Acetaminophen And Codeine

489 interactions 489 explained in plain English 313 cited references

Also sold as: Capital® & Codeine Codrix® Empracet® (#3, #4) Papa-deine® (#3, #4) Phenaphen® with Codeine (#2, #3, #4) Proval® #3 Tylenol with Codeine Tylenol® with Codeine (#3, #4)

About Acetaminophen And Codeine

The combination of acetaminophen and codeine is used to relieve mild to moderate pain. Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body. Codeine belongs to a class of medications cal… Read the full Acetaminophen And Codeine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 2, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Naltrexone Methylene Blue Mavorixafor Moclobemide Ozanimod Phenelzine

14 Contraindicated 444 Major 26 Moderate 5 Minor

All (489) Contraindicated (14) Major (444) Moderate (26) Minor (5)

Major

Acetaminophen And Codeine Methylprednisolone Depo-Medrol Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Acetaminophen And Codeine Metoclopramide Explained Increased risk of CNS depression Details Acetaminophen And Codeine Metolazone Explained Reduced diuretic efficacy Details Acetaminophen And Codeine Midazolam Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Acetaminophen And Codeine Mifepristone Korlym Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Milnacipran Savella Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Mirabegron Myrbetriq Explained Increased codeine exposure and reduced active metabolite (morphine) exposure Details Acetaminophen And Codeine Mirtazapine Mirataz Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Mitotane Lysodren Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Acetaminophen And Codeine Mobocertinib Exkivity Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Acetaminophen And Codeine Modafinil Provigil Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Acetaminophen And Codeine Molindone Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Moricizine Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Morphine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Acetaminophen And Codeine Morphine Sulfate Liposome Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Acetaminophen And Codeine Nafcillin Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Acetaminophen And Codeine Nalbuphine Explained Reduced analgesic effect and/or precipitation of withdrawal symptoms, an increased risk of serotonin syndrome and an increased ris... Details Acetaminophen And Codeine Naratriptan Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Nefazodone Explained Increased codeine and morphine exposure and an increased risk of serotonin syndrome Details Acetaminophen And Codeine Nelfinavir Viracept Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Netupitant Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Nevirapine Viramune Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Acetaminophen And Codeine Nicomorphine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Acetaminophen And Codeine Nilotinib Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Nitrazepam Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Acetaminophen And Codeine Nitrous Oxide Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Nordazepam Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Acetaminophen And Codeine Nortriptyline Explained Increased risk of paralytic ileus; increased risk of serotonin syndrome Details Acetaminophen And Codeine Olanzapine Explained Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Oliceridine Olinvyk Explained Increased risk of serotonin syndrome, an increased risk of hypotension, profound sedation, respiratory depression, coma and death Details Acetaminophen And Codeine Omaveloxolone Skyclarys Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Acetaminophen And Codeine Ondansetron Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Opipramol Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Opium Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Acetaminophen And Codeine Opium Alkaloids Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Acetaminophen And Codeine Orphenadrine Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus, increased risk of profound sedation, re... Details Acetaminophen And Codeine Oxazepam Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Acetaminophen And Codeine Oxcarbazepine Oxtellar Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Acetaminophen And Codeine Oxitropium Bromide Explained An increased risk of paralytic ileus Details Acetaminophen And Codeine Oxybutynin Ditropan Explained An increased risk of paralytic ileus Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.