J2540
J2540 – Injection, penicillin g potassium, up to 600,000 units · NDC Crosswalk & Billing Units
HCPCS Level II J-code · Medicare Part B drug billing
J-code
● 23 NDCs crosswalked per 600000 UNITS $0.637/unit ASP+6%
📋 J2540 summary
J2540 is a HCPCS Level II J-code used to bill penicillin g potassium, up to 600,000 units, billed per 600000 UNITS. The number of billing units to report depends on the dose administered and the NDC/package billed — use the calculator below.
Brand names associated with J2540: Pfizerpen, Penicillin G Potassium, Buffered Penicillin G Potassium
Code J2540
Billing unit 600000 UNITS Payment limit $0.637/unit NDC-Crosswalk 23
Quarter Q3 2026
RxCUI Atlas Trace the drug concept →
⚠ An NDC↔HCPCS crosswalk and a published payment limit do not guarantee payer coverage or payment. Always verify the current payer policy and claim format before billing.
🗂️ Key billing facts
HCPCS codeJ2540
DescriptorInjection, penicillin g potassium, up to 600,000 units
Billing unit600000 UNITS
Payment limit / unit$0.637
Est. ASP / unit$0.601 est.
Mapped NDCs23
Data periodQ3 2026
Last updated2026-08-20
💊 About Penicillin G (Potassium, Sodium) Injection DRUG GUIDE
Penicillin G Potassium for Injection is used to treat serious infections caused by bacteria that are susceptible to penicillin.
It covers a wide range of conditions, including bloodstream infections (septicemia), meningitis, pneumonia, endocarditis (heart valve infection), and pericarditis (infection around the heart).It is also used for infections such as syphilis (including neurosyphilis and congenital syphilis), anthrax, diphtheria, botulism, tetanus, gas gangrene, disseminated gonococcal infections, listeria infections, and rat-bite fever, among others.
Some uses are as adjunctive therapy — meaning penicillin G supports, but does not replace, other treatments like antitoxins.
Clinical overview from our editorial drug guide for Penicillin G (Potassium, Sodium) Injection. For billing reference, see the sections above.
🧾 Billing & reimbursement HCPCS · CMS · EFF. Q3 2026
📅 Payment limits effective Q3 2026 — from the CMS Medicare Part B Payment Limit File (revised quarterly).
Medicare payment limit / unit
$0.637
Est. ASP / unit
$0.601 est.
Est. after 2% sequester
$0.624
HCPCS dosage
600000 UNITS
The CMS payment limit is the Medicare Part B drug allowance (ASP + 6%, statutory). After the 2% federal sequester the effective payment is ≈ ASP + 4.3%; estimated ASP = payment limit ÷ 1.06. Source: CMS Medicare Part B Payment Limit File (quarterly), Q3 2026.
Full HCPCS code details (official CMS record)
Long descriptionInjection, penicillin g potassium, up to 600,000 units
CoverageD — Special coverage instructions apply
Pricing indicator51 — Drug — priced under the ASP methodology
Type of service1 — Medical care
BETOS-2O1E
ASC payment group—
Action codeN — No maintenance this year
Effective date1997-01-01
Date added1982-01-01
Source: CMS HCPCS Level II code file (imported via admin).
🧮 Dosing & billing-units calculator HCPCS UNITS
One billing unit of J2540 = 600,000 units. Enter a regimen to convert dose → billing units and project a full course.
Billing units = dose ÷ HCPCS unit size. Most payers require whole units — round per the payer's policy. “Est. Medicare pay” uses the current payment limit. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (JZ when none is discarded) where allowed. Always verify payer-specific rounding before billing.
🔁 NDCs that bill under J2540 WITH EST. MEDICARE PAY
23 NDCs map to J2540. Bill units = how many HCPCS units one package represents. Est. pay / pkg = payment limit ($0.637/unit) × that package's bill units.
| NDC (11-digit) | Drug | Labeler | Package | Strength | Bill units | Est. pay / pkg | NADAC / unit | Status | Source |
|---|---|---|---|---|---|---|---|---|---|
| 00049-0420-10 | Pfizerpen penicillin G potassium 5000000 [iU]/1 POWDER, FOR SOLUTION | Roerig | 10 VIAL in 1 CARTON (0049-0420-10) / 1 PO... | 5000000 [iU]/1 | 84 | $53.51 | — | ● Active | CMS ASP |
| 00049-0430-20 | Pfizerpen penicillin G potassium 20000000 [iU]/1 POWDER, FOR SOLUTION | Roerig | 1 VIAL in 1 CARTON (0049-0430-20) / 1 POW... | 20000000 [iU]/1 | 34 | $21.66 | — | ● Active | CMS ASP |
| 00049-0520-22 | Pfizerpen penicillin G potassium 5000000 [iU]/1 POWDER, FOR SOLUTION | Roerig | 10 VIAL in 1 CARTON (0049-0520-22) / 1 PO... | 5000000 [iU]/1 | 84 | $53.51 | — | ● Active | CMS ASP |
| 00049-0520-83 | Pfizerpen penicillin G potassium 5000000 [iU]/1 POWDER, FOR SOLUTION | Roerig | 10 VIAL in 1 CARTON (0049-0520-83) / 1 PO... | 5000000 [iU]/1 | 84 | $53.51 | — | ● Active | CMS + PDAC |
| 00049-0530-22 | Pfizerpen penicillin G potassium 20000000 [iU]/1 POWDER, FOR SOLUTION | Roerig | 1 VIAL in 1 CARTON (0049-0530-22) / 1 POW... | 20000000 [iU]/1 | 34 | $21.66 | — | ● Active | CMS ASP |
| 00049-0530-28 | Pfizerpen penicillin G potassium 20000000 [iU]/1 POWDER, FOR SOLUTION | Roerig | 1 VIAL in 1 CARTON (0049-0530-28) / 1 POW... | 20000000 [iU]/1 | 34 | $21.66 | — | ● Active | CMS + PDAC |
| 00338-1023-41 | PENICILLIN G POTASSIUM 2000000 [iU]/50mL INJECTION, SOLUTION | Baxter | 50 mL in 1 BAG (0338-1023-41) | 2000000 [iU]/50mL | 4 | $2.55 | — | ● Active | CMS + PDAC |
| 00338-1025-41 | PENICILLIN G POTASSIUM 3000000 [iU]/50mL INJECTION, SOLUTION | Baxter | 50 mL in 1 BAG (0338-1025-41) | 3000000 [iU]/50mL | 5 | $3.19 | — | ● Active | CMS + PDAC |
| 00781-6135-95 | Penicillin G Potassium 5000000 [iU]/1 INJECTION, POWDER, FOR SOLUTION | Sandoz | 10 VIAL in 1 CARTON (0781-6135-95) / 1 IN... | 5000000 [iU]/1 | 84 | $53.51 | — | ● Active | CMS + PDAC |
| 00781-6136-94 | Penicillin G Potassium 20000000 [iU]/1 INJECTION, POWDER, FOR SOLUTION | Sandoz | 1 VIAL in 1 CARTON (0781-6136-94) / 1 INJ... | 20000000 [iU]/1 | 34 | $21.66 | — | ● Active | CMS + PDAC |
| 25021-0153-20 | Penicillin G Potassium 5000000 [iU]/1 INJECTION, POWDER, FOR SOLUTION | Sagent | 10 VIAL in 1 CARTON (25021-153-20) / 1 IN... | 5000000 [iU]/1 | 84 | $53.51 | — | ● Active | CMS ASP |
| 25021-0154-51 | Penicillin G Potassium 20000000 [iU]/1 INJECTION, POWDER, FOR SOLUTION | Sagent | 1 VIAL in 1 CARTON (25021-154-51) / 1 INJ... | 20000000 [iU]/1 | 34 | $21.66 | — | ● Active | CMS + PDAC |
| 44567-0311-10 | Penicillin G Potassium 5000000 [iU]/1 INJECTION, POWDER, FOR SOLUTION | WG | 10 VIAL in 1 TRAY (44567-311-10) / 1 INJE... | 5000000 [iU]/1 | 84 | $53.51 | — | ● Active | CMS ASP |
| 44567-0312-01 | Penicillin G Potassium 20000000 [iU]/1 INJECTION, POWDER, FOR SOLUTION | WG | 1 VIAL in 1 CARTON (44567-312-01) / 1 INJ... | 20000000 [iU]/1 | 34 | $21.66 | — | ● Active | CMS ASP |
| 51662-1436-01 | BUFFERED PENICILLIN G POTASSIUM 5000000 [iU]/1 INJECTION, POWDER, FOR SOLUTION | HF | 1 INJECTION, POWDER, FOR SOLUTION in 1 VIA... | 5000000 [iU]/1 | 9 | $5.73 | — | Obsolete | CMS ASP |
| 70860-0126-20 | Penicillin G Potassium | Athenex | — | — | 84 | $53.51 | — | — | CMS ASP |
| 70860-0127-51 | Penicillin G Potassium 20000000 [iU]/1 INJECTION, POWDER, FOR SOLUTION | Athenex | 1 VIAL in 1 CARTON (70860-127-51) / 1 INJ... | 20000000 [iU]/1 | 34 | $21.66 | — | ● Active | CMS ASP |
| 72603-0210-10 | Penicillin G Potassium 5000000 [iU]/1 INJECTION, POWDER, FOR SOLUTION | NorthStar | 10 VIAL in 1 CARTON (72603-210-10) / 1 IN... | 5000000 [iU]/1 | 84 | $53.51 | — | ● Active | CMS ASP |
| 72603-0345-01 | Penicillin G Potassium 20000000 [iU]/1 INJECTION, POWDER, FOR SOLUTION | NorthStar | 1 VIAL in 1 CARTON (72603-345-01) / 1 INJ... | 20000000 [iU]/1 | 34 | $21.66 | — | ● Active | CMS ASP |
| 83634-0102-20 | Penicillin G Potassium 5000000 [iU]/1 INJECTION, POWDER, FOR SOLUTION | Avenacy | 10 VIAL in 1 CARTON (83634-102-20) / 1 IN... | 5000000 [iU]/1 | 84 | $53.51 | — | ● Active | CMS ASP |
| 83634-0103-51 | Penicillin G Potassium 20000000 [iU]/1 INJECTION, POWDER, FOR SOLUTION | Avenacy | 1 VIAL in 1 CARTON (83634-103-51) / 1 INJ... | 20000000 [iU]/1 | 34 | $21.66 | — | ● Active | CMS ASP |
| 54868-4488-00 | PENICILLIN G POTASSIUM (VIAL,PHARMACY BOTTLE) 20 Million U | Unknown | — | — | 33.333 | $21.23 | — | — | PDAC |
| 00338-1021-41 | PENICILLIN G POTASSIUM 1000000 [iU]/50mL INJECTION, SOLUTION | Baxter | 50 mL in 1 BAG (0338-1021-41) | 1000000 [iU]/50mL | 0.033 | $0.02 | — | Obsolete | PDAC |
NDC→HCPCS mappings come from the CMS ASP NDC-HCPCS crosswalk; additional DME MAC / DMEPOS mappings come from PDAC and are labeled separately. NADAC from CMS (weekly). “Status” reflects the product's marketing / obsolete flag in the NDC directory. Presence or absence here does not determine Medicare coverage. Linked NDCs open the full product page.
📊 Medicare utilization & spend CMS · PART B · 2026 (Q1)
Period
Total Part B spend
$1.1K
Claims
42
Beneficiaries
19
Spend / beneficiary
$56.60
Spend / claim
$25.61
Trend by period
Where J2540 ranks among Part B drugs · 2026 (Q1) · neighbors ±5
Total spending — #768 of 824
#763
CEFOXITIN SODIUM* J0694
$1.2K
#764
GASTROGRAFIN* Q9963
$1.1K
#765
VANCOMYCIN HCL(J3374... J3374
$1.1K
#766
METHOCARBAMOL* J2800
$1.1K
#767
TYZAVAN* J3375
$1.1K
#768
PENICILLIN G POTASSI... J2540
$1.1K
#769
STREPTOMYCIN SULFATE J3000
$1.1K
#770
AMPHOTERICIN B J0285
$1.1K
#771
HAVRIX* 90632
$1K
#772
TIGECYCLINE* J3243
$940.10
#773
METRO IV* J1836
$932.49
Total claims — #711 of 824
#706
ABILIFY ASIMTUFII J0402
43
#707
COMPLETE AA, PER SQ... Q4303
43
#708
AZACTAM* J0457
42
#709
BERINERT J0597
42
#710
CALCIUM GLUCONATE-NA... J0613
42
#711
PENICILLIN G POTASSI... J2540
42
#712
BIOVANCE 1 SQUARE CM... Q4154
42
#713
VITOGRAFT, PER SQ CM... Q4317
42
#714
ELELYSO J3060
41
#715
FEIBA J7198
40
#716
ERAXIS J0348
39
Top Medicare Part B drugs by the selected metric. Click any drug to open its J-code page. Source: CMS Medicare Quarterly Part B Spending by Drug.
Full breakdown by period (2)
| Period | Total spend | Beneficiaries | Claims | $/beneficiary | $/claim |
|---|---|---|---|---|---|
| 2026 (Q1) | $1.1K | 19 | 42 | $56.60 | $25.61 |
| 2025 (Q1-Q4) | $11.6K | 119 | 394 | $97.16 | $29.35 |
Provider-administered (Part B) spend, calculated for the whole HCPCS code (CMS does not publish Medicare spend per individual NDC). Self-administered use is covered under Part D instead. A blank patient count means fewer than 11 people — CMS hides counts that small to protect privacy. Source: CMS Medicare Quarterly Part B Spending by Drug (data.cms.gov), updated quarterly.
📈 Medicare Part B claims detail CMS PSPS · 2024
Calendar-year 2024 Medicare Part B fee-for-service activity for this HCPCS code, summed across all carriers, localities and specialties (CMS Physician/Supplier Procedure Summary). A “service” is one billed line/unit — not one claim — so counts run higher than claim counts.
Allowed charges
$11.7K
Medicare paid
$9.2K
Submitted services
67,638
Denial rate
78.6%
Allowed / service
$0.81
Submitted charges
$364K
Source: CMS Physician/Supplier Procedure Summary (PSPS), CY2024 — Medicare Part B carrier + DME fee-for-service claims (excludes Medicare Advantage). Figures are for the whole HCPCS code, which may cover uses beyond this drug. ⚠ CMS hides any figure covering fewer than 11 patients (a privacy rule), so totals — especially denials and low-volume codes — run a little low.
🗺️ Where J2540 is utilized CMS · BY PROVIDER · 2024
Medicare Part B services for this code by the rendering provider's state — 109 services across 1 states & territories in 2024 (CMS reports include DC and U.S. territories). Switch to per 100k to compare states fairly regardless of population. Hover or tap a state for its top ZIP codes.
Hover or tap a state to see its numbers + top ZIP codes.
Per-capita = services ÷ 2023 state population × 100,000 (so high-population states aren't automatically "hotter"). Counts reflect the provider's location, not the patient's. Providers with fewer than 11 patients are hidden by CMS for privacy, so totals run low and per-100k can be noisy in small states — read this as relative geography, not exact counts. Source: CMS Medicare Physician & Other Practitioners — by Provider and Service, 2024.
📊 What bills under J2540
J-codes are billing codes often used for drugs billed under the medical benefit. This connects the billing code to the NDC package records it covers, by ingredient and labeler.
NDC products by ingredient
NDC products by labeler
🗃️ Data sources & freshness
Every figure on this page is computed from public datasets. Here's what each section draws on and how current it is.
HCPCS code & descriptor
CMS HCPCS Level II code file
Loaded
Payment limit & billing unit
CMS Medicare Part B ASP Pricing File (quarterly)
Q3 2026 · as of 2026-08-20
NDC ↔ HCPCS crosswalk
CMS ASP NDC-HCPCS crosswalk + DMEPDAC (PDAC)
23 NDCs mapped
NADAC acquisition cost
CMS National Average Drug Acquisition Cost (weekly)
Not available for mapped NDCs
Utilization & spend
CMS Part B Spending by Drug · PSPS · Physician & Other Practitioners
Latest data year 2026
Figures are estimates for reference and may lag the source files. Always verify against the current CMS files and your payer's policy before submitting claims.
⚠️ Practical billing caveats
- A crosswalk is not coverage. An NDC mapping or a published payment limit does not guarantee a payer will cover or pay this code. Check the specific plan's policy.
- Units ≠ milligrams. Bill the number of HCPCS units (dose ÷ the code's unit size), not the milligram dose. Use the calculator above.
- Discarded drug. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (and JZ when nothing is discarded) where the payer allows.
- Rounding & partial units. Many payers require whole units; round per the payer's policy, not automatically up.
- The code can cover more than this drug. Some HCPCS codes span multiple products or strengths — confirm the exact code for the product administered.
- Figures lag. ASP limits change quarterly and utilization data are released with a delay. Verify against the current CMS files before billing.
❓ J2540 billing FAQ
What is HCPCS code J2540?
J2540 is a HCPCS Level II J-code used to bill Injection, penicillin g potassium, up to 600,000 units under Medicare Part B and most medical (not pharmacy) benefits.
What is the billing unit for J2540?
One unit of J2540 represents 600000 UNITS. Report the number of units equal to the dose administered divided by 600000 UNITS.
How many units of J2540 should I bill?
Divide the dose administered by the code's unit size (600000 UNITS) to get the number of billing units, then round per your payer's policy. The calculator on this page converts a dose into billing units and projects a full course.
How much does Medicare pay for J2540?
The Medicare Part B payment limit is $0.637 per unit (Q3 2026), based on ASP + 6%. After the 2% sequester the effective payment is about $0.624 per unit. Payment limits are revised quarterly.
Which NDCs bill under J2540?
23 NDCs currently map to J2540 in the CMS ASP NDC-HCPCS crosswalk. See the NDC crosswalk table above for each product, package, billing units and estimated reimbursement.
Does a crosswalk mean J2540 is covered?
No. An NDC-to-HCPCS crosswalk and a published payment limit do not guarantee coverage or payment. Coverage depends on the payer, the diagnosis and the site of care — always verify the current policy before billing.
For professional billing reference only — verify against the current CMS files before submitting claims.