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Acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / doxylamine succinat... — RxCUI 1431245

RxNorm drug concept · Semantic clinical drug
RxCUI 1431245 Semantic clinical drug · SCD ● Current RxNorm concept 89 FDA products 100 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1431245
Official nameAcetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / doxylamine succinate 0.417 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asacetaminophen 325 MG / dextromethorphan HBr 10 MG / doxylamine succinate 6.25 MG / phenylephrine HCl 5 MG per 15 ML Oral Solution; acetaminophen 650 MG / dextromethorphan HBr 20 MG / doxylamine succinate 12.5 MG / phenylephrine HCl 10 MG in 30 mL Oral Solution; acetaminophen 650 MG / dextromethorphan HBr 20 MG / doxylamine succinate 12.5 MG / phenylephrine HCl 10 MG per 30 ML Oral Solution; APAP 21.7 MG/ML / Dextromethorphan Hydrobromide 0.667 MG/ML / doxylamine succinate 0.417 MG/ML / Phenylephrine Hydrochloride 0.333 MG/ML Oral Solution
FDA products mapped89
Package NDCs mapped100
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Phenylephrine: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • Yes, it's the same active ingredient, but used in very different ways depending on the form. The nasal spray delivers a tiny amount directly to the nasal lining to temporarily shri...
  • I see phenylephrine in nasal sprays at the pharmacy AND as an IV drug in the hospital — is it really the same medication?
  • You should check with your doctor first. Phenylephrine constricts blood vessels, which can raise blood pressure and put extra strain on the heart — even from a nasal spray. If you...
  • Can I use the nasal spray if I have high blood pressure or heart disease?
📖 Read our full Phenylephrine guide →

🕸️ Concept Web — How Acetaminophen 21.7 MG/ML / dextromethorphan hydr... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / doxylamine succinate 0.417 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution RxCUI 1431245

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 8

    The active substance itself — no strength, form, or brand attached yet.

    • Acetaminophen 161
    • Dextromethorphan 3289
    • Doxylamine 3642
    • Phenylephrine 8163
    • Acetaminophen / dextromethorphan / doxylamine / phenylephrine 1008701
    • Dextromethorphan hydrobromide 102490
    • Doxylamine succinate 23665
    • Phenylephrine hydrochloride 8164
  2. Dose forms 9

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Acetaminophen / dextromethorphan / doxylamine / phenylephrine Oral Solution 647202
    • Acetaminophen / dextromethorphan hydrobromide / doxylamine succinate / phenylephrine hydrochloride Oral Solution 2649073
    • Acetaminophen / dextromethorphan / doxylamine / phenylephrine Oral Liquid Product 1155607
    • Acetaminophen / dextromethorphan / doxylamine / phenylephrine Oral Product 1155896
    • Acetaminophen / dextromethorphan hydrobromide / doxylamine succinate / phenylephrine hydrochloride Oral Liquid Product 2663084
    • Acetaminophen / dextromethorphan hydrobromide / doxylamine succinate / phenylephrine hydrochloride Oral Product 2660518
    • Oral Solution 316968
    • Oral Liquid Product 1151137
    • +1 more in this family
  3. Clinical & branded drugs 4

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

    • Acetaminophen 21.7 MG/ML 332581
    • Dextromethorphan hydrobromide 0.667 MG/ML 1014004
    • Doxylamine succinate 0.417 MG/ML 1042674
    • Phenylephrine hydrochloride 0.333 MG/ML 1039296
  4. Packs 1

    Fixed collections of drugs packaged and sold together, like dose packs.

Showing up to 8 concepts per family — 21 of 22 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

📦 FDA Products & Package NDCs

89 products · 100 package NDCs
100 package NDCs map to RxCUI 1431245 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00113-0019-40 354 mL in 1 BOTTLE (0113-0019-40) Good Sense Severe NightTime L. Perrigo Company 2015-11-24
00113-0763-40 354 mL in 1 BOTTLE (0113-0763-40) Good Sense Severe NightTime Cold and Flu L. Perrigo Company 2013-11-19
00113-2501-40 354 mL in 1 BOTTLE (0113-2501-40) good sense night time cold and flu L. Perrigo Company 2023-07-05
00113-5970-02 1 KIT in 1 CARTON (0113-5970-02) * 354 mL in 1 BOTTLE (011... GOODSENSE COMBO PACK DAYTIME AND NIGHTTIME L. Perrigo Company 2026-02-20
00363-0331-26 237 mL in 1 BOTTLE (0363-0331-26) Night Time Severe Cold and Flu Walgreen Company 2020-11-13
00363-0577-02 1 KIT in 1 CARTON (0363-0577-02) * 355 mL in 1 BOTTLE (036... daytime nighttime severe cold and flu Walgreen Company 2015-07-23
00363-0623-40 355 mL in 1 BOTTLE (0363-0623-40) severe cold and flu Walgreen Company 2015-07-23
00363-0763-40 355 mL in 1 BOTTLE (0363-0763-40) Severe Cold and Flu Walgreen Company 2013-11-21
00363-1597-02 1 KIT in 1 CARTON (0363-1597-02) * 355 mL in 1 BOTTLE (036... Severe Cold and Flu Walgreen Company 2014-09-08
00363-2029-40 355 mL in 1 BOTTLE (0363-2029-40) nighttime severe cold and flu Walgreen Company 2023-07-08
00363-6105-24 1 KIT in 1 PACKAGE (0363-6105-24) * 354 mL in 1 BOTTLE (03... Walgreen Day Time NightTime Cold and Flu Relief WALGREENS CO. 2021-02-10
00363-6142-12 354 mL in 1 BOTTLE, PLASTIC (0363-6142-12) Walgreen NightTime Cold and Flu relief WALGREENS CO. 2023-04-17
11673-0322-01 354 mL in 1 BOTTLE (11673-322-01) Nighttime Severe Honey Cold and Flu TARGET CORPORATION 2024-06-30
11673-0328-02 1 KIT in 1 CARTON (11673-328-02) * 354 mL in 1 BOTTLE * 3... Daytime and Nighttime Severe Honey Cold and Flu TARGET CORPORATION 2024-05-01
11673-0739-02 1 KIT in 1 BOTTLE (11673-739-02) * 355 mL in 1 BOTTLE * 3... Daytime Severe and Nighttime Severe cold and flu TARGET CORPORATION 2024-05-01
11673-0791-02 1 KIT in 1 CARTON (11673-791-02) * 354 mL in 1 BOTTLE * 3... Daytime and Nighttime Severe Honey Cold and Flu TARGET CORPORATION 2024-05-01
11673-0824-02 1 KIT in 1 BOTTLE (11673-824-02) * 355 mL in 1 BOTTLE * 3... Daytime Severe and Nighttime Severe cold and flu TARGET CORPORATION 2024-05-01
11673-0828-01 354 mL in 1 BOTTLE (11673-828-01) Nighttime severe cold and flu TARGET CORPORATION 2024-06-30
11822-0328-01 1 KIT in 1 CARTON (11822-0328-1) * 355 mL in 1 BOTTLE (118... daytime nighttime severe cold and flu relief Rite Aid Corporation 2015-07-24
11822-0511-01 355 mL in 1 BOTTLE (11822-0511-1) nighttime severe cold and flu relief Rite Aid Corporation 2015-07-23
11822-0763-01 355 mL in 1 BOTTLE (11822-0763-1) severe cold and flu relief Rite Aid Corporation 2014-06-27
11822-4099-00 355 mL in 1 BOTTLE (11822-4099-0) severe cold and flu relief Rite Aid Corporation 2023-06-30
21130-0129-40 355 mL in 1 BOTTLE (21130-129-40) Signature Care Nighttime Severe Cold and Flu Relief Safeway 2016-01-24
30142-0763-40 354 mL in 1 BOTTLE (30142-763-40) NightTime Severe Cold and Flu Kroger Company 2014-08-13
36800-0291-40 355 mL in 1 BOTTLE (36800-291-40) topcare nite time cold and flu Topco Associates LLC 2015-08-04
36800-0597-02 1 KIT in 1 CARTON (36800-597-02) * 355 mL in 1 BOTTLE (368... Topcare Day Time Nite Time Cold and Flu Topco Associates LLC 2014-06-28
37000-0045-24 1 KIT in 1 PACKAGE (37000-045-24) * 354 mL in 1 BOTTLE, PL... Vicks DayQuil and Vicks NyQuil Severe Cold and Flu The Procter & Gamble Manufacturing Company 2014-07-31
37000-0812-01 30 mL in 1 BOTTLE, PLASTIC (37000-812-01) Vicks NyQuil Severe Cold and Flu The Procter & Gamble Manufacturing Company 2020-10-13
37000-0812-04 4 BOTTLE, PLASTIC in 1 PACKAGE (37000-812-04) / 30 mL in 1... Vicks NyQuil Severe Cold and Flu The Procter & Gamble Manufacturing Company 2021-07-13
37000-0812-08 236 mL in 1 BOTTLE, PLASTIC (37000-812-08) Vicks NyQuil Severe Cold and Flu The Procter & Gamble Manufacturing Company 2013-07-22
37000-0812-12 354 mL in 1 BOTTLE, PLASTIC (37000-812-12) Vicks NyQuil Severe Cold and Flu The Procter & Gamble Manufacturing Company 2013-07-22
37000-0812-24 2 BOTTLE, PLASTIC in 1 PACKAGE (37000-812-24) / 354 mL in 1... Vicks NyQuil Severe Cold and Flu The Procter & Gamble Manufacturing Company 2013-07-22
37000-0814-24 1 KIT in 1 PACKAGE (37000-814-24) * 354 mL in 1 BOTTLE, PL... Vicks DayQuil and Vicks NyQuil Severe Cold and Flu The Procter & Gamble Manufacturing Company 2013-07-22
37000-0815-08 236 mL in 1 BOTTLE, PLASTIC (37000-815-08) Vicks NyQuil Severe Cold and Flu The Procter & Gamble Manufacturing Company 2014-07-21
37000-0815-12 354 mL in 1 BOTTLE, PLASTIC (37000-815-12) Vicks NyQuil Severe Cold and Flu The Procter & Gamble Manufacturing Company 2014-07-21
37000-0815-36 3 BOTTLE, PLASTIC in 1 PACKAGE, COMBINATION (37000-815-36)... Vicks NyQuil Severe Cold and Flu The Procter & Gamble Manufacturing Company 2014-07-21
37808-0763-40 355 mL in 1 BOTTLE (37808-763-40) nighttime severe cold and flu H E B 2016-04-11
41163-0763-40 355 mL in 1 BOTTLE (41163-763-40) equaline nighttime severe cold and flu United Natural Foods, Inc. dba UNFI 2014-07-31
41226-0767-01 354 mL in 1 BOTTLE (41226-767-01) Severe Cold and Flu Nighttime Honey Kroger 2024-04-30
41226-0775-01 354 mL in 1 BOTTLE (41226-775-01) Nighttime Severe Cold and Flu Kroger 2024-04-30
41226-0776-02 2 BOTTLE in 1 CARTON (41226-776-02) / 1 KIT in 1 BOTTLE *... Severe Cold and Flu Daytime and Nighttime Kroger 2026-04-01
41250-0597-02 1 KIT in 1 KIT (41250-597-02) * 355 mL in 1 BOTTLE (41250-... NiteTime DayTime Cold and Flu Meijer Distribution Inc 2013-12-30
41250-0763-40 355 mL in 1 BOTTLE (41250-763-40) Nitetime Cold and Flu Meijer Distribution Inc 2013-12-11
41250-0811-40 355 mL in 1 BOTTLE (41250-811-40) nitetime cold and flu Meijer Distribution Inc 2015-07-23
41250-0919-02 1 KIT in 1 CARTON (41250-919-02) * 355 mL in 1 BOTTLE (412... DAYTIME COLD AND FLU NITETIME COLD AND FLU Meijer Distribution Inc 2019-03-29
41520-0561-40 355 mL in 1 BOTTLE (41520-561-40) CareOne Nighttime Severe Cold and Flu American Sales Company 2016-04-11
42507-0020-40 355 mL in 1 BOTTLE (42507-020-40) Severe Cold and Flu HyVee Inc 2015-09-08
42507-0597-02 1 KIT in 1 CARTON (42507-597-02) * 355 mL in 1 BOTTLE * 3... Severe Cold and Flu Nighttime Daytime HyVee Inc 2014-05-19
42507-0763-40 355 mL in 1 BOTTLE (42507-763-40) Severe Cold and Flu Night time HyVee Inc 2014-01-12
42507-0861-40 355 mL in 1 BOTTLE (42507-861-40) severe cold and flu HyVee Inc 2026-01-28
Observed labelers: The Procter & Gamble Manufacturing Company (15) · TARGET CORPORATION (6) · Walgreen Company (6) · Amazon.com Services LLC (5) · CVS PHARMACY (5) · Kenvue Brands LLC (5) · +26 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.