Acetaminophen And Codeine

489 interactions 489 explained in plain English 313 cited references

Also sold as: Capital® & Codeine Codrix® Empracet® (#3, #4) Papa-deine® (#3, #4) Phenaphen® with Codeine (#2, #3, #4) Proval® #3 Tylenol with Codeine Tylenol® with Codeine (#3, #4)

About Acetaminophen And Codeine

The combination of acetaminophen and codeine is used to relieve mild to moderate pain. Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body. Codeine belongs to a class of medications cal… Read the full Acetaminophen And Codeine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 2, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Naltrexone Methylene Blue Mavorixafor Moclobemide Ozanimod Phenelzine

14 Contraindicated 444 Major 26 Moderate 5 Minor

All (489) Contraindicated (14) Major (444) Moderate (26) Minor (5)

Major

Acetaminophen And Codeine Oxycodone Oxaydo Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Acetaminophen And Codeine Oxymorphone Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Acetaminophen And Codeine Palbociclib Ibrance Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Paliperidone Erzofri Explained An increased risk of CNS depression Details Acetaminophen And Codeine Palonosetron Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Papaveretum Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Acetaminophen And Codeine Paregoric Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Acetaminophen And Codeine Paritaprevir Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Paroxetine Paxil Explained Increased risk of paralytic ileus, an increased risk of serotonin syndrome, an increased codeine exposure and reduced active metab... Details Acetaminophen And Codeine Pentazocine Explained Reduced analgesic effect and/or precipitation of withdrawal symptoms, an increased risk of serotonin syndrome and an increased ris... Details Acetaminophen And Codeine Pentobarbital Fatal-Plus Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Perampanel FYCOMPA Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Perazine Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Periciazine Explained Risk of enhanced CNS depression Details Acetaminophen And Codeine Perphenazine Explained Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Phenobarbital Fidoquel Explained Increased risk of CNS depression and reduced codeine exposure Details Acetaminophen And Codeine Pimozide Explained Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Pinazepam Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Acetaminophen And Codeine Pipenzolate Bromide Explained An increased risk of paralytic ileus Details Acetaminophen And Codeine Piperacetazine Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Pipotiazine Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Pirenzepine Explained An increased risk of paralytic ileus Details Acetaminophen And Codeine Piretanide Explained Reduced diuretic efficacy Details Acetaminophen And Codeine Piritramide Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Acetaminophen And Codeine Pixantrone Explained Increased CYP1A2 substrate exposure Details Acetaminophen And Codeine Pneumococcal 13-Valent Vaccine, Diphtheria Conjugate Explained An inadequate immunologic response to the vaccine Details Acetaminophen And Codeine Polythiazide Explained Reduced diuretic efficacy Details Acetaminophen And Codeine Posaconazole Noxafil Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Potassium Oxybate Xywav Explained An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Acetaminophen And Codeine Prazepam Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Acetaminophen And Codeine Prednisone Deltasone Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Acetaminophen And Codeine Pregabalin Bonqat Explained An increased risk of respiratory depression Details Acetaminophen And Codeine Primidone Mysoline Explained Increased risk of CNS depression and reduced codeine exposure Details Acetaminophen And Codeine Probenecid Explained Increased risk of acetaminophen exposure and an increased risk of acetaminophen-related adverse reactions Details Acetaminophen And Codeine Prochlorperazine Explained Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Procyclidine Explained An increased risk of paralytic ileus Details Acetaminophen And Codeine Promazine Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Promethazine Phenadoz Explained Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Propantheline Probanthine Explained An increased risk of paralytic ileus Details Acetaminophen And Codeine Propiverine Explained An increased risk of paralytic ileus Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.