Herb & supplement monograph

Maitake Mushroom Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by ·Updated July 2026
What is this page for?

First and foremost: how Maitake Mushroom interacts with medications. The heart of this page is the interaction list — every drug Maitake Mushroom is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Maitake Mushroom is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Maitake Mushroom Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the risk of a clinically significant Maitake Mushroom drug interaction is moderate for most people, and it centers on medicines that affect blood sugar, blood pressure, or blood clotting. None of the listed interactions are rated major, but all are rated moderate, and most rest on theoretical or limited evidence.

Interactions deserving the most attention

The best-documented concern is with diabetes medications, since human research shows a maitake extract can lower blood glucose, so adding it could push blood sugar too low. Warfarin also deserves care: in one case report, a patient stable on warfarin developed a markedly elevated INR, a sign of increased bleeding risk, after a week of maitake extract. A possible drop in blood pressure with blood pressure medications has been seen only in animal research, so it is less certain but worth knowing about.

What the rest of the list means

Although the list of interacting medications is long, it reflects a few broad concerns, mainly effects on blood sugar, blood pressure, and clotting, applied across many drugs. Most of these interactions are predicted rather than proven, and outside the warfarin case report, harmful combinations have not been clearly shown in people.

Check your medications against Maitake Mushroom

Based on HelloPharmacist’s Maitake Mushroom interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Maitake Mushroom

260 medications have a known interaction with Maitake Mushroom, graded by severity. Select any drug for the full evidence-based detail.

2,830 drugs
AcarboseGlucobay, Prandase, Precose
Moderate Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Maitake Mushroom + Acarbose interaction Acarbose drug page: uses, dosage & side effects
AcebutololRhotral, Sectral
Moderate Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Maitake Mushroom + Acebutolol interaction Acebutolol drug page: uses, dosage & side effects
AcetazolamideAk-Zol, Diamox
Moderate Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Maitake Mushroom + Acetazolamide interaction Acetazolamide drug page: uses, dosage & side effects
AcetohexamideDymelor
Moderate Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Maitake Mushroom + Acetohexamide interaction
AlbiglutideTanzeum
Moderate Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Maitake Mushroom + Albiglutide interaction
AliskirenTekturna
Moderate Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Maitake Mushroom + Aliskiren interaction Aliskiren drug page: uses, dosage & side effects
AlogliptinNesina
Moderate Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Maitake Mushroom + Alogliptin interaction Alogliptin drug page: uses, dosage & side effects
Alogliptin, MetforminKazano
Moderate Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Maitake Mushroom + Alogliptin, Metformin interaction
Alogliptin, PioglitazoneOseni
Moderate Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Maitake Mushroom + Alogliptin, Pioglitazone interaction
AmbrisentanLetairis, Volibris
Moderate Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Maitake Mushroom + Ambrisentan interaction Ambrisentan drug page: uses, dosage & side effects
AmilorideAmilamont, Midamor
Moderate Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Maitake Mushroom + Amiloride interaction Amiloride drug page: uses, dosage & side effects
Amiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
Moderate Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Maitake Mushroom + Amiloride, Hydrochlorothiazide interaction Amiloride, Hydrochlorothiazide drug page: uses, dosage & side effects
AmlodipineNorliqva
Moderate Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Maitake Mushroom + Amlodipine interaction Amlodipine drug page: uses, dosage & side effects
Amlodipine BenzoateKaterzia
Moderate Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Maitake Mushroom + Amlodipine Benzoate interaction Amlodipine Benzoate drug page: uses, dosage & side effects
Amlodipine BesilateIstin
Moderate Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Maitake Mushroom + Amlodipine Besilate interaction
Amlodipine BesylateNorvasc
Moderate Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Maitake Mushroom + Amlodipine Besylate interaction Amlodipine Besylate drug page: uses, dosage & side effects
Amlodipine Besylate, BenazeprilLotrel
Moderate Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Maitake Mushroom + Amlodipine Besylate, Benazepril interaction
Amlodipine, CelecoxibConsensi
Moderate Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Maitake Mushroom + Amlodipine, Celecoxib interaction
Ammonium ChlorideAmmonium Chloride
Moderate Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Maitake Mushroom + Ammonium Chloride interaction
Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
Moderate Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full Maitake Mushroom + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interaction
AprocitentanTryvio
Moderate Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Maitake Mushroom + Aprocitentan interaction Aprocitentan drug page: uses, dosage & side effects
AtenololAtenix, Tenormin
Moderate Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Maitake Mushroom + Atenolol interaction Atenolol drug page: uses, dosage & side effects
Atenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
Moderate Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Maitake Mushroom + Atenolol, Chlortalidone interaction
Atenolol, ChlorthalidoneTenoretic
Moderate Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Maitake Mushroom + Atenolol, Chlorthalidone interaction
AzilsartanEdarbi
Moderate Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Maitake Mushroom + Azilsartan interaction Azilsartan drug page: uses, dosage & side effects
Azilsartan, ChlorthalidoneEdarbyclor
Moderate Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Maitake Mushroom + Azilsartan, Chlorthalidone interaction
BenazeprilLotensin
Moderate Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Maitake Mushroom + Benazepril interaction Benazepril drug page: uses, dosage & side effects
Benazepril, HydrochlorothiazideLotensin HCT
Moderate Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Maitake Mushroom + Benazepril, Hydrochlorothiazide interaction
BendroflumethiazideAprinox, Naturetin, Neo-NaClex
Moderate Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Maitake Mushroom + Bendroflumethiazide interaction
Bendroflumethiazide, NadololCorzide
Moderate Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.

Read the full Maitake Mushroom + Bendroflumethiazide, Nadolol interaction
Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Maitake Mushroom combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The big picture

The kinds of drugs Maitake Mushroom affects

Every type of medication (drug category) Maitake Mushroom is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 3 drug categories Maitake Mushroom interacts with
Antidiabetes DrugsAntihypertensive DrugsWarfarin (coumadin)
Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
Monograph

Maitake Mushroom: Uses, Safety & Side Effects

Medically reviewed by · Reviewed July 2026 ·
The bottom line

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence is still limited and not strong enough to recommend it as a treatment. It is generally well tolerated as food, but talk to your pharmacist or doctor before using concentrated supplements.

Maitake Mushroom
Scientific name
Grifola frondosa
Family
Meripilaceae
Part used
Fruiting body (mushroom) and mycelium; also purified extracts such as the 'D-fraction'
Common forms
Capsules, tablets, powders, liquid extracts (D-fraction/SX-fraction), and whole mushroom used as food
People commonly use it for
  • Immune support
  • Blood sugar support in diabetes
  • High blood pressure
  • High cholesterol
  • General wellness and antioxidant support

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Generally well tolerated as food, but supplement safety has not been fully studied.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Jump to a section

Overview

Maitake (Grifola frondosa) is an edible mushroom that grows in clusters at the base of trees, especially oaks. It is native to parts of Japan, China, and North America. Its overlapping, fan-shaped caps give it the nickname "hen of the woods." In Japanese, "maitake" is often said to mean "dancing mushroom."

Maitake has been eaten as food for a long time and is valued for its rich, savory flavor. It has also been used in traditional Japanese medicine. Today it is sold both as a culinary mushroom and as a dietary supplement in capsules, powders, and liquid extracts. Supplement makers often highlight beta-glucan compounds such as the "D-fraction" and a protein-bound component called the "SX-fraction."

How it works

Maitake contains complex sugars called beta-glucans, including the much-discussed "D-fraction." In laboratory and animal research, beta-glucans appear to interact with immune cells and may influence how the immune system responds.

Other proposed effects, such as helping with blood sugar or blood pressure, may come from the way these mushroom compounds affect metabolism and blood vessels. Maitake also contains antioxidants that may help reduce cell-damaging molecules.

It is important to know that most of these mechanisms are based on lab and animal research, not on strong human studies. The exact way maitake works in the body is still not fully understood.

Effectiveness

Does Maitake Mushroom work?

Here’s what the research actually shows for each use — graded by Natural Medicines and reviewed by .

Evidence overview · 17 uses evaluated
17 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Maitake Mushroom, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 17 conditions — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Allergic rhinitis (hay fever)
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral maitake mushroom for allergic rhinitis, there is insufficient reliable information about the clinical effects of maitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate Chemotherapy-induced anemia
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral maitake mushroom for preventing chemotherapy-induced anemia, there is insufficient reliable information about the clinical effects of maitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate Chemotherapy-induced diarrhea
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral maitake mushroom for preventing chemotherapy-induced diarrhea, there is insufficient reliable information about the clinical effects of maitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate Chemotherapy-induced leukopenia
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral maitake mushroom for preventing chemotherapy-induced leukemia, there is insufficient reliable information about the clinical effects of maitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate Chemotherapy-induced nausea and vomiting (CINV)
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral maitake mushroom for preventing CINV, there is insufficient reliable information about the clinical effects of maitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate Chemotherapy-related fatigue
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral maitake mushroom for preventing chemotherapy-related fatigue, there is insufficient reliable information about the clinical effects of maitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate Chronic fatigue syndrome (CFS)
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral maitake mushroom for CFS, there is insufficient reliable information about the clinical effects of maitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate Coronavirus disease 2019 (COVID-19)
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral maitake mushroom for COVID-19, there is insufficient reliable information about the clinical effects of maitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate Diabetes
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral maitake mushroom for diabetes, there is insufficient reliable information about the clinical effects of maitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate HIV/AIDS
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral maitake mushroom for HIV/AIDS, there is insufficient reliable information about the clinical effects of maitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate Hyperlipidemia
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral maitake mushroom for hyperlipidemia, there is insufficient reliable information about the clinical effects of maitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate Hypertension
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral maitake mushroom for hypertension, there is insufficient reliable information about the clinical effects of maitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate Laryngeal cancer
Rating & evidence shown verbatim from Natural Medicines

It is unclear if maitake mushroom is beneficial for improving quality of life in patients with laryngeal cancer.

Insufficient Reliable Evidence To Rate Myelodysplastic syndromes
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral maitake mushroom for myelodysplastic syndromes, there is insufficient reliable information about the clinical effects of maitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate Obesity
Rating & evidence shown verbatim from Natural Medicines

Although there has been interest in using oral maitake mushroom for obesity, there is insufficient reliable information about the clinical effects of maitake mushroom for this purpose.

Insufficient Reliable Evidence To Rate Pharyngeal cancer
Rating & evidence shown verbatim from Natural Medicines

It is unclear if maitake mushroom is beneficial for improving quality of life in patients with pharyngeal cancer.

Insufficient Reliable Evidence To Rate Polycystic ovary syndrome (PCOS)
Rating & evidence shown verbatim from Natural Medicines

Maitake mushroom may have some benefit in PCOS, but it does not appear to be as effective as clomiphene.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

Maitake eaten as food is generally considered safe for most people. Concentrated supplements have not been studied as thoroughly, so their long-term safety is less certain.

Because maitake may lower blood sugar, people with diabetes or low blood sugar should use caution and monitor closely. It may also affect blood pressure, so those with blood pressure concerns should be careful. People with mushroom allergies should avoid it.

Pregnancy and breastfeeding: there is not enough reliable safety information, so concentrated maitake supplements should be avoided during pregnancy and while breastfeeding. Eating maitake as a normal food is likely fine, but check with your doctor if you are unsure.

Always talk to your pharmacist or doctor before starting maitake, especially if you take medications or have a chronic health condition.

Side effects

Maitake is usually well tolerated. When side effects occur, they are typically mild and may include upset stomach, nausea, or digestive discomfort.

Because it may lower blood sugar, watch for symptoms of low blood sugar such as shakiness, sweating, or dizziness, especially if you have diabetes. Allergic reactions are possible, particularly in people sensitive to mushrooms. Stop use and seek medical care if you notice signs of an allergic reaction such as rash, swelling, or trouble breathing.

Maitake Mushroom: Reported Adverse Effects

Documented safety reports on Maitake Mushroom from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.

Orally, maitake mushroom is generally well tolerated.

Most Common Adverse Effects:

Orally: Gastrointestinal effects, including diarrhea and epigastric pain.

Reports by condition
Diarrhea Gastrointestinal

In clinical research of a polysaccharide extract from maitake mushroom, one patient reported nausea and 2 out of 26 reported epigastric pain. In a clinical trial of a liquid extract from maitake mushroom, 2 out of 21 patients experienced diarrhea, and one experienced nausea. One patient withdrew from the study due to diarrhea.

  1. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
  2. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
  3. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47.
Pruritus Dermatologic

In a clinical trial, one patient experienced rash and pruritus after two doses of maitake mushroom polysaccharide extract. The allergic reaction cleared without intervention.

  1. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

Adverse-effects data: Natural Medicines, Therapeutic Research Center

Dosing

There is no official, well-established dose for maitake supplements. Products vary widely in strength and in how they are prepared, including whole mushroom powders and standardized extracts like the D-fraction.

The best approach is to follow the directions on the product label and to choose products from reputable brands. Because doses and product quality differ, check with your pharmacist or doctor before starting, especially if you have diabetes, blood pressure problems, or take other medicines.

Pregnancy & Breastfeeding

Maitake Mushroom & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Maitake Mushroom & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 8 references that drive our Maitake Mushroom monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
  2. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
  3. Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
  4. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
  5. Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
  6. Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed
  7. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
  8. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Brand directory

Brands that make products with Maitake Mushroom

427 brands in our database make a supplement containing Maitake Mushroom.

Product directory

Supplement products with Maitake Mushroom

1,831 products in our database contain Maitake Mushroom. Open any to see its full ingredient list and every drug interaction we check.

10 in 1 Mushroom Essentials Raspberry Flavor by SeniorLife Health Gummy Or Jelly 60 Gummy(ies) View ingredients & interactions 10 Shrooms by Oweli Capsule 60 Veggie Capsule(s) View ingredients & interactions 100% Fermented Organic Greens Organic Chocolate by Natural Factors Whole Earth & Sea Powder 7.7 Ounce(s) · 219 Gram(s) View ingredients & interactions 100% Fermented Organic Greens Unflavored by Natural Factors Whole Earth & Sea Powder 6.9 Ounce(s) · 195 Gram(s) View ingredients & interactions 20 Veggies & Mushrooms by PureMax Labs YummyVite Capsule 60 Capsule(s) View ingredients & interactions 4Life Transfer Factor Plus by 4Life Capsule 60 Capsule(s) View ingredients & interactions 4Life Transfer Factor Plus RiteStart Men by 4Life Unknown 30 Packet(s) View ingredients & interactions 5 Defenders Capsules by Real Mushrooms Capsule 90 Capsule(s) View ingredients & interactions 5 Defenders Capsules by Real Mushrooms Capsule 200 Capsule(s) View ingredients & interactions 5 Defenders Powder by Real Mushrooms Powder 100 Gram(s) · 3.53 Ounce(s) View ingredients & interactions 5 Defenders Powder by Real Mushrooms Powder 45 Gram(s) · 1.59 Ounce(s) View ingredients & interactions 7M+ by Organixx Capsule 60 Veggie Cap(s) View ingredients & interactions 8 Mushroom Complex by BioSchwartz Capsule 60 Veggie Capsule(s) View ingredients & interactions 8-in-1 Myco Ultra by Holistic Labs Ltd. Capsule 60 Vegetarian Capsule(s) View ingredients & interactions A.R.M. by Paradise Capsule 60 Vegetarian Capsule(s) View ingredients & interactions Active Immunity by Akasha Naturals Tablet Or Pill 90 Tablet(s) View ingredients & interactions Acute Immune Benefits by DaVinci Benefits Line Liquid 4 Ounce(s) · 120 mL View ingredients & interactions Acute Immune Benefits Liquid by DaVinci Benefits Line Liquid 1 Fluid Ounce(s) · 30 mL View ingredients & interactions Adam's Vitality by Logos Nutritionals Capsule 90 Capsule(s) View ingredients & interactions Adaptogenic by Anima Mundi Liquid 4 Ounce(s) · 113 Gram(s) View ingredients & interactions Add Lib by Oceanus Naturals Capsule 60 Capsule(s) View ingredients & interactions Adrenasyl +BioPerine by Approved Science Capsule 60 Capsule(s) View ingredients & interactions Adult's Daily Immune Wellness by Buried Treasure Liquid Nutrients Liquid 16 fl. Oz. · 473 mL View ingredients & interactions Advanced by Stresstabs Tablet Or Pill 60 Tablet(s) View ingredients & interactions
Pharmacist Counseling Corner

Maitake Mushroom: Common Questions

What is Maitake Mushroom used for, and does it work?
People use Maitake Mushroom for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Maitake Mushroom interact with prescription medications?
Yes. We list 260 medications with a known interaction with Maitake Mushroom. Use the checker above to see how Maitake Mushroom interacts with a specific drug.
How are Maitake Mushroom interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Maitake Mushroom with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Maitake Mushroom interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Maitake Mushroom used for?
People commonly use maitake for immune support and to help with blood sugar, blood pressure, or cholesterol. However, strong human evidence is lacking, so it should not replace proven treatments.
Is maitake safe to take?
Maitake eaten as food is generally safe for most people, and supplements are usually well tolerated. Still, concentrated supplements are less studied, so check with your pharmacist or doctor first, especially if you have a health condition.
Can I take maitake if I'm pregnant or breastfeeding?
Eating maitake as a normal food is likely fine, but there isn't enough safety data on concentrated supplements, so it's best to avoid maitake supplements during pregnancy and breastfeeding.
Does maitake lower blood sugar?
Some early research suggests maitake may have a blood-sugar-lowering effect, but the evidence is limited. If you have diabetes, monitor your blood sugar closely and talk to your healthcare provider before using it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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