Can You Take NyQuil With Advil?

Yes, NyQuil can safely be taken with Advil (ibuprofen). The pharmacist discusses this and more in our latest question and answer.


I am looking for some advice. I was wondering if it was okay to use NyQuil and Advil together? I use NyQuil every once in a while to sleep and Advil I'd say every few days. I just want to make sure they are safe.

Asked by John On May 13, 2022

Answered by
Medical Content Reviewed By HelloPharmacist Staff

Published May 13, 2022
Last updated May 31, 2022

Key points

  • There is no drug interaction between Advil and NyQuil. They can be safely taken together. However, NyQuil already contains the analgesic acetaminophen. Therefore, taking Advil may not be necessary.

NyQuil and Advil (ibuprofen) can be safely together, but it may not be necessary as NyQuil already contains the pain reliever acetaminophen (which is the active ingredient in Tylenol).

NyQuil contains 3 active ingredients (NyQuil Severe contains 4):

If you are looking for pain relief, in addition, to helping with sleeping at night, simply taking NyQuil may do the trick for you because of the acetaminophen it contains.

However, Advil (ibuprofen) is a different type of pain reliever than acetaminophen.

It is an NSAID (non-steroidal anti-inflammatory drug), which helps to reduce and relieve inflammation. acetaminophen does not have anti-inflammatory properties.

There is no drug interaction between Advil and any of the ingredients in NyQuil.

Taking both together would most likely provide greater pain relief than taking either alone and you will have the benefit of the anti-inflammatory effects from Advil.

In fact, there are several studies that suggest taking acetaminophen (in NyQuil) and Advil (ibuprofen) close to one another, or cycling them every 2-3 hours, provides far better pain relief than either alone.

Be sure to always take Advil with food as it can cause an upset stomach and long-term use increases the risk of stomach ulcers. Taking it every once in a while, on an as-needed basis, is generally considered to be safe.



  • Alternating Acetaminophen and Ibuprofen, PubMed
  • Vicks Manufacturer Website, Vicks

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