Acetaminophen Injection

Name: Acetaminophen Injection Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

28 interactions 489 cited references

Also sold as: Acephen Anacin AF Bactimicina Cetafen Comtrex Sore Throat Relief CounterAct Pain Feverall Little Fevers Mapap Nortemp Ofirmev® Panadol Pharbetol Redutemp Ringl Tactinal Tempra Quicklets Tycolene Tylenol Tylenol Gelcap Extra Strength

About Acetaminophen Injection

Acetaminophen injection is a pain reliever and fever reducer used to treat mild to moderate pain and fever, or severe pain when combined with opioids. Read the full Acetaminophen Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Articaine Carbamazepine Exenatide Flucloxacillin Imatinib Isoniazid

10 Major 13 Moderate 5 Minor

All (28) Major (10) Moderate (13) Minor (5)

Minor

Acetaminophen Injection Chloramphenicol Chloramphenicol toxicity (vomiting, hypotension, hypothermia) Details Acetaminophen Injection Cholestyramine Prevalite Decreased acetaminophen effectiveness Details Acetaminophen Injection Fenoldopam Increased fenoldopam concentration Details Acetaminophen Injection Lamotrigine Lamictal Decreased lamotrigine effectiveness Details Acetaminophen Injection Metyrapone Metopirone An increased risk of acetaminophen toxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.