Can You Take Mucinex And Sudafed Together?
In our latest question and answer, the pharmacists discusses whether or not Mucinex (guaifenesin) can be taken safely with Sudafed (pseudoephedrine).

Question
Can you take Mucinex (guaifenesin) and Sudafed (pseudoephedrine) together?

Answered by Dr. Brian Staiger, PharmD
Medical Content Reviewed By HelloPharmacist
Staff
Last updated Apr 17, 2025
Key points
- There is no known drug interaction between Sudafed (pseudoephedrine) and Mucinex (guaifenesin). They are considered safe to take together.
- Several over-the-counter products contain both drugs in a single pill, such as Mucinex-D.
Answer
Mucinex (guaifenesin), a commonly used over-the-counter expectorant, can be safely taken in combination with Sudafed (pseudoephedrine), a nasal decongestant. There are no known interactions between the two medications.
In fact, there are a variety of over-the-counter products that combine both ingredients into a single product for ease of administration.
What Is Mucinex?
Mucinex (guaifenesin) is classified as an expectorant and mucolytic. It loosens and thins phlegm and bronchial secretions, which in turn helps to ease expectoration.
The less viscous secretions help to increase the efficiency of our "mucociliary clearance mechanism", changing a dry, unproductive cough to a more productive one.
What Is Sudafed?
Sudafed (pseudoephedrine) is classified as a sympathomimetic nasal decongestant. It works by causing vasoconstriction and shrinking swollen nasal passages, which help to increase nasal airflow and reduce nasal congestion.
Taking Mucinex With Sudafed
As mentioned above, Mucinex and Sudafed can be taken together and both are available in combination in a single product.
Taking both Sudafed and Mucinex at the same time can often help to alleviate symptoms more than either product alone.
In many cases, Sudafed can increases sinus drainage, potentially worsening chest congestion, and postnasal drip. Combining Sudafed and Mucinex can help to reduce nasal congestion while also helping to relieve postnasal drip and chest congestion.
Examples of products that contain both Mucinex and Sudafed are:
- Mucinex-D 12 Hour
- Mucinex-D 24 Hour
- Sunmark Mucus Relief D
- Chest Congestion Relief D
Final Words
You can feel safe using both Mucinex and Sudafed together or using a single product that combines the two.
Thanks for reaching out and I hope you found this answer helpful.
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Dr. Brian Staiger, PharmD
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