 4 ug/mL INJECTION, SOLUTION | Sun | 1 VIAL in 1 CARTON (70095-031-01) / 10 mL... | 4 ug/mL | 40 | $142.48 | $20.441 | ● Active | CMS + PDAC |
| 83634-0451-01 | Desmopressin Acetate 4 ug/mL INJECTION, SOLUTION | Avenacy, | 10 VIAL in 1 CARTON (83634-451-01) / 1 mL... | 4 ug/mL | 40 | $142.48 | $20.441 | ● Active | CMS + PDAC |
| 83634-0451-10 | Desmopressin Acetate 4 ug/mL INJECTION, SOLUTION | Avenacy, | 1 VIAL in 1 CARTON (83634-451-10) / 10 mL... | 4 ug/mL | 40 | $142.48 | $20.441 | ● Active | CMS + PDAC |
| 43598-0931-09 | DESMOPRESSIN ACETATE 4 ug/mL INJECTION | Dr.Reddys' | 10 AMPULE in 1 BOX (43598-931-09) / 1 mL... | 4 ug/mL | 40 | $142.48 | — | ● Active | CMS + PDAC |
| 55566-2200-00 | DDAVP Desmopressin Acetate 4 ug/mL INJECTION | Ferring | 10 AMPULE in 1 CARTON (55566-2200-0) / 1... | 4 ug/mL | 40 | $142.48 | — | ● Active | CMS + PDAC |
| 55566-2300-00 | DDAVP Desmopressin Acetate 4 ug/mL INJECTION | Ferring | 1 VIAL, MULTI-DOSE in 1 CARTON (55566-2300... | 4 ug/mL | 40 | $142.48 | — | ● Active | CMS + PDAC |
| 69918-0899-10 | Desmopressin Acetate 4 ug/mL SOLUTION | Nordic | 10 AMPULE in 1 CARTON (69918-899-10) / 1... | 4 ug/mL | 40 | $142.48 | — | ● Active | CMS ASP |
| 69918-0899-11 | Desmopressin Acetate 4 ug/mL SOLUTION | Nordic | 10 AMPULE in 1 CARTON (69918-899-11) / 1... | 4 ug/mL | 40 | $142.48 | — | ● Active | CMS + PDAC |
| 70860-0454-01 | Desmopressin Acetate | Athenex | — | — | 40 | $142.48 | — | — | CMS + PDAC |
| 70860-0454-10 | Desmopressin Acetate | Athenex | — | — | 40 | $142.48 | — | — | CMS + PDAC |
| 43598-0931-11 | DESMOPRESSIN ACETATE (USP;SDV,PF,LATEX-FREE) 4 MCG/1 ML | Unknown | — | — | 4 | $14.25 | — | — | PDAC |
| 16714-0015-01 | DESMOPRESSIN ACETATE (LATEX-FREE) 4 MCG/1 ML | Unknown | — | — | 4 | $14.25 | — | — | PDAC |
| 00409-2265-01 | DESMOPRESSIN ACETATE (UNI-AMP) 4 MCG/ML | Unknown | — | — | 4 | $14.25 | — | — | PDAC |
| 00703-5054-01 | DESMOPRESSIN ACETATE (M.D.V.) 4 MCG/ML | Unknown | — | — | 4 | $14.25 | — | — | PDAC |
| 00703-5051-03 | DESMOPRESSIN ACETATE (VIAL) 4 MCG/ML | Unknown | — | — | 4 | $14.25 | — | — | PDAC |
NDC→HCPCS mappings come from the CMS ASP NDC-HCPCS crosswalk; additional DME MAC / DMEPOS mappings come from PDAC and are labeled separately. NADAC from CMS (weekly). “Status” reflects the product's marketing / obsolete flag in the NDC directory. Presence or absence here does not determine Medicare coverage. Linked NDCs open the full product page.
📊 Medicare utilization & spend CMS · PART B · 2026 (Q1)
Period
Total Part B spend
$3.6K
Claims
49
Beneficiaries
43
Spend / beneficiary
$83.18
Spend / claim
$72.99
Trend by period
Where J2597 ranks among Part B drugs · 2026 (Q1) · neighbors ±5
Total spending — #721 of 824
#716
DIAZEPAM J3360
$3.9K
#717
COMIRNATY (5-11Y)* 91319
$3.8K
#718
ERAXIS J0348
$3.8K
#719
ACETAMINOPHEN(J0131) J0131
$3.7K
#720
VASOPRESSIN-0.9% NAC... J2601
$3.7K
#721
DDAVP* J2597
$3.6K
#722
DEMEROL* J2175
$3.4K
#723
LEVOTHYROXINE SODIUM... J0650
$3.4K
#724
MESNA* J9209
$3.4K
#725
CYSTO-CONRAY II* Q9958
$3.3K
#726
ENGERIX-B PEDIATRIC-... 90744
$3.2K
Total claims — #697 of 824
#692
ADYNOVATE J7207
54
#693
EDARAVONE* J1301
53
#694
LABETALOL HCL J1920
53
#695
ABIO XPL ABIO XPL HY... Q4355
52
#696
SYNOJOYNT, INJ., 1 M... J7331
50
#697
DDAVP* J2597
49
#698
YESINTEK Q5100
49
#699
ENVERSE, PER SQ CM** Q4258
47
#700
COMIRNATY (5-11Y)* 91319
46
#701
AZMIRO J1072
46
#702
AMPHADASE J3470
45
Top Medicare Part B drugs by the selected metric. Click any drug to open its J-code page. Source: CMS Medicare Quarterly Part B Spending by Drug.
Full breakdown by period (2)
| Period | Total spend | Beneficiaries | Claims | $/beneficiary | $/claim |
|---|---|---|---|---|---|
| 2026 (Q1) | $3.6K | 43 | 49 | $83.18 | $72.99 |
| 2025 (Q1-Q4) | $272.5K | 2,335 | 2,615 | $116.72 | $104.22 |
Provider-administered (Part B) spend, calculated for the whole HCPCS code (CMS does not publish Medicare spend per individual NDC). Self-administered use is covered under Part D instead. A blank patient count means fewer than 11 people — CMS hides counts that small to protect privacy. Source: CMS Medicare Quarterly Part B Spending by Drug (data.cms.gov), updated quarterly.
📈 Medicare Part B claims detail CMS PSPS · 2024
Calendar-year 2024 Medicare Part B fee-for-service activity for this HCPCS code, summed across all carriers, localities and specialties (CMS Physician/Supplier Procedure Summary). A “service” is one billed line/unit — not one claim — so counts run higher than claim counts.
Allowed charges
$18.1K
Medicare paid
$13.9K
Submitted services
5,560
Denial rate
22.0%
Allowed / service
$4.17
Submitted charges
$133.6K
Source: CMS Physician/Supplier Procedure Summary (PSPS), CY2024 — Medicare Part B carrier + DME fee-for-service claims (excludes Medicare Advantage). Figures are for the whole HCPCS code, which may cover uses beyond this drug. ⚠ CMS hides any figure covering fewer than 11 patients (a privacy rule), so totals — especially denials and low-volume codes — run a little low.
📊 What bills under J2597
J-codes are billing codes often used for drugs billed under the medical benefit. This connects the billing code to the NDC package records it covers, by ingredient and labeler.
NDC products by ingredient
NDC products by labeler
🗃️ Data sources & freshness
Every figure on this page is computed from public datasets. Here's what each section draws on and how current it is.
HCPCS code & descriptor
CMS HCPCS Level II code file
Loaded
Payment limit & billing unit
CMS Medicare Part B ASP Pricing File (quarterly)
Q3 2026 · as of 2026-08-20
NDC ↔ HCPCS crosswalk
CMS ASP NDC-HCPCS crosswalk + DMEPDAC (PDAC)
26 NDCs mapped
NADAC acquisition cost
CMS National Average Drug Acquisition Cost (weekly)
Available for mapped NDCs
Utilization & spend
CMS Part B Spending by Drug · PSPS · Physician & Other Practitioners
Latest data year 2026
Figures are estimates for reference and may lag the source files. Always verify against the current CMS files and your payer's policy before submitting claims.
⚠️ Practical billing caveats
- A crosswalk is not coverage. An NDC mapping or a published payment limit does not guarantee a payer will cover or pay this code. Check the specific plan's policy.
- Units ≠ milligrams. Bill the number of HCPCS units (dose ÷ the code's unit size), not the milligram dose. Use the calculator above.
- Discarded drug. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (and JZ when nothing is discarded) where the payer allows.
- Rounding & partial units. Many payers require whole units; round per the payer's policy, not automatically up.
- The code can cover more than this drug. Some HCPCS codes span multiple products or strengths — confirm the exact code for the product administered.
- Figures lag. ASP limits change quarterly and utilization data are released with a delay. Verify against the current CMS files before billing.
❓ J2597 billing FAQ
What is HCPCS code J2597?
J2597 is a HCPCS Level II J-code used to bill Injection, desmopressin acetate, per 1 mcg under Medicare Part B and most medical (not pharmacy) benefits.
What is the billing unit for J2597?
One unit of J2597 represents 1 MCG. Report the number of units equal to the dose administered divided by 1 MCG.
How many units of J2597 should I bill?
Divide the dose administered by the code's unit size (1 MCG) to get the number of billing units, then round per your payer's policy. The calculator on this page converts a dose into billing units and projects a full course.
How much does Medicare pay for J2597?
The Medicare Part B payment limit is $3.562 per unit (Q3 2026), based on ASP + 6%. After the 2% sequester the effective payment is about $3.491 per unit. Payment limits are revised quarterly.
Which NDCs bill under J2597?
26 NDCs currently map to J2597 in the CMS ASP NDC-HCPCS crosswalk. See the NDC crosswalk table above for each product, package, billing units and estimated reimbursement.
Does a crosswalk mean J2597 is covered?
No. An NDC-to-HCPCS crosswalk and a published payment limit do not guarantee coverage or payment. Coverage depends on the payer, the diagnosis and the site of care — always verify the current policy before billing.
For professional billing reference only — verify against the current CMS files before submitting claims.