Elbasvir; Grazoprevir Tablet shortage
Elbasvir; Grazoprevir Tablet is currently listed in shortage by the FDA. The FDA lists 1 affected product. This page was last refreshed from FDA data on Oct 2, 2026.
Zepatier (elbasvir/grazoprevir) tablets are being discontinued by Merck Sharp & Dohme, and this change may be permanent. No other manufacturers make this medicine, so it will not be available after December 1, 2025.
Don’t stop or change your therapy on your own — talk with your prescriber about the plan that fits you, and ask your pharmacist what’s actually available.
Do you take this drug? See the ‘What to do’ recommendation from Dr. Brian Staiger, PharmD →What’s in shortage — at a glance
These figures count only the manufacturers that reported this shortage to the FDA — not every company that makes Elbasvir; Grazoprevir Tablet. Other makers that haven’t reported a problem are shown in the green card below.
Shortage timeline
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Oct 17, 2025Currently in shortage1 of 1 product affected.
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Oct 17, 2025First reported to the FDA1 product first listed.
Built from FDA posting and update dates. The end date FDA publishes is the posting/update date, not a true resolution date, so durations are approximate.
What exactly is on backorder — by manufacturer
Manufacturer: Merck Sharp & Dohme LLC 📞 800-672-6372 1 NDC click to expand
| Status | NDC / product | Strength | Availability | Related information | Reason |
|---|---|---|---|---|---|
| To Be Discontinued | Zepatier, Tablet, 50 mg; 100 mg (NDC 0006-3074-02) | — | — | To be discontinued December 1, 2025 | — |
These rows are manufacturer reports to the FDA for Elbasvir; Grazoprevir Tablet — they do not necessarily cover every manufacturer that makes this drug. A company appears here only if it told the FDA it has a supply problem, so other makers may still have stock. That’s the basis for the Where else can I get Elbasvir; Grazoprevir Tablet? options further down this page.
Why is Elbasvir; Grazoprevir Tablet in shortage?
Merck Sharp & Dohme has reported to the FDA that they will be permanently stopping production of Zepatier (elbasvir 50 mg / grazoprevir 100 mg) tablets — specifically the package under NDC 0006-3074-02 — as of December 1, 2025. This means that particular product from this manufacturer will no longer be made or supplied after that date.
No specific reason for this decision was shared publicly with the FDA — Merck simply did not provide one. It's also worth knowing that this report reflects only what Merck has filed, so it speaks only to their version of this product.
Based on the manufacturer-reported reason(s) and notes on file with the FDA for Elbasvir; Grazoprevir Tablet, summarized in plain English by HelloPharmacist. A drug can be short for more than one reason, and the FDA updates these as manufacturers report changes.
What should I do if I take Elbasvir; Grazoprevir Tablet?
Elbasvir-grazoprevir (the brand Zepatier) is currently on the FDA drug-shortage list. I want to walk you through what that means for the strength you take.
This product comes as a combined tablet, and both of its strengths are affected the same way. The 50 mg / 100 mg tablet has no available source reported right now, and there is no separately supplied strength that is unaffected.
The reason listed is that this product is being discontinued, with a date of December 1, 2025. Because this is a planned discontinuation rather than a temporary supply gap, this change may be permanent. For that reason, the most important next step is a conversation with the person who prescribes this medicine.
Here is what I suggest, in order:
- Do not stop, skip, or change your doses on your own — keep taking it as prescribed while you sort out next steps.
- Talk with your prescriber or pharmacist soon about a plan, since this product is set to be discontinued and our records show no other maker supplying the same medicine.
- For reference, the manufacturer's contact number is listed on this page, though your pharmacy usually handles those calls.
This information comes from national, manufacturer-reported FDA data and may not match your local pharmacy's actual stock. Your care team can guide you to the right plan for you.
- Don’t stop or change the medication on your own — talk to your prescriber first.
- If this is part of an ongoing or essential regimen (for example HIV treatment or prevention, seizure, heart, transplant, diabetes or mental-health medicines), do not skip or ration doses — contact your pharmacist or prescriber right away to arrange continued supply before you run out.
- Ask your pharmacy to check other manufacturers, strengths, package sizes, and nearby stores.
- Ask your prescriber whether a different strength, formulation, or the brand/generic version is appropriate.
Uses, dosing, side effects, prices, and the complete FDA label — written in plain English and pharmacist-reviewed.
Therapeutic equivalents & pricing 1 productclick to expand
Orange Book–rated equivalents of the affected strengths, with the latest NADAC price (a federal retail-acquisition benchmark, not your copay) and an evidence-based availability label. Cheapest first.
| Product | Manufacturer | Package | NADAC $/unit | AB rating | Availability |
|---|---|---|---|---|---|
| Zepatier 50 mg/1; 100 mg | Merck | 14 tablets | — | — | FDA listed |
Equivalents share the same ingredient, strength, dosage form and route; an AB rating means the FDA considers them substitutable. NADAC is a national retail-pharmacy acquisition benchmark from CMS — not what you pay. Availability is inferred from recent pricing, not a stock check.
Other drugs in the same treatment class
These are different medicines — not other versions of Elbasvir; Grazoprevir Tablet — that fall in the same broad treatment class (hepatitis c virus- ns5a and ns3/4a inhibitor comb) . They are not automatic substitutes: they can differ in how they work, dosing, effectiveness, side effects and what they’re approved to treat. Do not switch on your own. This list is for information only — ask your prescriber or pharmacist whether any of them is appropriate for you.
Identity & classification
Where does this data come from?
Other antiviral shortages
Elbasvir; Grazoprevir Tablet shortage FAQs
Is Elbasvir; Grazoprevir Tablet in shortage?
Which products are affected?
When will Elbasvir; Grazoprevir Tablet be available again?
What should I do if I take Elbasvir; Grazoprevir Tablet?
Still have a question about the Elbasvir; Grazoprevir Tablet shortage?
Ask a pharmacist about this shortage →View Elbasvir; Grazoprevir Tablet on the FDA drug-shortage database →
Where does this data come from?
/drug/shortages) — drug, manufacturer & contact, NDC/product, status, availability, reason, therapeutic category and posting/update dates. Current / To Be Discontinued = active; Resolved is kept for history. The Supply-Risk rating is assessed per active ingredient and adds the FDA NDC Directory (still-marketed manufacturers by ingredient & form); same-medicine and equivalent products use First Databank classification + CMS NADAC pricing; Medicaid use + most-affected states come from CMS Medicaid State Drug Utilization Data. Reference only — confirm current status with the manufacturer or FDA before acting on it.