Acetaminophen And Codeine

Name: Acetaminophen And Codeine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

489 interactions 489 explained in plain English 313 cited references

Also sold as: Capital® & Codeine Codrix® Empracet® (#3, #4) Papa-deine® (#3, #4) Phenaphen® with Codeine (#2, #3, #4) Proval® #3 Tylenol with Codeine Tylenol® with Codeine (#3, #4)

About Acetaminophen And Codeine

The combination of acetaminophen and codeine is used to relieve mild to moderate pain. Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body. Codeine belongs to a class of medications cal… Read the full Acetaminophen And Codeine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 2, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Naltrexone Methylene Blue Mavorixafor Moclobemide Ozanimod Phenelzine

14 Contraindicated 444 Major 26 Moderate 5 Minor

All (489) Contraindicated (14) Major (444) Moderate (26) Minor (5)

Moderate

Acetaminophen And Codeine Warfarin Coumadin Explained An increased risk of bleeding Details Acetaminophen And Codeine Zidovudine Retrovir Explained Neutropenia; acetaminophen toxicity (hepatotoxicity) Details Acetaminophen And Codeine Cabbage Explained Decreased acetaminophen effectiveness Details Acetaminophen And Codeine Uric Acid Measurement Explained Falsely increased serum uric acid levels Details

Minor

Acetaminophen And Codeine Chloramphenicol Explained Chloramphenicol toxicity (vomiting, hypotension, hypothermia) Details Acetaminophen And Codeine Cholestyramine Prevalite Explained Decreased acetaminophen effectiveness Details Acetaminophen And Codeine Fenoldopam Explained Increased fenoldopam concentration Details Acetaminophen And Codeine Lamotrigine Lamictal Explained Decreased lamotrigine effectiveness Details Acetaminophen And Codeine Metyrapone Metopirone Explained An increased risk of acetaminophen toxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.