Acetaminophen And Codeine

489 interactions 489 explained in plain English 313 cited references
Also sold as: Capital® & Codeine Codrix® Empracet® (#3, #4) Papa-deine® (#3, #4) Phenaphen® with Codeine (#2, #3, #4) Proval® #3 Tylenol with Codeine Tylenol® with Codeine (#3, #4)
About Acetaminophen And Codeine

The combination of acetaminophen and codeine is used to relieve mild to moderate pain. Acetaminophen is in a class of medications called analgesics (pain relievers) and antipyretics (fever reducers). It works by changing the way the body senses pain and by cooling the body. Codeine belongs to a class of medications cal… Read the full Acetaminophen And Codeine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 2, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Naltrexone Methylene Blue Mavorixafor Moclobemide Ozanimod Phenelzine
14 Contraindicated 444 Major 26 Moderate 5 Minor
All (489) Contraindicated (14) Major (444) Moderate (26) Minor (5)

Major

Acetaminophen And Codeine Levodopa Inbrija Explained An increased risk of CNS depression Details Acetaminophen And Codeine Levomilnacipran Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Levorphanol Xyvona Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Acetaminophen And Codeine Lidocaine Akten Explained An increased risk of methemoglobinemia Details Acetaminophen And Codeine Lisdexamfetamine Arynta Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Lithium Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Lofepramine Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Lofexidine Explained Increased risk of CNS depressant effects Details Acetaminophen And Codeine Lomitapide Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Lonafarnib Zokinvy Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Loprazolam Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Acetaminophen And Codeine Lorazepam Ativan Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Acetaminophen And Codeine Lorcaserin Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Lorlatinib Lorbrena Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Acetaminophen And Codeine Lormetazepam Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Acetaminophen And Codeine Loxapine Adasuve Explained Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Lumacaftor Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Acetaminophen And Codeine Lumefantrine Explained Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse reactions Details Acetaminophen And Codeine Magnesium Oxybate Xywav Explained An increased risk of CNS depression and clinically significant respiratory depression, obtundation, hypotension, profound sedation... Details Acetaminophen And Codeine Maribavir Livtencity Explained Increased codeine and morphine exposure Details Acetaminophen And Codeine Mavacamten Camzyos Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Acetaminophen And Codeine Meclizine Antivert Explained Increased risk of paralytic ileus and an increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Medazepam Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Acetaminophen And Codeine Melitracen Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Melperone Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Mepenzolate Explained An increased risk of paralytic ileus Details Acetaminophen And Codeine Meperidine Demerol Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Acetaminophen And Codeine Mephobarbital Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Meprobamate Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Meptazinol Explained An increased risk of hypotension, respiratory depression, profound sedation, coma and reduced analgesic effect or precipitation of... Details Acetaminophen And Codeine Mesoridazine Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Metaclazepam Explained An increased risk of hypotension, respiratory depression, profound sedation, coma, and death Details Acetaminophen And Codeine Metaxalone Skelaxin Explained Increased risk of serotonin syndrome, an increased risk of respiratory depression and an increased risk of CNS depression Details Acetaminophen And Codeine Methadone Diskets Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Acetaminophen And Codeine Methamphetamine Desoxyn Explained Increased risk of serotonin syndrome Details Acetaminophen And Codeine Methdilazine Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Methocarbamol Atmeksi Explained Increased risk of profound sedation, respiratory depression, coma and death Details Acetaminophen And Codeine Methohexital Brevital Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Methotrimeprazine Explained An increased risk of respiratory and CNS depression Details Acetaminophen And Codeine Methyclothiazide Explained Reduced diuretic efficacy Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.