Acetaminophen And Codeine

489 interactions 489 explained in plain English 313 cited references

Also sold as: Capital® & Codeine Codrix® Empracet® (#3, #4) Papa-deine® (#3, #4) Phenaphen® with Codeine (#2, #3, #4) Proval® #3 Tylenol with Codeine Tylenol® with Codeine (#3, #4)

About Acetaminophen And Codeine

The combination of acetaminophen and codeine is used to relieve mild to moderate pain. Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body. Codeine belongs to a class of medications cal… Read the full Acetaminophen And Codeine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 2, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Naltrexone Methylene Blue Mavorixafor Moclobemide Ozanimod Phenelzine

14 Contraindicated 444 Major 26 Moderate 5 Minor

All (489) Contraindicated (14) Major (444) Moderate (26) Minor (5)

Major

Acetaminophen And Codeine Propofol Diprivan Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Protriptyline Explained Increased risk of paralytic ileus; increased risk of serotonin syndrome Details Acetaminophen And Codeine Quazepam Doral Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Acetaminophen And Codeine Quetiapine Seroquel Explained Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Quinethazone Explained Reduced diuretic efficacy Details Acetaminophen And Codeine Quinine Explained Increased codeine exposure and reduced active metabolite (morphine) exposure Details Acetaminophen And Codeine Ramelteon Rozerem Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Ranitidine Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Ranolazine Aspruzyo Explained Increased codeine exposure Details Acetaminophen And Codeine Relacorilant Lifyorli Explained Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse reactions Details Acetaminophen And Codeine Remifentanil Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Acetaminophen And Codeine Remimazolam Byfavo Explained Increased risk of profound sedation, respiratory depression, coma, and death Details Acetaminophen And Codeine Remoxipride Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Ribociclib Kisqali Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Rifabutin Mycobutin Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Acetaminophen And Codeine Rifampin Rifadin Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Acetaminophen And Codeine Rifapentine Priftin Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Acetaminophen And Codeine Ritlecitinib Litfulo Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Ritonavir Norvir Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Rizatriptan Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Rolapitant Varubi Explained Increased codeine exposure and reduced active metabolite (morphine) exposure Details Acetaminophen And Codeine Ropeginterferon Alfa-2B-Njft Besremi Explained Increased risk of sedation Details Acetaminophen And Codeine Saquinavir Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Schisandra Sphenanthera Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Scopolamine Pamine Explained Increased or potentiated scopolamine effects, an increased risk of CNS depression and an increased risk of paralytic ileus Details Acetaminophen And Codeine Secobarbital Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Sertindole Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Sertraline Explained Increased risk of serotonin syndrome, increased codeine exposure and reduced active metabolite (morphine) exposure Details Acetaminophen And Codeine Sibutramine Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Sodium Oxybate Lumryz Explained An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Acetaminophen And Codeine Solifenacin Vesicare Explained An increased risk of paralytic ileus Details Acetaminophen And Codeine Spironolactone Aldactone Explained Reduced diuretic efficacy Details Acetaminophen And Codeine St John's Wort Explained Reduced opioid efficacy, precipitation of opioid withdrawal, and an increased risk of serotonin syndrome Details Acetaminophen And Codeine Stramonium Explained An increased risk of paralytic ileus Details Acetaminophen And Codeine Sufentanil Dsuvia Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Acetaminophen And Codeine Sulpiride Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Sumatriptan Imitrex Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Suvorexant Belsomra Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Tapentadol Nucynta Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Acetaminophen And Codeine Tazemetostat Tazverik Explained Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.