Add Lib Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Add Lib against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Add Lib is a dietary supplement by Oceanus Naturals with 9 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 1,231 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Passionflower extract, Fenugreek seed extract, Maitake extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Add Lib by Oceanus Naturals
Ask about any prescription or over-the-counter medication and we check it for interactions with Add Lib by Oceanus Naturals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Add Lib by Oceanus Naturals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Add Lib contains 9 ingredients total. The active components include vitamin B12, a B-complex vitamin critical for energy and nerve function; fenugreek seed extract, used traditionally for sexual health and blood sugar support; cordyceps sinensis extract, an adaptogenic mushroom; maitake mushroom extract, another immune-supporting fungus; passionflower extract, known for calming effects; American ginseng extract, an adaptogen used for vitality; maca extract, a root vegetable supplement; and damiana extract, used in herbal traditions for sexual wellness.
There's also wulinshen extract, a proprietary ingredient we couldn't verify. The product uses microcrystalline cellulose and dicalcium phosphate as inactive ingredients.
Does it work?
Moderate evidence
The evidence is mixed and often limited. Vitamin B12 is effective for B12 deficiency itself and for Imerslund-Grasbeck disease, and likely effective for cyanide poisoning, though that's not what most people take it for here.
Fenugreek, passionflower, and American ginseng each show possibly effective ratings for sexual dysfunction and related concerns — fenugreek for dysmenorrhea as well, passionflower for insomnia and pre-procedural anxiety. Cordyceps, maitake, and maca all carry insufficient evidence ratings for their listed uses — meaning the science isn't established enough in our data to say whether they work.
Damiana also lacks reliable evidence for sexual dysfunction and its other claimed uses. Because many of these are in a proprietary blend, you're not seeing individual doses, which matters for what the research actually tested.
How safe is it?
Well-documented data
Most ingredients are generally well tolerated when used short-term. Vitamin B12 is very safe orally — your body excretes excess in urine, and it's safe in pregnancy and breastfeeding at normal amounts.
Fenugreek commonly causes digestive upset (bloating, diarrhea, nausea) and rare severe allergic reactions; avoid medicinal doses in pregnancy but it's sometimes used to boost milk supply. Cordyceps and maitake are okay short-term but safety data are limited; both should be avoided in pregnancy and breastfeeding.
Passionflower causes drowsiness and dizziness and should be avoided in pregnancy and breastfeeding. American ginseng may cause headache and should be avoided in pregnancy; breastfeeding safety is unknown.
Maca and damiana have minimal human safety data; both should be avoided in pregnancy and breastfeeding. One case report linked cordyceps to liver inflammation, though it's unclear if cordyceps was responsible.
Meds to double-check
Major interaction found
Check your exact medications before starting — especially if you take warfarin (a blood thinner; American ginseng may reduce its effectiveness), diabetes drugs (several ingredients may lower blood sugar further), sedatives or anti-anxiety medications (passionflower adds to their effects), blood thinners or antiplatelet drugs like clopidogrel (fenugreek and cordyceps), blood pressure medications like metoprolol (fenugreek), immunosuppressants (cordyceps and American ginseng), MAOIs or other antidepressants (American ginseng), or theophylline, phenytoin, or sildenafil (all interactions with fenugreek). If no interactions are documented for an ingredient we could check, we'll note that — but absence of documented interactions is not a guarantee none exist.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
Add Lib is designed as a supplement for sexual health and general vitality, mixing adaptogens, mushroom extracts, and traditional herbs. If you take warfarin, diabetes medications, sedatives, immunosuppressants, or MAOIs, you need to check your exact prescriptions with the tool below — several ingredients may affect how they work.
Talk to your pharmacist or doctor before starting, especially if you're pregnant, breastfeeding, or on any regular medication.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 8 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2011.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Add Lib, straight from the product label.
| Brand | Oceanus Naturals |
|---|---|
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Nov 25, 2011 |
| DSLD ID | 2580 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult Female (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Add Lib by Oceanus Naturals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Vitamin B12 | 60 mcg | 1000% |
| Proprietary Blend | 655 mg | -- |
| Fenugreek seed extract | 0 NP | -- |
| Cordyceps sinensis extract | 0 NP | -- |
| Maitake extract | 0 NP | -- |
| Wulinshen extract | 0 NP | -- |
| Passionflower extract | 0 NP | -- |
| American Ginseng extract | 0 NP | -- |
| Maca extract | 0 NP | -- |
| Damiana extract | 0 NP | -- |
Other ingredients: Microcrystalline Cellulose, Dicalcium Phosphate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
dietary supplement
Suggested/Recommended/Usage/Directions
Suggested Use: Take 1 or 2 capsules in the morning with food.
FDA Disclaimer Statement
This product has not been evaluated by the FDA and is not intended to treat, cure or prevent any disease.
Formula
women
General Statements
Add Lib is 100% natural and hormone-free.
Add Lib is formulated with all natural plant and mushroom extracts, antioxidants, vitamins and other phytonutrients to promote energy, a healthy mood and sexual desire.
Add Lib is not a drug, nor a hormone, rather a revolutionary women’s health supplement. Add Lib supports a healthy body and mind – improving overall energy, while reducing stress and anxiety. Add Lib’s all natural ingredients promote passion and vitality, as well as a healthy balanced mood. It contains powerful phytonutrients to stimulate sexual desire and enhance your libido. Add Lib capsules are formulated with 9 effective ingredients including mushroom extracts, antioxidants and vitamins.
Add Lib naturally promotes energy, a healthy mood and sexual desire
all natural supplement
Benefits
Cordyceps improves energy and vitality levels while promoting respiratory, circulatory, sexual and immune health.
Damiana Extract has been used for hundreds of years to increase sexual desire and relieve stress and anxiety.
Energy | Mood | Desire
Fenugreek Seed Extract promotes healthy libido functions as well as improves body composition, mood and cognition. (contains 50% saponins)
Ginseng and Maca Extracts increase energy, stamina, and endurance, and improve focus.
Ignite your life’s passions
libido enhancement
Maca is growing in world popularity due to its energizing effects and aphrodisiac qualities.
Made in USA
Maitake Extract benefits immune and cardiovascular health.
Passionflower helps keep your body and mind balanced and reduces anxiety.
The Cordyceps in Add Lib helps improve energy and vitality levels while promoting respiratory, circulatory, sexual and immune health. See side panel for more ingredient benefits.
Vitamin B12 is needed for healthy digestion and is known for its energy enhancement benefits.
Wulinshen may help support normal sleep and a healthy mood.
Precautions
Cautions: ·Do not use if pregnant or lactating ·Keep out of reach of children ·Store at room temperature (60-86°F) ·Do not use if blister is torn or broken
Brand IP Statement(s)
©2010 Oceanus Naturals
Formulation
Add Lib is Hormone-free
hormone-free
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Add Lib by Oceanus Naturals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Add Lib by Oceanus Naturals
These are the 9 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Vitamin B12
Interacts with20 drugs
Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...
Vitamin B12 monograph & interactionsProprietary Blend
- › Fenugreek seed extract
- › Cordyceps sinensis extract
- › Maitake extract
- › Wulinshen extract
- › Passionflower extract
- › American Ginseng extract
- › Maca extract
- › Damiana extract
Other (inactive) ingredients: Microcrystalline Cellulose, Dicalcium Phosphate. These complete the product’s ingredient list but are not active constituents.
Add Lib by Oceanus Naturals Drug Interactions
HelloPharmacist Interaction Report
Add Lib by Oceanus Naturals contains nine ingredients, several of which interact with medications.
The most serious interaction we've documented is American ginseng with warfarin (Coumadin) — a blood thinner. American ginseng appears to reduce warfarin's effectiveness, lowering the international normalized ratio (INR), which measures blood-thinning strength.
This is a Major-severity interaction.
Read the full breakdown — every affected drug type, severity by severity
Fenugreek seed extract carries Moderate interactions with blood thinners and blood-clotting medications (anticoagulants and antiplatelets like warfarin and clopidogrel), diabetes drugs, blood pressure medications, and several others including theophylline, phenytoin, and sildenafil. Cordyceps, maitake, and passionflower each have Moderate interactions with blood thinners, diabetes drugs, and other classes.
Passionflower also interacts Moderately with sedatives (CNS depressants) and Minor with certain enzyme-related drugs. American ginseng additionally interacts Moderately with diabetes drugs, immunosuppressants, and MAOIs (a class of antidepressants).
Damiana and vitamin B12 carry Moderate and Minor interactions, respectively, with diabetes medications.
Wulinshen extract could not be checked — we hold no data for it. Maca has no documented interactions in our data.
Altogether, these interactions span 1,216 individual medications. Use the medication checker on this page with your exact drugs before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Add Lib?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Add Lib interact with 1,231 drugs. Click any drug to see the details.
7 of the 9 ingredients in Add Lib interact with drugs. Each result below shows which ingredient is responsible. Passionflower extract Fenugreek seed extract Maitake extract Cordyceps sinensis extract American Ginseng extract Damiana extract Vitamin B12
WarfarinWarfarin
How Warfarin interacts with Add Lib — through 5 ingredients. Tap an ingredient for the detail:
American Ginseng ExtractWarfarin (coumadin) Major
Interaction Summary
American ginseng seems to decrease the effectiveness of warfarin therapy.
Read the full American Ginseng Extract + Warfarin interactionFenugreek Seed ExtractAnticoagulant/antiplatelet Drugs, Warfarin (coumadin) Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract + Warfarin interactionMaitake ExtractWarfarin (coumadin) Moderate
Interaction Summary
There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
Read the full Maitake Extract + Warfarin interactionCordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Warfarin interactionPassionflower ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Extract + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with Add Lib — through 5 ingredients. Tap an ingredient for the detail:
American Ginseng ExtractWarfarin (coumadin) Major
Interaction Summary
American ginseng seems to decrease the effectiveness of warfarin therapy.
Read the full American Ginseng Extract + Warfarin Sodium interactionFenugreek Seed ExtractWarfarin (coumadin), Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Read the full Fenugreek Seed Extract + Warfarin Sodium interactionMaitake ExtractWarfarin (coumadin) Moderate
Interaction Summary
There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
Read the full Maitake Extract + Warfarin Sodium interactionCordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Warfarin Sodium interactionPassionflower ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Extract + Warfarin Sodium interaction6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Add Lib — through 2 ingredients. Tap an ingredient for the detail:
American Ginseng ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Extract + 6-mercaptopurine interactionCordyceps Sinensis ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps Sinensis Extract + 6-mercaptopurine interactionAbciximabReoPro
How Abciximab interacts with Add Lib — through 2 ingredients. Tap an ingredient for the detail:
Cordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Abciximab interactionFenugreek Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Add Lib — through 3 ingredients. Tap an ingredient for the detail:
Cordyceps Sinensis ExtractImmunosuppressants, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Read the full Cordyceps Sinensis Extract + Abrocitinib interactionFenugreek Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract + Abrocitinib interactionAmerican Ginseng ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
Read the full American Ginseng Extract + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Add Lib — through 4 ingredients. Tap an ingredient for the detail:
Fenugreek Seed ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Read the full Fenugreek Seed Extract + Acarbose interactionMaitake ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Maitake Extract + Acarbose interactionDamiana ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking damiana with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Damiana Extract + Acarbose interactionAmerican Ginseng ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full American Ginseng Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Add Lib — through 2 ingredients. Tap an ingredient for the detail:
Maitake ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Maitake Extract + Acebutolol interactionFenugreek Seed ExtractAntihypertensive Drugs Minor
Interaction Summary
Fenugreek may also have an additive effect on blood pressure-lowering medications.
Read the full Fenugreek Seed Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Add Lib — through 2 ingredients. Tap an ingredient for the detail:
Cordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Acenocoumarol interactionFenugreek Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Add Lib — through 1 ingredient. Tap an ingredient for the detail:
Passionflower ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Extract + Acepromazine interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Add Lib — through 2 ingredients. Tap an ingredient for the detail:
Fenugreek Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract + Acetaminophen, Aspirin interactionCordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Add Lib — through 3 ingredients. Tap an ingredient for the detail:
Cordyceps Sinensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Cordyceps Sinensis Extract + Acetaminophen, Aspirin, Caffeine interactionFenugreek Seed ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Read the full Fenugreek Seed Extract + Acetaminophen, Aspirin, Caffeine interactionPassionflower ExtractCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Add Lib — through 1 ingredient. Tap an ingredient for the detail:
Passionflower ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Add Lib — through 1 ingredient. Tap an ingredient for the detail:
Passionflower ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Add Lib — through 1 ingredient. Tap an ingredient for the detail:
Passionflower ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Add Lib — through 1 ingredient. Tap an ingredient for the detail:
Passionflower ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Add Lib — through 1 ingredient. Tap an ingredient for the detail:
Passionflower ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Add Lib — through 1 ingredient. Tap an ingredient for the detail:
Passionflower ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Add Lib — through 1 ingredient. Tap an ingredient for the detail:
Passionflower ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Add Lib — through 1 ingredient. Tap an ingredient for the detail:
Passionflower ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Add Lib — through 1 ingredient. Tap an ingredient for the detail:
Passionflower ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
Read the full Passionflower Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorzoxazone, CodeineAcetazone Forte C8, Parafon Forte C8
How Acetaminophen, Chlorzoxazone, Codeine interacts with Add Lib — through 1 ingredient. Tap an ingredient for the detail:
Passionflower ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Extract + Acetaminophen, Chlorzoxazone, Codeine interactionAcetaminophen, CodeineTylenol No.3, Tylenol w/ Codeine
How Acetaminophen, Codeine interacts with Add Lib — through 1 ingredient. Tap an ingredient for the detail:
Passionflower ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Extract + Acetaminophen, Codeine interactionAcetaminophen, Codeine, DoxylamineMersyndol
How Acetaminophen, Codeine, Doxylamine interacts with Add Lib — through 1 ingredient. Tap an ingredient for the detail:
Passionflower ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Extract + Acetaminophen, Codeine, Doxylamine interactionAcetaminophen, Codeine, MethocarbamolAcetaminophen, Codeine, Methocarbamol, Robaxacet 8
How Acetaminophen, Codeine, Methocarbamol interacts with Add Lib — through 1 ingredient. Tap an ingredient for the detail:
Passionflower ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Extract + Acetaminophen, Codeine, Methocarbamol interactionAcetaminophen, Dichloralantipyrine, IsomethepteneAmidrine, Midchlor, Migquin, Migratine
How Acetaminophen, Dichloralantipyrine, Isometheptene interacts with Add Lib — through 1 ingredient. Tap an ingredient for the detail:
Passionflower ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Extract + Acetaminophen, Dichloralantipyrine, Isometheptene interactionAcetaminophen, Dichloralphenazone, IsomethepteneMidrin
How Acetaminophen, Dichloralphenazone, Isometheptene interacts with Add Lib — through 1 ingredient. Tap an ingredient for the detail:
Passionflower ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Extract + Acetaminophen, Dichloralphenazone, Isometheptene interactionAcetaminophen, Dichlorophenazone, IsometheptaneIsocom
How Acetaminophen, Dichlorophenazone, Isometheptane interacts with Add Lib — through 1 ingredient. Tap an ingredient for the detail:
Passionflower ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Extract + Acetaminophen, Dichlorophenazone, Isometheptane interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with Add Lib — through 1 ingredient. Tap an ingredient for the detail:
Passionflower ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Extract + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with Add Lib — through 1 ingredient. Tap an ingredient for the detail:
Passionflower ExtractCns Depressants Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Extract + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, HydrocodoneAnexsia, Anodynos DHC, Azdone, Co-Gesic, Doucet, Lorcet +9 more
How Acetaminophen, Hydrocodone interacts with Add Lib — through 1 ingredient. Tap an ingredient for the detail:
Passionflower ExtractCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Read the full Passionflower Extract + Acetaminophen, Hydrocodone interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Add Lib with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Passionflower extract
Cns Depressants
Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Research in animals and humans shows that passion flower has sedative effects which can be additive when used with sedative medications like lorazepam.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
In vitro research suggests that passion flower can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
In vitro research shows that the passion flower constituents apigenin and vitexin inhibit OATP2B1 and OATP1A2. This inhibition may be dose-dependent. One specific high-flavonoid passion flower extract (Valverde) seems to inhibit OATP2B1 and OATP1A2, while another extract with a lower flavonoid concentration (Arkocaps) shows less potent inhibition. OATPs are responsible for the uptake of drugs and other compounds into the body; however, the specific activities of OATP2B1 and OATP1A2 are not well characterized.
Fenugreek seed extract
Anticoagulant/Antiplatelet Drugs
Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .
Antidiabetes Drugs
Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.
Clopidogrel (Plavix)
Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.
Metoprolol (Toprol)
Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.
Phenytoin (Dilantin)
Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.
Sildenafil (Viagra)
Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.
Theophylline
Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.
Warfarin (Coumadin)
Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.
Antihypertensive Drugs
Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.
Maitake extract
Antidiabetes Drugs
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.
Antihypertensive Drugs
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.
Warfarin (Coumadin)
There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.
Cordyceps sinensis extract
Anticoagulant/Antiplatelet Drugs
Theoretically, cordyceps may increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
In vitro and animal research suggests that cordyceps extract inhibits platelet aggregation and function. However, this interaction has not been reported in humans.
Immunosuppressants
Theoretically, concurrent use of cordyceps might interfere with immunosuppressive therapy.
Animal and in vitro research suggests that cordyceps stimulates the immune system. However, limited clinical research suggests that taking cordyceps may lower the necessary therapeutic dose of the immunosuppressant cyclosporine, which suggests that cordyceps may have an immunosuppressive effect.
Testosterone
Theoretically, concurrent use of cordyceps and testosterone might have additive effects.
Animal research suggests that cordyceps can increase testosterone levels. The clinical significance of this finding is unclear.
American Ginseng extract
Warfarin (Coumadin)
American ginseng seems to decrease the effectiveness of warfarin therapy.
Healthy patients receiving warfarin 5 mg daily, who also take American ginseng 1 gram twice daily, seem to have a significantly reduced international normalized ratio (INR).
Antidiabetes Drugs
Theoretically, taking American ginseng with antidiabetes drugs might increase the risk of hypoglycemia.
American ginseng seems to lower postprandial blood glucose. Theoretically, concomitant use with antidiabetes drugs might enhance blood glucose lowering effects and possibly cause hypoglycemia.
Immunosuppressants
Theoretically, American ginseng use might interfere with immunosuppressive therapy.
American ginseng seems to stimulate immune function. Theoretically, American ginseng might decrease the effectiveness of immunosuppressant drugs.
Monoamine Oxidase Inhibitors (Maois)
Theoretically, American ginseng can interfere with MAOI therapy.
There is one case report of insomnia, headache, and tremors when an unspecified ginseng product was used with phenelzine (Nardil), an MAOI. There is also one case report of hypomania when an unspecified ginseng product was used with phenelzine. Theoretically, American ginseng may interfere with MAOI therapy.
Damiana extract
Antidiabetes Drugs
Theoretically, taking damiana with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that taking damiana lowers blood glucose level.
Vitamin B12
Metformin (Glucophage)
Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.
Brand information
Manufacturer and brand details for Add Lib, from the product label.
Add Lib by Oceanus Naturals: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Add Lib’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Vitamin B12
Interacts with 20 drugsVitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...
Read the full Vitamin B12 monograph → Herb & supplement monographFenugreek
Interacts with 389 drugsFenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. Some early research is encouraging for blo...
Read the full Fenugreek monograph → Herb & supplement monographCordyceps
Interacts with 249 drugsCordyceps is a fungus used in traditional Chinese medicine for energy, exercise performance, and lung and immune support. Human research is limited and mostly low quality, so its benefits ar...
Read the full Cordyceps monograph → Herb & supplement monographMaitake Mushroom
Interacts with 260 drugsMaitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...
Read the full Maitake Mushroom monograph → Herb & supplement monographPassion Flower
Interacts with 836 drugsPassion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restlessness, but the evidence is limited and mo...
Read the full Passion Flower monograph → Herb & supplement monographAmerican Ginseng
Interacts with 217 drugsAmerican ginseng is an herbal root used as an 'adaptogen' to support energy, stress, immune function, and blood sugar. Some uses—such as reducing the chance or length of colds and modestly l...
Read the full American Ginseng monograph → Herb & supplement monographMaca
Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire and some menopause symptoms, but the evide...
Read the full Maca monograph → Herb & supplement monographDamiana
Interacts with 86 drugsDamiana is a traditional herb most famous as an aphrodisiac and mild mood-lifter, but solid human evidence for any of its uses is very limited. It is generally well tolerated in the small am...
Read the full Damiana monograph →Sources & How We Checked
Add Lib's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 116 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vitamin B12 30 references
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- Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
- Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
- Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
- Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
- Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
- Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
- Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
- Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
- Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
- Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
- Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
- Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
- Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
- Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
- Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
- Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
- Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
- Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
- Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
- Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
- Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
- Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
- Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
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- Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
- Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
- Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
- Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
- Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed
Fenugreek 30 references
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- Sharma RD, Raghuram TC, Rao NS. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutr 1990;44:301-6.
- Patil SP, Niphadkar PV, Bapat MM. Allergy to fenugreek (Trigonella foenum graecum). Ann Allergy Asthma Immunol 1997;78:297-300. PubMed
- Lambert J, Cormier J. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy 2001;21:509-12. PubMed
- Bordia A, Verma SK, Srivastava KC. Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty PubMed
- Yalcin SS, Tekinalp G, Ozalp I. Peculiar odor of traditional food and maple syrup urine disease. Pediatr Int 1999;41:108-9. PubMed
- Sewell AC, Mosandl A, Bohles H. False diagnosis of maple syrup urine disease owing to ingestion of herbal tea. N Engl J Med 1999;341:769.. PubMed
- Abdo MS, al-Kafawi AA. Experimental studies on the effect of Trigonella foenum-graecum (abstract). Planta Med 1969;17:14-8.
- Gupta A, Gupta R, Lal B. Effect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled study. J Assoc Physicians India 2001;49:1057-61.
- Gabay MP. Galactogogues: medications that induce lactation. J Hum Lact 2002;18:274-9. PubMed
- Chevassus H, Gaillard JB, Farret A, et al. A fenugreek seed extract selectively reduces spontaneous fat intake in overweight subjects. Eur J Clin Pharmacol 2010;66(5):449-55. PubMed
- Turkyilmaz C, Onal E, Hirfanoglu IM, et al. The effect of galactagogue herbal tea on breast milk production and short-term catch-up of birth weight in the first week of life. J Altern Complement Med 2011;17(2):139-42. PubMed
- Swafford S, Berens P. Effect of fenugreek on breast milk volume. Abstract presented at: 5th International Meeting of the Academy of Breastfeeding Medicine; September 11-13,2000, Tucson, Arizona.
- Abdel-Barry, J. A., Abdel-Hassan, I. A., Jawad, A. M., and al Hakiem, M. H. Hypoglycaemic effect of aqueous extract of the leaves of Trigonella foenum-graecum in healthy volunteers. East Mediterr.Health J 2000;6(1):83-88. DOI
- Parvizpur, A., Ahmadiani, A., and Kamalinejad, M. Probable role of spinal purinoceptors in the analgesic effect of Trigonella foenum (TFG) leaves extract. J Ethnopharmacol 3-8-2006;104(1-2):108-112. PubMed
- Mora, A., Herrrera, A., Lopez, C., Dahbi, G., Mamani, R., Pita, J. M., Alonso, M. P., Llovo, J., Bernardez, M. I., Blanco, J. E., Blanco, M., and Blanco, J. Characteristics of the Shiga-toxin-producing enteroaggregative Escherichia coli O104:H4 German ou
- Blanco, J. [Stx2a-producing enteroaggregative Escherichia coli O104:H4-ST678. Microbiological diagnostic already, for this and other STEC/VTEC serotypes!]. Enferm.Infecc.Microbiol.Clin. 2012;30(2):84-89.
- Beutin, L. and Martin, A. Outbreak of Shiga toxin-producing Escherichia coli (STEC) O104:H4 infection in Germany causes a paradigm shift with regard to human pathogenicity of STEC strains. J Food Prot. 2012;75(2):408-418. PubMed
- King LA, Nogareda F, Weill FX, Mariani-Kurkdjian P, Loukiadis E, Gault G, Jourdan-DaSilva N, Bingen E, Macé M, Thevenot D, Ong N, Castor C, Noël H, Van Cauteren D, Charron M, Vaillant V, Aldabe B, Goulet V, Delmas G, Couturier E, Le Strat Y, Combe C, Delm
- Reeder C, Legrand A, O'Connor-Von SK. The Effect of Fenugreek on Milk Production and Prolactin Levels in Mothers of Preterm Infants. Clinical Lactation 2013;4(4):159-165. DOI
- Al-Jenoobi FI, Ahad A, Mahrous GM, Al-Mohizea AM, AlKharfy KM, Al-Suwayeh SA. Effects of fenugreek, garden cress, and black seed on theophylline pharmacokinetics in beagle dogs. Pharm Biol 2015;53(2):296-300. PubMed
- Rao A, Steels E, Inder WJ, Abraham S, Vitetta L. Testofen, a specialised Trigonella foenum-graecum seed extract reduces age-related symptoms of androgen decrease, increases testosterone levels and improves sexual function in healthy aging males in a doubl
- Steels E, Rao A, Vitetta L. Physiological aspects of male libido enhanced by standardized Trigonella foenum-graecum extract and mineral formulation. Phytother Res. 2011 Sep;25(9):1294-300.
- Gong J, Fang K, Dong H, Wang D, Hu M, Lu F. Effect of fenugreek on hyperglycaemia and hyperlipidemia in diabetes and prediabetes: A meta-analysis. J Ethnopharmacol. 2016 Dec 24;194:260-268. PubMed
- Ouzir M, El Bairi K, Amzazi S. Toxicological properties of fenugreek (Trigonella foenum graecum). Food Chem Toxicol. 2016 Oct;96:145-54. PubMed
- Khodamoradi K, Khosropanah MH, Ayati Z, et al. The Effects of Fenugreek on Cardiometabolic Risk Factors in Adults: A Systematic Review and Meta-analysis. Complement Ther Med. 2020;52:102416. PubMed
- Alkharfy K, Jan B, Alotaibi K, et al. Clopidogrel-herb Interactions: A Pharmacokinetic and Pharmacodynamic Assessment in a Rat Model. Curr Drug Metab 2021;22(12):969-977. PubMed
- Bin Jardan YA, Ahad A, Raish M, Alam MA, Al-Mohizea AM, Al-Jenoobi FI. Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension. Pharm Biol 2021;59(1):1088-1097. PubMed
- Al-Mohizea AM, Ahad A, El-Maghraby GM, et al. Effects of Nigella sativa, Lepidium sativum and Trigonella foenum-graecum on sildenafil disposition in beagle dogs. Eur J Drug Metab Pharmacokinet. 2015;40(2):219-24. PubMed
- Alkharfy KM, Al-Jenoobi FI, Al-Mohizea AM, et al. Effects of Lepidium sativum, Nigella sativa and Trigonella foenum-graceum on phenytoin pharmacokinetics in beagle dogs. Phytother Res. 2013;27(12):1800-4.
Cordyceps 14 references
- Zhu JS, Halpern GM, Jones K. The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med 1998;4:289-303.
- Zhu JS, Halpern GM, Jones K. The scientific rediscovery of a precious ancient Chinese herbal regimen: Cordyceps sinensis: part II. J Altern Complement Med 1998;4:429-57.
- Chen YJ, Shiao MS, Lee SS, Wang SY. Effect of Cordyceps sinensis on the proliferation and differentiation of human leukemic U937 cells. Life Sci 1997;60:2349-59. PubMed
- Zhao Y. [Inhibitory effects of alcoholic extract of Cordyceps sinensis on abdominal aortic thrombus formation in rabbits]. Chung Hua I Hsueh Tsa Chih (Taipei) 1991;71:612-5, 42.
- Chen GZ, Chen GL, Sun T, et al. Effects of Cordyceps sinensis on murine T lymphocyte subsets. Chin Med J (English) 1991;104:4-8.
- Zhu XY, Yu HY. [Immunosuppressive effect of cultured Cordyceps sinensis on cellular immune response]. Chung Hsi I Chieh Ho Tsa Chih 1990;10:485-7, 454.
- Hsu, C. C., Huang, Y. L., Tsai, S. J., Sheu, C. C., and Huang, B. M. In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells. Life Sci 9-5-2003;73(16):2127-2136. PubMed
- Ikumoto, T., Sasaki, S., Namba, H., Toyama, R., Moritoki, H., and Mouri, T. [Physiologically active compounds in the extracts from tochukaso and cultured mycelia of Cordyceps and Isaria]. Yakugaku Zasshi 1991;111(9):504-509. PubMed
- Wu, T. N., Yang, K. C., Wang, C. M., Lai, J. S., Ko, K. N., Chang, P. Y., and Liou, S. H. Lead poisoning caused by contaminated Cordyceps, a Chinese herbal medicine: two case reports. Sci.Total Environ. 4-5-1996;182(1-3):193-195. PubMed
- Hong T, Zhang M, Fan J. Cordyceps sinensis (a traditional Chinese medicine) for kidney transplant recipients (Review). Cochrane Database Syst Rev. 2015;(10):CD009698. doi: 10.1002/14651858.CD009698.pub2.
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- Bee Yean O, Zoriah A. Efficacy of Cordyceps sinensis as an adjunctive treatment in hemodialysis patients: a systematic review and Meta-analysis. J Tradit Chin Med. 2019;39(1):1-14.
- Thurian D, Montani M, Stickel F. Drug-induced, mixed-type hepatitis following ingestion of Cordyceps sinensis. Int J Clin Pharmacol Ther 2022;60(2):115-120. PubMed
- Yu X, Mao Y, Shergis JL, et al. Effectiveness and safety of oral Cordyceps sinensis on stable COPD of GOLD stages 2-3: Systematic review and meta-analysis. Evid Based Complement Alternat Med. 2019;2019:4903671.
Maitake Mushroom 8 references
- Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
- Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
- Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
- Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
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