Abrocitinib and Morphine Sulfate Liposome: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 10, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Morphine Sulfate Liposome
No brand names on recordAbrocitinib
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
You've been prescribed morphine (a strong pain medicine) along with abrocitinib (Cibinqo, used for eczema). Abrocitinib can slow down a natural "pump" in your body that normally helps clear morphine. That means more morphine can build up, possibly close to double the usual amount.
With extra morphine around, you could feel more drowsy than expected, dizzy, or have slowed breathing. The good news is this is something your care team can manage. They may check on you more closely and adjust your dose if needed. Keep taking both as prescribed, and reach out right away if you feel unusually sleepy or have trouble breathing.
Effect: Abrocitinib is a P-gp inhibitor; morphine is a P-gp substrate. Inhibition of P-gp-mediated efflux may increase morphine exposure (approximately 2-fold), raising the risk of hypotension, respiratory depression, profound sedation, and coma.
Direction: Increased morphine effect (neither drug is a prodrug here).
- Onset: unspecified
- Evidence: theoretical
- Severity: major
Management: If coadministration is required, monitor for CNS and respiratory depression exceeding expectation. Decrease the dose of morphine and/or abrocitinib as clinically indicated, individualized by the care team.
What happens
Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profound sedation, coma)
Interaction Deep Dive
Taking morphine together with a P-gp inhibitor can raise morphine exposure (by roughly 2-fold), thereby heightening the likelihood of adverse effects such as depression of the respiratory system and CNS. Should the combination be necessary, watch for indications of CNS depression. Assess patients for respiratory depression that could exceed what would normally be anticipated, and reduce the dose of morphine and/or the P-gp inhibitor as needed1234.
Why it happens (mechanism)
Inhibition of P-gp-mediated efflux transport by morphine
How to manage this interaction
Your care team can manage this combination safely. Based on the documented guidance:
- Keep taking both exactly as prescribed unless your prescriber tells you otherwise.
- Your team may monitor you more closely for signs of too much morphine, especially drowsiness, confusion, and slowed breathing.
- The dose of morphine and/or abrocitinib may need to be adjusted and individualized by your care team.
Tell your pharmacist or doctor right away if you notice unusual sleepiness, very slow or shallow breathing, dizziness, or feeling faint. Ask your pharmacist to review this pairing when you fill either prescription.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Abrocitinib and Morphine Sulfate Liposome together?
Abrocitinib can raise morphine levels (about 2-fold) and increase the risk of excess sedation and slowed breathing, so watch for those signs and let your care team adjust the dose or monitor you more closely. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Abrocitinib and Morphine Sulfate Liposome interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Abrocitinib and Morphine Sulfate Liposome interaction managed?
Your care team can manage this combination safely. Based on the documented guidance: Keep taking both exactly as prescribed unless your prescriber tells you otherwise. Your team may monitor you more closely for signs of too much morphine, especially drowsiness, confusion, and slowed breathing. The dose of morphine and/or abrocitinib may need to be adjusted and individualized by your care team. Tel… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Abrocitinib or Morphine Sulfate Liposome need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (4)
- Product Information: MS CONTIN(R) oral extended-release tablets, morphine sulfate oral extended-release tablets. Purdue Pharma LP (per FDA), Stamford, CT, 2023. DailyMed
- Product Information: KADIAN(R) oral extended-release capsules, morphine sulfate oral extended-release capsules. Allergan USA, Inc (per FDA), Madison, NJ, 2019. DailyMed
- Product Information: Morphine sulfate oral solution, morphine sulfate oral solution. Hikma Pharmaceuticals USA Inc (per FDA), Berkeley Heights, NJ, 2023. DailyMed
- Product Information: Morphine sulfate oral tablets, morphine sulfate oral tablets. Hikma Pharmaceuticals USA Inc.(Per FDA), Berkeley, NJ, 2023. DailyMed
Keep reading about Morphine Sulfate Liposome
Keep reading about Abrocitinib
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