Acetaminophen And Codeine

489 interactions 489 explained in plain English 313 cited references
Also sold as: Capital® & Codeine Codrix® Empracet® (#3, #4) Papa-deine® (#3, #4) Phenaphen® with Codeine (#2, #3, #4) Proval® #3 Tylenol with Codeine Tylenol® with Codeine (#3, #4)
About Acetaminophen And Codeine

The combination of acetaminophen and codeine is used to relieve mild to moderate pain. Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body. Codeine belongs to a class of medications cal… Read the full Acetaminophen And Codeine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 2, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Naltrexone Methylene Blue Mavorixafor Moclobemide Ozanimod Phenelzine
14 Contraindicated 444 Major 26 Moderate 5 Minor
All (489) Contraindicated (14) Major (444) Moderate (26) Minor (5)

Major

Acetaminophen And Codeine Tedizolid Phosphate Sivextro Explained An increased risk of serotonin syndrome Details Acetaminophen And Codeine Telaprevir Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Telithromycin Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Telotristat Ethyl Xermelo Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Acetaminophen And Codeine Temazepam Restoril Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Acetaminophen And Codeine Terodiline Explained An increased risk of paralytic ileus Details Acetaminophen And Codeine Tetrazepam Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Acetaminophen And Codeine Thiethylperazine Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Thiopental Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Thiopropazate Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Thioridazine Explained Reduced codeine and morphine exposure, increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Thiothixene Explained An increased risk of paralytic ileus Details Acetaminophen And Codeine Tianeptine Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Ticagrelor Brilinta Explained Reduced absorption of ticagrelor Details Acetaminophen And Codeine Tilidine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Acetaminophen And Codeine Tiotropium Explained An increased risk of paralytic ileus Details Acetaminophen And Codeine Tipranavir Aptivus Explained Increased codeine exposure and reduced active metabolite (morphine) exposure Details Acetaminophen And Codeine Tizanidine Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus, increased risk of profound sedation, re... Details Acetaminophen And Codeine Tolonium Chloride Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Tolterodine Detrol Explained An increased risk of paralytic ileus Details Acetaminophen And Codeine Topiramate Eprontia Explained Increased risk of CNS depression and reduced codeine exposure Details Acetaminophen And Codeine Torsemide Soaanz Explained Reduced diuretic efficacy Details Acetaminophen And Codeine Tramadol ConZip Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Acetaminophen And Codeine Trazodone Raldesy Explained An increased risk of serotonin syndrome and an increased risk of CNS depression Details Acetaminophen And Codeine Triamterene Dyrenium Explained Reduced diuretic efficacy Details Acetaminophen And Codeine Triazolam Halcion Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Acetaminophen And Codeine Trichlormethiazide Explained Reduced diuretic efficacy Details Acetaminophen And Codeine Trifluoperazine Explained Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Trifluperidol Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Triflupromazine Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Trihexyphenidyl Explained An increased risk of paralytic ileus Details Acetaminophen And Codeine Trimeprazine Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Trimipramine Explained Increased risk of paralytic ileus; increased risk of serotonin syndrome Details Acetaminophen And Codeine Trofinetide Daybue Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Troleandomycin Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Tropicamide Mydriacyl Explained An increased risk of paralytic ileus Details Acetaminophen And Codeine Trospium Explained An increased risk of paralytic ileus Details Acetaminophen And Codeine Tryptophan Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Tucatinib Tukysa Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Umeclidinium Explained An increased risk of paralytic ileus Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.