Acetaminophen Injection

28 interactions 489 cited references
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About Acetaminophen Injection

Acetaminophen injection is a pain reliever and fever reducer used to treat mild to moderate pain and fever, or severe pain when combined with opioids. Read the full Acetaminophen Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Articaine Carbamazepine Exenatide Flucloxacillin Imatinib Isoniazid
10 Major 13 Moderate 5 Minor
All (28) Major (10) Moderate (13) Minor (5)

Major

Acetaminophen Injection Articaine An increased risk of methemoglobinemia Details Acetaminophen Injection Carbamazepine Carbatrol An increased risk of acetaminophen hepatotoxicity and reduced acetaminophen exposure Details Acetaminophen Injection Exenatide Bydureon Reduced oral acetaminophen absorption and reduced efficacy of oral acetaminophen Details Acetaminophen Injection Flucloxacillin An increased risk of high anion gap metabolic acidosis (HAGMA) Details Acetaminophen Injection Imatinib Gleevec Increased acetaminophen levels Details Acetaminophen Injection Isoniazid An increased risk of hepatotoxicity Details Acetaminophen Injection Lidocaine Akten An increased risk of methemoglobinemia Details Acetaminophen Injection Pixantrone Increased CYP1A2 substrate exposure Details Acetaminophen Injection Pneumococcal 13-Valent Vaccine, Diphtheria Conjugate An inadequate immunologic response to the vaccine Details Acetaminophen Injection Probenecid Increased risk of acetaminophen exposure and an increased risk of acetaminophen-related adverse reactions Details

Moderate

Acetaminophen Injection Acenocoumarol Potentiation of anticoagulant effect Details Acetaminophen Injection Busulfan Busulfex Reduced busulfan clearance Details Acetaminophen Injection Diflunisal Dolobid An increased risk of acetaminophen toxicity (hepatotoxicity) Details Acetaminophen Injection Ethinyl Estradiol Increased ethinyl estradiol exposure and reduced acetaminophen exposure Details Acetaminophen Injection Fosphenytoin Cerebyx Decreased acetaminophen effectiveness and an increased risk of hepatotoxicity Details Acetaminophen Injection Lixisenatide Slowed absorption of acetaminophen Details Acetaminophen Injection Norethindrone Aygestin Increased ethinyl estradiol exposure and reduced acetaminophen exposure Details Acetaminophen Injection Norgestimate Increased ethinyl estradiol exposure and reduced acetaminophen exposure Details Acetaminophen Injection Phenytoin Dilantin Decreased acetaminophen effectiveness and an increased risk of hepatotoxicity Details Acetaminophen Injection Piperaquine Reduced exposure of CYP2E1 substrates Details Acetaminophen Injection Sulfinpyrazone Increased hepatotoxicity in acetaminophen overdose Details Acetaminophen Injection Warfarin Coumadin An increased risk of bleeding Details Acetaminophen Injection Zidovudine Retrovir Neutropenia; acetaminophen toxicity (hepatotoxicity) Details

Minor

Acetaminophen Injection Chloramphenicol Chloramphenicol toxicity (vomiting, hypotension, hypothermia) Details Acetaminophen Injection Cholestyramine Prevalite Decreased acetaminophen effectiveness Details Acetaminophen Injection Fenoldopam Increased fenoldopam concentration Details Acetaminophen Injection Lamotrigine Lamictal Decreased lamotrigine effectiveness Details Acetaminophen Injection Metyrapone Metopirone An increased risk of acetaminophen toxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.