Acetaminophen And Codeine
489 interactions 489 explained in plain English 313 cited references
Also sold as:
Capital® & Codeine
Codrix®
Empracet® (#3, #4)
Papa-deine® (#3, #4)
Phenaphen® with Codeine (#2, #3, #4)
Proval® #3
Tylenol with Codeine
Tylenol® with Codeine (#3, #4)
About Acetaminophen And Codeine
The combination of acetaminophen and codeine is used to relieve mild to moderate pain. Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body. Codeine belongs to a class of medications cal… Read the full Acetaminophen And Codeine drug information page →
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 2, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Major
Acetaminophen And Codeine Venlafaxine Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Verapamil Calan Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Vilazodone Viibryd Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Vonoprazan Voquezna Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Voriconazole Vfend Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Vortioxetine Trintellix Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Voxelotor Oxbryta Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Xipamide Explained Reduced diuretic efficacy Details Acetaminophen And Codeine Zaleplon Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Ziprasidone Geodon Explained Increased risk for serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) and an increased risk of CNS... Details Acetaminophen And Codeine Zolmitriptan Zomig Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Zolpidem Ambien Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Zopiclone Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Zotepine Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Zuranolone Zurzuvae Explained An increased risk of CNS depression Details Acetaminophen And Codeine Ethanol Explained An increased risk of hepatotoxicity Details Acetaminophen And Codeine Grapefruit Juice Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Tobacco Explained Reduced CYP1A2 substrates exposure DetailsModerate
Acetaminophen And Codeine Acenocoumarol Explained Potentiation of anticoagulant effect Details Acetaminophen And Codeine Artemether Explained Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Acetaminophen And Codeine Brimonidine Alphagan Explained An increased risk of CNS depression Details Acetaminophen And Codeine Busulfan Busulfex Explained Reduced busulfan clearance Details Acetaminophen And Codeine Carbachol Isopto Carbachol Explained An increased risk of CNS depression Details Acetaminophen And Codeine Clonidine Duraclon Explained An increased risk of sedation and somnolence Details Acetaminophen And Codeine Desflurane Suprane Explained Reduced desflurane (MAC) exposure needed to produce anesthesia Details Acetaminophen And Codeine Desmopressin DDAVP Explained Increased risk of water intoxication with hyponatremia Details Acetaminophen And Codeine Diflunisal Dolobid Explained An increased risk of acetaminophen toxicity (hepatotoxicity) Details Acetaminophen And Codeine Ethinyl Estradiol Explained Increased ethinyl estradiol exposure and reduced acetaminophen exposure Details Acetaminophen And Codeine Fosphenytoin Cerebyx Explained Decreased acetaminophen effectiveness and an increased risk of hepatotoxicity Details Acetaminophen And Codeine Ganaxolone Ztalmy Explained An increased risk of somnolence and sedation Details Acetaminophen And Codeine Kava Explained Increased central nervous system depression Details Acetaminophen And Codeine Lixisenatide Explained Slowed absorption of acetaminophen Details Acetaminophen And Codeine Norethindrone Aygestin Explained Increased ethinyl estradiol exposure and reduced acetaminophen exposure Details Acetaminophen And Codeine Norgestimate Explained Increased ethinyl estradiol exposure and reduced acetaminophen exposure Details Acetaminophen And Codeine Phenytoin Dilantin Explained Decreased acetaminophen effectiveness and an increased risk of hepatotoxicity Details Acetaminophen And Codeine Piperaquine Explained Reduced exposure of CYP2E1 substrates Details Acetaminophen And Codeine Rilzabrutinib Wayrilz Explained Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details Acetaminophen And Codeine Sevoflurane Petrem Explained Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Acetaminophen And Codeine Sulfinpyrazone Explained Increased hepatotoxicity in acetaminophen overdose Details Acetaminophen And Codeine Valerian Explained Additive central nervous system depression DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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