Acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / doxylamine succinat... — RxCUI 1431245
RxNorm drug concept · Semantic clinical drug
RxCUI 1431245
Semantic clinical drug · SCD
● Current RxNorm concept 89 FDA products
100 package NDCs
Snapshot Jul 14, 2026
What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.
🗂️ Key Facts
RxCUI1431245
Official nameAcetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / doxylamine succinate 0.417 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asacetaminophen 325 MG / dextromethorphan HBr 10 MG / doxylamine succinate 6.25 MG / phenylephrine HCl 5 MG per 15 ML Oral Solution; acetaminophen 650 MG / dextromethorphan HBr 20 MG / doxylamine succinate 12.5 MG / phenylephrine HCl 10 MG in 30 mL Oral Solution; acetaminophen 650 MG / dextromethorphan HBr 20 MG / doxylamine succinate 12.5 MG / phenylephrine HCl 10 MG per 30 ML Oral Solution; APAP 21.7 MG/ML / Dextromethorphan Hydrobromide 0.667 MG/ML / doxylamine succinate 0.417 MG/ML / Phenylephrine Hydrochloride 0.333 MG/ML Oral Solution
FDA products mapped89
Package NDCs mapped100
RxNorm release07/06/2026
Snapshot dataJul 14, 2026
📖 Skip the Codes — Read It in Plain English.
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📗 Our plain-language guide HelloPharmacist
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🕸️ Concept Web — How Acetaminophen 21.7 MG/ML / dextromethorphan hydr... Connects
One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept
Acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / doxylamine succinate 0.417 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution
RxCUI 1431245 Semantic clinical drug · SCD
Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.
-
Ingredients 8
The active substance itself — no strength, form, or brand attached yet.
-
Acetaminophen
161IN -
Dextromethorphan
3289IN -
Doxylamine
3642IN -
Phenylephrine
8163IN -
Acetaminophen / dextromethorphan / doxylamine / phenylephrine
1008701MIN -
Dextromethorphan hydrobromide
102490PIN -
Doxylamine succinate
23665PIN -
Phenylephrine hydrochloride
8164PIN
-
Acetaminophen
-
Dose forms 9
The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.
-
Acetaminophen / dextromethorphan / doxylamine / phenylephrine Oral Solution
647202SCDF -
Acetaminophen / dextromethorphan hydrobromide / doxylamine succinate / phenylephrine hydrochloride Oral Solution
2649073SCDFP -
Acetaminophen / dextromethorphan / doxylamine / phenylephrine Oral Liquid Product
1155607SCDG -
Acetaminophen / dextromethorphan / doxylamine / phenylephrine Oral Product
1155896SCDG -
Acetaminophen / dextromethorphan hydrobromide / doxylamine succinate / phenylephrine hydrochloride Oral Liquid Product
2663084SCDGP -
Acetaminophen / dextromethorphan hydrobromide / doxylamine succinate / phenylephrine hydrochloride Oral Product
2660518SCDGP -
Oral Solution
316968DF -
Oral Liquid Product
1151137DFG - +1 more in this family
-
Acetaminophen / dextromethorphan / doxylamine / phenylephrine Oral Solution
-
Clinical & branded drugs 4
Ingredient + strength + dose form. These are the concepts real FDA products actually carry.
-
Acetaminophen 21.7 MG/ML
332581SCDC -
Dextromethorphan hydrobromide 0.667 MG/ML
1014004SCDC -
Doxylamine succinate 0.417 MG/ML
1042674SCDC -
Phenylephrine hydrochloride 0.333 MG/ML
1039296SCDC
-
Acetaminophen 21.7 MG/ML
-
Packs 1
Fixed collections of drugs packaged and sold together, like dose packs.
Showing up to 8 concepts per family — 21 of 22 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.
🔀 Generic ⇄ Brand Crosswalk
The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.
Generic (Clinical) Concepts
-
{1 (acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / doxylamine succinate 0.417 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution) / 1 (acetaminophen 21.7 MG/ML / dextromethorphan hydrobromide 0.667 MG/ML / guaifenesin 13.3 MG/ML / phenylephrine hydrochloride 0.333 MG/ML Oral Solution) } Pack
GPCK · 2637731 -
Acetaminophen 21.7 MG/ML
SCDC · 332581 -
Dextromethorphan hydrobromide 0.667 MG/ML
SCDC · 1014004 -
Doxylamine succinate 0.417 MG/ML
SCDC · 1042674 -
Phenylephrine hydrochloride 0.333 MG/ML
SCDC · 1039296 -
Acetaminophen / dextromethorphan / doxylamine / phenylephrine Oral Solution
SCDF · 647202 -
Acetaminophen / dextromethorphan hydrobromide / doxylamine succinate / phenylephrine hydrochloride Oral Solution
SCDFP · 2649073 -
Acetaminophen / dextromethorphan / doxylamine / phenylephrine Oral Liquid Product
SCDG · 1155607 -
Acetaminophen / dextromethorphan / doxylamine / phenylephrine Oral Product
SCDG · 1155896 -
Acetaminophen / dextromethorphan hydrobromide / doxylamine succinate / phenylephrine hydrochloride Oral Liquid Product
SCDGP · 2663084
📦 FDA Products & Package NDCs
89 products · 100 package NDCs
100 package NDCs map to RxCUI 1431245 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
| Package NDC | Package | Brand / generic name | Labeler | Marketing start |
|---|---|---|---|---|
| 49035-0714-02 | 1 KIT in 1 CARTON (49035-714-02) * 355 mL in 1 BOTTLE (490... | Equate Daytime Nighttime Cold and Flu | Wal-Mart Stores Inc | 2020-03-18 |
| 49035-0807-40 | 355 mL in 1 BOTTLE (49035-807-40) | equate nighttime cold and flu | Wal-Mart Stores Inc | 2019-10-01 |
| 49580-0416-08 | 237 mL in 1 BOTTLE, PLASTIC (49580-0416-8) | Severe cold and flu Nighttime | P & L Development, LLC | 2015-08-31 |
| 49580-4160-08 | 237 mL in 1 BOTTLE, PLASTIC (49580-4160-8) | Severe cold and flu Nighttime | P & L Development, LLC | 2021-03-26 |
| 50580-0231-01 | 1 KIT in 1 PACKAGE (50580-231-01) * 240 mL in 1 BOTTLE, PL... | TYLENOL Cold Plus Flu Severe and TYLENOL COLD MAX CoPack | Kenvue Brands LLC | 2018-08-20 |
| 50580-0241-01 | 1 KIT in 1 PACKAGE (50580-241-01) * 240 mL in 1 BOTTLE, PL... | Tylenol Cold plus Flu Severe and Tylenol Cold Max | Kenvue Brands LLC | 2016-10-03 |
| 50580-0369-01 | 240 mL in 1 BOTTLE (50580-369-01) | Tylenol Cold plus Flu plus Cough Night | Kenvue Brands LLC | 2019-06-17 |
| 50580-0526-01 | 1 KIT in 1 PACKAGE (50580-526-01) * 240 mL in 1 BOTTLE (50... | Tylenol Cold Plus Flu Severe Day and Tylenol Cold Plus Flu Plus Cough Night 2-pack | Kenvue Brands LLC | 2019-10-28 |
| 50580-0529-01 | 1 KIT in 1 PACKAGE (50580-529-01) * 240 mL in 1 BOTTLE (50... | Tylenol Cold Plus Flu Severe Day and Tylenol Cold Plus Flu Plus Cough Night 3-Pack | Kenvue Brands LLC | 2019-08-05 |
| 51316-0156-24 | 1 KIT in 1 PACKAGE (51316-156-24) * 354 mL in 1 BOTTLE (51... | CVS DayTime and NightTime Value Pack Cold and Flu | CVS PHARMACY | 2023-03-10 |
| 51316-0179-40 | 355 mL in 1 BOTTLE (51316-179-40) | nighttime severe | CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED | 2023-06-28 |
| 51316-0533-40 | 355 mL in 1 BOTTLE (51316-533-40) | SEVERE COLD AND FLU | CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED | 2026-01-26 |
| 51316-0641-12 | 354 mL in 1 BOTTLE, PLASTIC (51316-641-12) | CVS NightTime Cold | CVS PHARMACY | 2023-01-09 |
| 55319-0138-16 | 1 KIT in 1 KIT (55319-138-16) * 237 mL in 1 BOTTLE, PLASTI... | Daytime Nighttime Severe Cold and Flu Relief | Family Dollar (FAMILY WELLNESS) | 2024-07-31 |
| 55319-0641-08 | 237 mL in 1 BOTTLE, PLASTIC (55319-641-08) | Severe Nighttime Cold and Flu Relief | Family Dollar (FAMILY WELLNESS) | 2024-07-31 |
| 55910-0716-08 | 237 mL in 1 BOTTLE, PLASTIC (55910-716-08) | Severe cold and flu Nighttime | Dolgencorp, Inc. (DOLLAR GENERAL & REXALL) | 2018-03-31 |
| 55910-0900-34 | 237 mL in 1 BOTTLE (55910-900-34) | dg health cold and flu | Dolgencorp, LLC | 2018-09-24 |
| 55910-0900-40 | 355 mL in 1 BOTTLE (55910-900-40) | dg health cold and flu | Dolgencorp, LLC | 2018-09-24 |
| 55910-0928-40 | 355 mL in 1 BOTTLE (55910-928-40) | DG Health Cold and Flu Severe | Dolgencorp Inc | 2023-06-29 |
| 55910-0931-16 | 1 KIT in 1 KIT (55910-931-16) * 237 mL in 1 BOTTLE * 237... | Daytime Nighttime Severe Cold and Flu Relief | Dolgencorp, Inc. (DOLLAR GENERAL & REXALL) | 2018-03-31 |
| 56062-0763-40 | 355 mL in 1 BOTTLE (56062-763-40) | nitetime severe | Publix Super Markets Inc | 2025-02-03 |
| 58593-0830-06 | 1 BOTTLE in 1 CARTON (58593-830-06) / 180 mL in 1 BOTTLE | Rompe Pecho Nighttime | EFFICIENT LABORATORIES INC | 2019-09-01 |
| 59640-0423-40 | 355 mL in 1 BOTTLE (59640-423-40) | Nighttime SEVERE | H E B | 2025-08-08 |
| 59779-0597-02 | 1 KIT in 1 CARTON (59779-597-02) * 355 mL in 1 BOTTLE (597... | Severe Nighttime Severe Daytime | CVS Pharmacy | 2013-12-27 |
| 59779-0763-40 | 355 mL in 1 BOTTLE (59779-763-40) | Severe Nighttime | CVS Pharmacy | 2013-12-27 |
| 69423-0807-08 | 236 mL in 1 BOTTLE, PLASTIC (69423-807-08) | VICKS NyQuil SEVERE HONEY FLAVOR COLD and FLU | Procter & Gamble Manufacturing Company | 2021-07-07 |
| 69423-0807-12 | 354 mL in 1 BOTTLE, PLASTIC (69423-807-12) | VICKS NyQuil SEVERE HONEY FLAVOR COLD and FLU | Procter & Gamble Manufacturing Company | 2021-07-07 |
| 69423-0808-24 | 1 KIT in 1 CARTON (69423-808-24) * 354 mL in 1 BOTTLE * 3... | VICKS DayQuil SEVERE NyQuil SEVERE HONEY FLAVOR COLD and FLU | The Procter & Gamble Manufacturing Company | 2020-04-28 |
| 69423-0968-06 | 177 mL in 1 BOTTLE, PLASTIC (69423-968-06) | Vicks NyQuil Severe Honey Cold and Flu | Procter & Gamble Manufacturing Company | 2024-07-09 |
| 69423-0968-08 | 236 mL in 1 BOTTLE, PLASTIC (69423-968-08) | Vicks NyQuil Severe Honey Cold and Flu | Procter & Gamble Manufacturing Company | 2021-07-07 |
| 69423-0968-12 | 354 mL in 1 BOTTLE, PLASTIC (69423-968-12) | Vicks NyQuil Severe Honey Cold and Flu | Procter & Gamble Manufacturing Company | 2021-07-07 |
| 69423-0989-08 | 236 mL in 1 BOTTLE, PLASTIC (69423-989-08) | NyQuil VapoCOOL SEVERE COLD and FLU plus CONGESTION | The Procter & Gamble Manufacturing Company | 2021-03-22 |
| 69423-0989-12 | 354 mL in 1 BOTTLE, PLASTIC (69423-989-12) | NyQuil VapoCOOL SEVERE COLD and FLU plus CONGESTION | The Procter & Gamble Manufacturing Company | 2021-03-22 |
| 69423-0991-24 | 1 KIT in 1 PACKAGE (69423-991-24) * 354 mL in 1 BOTTLE, PL... | DayQuil and NyQuil VapoCOOL SEVERE COLD and FLU plus CONGESTION | The Procter & Gamble Manufacturing Company | 2021-03-22 |
| 69842-0800-40 | 355 mL in 1 BOTTLE (69842-800-40) | Nighttime Severe | CVS Pharmacy | 2016-06-23 |
| 70677-1030-01 | 355 mL in 1 BOTTLE (70677-1030-1) | foster and thrive nighttime severe cold and flu relief | Strategic Sourcing Services LLC | 2023-06-30 |
| 72288-0189-40 | 355 mL in 1 BOTTLE (72288-189-40) | basic care nighttime severe cold and flu | Amazon.com Services LLC | 2022-01-21 |
| 72288-0597-02 | 1 KIT in 1 CARTON (72288-597-02) * 355 mL in 1 BOTTLE (722... | basic care daytime severe cold and flu nighttime severe cold and flu | Amazon.com Services LLC | 2021-03-11 |
| 72288-0601-40 | 355 mL in 1 BOTTLE (72288-601-40) | basic care nighttime severe cold and flu | Amazon.com Services LLC | 2022-04-22 |
| 72288-0639-40 | 355 mL in 1 BOTTLE (72288-639-40) | basic care nighttime severe cold and flu | Amazon.com Services LLC | 2021-08-26 |
| 72288-0711-02 | 1 KIT in 1 CARTON (72288-711-02) * 355 mL in 1 BOTTLE (722... | BASIC CARE DAYTIME NIGHTTIME SEVERE COLD AND FLU | Amazon.com Services LLC | 2025-12-18 |
| 76162-0202-40 | 355 mL in 1 BOTTLE (76162-202-40) | topcare nite time cold and flu | Topco Associates LLC | 2023-07-03 |
| 76162-0417-02 | 1 KIT in 1 CARTON (76162-417-02) * 355 mL in 1 BOTTLE (761... | TOPCARE HONEY FLAVOR COLD AND FLU RELIEF | Topco Associates LLC | 2025-08-06 |
| 79481-8999-00 | 355 mL in 1 BOTTLE (79481-8999-0) | night time cold and flu | Meijer, Inc. | 2023-06-30 |
| 79903-0122-12 | 355 mL in 1 BOTTLE (79903-122-12) | equate nighttime cold and flu | WALMART INC. | 2023-06-30 |
| 79903-0191-12 | 355 mL in 1 BOTTLE, PLASTIC (79903-191-12) | Cold and Flu plus Congestion Nighttime | WALMART INC. | 2023-08-16 |
| 79903-0348-24 | 1 KIT in 1 CARTON (79903-348-24) * 1 BOTTLE in 1 CARTON (7... | equate daytime nighttime cold and flu | WALMART INC. | 2025-07-07 |
| 84126-0326-24 | 1 KIT in 1 CARTON (84126-326-24) * 354 mL in 1 BOTTLE * 3... | VICKS DayQuil NyQuil SEVERE HONEY COLD and FLU | The Procter & Gamble Manufacturing Company | 2020-04-28 |
| 85828-0775-01 | 354 mL in 1 BOTTLE (85828-775-01) | Nighttime Severe Cold and Flu | Grocery Outlet, Inc. | 2026-03-24 |
| 85828-0776-02 | 1 KIT in 1 BOTTLE (85828-776-02) * 354 mL in 1 BOTTLE * 3... | Daytime Severe and Nighttime Severe Cold and Flu | Grocery Outlet, Inc. | 2026-03-02 |
Observed labelers:
The Procter & Gamble Manufacturing Company (15) ·
TARGET CORPORATION (6) ·
Walgreen Company (6) ·
Amazon.com Services LLC (5) ·
CVS PHARMACY (5) ·
Kenvue Brands LLC (5)
· +26 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.
🗃️ Sources & Limits
Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
- A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
- Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
- Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
- Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.
Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.